Dietary Restriction Research Articles

The Impact of Dietary Restrictions on Emotional Well-being and College Life

The Impact of Dietary Restrictions on Emotional Well-being and College Life

Social Support and Adherence to Treatment Regimens among Patients Undergoing Hemodialysis

Background/Objectives: Following recommended treatment plans is essential to the success of the treatment. In hemodialysis, adherence to the treatment regimen remains a challenge in many healthcare settings. Many factors, including the patient’s level of social support, influence treatment adherence, but few studies have addressed these relationships. Methods: A correlational cross-sectional design was used to assess the relationship between perceived social support and adherence to treatment regimens among patients undergoing hemodialysis. Self-reported surveys were used to collect data. Results: One hundred and twenty-one hemodialysis patients were recruited from two dialysis centers. Overall, 45.5% of participants demonstrated good adherence, 47.9% had moderate adherence, and 6.6% had poor adherence. Specifically, 76% of participants consistently took their prescribed medications, 75% regularly attended hemodialysis sessions, 67.8% adhered to dietary restrictions, and 62% followed fluid-intake guidelines. Perceived social support was reported as highest from family members (89.3%), followed by significant others (62.8%) and friends (49.6%). There were significant correlations between perceived social support and overall adherence to treatments among hemodialysis patients. Conclusions: This study provides evidence for positive relationships between perceived social support and adherence to treatment regimens among hemodialysis patients. It is recommended that professional caregivers intervene with clients and their families, prepare recreational and educational programs for patients undergoing hemodialysis, and inspire other researchers to suggest different social support models and approaches.

The Knowledge, Perception And Practices Of Myths Encountered Among Caregivers In Enugu, Nigeria: A Cross-Sectional Study

Introduction: Many beliefs concerning child care abound and these vary across all walks of life. Assessed the knowledge, perception and practice of these myths among care- givers of children living in Enugu. Our survey found that, there is still a high level of belief in myths and local practices among caregivers in Enugu. Methods:Study population- caregivers visiting paediatric outpatient clinics in Enugu. Sampling method- a hospital-based, cross-sectional study. Self- administered questionnaires were used to obtain information from the caregivers. Analysis-Data collected was analyzed using SPSS version 26.0 Results: shows that 83.7% of the study participants are females while 16.3% are males, giving the male to female ratio as 1:5. Most of the study participants (75.2%) were within the age bracket of 21 and 40 years and the mean ± SD age was 32.42 ± 9.83. The most prevalent belief is that the breast nipple must be washed before every feeding, reported by 64.2% of participants. The most commonly practiced belief is that teething causes symptoms, reported by 49.2% of respondents. This is followed by the belief that breast milk can become sour if not consumed for a long period, practiced by 46.6% of respondents. The third most practiced belief is related to "Jedi jedi" (30.6%), a condition locally associated with gastrointestinal distress.These findings highlight that, while traditional beliefs are pervasive across all age groups, younger participants are more likely to adhere to certain beliefs, particularly those related to dietary restrictions and traditional remedies for convulsions. Conclusion: It can be inferred from the findings of this survey that, there is still a high level of belief in myths and local practices among caregivers of children in Enugu, despite efforts to educate the general public about childhood illnesses. This study also shows that maternal education is an important factor for improved outcomes in paediatric care in our environment

Obesity prevention across the lifespan: assessing the efficacy of intervention studies and discussing future challenges.

Obesity is intricately linked with metabolic conditions that disrupt hormones and metabolism, often resulting in weight-related challenges. Given the heightened mortality rates associated with cardiovascular and metabolic disorders linked to obesity, there is a pressing call to mobilize medical professionals, researchers, and policymakers towards advocating for healthy lifestyles and preventing obesity. Traditionally, obesity prevention and treatment have been viewed as separate endeavors, with prevention primarily falling under public health initiatives and treatment within the purview of clinicians. However, this division has led to significant healthcare costs without a substantial reduction in obesity rates. Our search encompassed published articles focused on prevention, excluding any mention of "treatment". Data was gathered from diverse sources including academic databases, government health agency websites like the CDC, research organizations, clinical trials registries, and public health campaigns. Due to the diverse range of interventions (encompassing dietary modifications, physical activity promotion, policy initiatives, education, and community-based programs, either independently or in combination), and the variability in study design and population demographics, we conducted a narrative review to systematically present and critically analyze evidence on preventing overweight and obesity across different age groups. Effectively addressing obesity prevention necessitates a comprehensive, multidisciplinary approach that establishes an environment where healthier choices are accessible and viable for all. This requires collaborative efforts between individuals, communities, healthcare providers, policymakers, and industries to institute enduring change. Furthermore, there remains a critical need for national and international guidelines tailored to age-related risk factors, paving the way for innovative precision medicine approaches centered on salutogenesis rather than pathogenesis.

S3858 “Orange” You Glad It Wasn’t Jaundice? Carotenemia due to Dietary Modifications to Manage Crohn’s Disease

S3858 “Orange” You Glad It Wasn’t Jaundice? Carotenemia due to Dietary Modifications to Manage Crohn’s Disease

Eosinophilic esophagitis (EoE) in adults in Icelandic and international context

Eosinophilic esophagitis (EoE) is a common cause of swallowing difficulties in both children and adults. The incidence of EoE has been increasing over the past decades, which cannot be solely attributed to improved diagnostic techniques. EoE is more common in adults than in children. The diagnosis is confirmed by a biopsy from the esophageal mucosa showing a significant infiltration of eosinophils. Many patients respond to treatment with proton pump inhibitors, but those with severe EoE may require dietary modifications, topical steroids, and/or dilation of esophageal strictures. This review covers the incidence, risk factors, natural course, diagnosis, and treatment options for EoE, both within the Icelandic healthcare system andi n a broader context.

Nutritional Counseling and Mediterranean Diet in Adrenoleukodystrophy: A Real-Life Experience

Background/Objectives: Adrenoleukodystrophy (X-ALD) is a metabolic disorder caused by dysfunctional peroxisomal beta-oxidation of very-long-chain fatty acids (VLCFAs). A VLCFA-restricted Mediterranean diet has been proposed for patients and carriers to reduce daily VLCFA intake. Methods: We retrospectively evaluated plasma VLCFAs in a cohort of 36 patients and 20 carriers at baseline and after 1 year of restricted diet. Results: At T1, compliant adult patients had significantly lower C26:0 levels [1.7 (1.2) vs. 2.5 µmol/L (1.7), p < 0.05], C26:0/C22:0 ratio [0.04 (0.02) vs. 0.06 (0.03), p < 0.05], and triglycerides [93 (56.5) vs. 128 mg/dL (109.5), p < 0.05] than non-compliant ones. C26:0 [2.4 (1.7) vs. 1.7 (1.2) µmol/L, p < 0.05], the C26:0/C22:0 ratio [0.06 (0.04) vs. 0.04 (0.02), p < 0.05], and cholesterol [173.5 (68.3) mg/dL vs. 157 (54) mg/dL, p < 0.05] were significantly reduced in compliant adult patients at T1 vs. baseline. As for carriers, the C26:0/C22:0 ratio was lower [0.02 (0.01) vs. 0.04 (0.009), p < 0.05] at T1 in compliant carriers, as compared to non-compliant ones. The C26:0/C22:0 [0.03 (0.02) vs. 0.02 (0.01) p < 0.05] and C24:0/C22:0 [1.0 (0.2) vs. 0.9 (0.3), p < 0.05] ratios were significantly decreased at T1 vs. T0. Conclusions: A VLCFA-restricted diet is effective in reducing plasma VLCFA levels and their ratios and must be strongly encouraged as support to therapy.

Current Advances and Material Innovations in the Search for Novel Treatments of Phenylketonuria.

Phenylketonuria (PKU) is a genetically inherited disease caused by a mutation of the gene encoding phenylalanine hydroxylase (PAH) and is the most common inborn error of amino acid metabolism. A deficiency of PAH leads to increased blood and brain levels of phenylalanine (Phe), which may cause permanent neurocognitive symptoms and developmental delays if untreated. Current management strategies for PKU consist of early detection through neonatal screening and implementation of a restrictive diet with minimal amounts of natural protein in combination with Phe-free supplements and low-protein foods to meet nutritional requirements. For milder forms of PKU, oral treatment with synthetic sapropterin (BH4), the cofactor of PAH, may improve metabolic control of Phe and allow for more natural protein to be included in the patient's diet. For more severe forms, daily injections of pegvaliase, a PEGylated variant of phenylalanine ammonia-lyase (PAL), may allow for normalization of blood Phe levels. However, the latter treatment has considerable drawbacks, notably a strong immunogenicity of the exogenous enzyme and the attached polymeric chains. Research for novel therapies of PKU makes use of innovative materials for drug delivery and state-of-the-art protein engineering techniques to develop treatments which are safer, more effective, and potentially permanent.

Environmental sustainability and nutritional quality of different diets considering nutritional adequacy

This study examines how four diets change nutritionally and environmentally when the diets are nutritionally adjusted. Data on individual Belgian diets of omnivores (n = 131), pescovegetarians (n = 159), vegetarians (n = 494), and vegans (n = 78) were obtained, called non-adjusted diets. We assessed if diets met energy and nutrient intake requirements and calculated the Alternative Healthy Eating Index (AHEI)-2010. The environmental impact was evaluated by a cradle-to-grave life cycle assessment considering all midpoint indicators of the Environmental Footprint 3.0 and expressing the impact per “daily food and supplement intake by one Belgian adult”. The individual dietary intakes were adjusted nutritionally to meet the recommended energy and nutrition intakes using a quadratic programming algorithm. All diets had a significantly improved AHEI score but also a significantly increased water use (WU) when adjusting. The omnivore's diet demonstrated a significantly decreased carbon footprint (CF) while it significantly (except for vegans) raised for the restrictive diets due to adjustment. The omnivorous diet had the greatest improvements in AHEI (15.4), while WU increased the most among all diets (3.7 m3), primarily due to elevated fruit intake. The CF was reduced with 1.2 kg CO2 due to decreased red meat consumption. The AHEI of the vegan diet improved the second most of all diets (13.2) due to the intake of omega-3 supplements, while its WU rose the least of all diets (2.4 m3), and its CF barely increased (0.1 kg CO2-eq). The AHEI improvements of the vegetarian diet were similar to those of the vegan diet (12.5), while the one of the pescovegetarian diet was limited (3.5). The (pesco)vegetarian diet had an increase in WU (2.5 and 2.7 m3) and the highest increase in the CF (0.3 kg CO2-eq). Since nutritionally adjusted diets do not lead to similar nutritional and environmental improvements, this research highlights the need to assess both metrics.

S730 The Use of Non-Fasting Breath Gas Levels to Predict Response to a FODMAP Restricted Diet

S730 The Use of Non-Fasting Breath Gas Levels to Predict Response to a FODMAP Restricted Diet

A biological age based on common clinical markers predicts health trajectory and mortality risk in dogs.

Predicting aging trajectories through biomarkers of biological aging can guide interventions that optimize healthy lifespan in humans and companion animals. Differences in physiology, genetics, nutrition, and lifestyle limit the generalization of such biomarkers and may therefore require species-specific algorithms. Here, we compared correlations of standard clinical blood parameters with survival probability in humans with those of the two most common mammalian companion animals, cats and dogs, and highlighted universal and species-specific relationships. Based on this comparative analysis, we generated and validated an algorithm that predicts biological age in canines using a longitudinal dataset with health records, blood count, and clinical chemistry from 829 dogs spanning over 12years. Positive deviations of biological from chronological age (AgeDev) measured by this composite score significantly correlated with a decreased survival probability (hazard ratio = 1.75 per 1year of AgeDev, p = 3.7e - 06). Importantly, in nearly half of the dogs whose biological age was accelerated by more than 1year, none or only a single individual marker scored outside its respective reference range, suggesting practical applications for the detection of unfavorable health trajectories. Analyzing samples from a unique 14-year life-long diet restriction study, we show that restricted caloric intake lowers biological age, an effect that can be quantified at midlife years before a difference in survival is observed. Thus, a biological age clock based on clinical blood tests predicts the health trajectories of dogs for use in research and veterinary practice.

Restrictive Diets in Digestive Cancers: Prevalence, Contributing Factors, Foods Concerned and Patients' Beliefs (Prospective Study of 100 Cases)

Cancer is a major cause of disease-related malnutrition; the prevalence of malnutrition and muscle loss is high in digestive cancers and is thought to be associated with a poor prognosis. The aim of this prospective study is to investigate changes in dietary habits following a diagnosis of gastrointestinal cancer that are likely to cause or aggravate malnutrition, to assess the existence of restrictive diets involving the permanent elimination of certain essential aliments (meat, dairy products, etc.), to identify the factors that influence patients to adopt them, and to assess the degree to which patients believe in the effectiveness of these diets in curing cancer.  Materials and Methods: 100 patients aged 18 and over, diagnosed with one of the following digestive cancers: colorectal, gastric, pancreatic, oesophageal, hepatocellular carcinoma or biliary tract cancer; were interviewed using an electronic questionnaire.  Results: Among the patients we interviewed, 69% had adopted a restrictive diet following the diagnosis of digestive cancer. The products permanently eliminated included white sugar and/or sweetened foods in 83% of cases, red meat in 80%, tinned food in 77%, dairy products in 61%, spices in 54%, fried food in 49%, white meat and eggs not produced organically in 44%, processed meat in 33%, and all white meat and eggs in 17% and 14% respectively; This diet was recommended mainly by the patient’s entourage (friends and family) in 81% of cases, by other patients and their relatives (58%) and by personal research on the internet in 36% of cases. In addition, 37% of patients believe that this type of diet contributes to curing cancer.  Conclusion: 69% of patients in the study were on a restrictive diet, and more than a third of them believed that this diet could help cure their digestive cancers. Raising awareness among patients and their families is essential to prevent malnutrition and muscle loss, and thus improve the outcome of the cancer.

EFFECTS OF CARICA PAPAPYA SEED EXTRACT ON HISTOPATHOLOGICAL CHANGES IN AMINOGLYCOSIDE-TRIGGERED ACUTE NEPHROTOXICITY IN EXPERIMENTAL RATS

Background: Nephrotoxicity is an emerging complication arising with the use of multiple drugs and dietary modifications. The objective of this study was to determine the nephroprotective effect of aqueous extract of Carica papaya seeds in aminoglycoside induced acute nephrotoxicity in rats. Methods: This Quasi Experimental study was conducted on 30 Sprague Dawley rats. After nephrotoxicity was confirmed by measuring serum urea and creatinine levels histomorphological examination of kidney tissue was done. Results: Group A, Group C and Group B had a mean serum urea level of 24.70±1.633, 82.70±2.587 and 81.00±1.247 mg/dL respectively (p<0.05), showing nephrotoxicity on day 6. On day 11, mean blood urea level for Group C was 50.60±1.857 mg/dL (p<0.05) compared to Group B with mean blood urea level 78.60±1.240. The reduced mean blood urea levels of Group C in comparison to Group B indicated nephroprotection from aqueous extract of Carica papaya seeds. In Group A, Group B and Group C the mean serum creatinine level was 0.750±0.619, 1.980±0.467 and 2.030±0.667 mg/dL (p<0.05) respectively, on day 6 indicating nephrotoxicity with Gentamycin. Group B had mean serum creatinine levels of 1.920±0.0389 at day 11 while Group C had a mean serum creatinine of 1.380±0.611 after 5 days of therapy with Carica papaya seed aqueous extract on day 11 indicating nephroprotection. Conclusion: Aqueous extract of Carica papaya seeds has significant nephroprotective effects on aminoglycoside induced acute nephrotoxicity. Pak J Physiol 2024;20(3):3?7 DOI: https://doi.org/10.69656/pjp.v20i3.1637

IMPACT OF FOUR FAT-RICH INFANT FLOURS ON LIPID AND ATHEROGENIC PROFILE OF WISTAR RATS

Dietary fat content influences serum lipid parameters and the incidence of cardiovascular and coronary heart disease. The point of this study was to find out what happened to Wistar rats serum lipid profiles and atherogenic indices when they ate a high-fat PASLoc meal after they had been on a restricted diet. Forty-two male rats, 80 ± 5 days of age, were subjected to 19 days of food restriction and then fed PASLoc infant formula for 14 days. Blood samples from the rats were taken at the end of the periods of not eating and eating so that serum lipid constants (total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides) could be found and predictive parameters for atherosclerotic and coronary heart disease could be calculated. The results showed that dietary restriction led to an imbalance in serum parameters, with LDL cholesterol (0.11 ±0.01), HDL cholesterol (0.35 ±0.08), total cholesterol (0.60 ±0.07), and triglycerides (0.44 ±0.08) all decreasing. At the end of the dietary experiment, these constants improved according to the standards recommended for rats. Consumption of PASLoc flours had no negative effect on the Castelli indices (CRI-I and CRI-II), the atherogenic coefficient (CA), or the atherogenic plasma index (AIP). The fats contained in these flours do not represent an atherogenic health risk for children.

The Long-Term Effect of Kidney Transplantation on the Serum Fatty Acid Profile

Background: Epidemiologic evidence has demonstrated the prevalence of metabolic disorders and increased cardiovascular risk related to lipid metabolism disorders in kidney transplant recipients. Therefore, it is of great importance to understand lipid alterations and to look for ways to reduce cardiovascular risk in this patient group. Methods: Our study included 25 patients with chronic kidney disease undergoing kidney transplantation (KTx). Three blood samples were taken from each patient: before KTx, 3 months after KTx and 6–12 months after KTx. A series of biochemical blood tests and a detailed analysis of the serum fatty acid profile were performed. Results: In our previous study, the effects of kidney transplantation on serum fatty acid (FA) profile 3 months after the procedure were investigated. The current study shows the longer-term (6–12 months) effects of the procedure on the serum FA profile. We found that although n-3 polyunsaturated FA levels started to decrease 3 months after surgery, they normalized over a longer period of time (6–12 months). Furthermore, we observed a strong decrease in ultra-long-chain FAs and an increase in odd-chain FAs over a longer time after kidney transplantation. All of the above FAs may have an important impact on human health, including inflammation, cardiovascular risk or cancer risk. Conclusions: The changes in serum FA profiles after kidney transplantation are a dynamic process and that more detailed studies could provide an accurate indication for supplementation with some FAs or diet modification.

Dilated cardiomyopathy revealing Refsum disease: a case report

BackgroundRefsum disease is a rare autosomal recessive hereditary disorder of lipid metabolism that results in the accumulation of phytanic acid. This syndrome is characterized with a range of classic symptoms including ataxia, peripheral neuropathy, amyotrophy, retinopathy, ichthyosis, and hearing loss. Later in life, individuals with Refsum disease may present cardiac manifestations, such as arrhythmias or conduction defects (first-degree atrioventricular block and bundle branch block) and hypertrophic or dilated cardiomyopathy, leading to heart failure and sudden death. To the best of our knowledge, this is the first case revealed by cardiac manifestations described in literature.Case presentation: We report the case of 38-year-old white Moroccan male who was admitted in our department for an acute decompensated heart failure episode. Transthoracic echocardiography found a dilated cardiomyopathy with a reduced ejection fraction at 15%. Further evaluation showed different features of Refsum disease. High plasma level of phytanic acid confirmed the diagnosis. Cardiac manifestations are frequent in the late course of the adult Refsum disease and include, cardiomyopathy, electrical abnormalities, and sudden cardiac death. Moreover, arrhythmias remain one of the main causes of death in these patients.ConclusionRefsum’s disease is an autosomal recessive disorder. It presents as retinitis pigmentosa with anosmia, deafness ataxia, and cardiac defects. Current interventions for individuals with Refsum disease consist of dietary phytanic acid restriction and lipid apheresis to control symptoms and enhance quality of life.

Digital Education on Hospital Nutrition Diets: What Do Patients Want to Know?

Therapeutic nutrition plays an imperative role during a patient's hospital course. There is a tremendous body of literature that emphasizes the systematic delivery of information regarding hospital nutrition diets. A major component of delivering healthcare information is the principle of providing quality healthcare information, but this has not yet been investigated on hospital nutrition diets. This study aimed to evaluate the comprehension and readability of patient education materials regarding therapeutic hospital diets. The methodology employed the use of publicly available questions regarding hospital nutrition diets and categorized them per Rothwell's Classification of Questions. Additionally, the questions were extracted online and have an associated digital article linked to the question. These articles underwent analysis for readability scores. This study's findings reveal that most hospital diets do not meet the recommended grade-reading levels. This underscores the need for healthcare providers to enhance patient education regarding hospital diets. The prevalence of "Fact" questions showcases the importance of clearly explaining diets and dietary restrictions to patients.

Clinical and biochemical evolution after partial dietary liberalization of two cases of galactosemia due to galactose mutarotase deficiency

BackgroundThe recommended diet attitude in the recently described galactose mutarotase (GALM) deficiency is not yet established. We describe two 9-years twins who remain asymptomatic despite prolonged partial dietary liberalization from 18 months of age, after two periods of galactose-free diet. It represents the second report in Europe of GALM deficiency.Case presentationTwo male monochorionic diamniotic twins were detected through newborn screening by galactosuria and increased total blood galactose. They started galactose dietary restriction with biochemical normalization. After exclusion of the three previously described types of galactosemia, a progressively galactose reintroduction was initiated. The clinical follow-up developed include neurological assessment and intelligence quotient, annual ophthalmological evaluation and biannual abdominal ultrasound; whereas the biochemical assessment comprises quarterly determinations of galactose 1-phosphate and galactosuria and annual determination of liver and renal function, 25-OH-vitamin D and calcium levels. Sanger sequencing of GALM gene was complemented by the study of gene dose using SNPs array and a protein modeling to study the conformational changes induced in GALM protein. In both siblings a novel and complete deletion of exon 4 in GALM gene was detected. Both remained asymptomatic, with normal growth and intellectual development, despite dietary liberalization. Evolutionarily, the biochemical profile in blood remained normal with intermittent galactosuria.ConclusionsThe absence of clinical involvement after 7 years of dietary liberalization is interesting to expand the knowledge about the recommended dietary management in this pathology.

Pengaruh Pemberian Slimber Ice terhadap Intensitas Rasa Haus Pasien Gagal Ginjal Kronik yang Menjalani Hemodialisa di RS Santa Elisabeth Medan Tahun 2024

Chronic kidney failure patients experience excess fluid, so fluid restrictions are needed. Fluid restrictions in hemodialysis patients cause dry mouth. The dry mouth experienced by the patient can cause high thirst, high thirst can cause non-compliance with a fluid restricted diet. As a result of limiting fluid intake carried out ini hemodialysis patients, it results in a feeling of thirst which causes the patient to have the desire to drink. The aim of this study is to determine the effect of giving slimber ice on the intensity of thirst in patients with chornic kidney failure undergoing hemmodialysis. This research uses one group pretest-posttest design. The sampling technique is purposive sampling with a total of 20 respondents. The instrument used in this research is the Visual Analogue Scale fo Assessment of Thirst Intensity. The research results showed that the average thirst intensity score of patients with chronic kidney failure undergoing pre-intervention hemodialysis was 4.80, standard deviation 1,936, and post test intervention 3.10,, standard deviation 1,410. The result of statistical tests show that there is an effect of giving slimber ice on the intensity of thirst in patients with chronic kidney failure undergoing hemodialysis. The results of the paired t-test, obtain p value = 0.001. This intervention can be a form of therapeutic management that can be applied to reduce complaints of thirst at home or in hospital.

Irritable Bowel Syndrome - current state of knowledge

Introduction and objective: Irritable bowel syndrome (IBS) is a common gastroenterological disorder affecting 9% to 23% of the population worldwide. The disease causes recurrent abdominal pain and abnormal bowel movements without visible anatomical or biochemical changes and diagnosis is often difficult. The purpose of this paper is to analyze the current knowledge of the pathophysiology, risk factors, diagnosis and treatment of IBS. Review methods: The literature available in the PubMed database was reviewed using the following key words: "irritable bowel syndrome," "constipation," "diarrhea", "abdominal pain", "diagnostics", "treatment". 49 articles were included in the review and 80% were from 2016-2024. Current state of knowledge: The pathophysiology of IBS is not fully understood, but it is recognized that the disease is a disorder of the gut-brain axis. It can lead to abnormal secretion of serotonin and dopamine, which affects symptoms. The diagnosis of IBS is based on the Rome IV Criteria, defining the characteristics and severity of symptoms. Summary: IBS is a disorder that significantly affects quality of life. Diagnosis is based on the exclusion of organic diseases and meeting certain criteria. Treatment includes both dietary modification and pharmacotherapy aimed at relieving symptoms. Despite advances in research, the pathophysiology of IBS is still not fully understood, making it difficult to develop effective treatments.