AbstractThis study examined the spatial distribution of road traffic crashes, mortality and morbidity in Nigeria for the period 2007–2017. The influence of exposure, road network and socio‐demographic characteristics on fatalities and injuries was analysed. Data were obtained from Federal Road Safety Corps and Annual Abstract of Statistics. Spatial statistical techniques were employed to determine the pattern of crashes, mortality and morbidity. Ordinary least squares and geographically weighted regression models were used to identify significant variables. Crashes and mortality declined by 47.9 per cent and 46.3 per cent respectively, while morbidity increased by 78.6 per cent. Crashes, mortality and morbidity were significantly clustered and high in Niger, Kaduna, FCT, Kogi and Nassarawa States. FCT recorded the highest crashes and injured persons, while Kaduna recorded the highest fatalities. Variables that significantly influenced spatial variation of mortality and morbidity were length of asphaltic concrete, surfaced dressed and earth roads, unemployment and population density. This study shows that type of road is a major factor that contributes to road crash mortality and morbidity. Crash countermeasures such as implementation of safety standards during road construction, speed reduction strategies and enforcement of seat belt use and child restraint should be implemented.