Restrictive Limits Research Articles

Artificial intelligence in routine blood tests

Routine blood tests drive diagnosis, prognosis, and monitoring in traditional clinical decision support systems. As a routine diagnostic tool with standardized laboratory workflows, clinical blood analysis offers superior accessibility to a comprehensive assessment of physiological parameters. These parameters can be integrated and automated at scale, allowing for in-depth clinical inference and cost-effectiveness compared to other modalities such as imaging, genetic testing, or histopathology. Herein, we extensively review the analytical value of routine blood tests leveraged by artificial intelligence (AI), using the ICD-10 classification as a reference. A significant gap exists between standard disease-associated features and those selected by machine learning models. This suggests an amount of non-perceived information in traditional decision support systems that AI could leverage with improved performance metrics. Nonetheless, AI-derived support for clinical decisions must still be harmonized regarding external validation studies, regulatory approvals, and clinical deployment strategies. Still, as we discuss, the path is drawn for the future application of scalable artificial intelligence (AI) to enhance, extract, and classify patterns potentially correlated with pathological states with restricted limitations in terms of bias and representativeness.

Enhancing urban wastewater treatment: Chlorella vulgaris performance in tertiary treatment and the impact of anaerobic digestate addition

The rising urban wastewater discharge into waterways resulted in harmful environmental effects. Microalgae can bioremediate wastewaters by removing contaminants such as nitrogen and phosphorus and can be rather tolerant to toxic compounds. Managing the anaerobic digestate resulting from sludge treatment in wastewater treatment plants faces some obstacles related to its high contaminant content. This work aims to study the ability of the microalga Chlorella vulgaris to perform the tertiary treatment of urban wastewater, assessing its growth, nutrient removal and the effect of the addition of digestate at different concentrations in this treatment phase. A secondary effluent was supplied with 1% (M1), 5% (M5) and 10% (M10) (v/v) of anaerobic digestate and used to culture microalgae. An assay using only secondary effluent was also performed (S). C. vulgaris grew successfully in all effluents except for the M10, and the highest specific growth rate was obtained in the M1 assay, 0.35 ± 0.01 d−1. Ammonium-nitrogen was completely removed in the S, M1 and M5 assays (>99.9%). Microalgae successfully removed phosphate-phosphorus from the tested effluents, achieving a negligible concentration in the M1 assay and a removal efficiency of 96.2 ± 0.2%, 51 ± 2%, and 43 ± 3% in S, M5 and M10, respectively. These results showed that microalgal cultures could efficiently remediate the secondary effluent and its mixture with 1% (v/v) of anaerobic digestate, achieving nutrient concentrations below the current legislation limits and the more restrictive limits predicted for future legislation.

Macronutrients, metals, and metalloid concentrations in non-industrial wood ash in relation to provincial land application limits in Ontario, Canada

Non-industrial wood ash (NIWA) provided by residents who heat with wood, is rich in base-cations and other nutrients and may be used as a forest soil amendment to return nutrients lost through acid deposition. However, due to concerns regarding high trace metal concentrations, most wood ash is landfilled in Canada. This study investigated the chemical variability of NIWA of individual samples and homogenized mixtures to determine if they met Ontario provincial trace metal restriction limits. One hundred and seven ash and 10 charcoal samples collected from residents of Muskoka, Ontario, and three 10-sample composites were analyzed. Chemical composition varied among individual samples, but nutrient levels were within or higher than reported ranges for industrial wood ash, while trace metal values were lower. Ninety-seven percent (104 of 107) of the samples were within Ontario Regulation 267/03 of the Nutrient Management Act, and after homogenization, all samples were below soil application restriction limits. This study indicates that NIWA can be safely used as a forest soil amendment but recommends routine testing of batch samples prior to application.

Exome sequencing identifies ADGRG4 G-protein-coupled receptors gene as a novel cancer biomarker in ovarian cancer patients from North India.

Adhesion G protein-coupled receptor G4 (ADGRG4) is a G protein-coupled receptor (GPCR) that belongs to the adhesion family. Participation of ADGRG4 in cell adhesion and migration, signaling pathway activation, influence on angiogenesis, and modulation of immune responses are some of the possible ways through which it may contribute to oncogenesis. Conducting extensive omics studies poses budgetary challenges to small labs in peripheral areas, primarily due to restricted research funding and resource limitations. Here we propose a low-budget model for biomarker screening. A total of 11 ovarian cancer samples were sent for exome sequencing. Among various genes, ADGRG4 variants were present in all 11 samples and thus were chosen as a potential biomarker in the present population. However, the precise role of ADGRG4 in cancer is not fully understood. The present study aims to look at the association between the ADGRG4 gene variants and their risk of ovarian cancer in the North Indian region of Jammu and Kashmir, India. Overall, 235 individuals (115 cases and 120 healthy controls) were genotyped for the selected biomarker using Sanger sequencing. Logistic regression was used to assess the relationship between the variant and ovarian cancer. A statistically significant association was identified between the ADGRG4 variant rs5930932 polymorphism and the incidence of ovarian cancer among the study population. When corrected for age and BMI, the dominating OR of variant rs5930932 was 1.035 (1.003-1.069) under HWE patients (0.95) and controls (0.18), with a p-value of (0.03). According to the findings of the current investigation, the ADGRG4 gene variant rs5930932 increases the chance of developing ovarian cancer in the studied population.

Carving out a Glycoside Hydrolase Active Site for Incorporation into a New Protein Scaffold Using Deep Network Hallucination.

Enzymes are indispensable biocatalysts for numerous industrial applications, yet stability, selectivity, and restricted substrate recognition present limitations for their use. Despite the importance of enzyme engineering in overcoming these limitations, success is often challenged by the intricate architecture of enzymes derived from natural sources. Recent advances in computational methods have enabled the de novo design of simplified scaffolds with specific functional sites. Such scaffolds may be advantageous as platforms for enzyme engineering. Here, we present a strategy for the de novo design of a simplified scaffold of an endo-α-N-acetylgalactosaminidase active site, a glycoside hydrolase from the GH101 enzyme family. Using a combination of trRosetta hallucination, iterative cycles of deep-learning-based structure prediction, and ProteinMPNN sequence design, we designed proteins with 290 amino acids incorporating the active site while reducing the molecular weight by over 100 kDa compared to the initial endo-α-N-acetylgalactosaminidase. Of 11 tested designs, six were expressed as soluble monomers, displaying similar or increased thermostabilities compared to the natural enzyme. Despite lacking detectable enzymatic activity, the experimentally determined crystal structures of a representative design closely matched the design with a root-mean-square deviation of 1.0 Å, with most catalytically important side chains within 2.0 Å. The results highlight the potential of scaffold hallucination in designing proteins that may serve as a foundation for subsequent enzyme engineering.

An autonomous ore packing system through deep reinforcement learning

In the contemporary era, the limited availability of terrestrial resources has prompted an increasing number of nations to turn their attention towards space, wherein extraterrestrial minerals hold considerable allure for both resource provisioning and scientific inquiry. Numerous nations have initiated the deployment of unmanned operational platforms towards extraterrestrial asteroids with the objective of accomplishing sampling return missions. Given the restricted storage capacity and energy limitations of these platforms, the optimization of mineral placement algorithms assumes paramount importance in enhancing the efficacy of these missions. In this paper, we propose an autonomous ore packing system capable of autonomously measuring ore characteristics and addressing the ore packing optimization problem in extraterrestrial unfamiliar environments. A deep reinforcement learning method that utilizes physical constraints to enhance overall performance was proposed to solve the ore packing problem with uncertainty, while meeting the high demands for real-time performance in the mission. To augment the autonomy and adaptability of our approach, we leverage advanced visual technology to transform the spatial distribution of bin utilization and the characteristics of the ore into a matrix representation. This empowers the robotic system to autonomously perceive bin information and capture essential ore features. The empirical findings substantiate that our algorithm attains a human-level performance in the majority of instances, rendering an approximate optimal solution within a concise timeframe. Additionally, we introduce a novel reinforcement learning training technique known as Maximum Worth Reinforcement Learning (MWRL) to address the optimization conundrum associated with incomplete Markov chains, which outperforms existing approaches in our comparative analysis. Lastly, we validate the efficacy of our algorithm in real-world scenarios by deploying it on a robotic manipulator.

Ghana’s Health Professions Regulatory Bodies Act, 2013 (Act 857) and its Adequacy in Governing Healthcare Delivery and Medical Negligence Issues

Ghana instituted the Health Professions Regulatory Bodies Act, 2013 (Act 857) as landmark legislation seeking to enhance accountability, quality, and ethics in healthcare delivery through establishment of Regulatory Councils governing licensing, practice standards, continuing education and discipline across doctors, nurses, pharmacists and allied health professions. This analysis evaluates adequacies and shortcomings in Act 857’s frameworks to uphold standards of care and address medical negligence five years post-enactment. Progress is visible in standardized licensing protocols enabling oversight on practitioner competence via license issuance premised on education levels cleared by exams and checks. Channeling complaints through uniform procedures and linking license retention to ethical practice foster transparency. However, Act 857 falls short on comprehensively governing healthcare delivery systems issues beyond workforce such as infrastructure standards and access inequities exacerbating quality limitations and negligence risks. Narrow focus on professional self-regulation also constrains capacities to fully enforce broader quality benchmarks relating patient experience, technology support etc. Additionally, while intending to elevate conduct, complainant-driven procedures and restrictive litigation limitation periods instituted constrain efficacies in optimizing deterrence, accountability and access to justice for victims of medical negligence. Considerable legislative reforms are imperative to institute unified healthcare infrastructure standards and access equity provisions while rebalancing laws to enable equitable patient protections when harmed by substandard care. Implementation strategies also require realignment, beyond workforce to system-wide accountability, to actualize healthcare delivery enhancement goals via Act 857.

Pore-network modelling of transverse dispersion in porous media under non-Darcy flow conditions

This work is concerned, for the first time, with estimating the transverse dispersion coefficient under non-Darcy laminar flow conditions in porous media using pore-network modeling. The pore-network modelling approach and the mixed cell method are adopted to simulate both the steady laminar flow and the transient transport of solute for Berea and Bentheimer sandstone samples. For non-Darcy flow, the inertial effect is attributed to the quadratic increase of the pore throat mean velocity, which is embedded in the pressure head losses at either expansion or contraction located at the two ends of any pore throat. A time dependent function, based on both Péclet number and average residence time within the pore throat, is used to incorporate the effect of nonuniform pore throat velocity in the dispersion coefficient. A restrictive upper limit of the time step interval is introduced to prevent numerical overshoots of the concentrations calculated over time. For the same pressure gradient through the sample, the results show a decrease in both Péclet number and the coefficient of transverse dispersion in case of adopting the non-Darcy flow condition instead of the Darcy flow one. The percentage of decrease is up to 20 % for the maximum applied pressure gradient through the sample.

A scoping review of E-scooter safety: Delightful urban slalom or injury epidemic?

IntroductionE-scooters are a convenient, relatively inexpensive and fun new mode of transportation with rapidly increased use in cities throughout the world. Despite the popularity of e-scooters, increases in rider injuries and fatalities have become a public health concern. Objective. To characterize the types of safety issues associated with e-scooter use. Methods. Scoping review methods focused on any safety issues associated with the use of dockless, stand-up, motorized, electric kick scooters from companies offering short-term rentals or through private ownership, published in English between January 2017 and March 2022. Databases included Academic Search Complete, Business Source Complete, Google Scholar, PsychINFO, PubMed, Scopus, SocINDEX, TRID Database, and Web of Science databases. After abstract screening and full text review, a total of 81 studies were included in the scoping review. Results. Few e-scooter riders wear helmets except where legally required. Alcohol impairment is a primary contributor to e-scooter injuries. Younger males, underage riding, double riding, speeding and rider distraction were also identified as behavioural contributors to e-scooter injury crashes. Environmental contributors included crash locations (e.g., sidewalks, bike paths, roads) parking issues (e.g., tripping hazard), fixed object collisions (e.g., lampposts, parked cars), road surface and slope (e.g., uneven, curbs, downhills) and insufficient nighttime visibility. E-scooter reliability was affected by brake failures and design limitations (e.g., stability over rough terrain). Injury patterns included mechanism of injury (loss of balance and/or control, fall) and moving object collisions (e.g., vehicles, pedestrians, bicyclists). The head, face, upper and lower extremities were the most common anatomical locations injured. Fractures, contusions, concussions, lacerations, and sprains were the most frequent injury types. Discussion. Policies, regulations and interventions that address helmet requirements, alcohol and drug use, rider skill and knowledge acquisition, restrictive speed limits, education and enforcement are discussed with respect to evidence-based safety guidance for transportation policy and decision makers. Conclusion. Behavioural, environmental and device design safety issues associated with e-scooter use require effective interventions to reduce the frequency and severity of rider injuries.

Моделирование инвестиций в техническое обновление и рост ESG-рейтинга компаний

The subject of the study is the accelerated technical and economic development of Russia in order to achieve national goals, which requires the creation of a special mechanism for the formation and implementation of investment projects within the framework of public administration. Simultaneously with technical, technological and economic development, the requirements of the green economy must be fulfilled, which are specified using ESG criteria. The aim of the work is to improve the rating of companies through effective investments while simultaneously implementing projects aimed at technical infrastructure renovation. The result of the work was the creation of an economic and mathematical model that allows you to choose projects aimed at increasing the ESG rating of companies and implementing technical updates, including import substitution with domestic analogues or the implementation of technical and technological innovations. Based on an overview of a wide range of methods and algorithms for finding solutions to an optimal set of projects within the framework of a mathematical programming model with Boolean variables, it is proposed to use a modification of the Faure and Malgrange method, the algorithm of which is given in the text of the article. The conclusions are drawn that the generated model and the given algorithm are a flexible tool that allows you to obtain a set of projects that require minimal investment within the limits of restrictions on the indicators of technical renewal of the company and the values of ESG criteria for different companies and using a different number of criteria.

Конституционный принцип свободы труда в чрезвычайных условиях: старые проблемы и новые вызовы

The purpose of this scientific article was to identify theoretical and practical problems that arise in the process of implementing the principle of freedom of work in a state of emergency, the presence of an emergency situation and the introduction of a high-alert regime. The task is to outline ways to eliminate contradictions in labor legislation and law enforcement practice. To achieve this goal, the scientific literature devoted to the problems of restricting the labor rights of citizens during the period of various emergency regimes, including the high-alert regime, has been studied. The empirical basis of the work was the materials of judicial practice of the Constitutional Court of the Russian Federation and courts of general jurisdiction in cases of transfer of employees to other jobs in accordance with parts 2 and 3 of Article 72.2 of the Labor Code of the Russian Federation. The cases reviewed related to two periods – before and after the introduction of a high-alert regime in the country in connection with the COVID-19 coronavirus epidemic. An attempt has been made to trace changes in the approaches of judicial authorities to the grounds that employers use to transfer employees without their consent to another job. The author joins the opinion of a number of researchers who draw attention to the contradictory nature of the subordinate law-making of state authorities of the Russian Federation and its subjects aimed at countering the spread of coronavirus. The need to specify the powers of the President of the Russian Federation, executive authorities of the Russian Federation and its subjects in Article 5 of the Labor Code of the Russian Federation as a permanent norm in case of various kinds of crisis situations is supported. It is necessary to clarify at the legislative level the rights of employees, which may be restricted in the event of a state of emergency, the presence of an emergency situation or the establishment of a high-alert regime, to determine the limits of such restrictions. In conclusion, it is proposed to make specific changes to parts 2 and 3 of Article 72.2 of the Labor Code of the Russian Federation to specify cases and situations where transfer to another job is permissible without the consent of the employee.

Field of View Restriction and Snap Turning as Cybersickness Mitigation Tools.

Multiple tools are available to reduce cybersickness (sickness caused by virtual reality), but past research has not investigated the combined effects of multiple mitigation tools. Field of view (FOV) restriction limits peripheral vision during self-motion, and ample evidence supports its effectiveness for reducing cybersickness. Snap turning involves discrete rotations of the user's perspective without presenting intermediate views, although reports on its effectiveness at reducing cybersickness are limited and equivocal. Both mitigation tools reduce the visual motion that can cause cybersickness. The current study (N = 201) investigated the individual and combined effects of FOV restriction and snap turning on cybersickness when playing a consumer virtual reality game. FOV restriction and snap turning in isolation reduced cybersickness compared to a control condition without mitigation tools. Yet, the combination of FOV restriction and snap turning did not further reduce cybersickness beyond the individual tools in isolation, and in some cases the combination of tools led to cybersickness similar to that in the no mitigation control. These results indicate that caution is warranted when combining multiple cybersickness mitigation tools, which can interact in unexpected ways.

Complete infinitesimal prolongation of the Riemann–Liouville and Caputo derivatives

This paper presents the infinitesimal prolongation to Riemann–Liouville and Caputo fractional derivatives without the restrictive lower limit fixed in the integrals, when applicated to the transformation group. The properties are presented, and the examples are illustrated along with the symmetry to fractional derivative criteria.

Prohibition of cross-border water transport in the conditions of the Slovak Republic and its legal consequences

The Slovak Republic decided to protect its water resources by prohibiting cross-border water transport. The ban was incorporated into the Constitution of the Slovak Republic. As an administrative regulation, this constitutional norm was subsequently detailed in ordinary legislation, namely the Water Act. The adoption of this ban has raised doubts about its compatibility with the European Union (EU) law, in particular, regarding the quantitative restrictions on exports and imports of goods between the member states. This constitutional prohibition and the subsequent administrative regulation have caused interpretative and applicative confusion. Therefore, in this paper, the author assesses the limits of possible restrictions on water transport across the Slovak Republic borders, taking into account the limits resulting from the EU law. This study aims to analyze and assess the manner and consequences of the constitutional ban on water transport across the Slovak Republic’s national borders.

Genome-wide detection of Wolbachia in natural Aedes aegypti populations using ddRAD-Seq.

Wolbachia, an endosymbiotic bacterium, is globally used to control arboviruses because of its ability to block arboviral replication and manipulate the reproduction of Wolbachia host, Aedes aegypti. Polymerase chain reaction (PCR)-based Wolbachia detection has been recently reported from natural Ae. aegypti populations. However, due to the technical limitations of PCR, such as primer incompatibility, PCR-based assays are not sufficiently reliable or accurate. In this study, we examined double digestion restriction site-associated DNA sequencing (ddRAD-Seq) efficiency and limitations in Wolbachia detection and quantification in field-collected Ae. aegypti natural populations in Metro Manila, the Philippines, compared with PCR-based assays. A total of 217 individuals Ae. aegypti were collected from Metropolitan Manila, Philippines. We separated it into 14 populations consisting of 7 female and male populations. We constructed a library for pool ddRAD-Seq per population and also screened for Wolbachia by PCR assays using wsp and 16S rRNA. Wolbachia density per population were measured using RPS17 as the housekeeping gene. From 146,239,637 sequence reads obtained, 26,299 and 43,778 reads were mapped across the entire Wolbachia genome (with the wAlbA and wAlbB strains, respectively), suggesting that ddRAD-Seq complements PCR assays and supports more reliable Wolbachia detection from a genome-wide perspective. The number of reads mapped to the Wolbachia genome per population positively correlated with the number of Wolbachia-infected individuals per population based on PCR assays and the relative density of Wolbachia in the Ae. aegypti populations based on qPCR, suggesting ddRAD-Seq-based semi-quantification of Wolbachia by ddRAD-Seq. Male Ae. aegypti exhibited more reads mapped to the Wolbachia genome than females, suggesting higher Wolbachia prevalence rates in their case. We detected 150 single nucleotide polymorphism loci across the Wolbachia genome, allowing for more accurate the detection of four strains: wPip, wRi, TRS of Brugia malayi, and wMel. Taken together, our results demonstrate the feasibility of ddRAD-Seq-based Wolbachia detection from field-collected Ae. aegypti mosquitoes.

"It's very saddening, you keep on wondering when the symptoms will be over": A qualitative study exploring the long-term chikungunya disease impact on daily life and well-being, 6 years after disease onset.

Long-term chikungunya is a mosquito-borne disease, characterized by disabling rheumatic symptoms persisting for years, after infection with the chikungunya virus. Previous studies focused on assessing the well-being of affected individuals from a quantitative perspective using generic instruments, and have reported physical and psychological impairment. However, a common critique is that generic instrument's structured responses and pre-defined health domains selected by health professionals, may not capture the full extent of well-being impairment experienced by patients. This study aimed to explore in-depth to which extent long-term chikungunya disease impacts daily living and the physical, psychological, and social well-being from the experiences and perspective of affected individuals. Using open-ended questions, in-depth interviews were conducted with 20 purposively selected individuals with long-term chikungunya disease, in Curaçao. Interview audio-recordings were transcribed verbatim. The data were thematically analyzed. Living with persistent rheumatic symptoms affected the participant's daily living and well-being in several ways: experience of physical impact (restricted physical functioning and limitations in activities of daily life); experience of psychological impact (altered emotional state, fear of walking and running, psychosocial aspects of footwear adaptations, and uncertainty about disease progression and future health); and experience of social impact (social isolation and impaired relational maintenance, social dependency, challenges of social support, at-work productivity loss, and giving up leisure activities after work). This study, the first of its kind, indicated that the adverse impact of long-term chikungunya disease is currently underreported. The persistent rheumatic symptoms had a negative effect on functional ability, which in turn impacted broad aspects of daily life and well-being, beyond what is captured by generic instruments. In the view of the findings, physical exercise programs including manual therapy, aerobics, resistance and stretching exercises, and orthopaedic footwear interventions in a multidisciplinary patient-centred approach may improve physical function and subsequently overall well-being.

The Activity of the “Renaşterea” Priesthood Society from Oltenia, in the Socio-Cultural and Political Context from 1938–1940 and the Establishment of the Social Service Institution

"This paper approaches one of the faces of transposition into practice mechanism of inter-institutional cooperation, enforced thru the Social Service law, in October, 1938. The case of the Priesthood Society “Renaşterea”, socio-professional society that united the active and retired priests and deacons from Oltenia, of which social activity interfered/intersected, mostly, with the activity of the new institution, can be considered a similar pattern also for the integration of other institutions and associations that activated prior to 1938 in the socio-cultural field. The analysis has in the centre the idea that the politic register of Carol II royal dictatorship was a reference point that should have been considered by all public institutions and organisations to operate. Based on the analysis of some archive documents (consisting in the reports of the “Renaşterea” Society, the correspondence between the representatives of the society and the administrative and cultural authorities), the two parts of the article highlights the organisational and functional complications the Social Service law caused to the “Renaşterea” Priesthood Society, and also the efforts of this socio-professional association to keep the continuity of its existence, and also the place earned over time within local communities. In this matter, the necessity of integration/connection of its activity with the newly formed institution appeared as a forced compromise solution, determined by the restrictive limits of the Carlist regime."

교수의 자유에 대한 제한과 그 한계

This paper attempted to identify the possibilities and limits of restrictions on the freedom of professor’s lecturing, which is a constitutional right under the Korean Constitution, through a commentary on the Supreme Court's 2014Do3923 decision.
 The core issue of the 2014Do3923 decision commented in this paper is whether the professor's conduct of lecturing by distributing press articles unfavorable to a presidential election candidate as part of the lecture content and method can be considered a violation of the Public Official Election Act, in relation to academic freedom, especially the freedom of professor’s lecturing.
 Among academic freedoms, which are constitutional rights guaranteed under the Korean Constitution, there is little in-depth prior research on the scope or degree of protection, restrictions, and limits on the freedom of professor’s lecturing.
 The significance of the Supreme Court's 2014Do3923 decision is summarized as follows.
 First, this decision is significant as the first Supreme Court’s ruling regarding restrictions on the freedom of professor’s lecturing and its limits. In particular, there were almost no court rulings or decisions of the Constitutional Court that directly address the relationship between the freedom of professor’s lecturing and positive law or deal in depth with the content, possibility of restrictions, and limits of the freedom of professor’s lecturing. In this respect, the Supreme Court's 2014Do3923 decision directly addresses the relationship between the freedom of professor’s lecturing and the Public Official Election Act, and argues in depth the content of the freedom of professor’s lecturing, the possibility of restrictions, and its limits. It can be positioned as the ‘first’ Supreme Court ruling that ‘directly’ addresses the possibility of restrictions, and its limits.
 Second, the legal principles regarding the restrictions on the freedom of professor’s lecturing and their limits presented in this ruling can present theoretically and practically meaningful judicial judgment standards in actual cases related to the freedom of professor’s lecturing in the future.

Constraining self-interacting fermionic dark matter in admixed neutron stars using multimessenger astronomy

ABSTRACT We investigate the structure of admixed neutron stars with a regular hadronic component and a fraction of fermionic self-interacting dark matter. Using two limiting equations of state for the dense baryonic interior, constructed from piecewise generalized polytropes, and an asymmetric self-interacting fermionic dark component, we analyse different scenarios of admixed neutron stars depending on the mass of dark fermions mχ, interaction mediators mϕ, and self-interacting strengths g. We find that the contribution of dark matter to the masses and radii of neutron stars leads to tension with mass estimates of the pulsar J0453+1559, the least massive neutron star, and with the constraints coming from the GW170817 event. We discuss the possibilities of constraining dark matter model parameters g and y ≡ mχ/mϕ, using current existing knowledge on neutron star estimations of mass, radius, and tidal deformability, along with the accepted cosmological dark matter freeze-out values and self-interaction cross-section to mass ratio, σSI/mχ, fitted to explain Bullet, Abell, and dwarf galaxy cluster dynamics. By assuming the most restrictive upper limit, σSI/mχ < 0.1 cm2 g−1, along with dark matter freeze-out range values, the allowed g–y region is 0.01 ≲ g ≲ 0.1, with 0.5 ≲ y ≲ 200. For the first time, the combination of updated complementary restrictions is used to set constraints on self-interacting dark matter.

Search for Z′ bosons decaying to pairs of heavy Majorana neutrinos in proton-proton collisions at s\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$ \\sqrt{s} $$\\end{document} = 13 TeV

A search for the production of pairs of heavy Majorana neutrinos (Nℓ) from the decays of Z′ bosons is performed using the CMS detector at the LHC. The data were collected in proton-proton collisions at a center-of-mass energy of s\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$ \\sqrt{s} $$\\end{document} = 13 TeV, with an integrated luminosity of 138 fb−1. The signature for the search is an excess in the invariant mass distribution of the final-state objects, two same-flavor leptons (e or μ) and at least two jets. No significant excess of events beyond the expected background is observed. Upper limits at 95% confidence level are set on the product of the Z′ production cross section and its branching fraction to a pair of Nℓ, as functions of Nℓ and Z′ boson masses (mNℓ\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$ {m}_{{\ extrm{N}}_{\\ell }} $$\\end{document} and mZ′\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$ {m}_{{\ extrm{Z}}^{\\prime }} $$\\end{document}, respectively) for mZ′\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$ {m}_{{\ extrm{Z}}^{\\prime }} $$\\end{document} from 0.4 to 4.6 TeV and mNℓ\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$ {m}_{{\ extrm{N}}_{\\ell }} $$\\end{document} from 0.1 TeV to mZ′\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$ {m}_{{\ extrm{Z}}^{\\prime }} $$\\end{document}/2. In the theoretical framework of a left-right symmetric model, exclusion bounds in the mNℓ\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$ {m}_{{\ extrm{N}}_{\\ell }} $$\\end{document}-mZ′\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$ {m}_{{\ extrm{Z}}^{\\prime }} $$\\end{document} plane are presented in both the electron and muon channels. The observed upper limit on mZ′\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$ {m}_{{\ extrm{Z}}^{\\prime }} $$\\end{document} reaches up to 4.42 TeV. These are the most restrictive limits to date on the mass of Nℓ as a function of the Z′ boson mass.