Aim: This review aims to synthesize current understanding of the multifaceted impacts of climate change on agriculture, examine adaptive strategies to maintain food security, and offer insights into sustainable farming practices. Objectives: The objectives are to: (1) identify the potential causes of climate change, (2) assess its effects on agriculture, and (3) discuss mitigation strategies and sustainable farming practice. Methodology: A systematic review of the literature has been performed. We conducted an in-depth study of previous research, reports, and related literature. Sources were selected based on relevance and credibility to provide a thorough examination of the impacts of climate change on agriculture. Analysis: The analysis focused on categorizing the direct and indirect effects of climate change on agricultural systems, understanding changes in crop yield, plant physiology and metabolism, and evaluating the effectiveness of various mitigation strategies. Result Findings: The findings indicate that the greenhouse effect, driven by gases such as CO2, CH4, and H2O, leads to global temperature increases. The concentration of these gases is rising, with the global average temperature expected to increase by 2°C by 2100, causing significant economic losses. While this increase has boosted plant growth and productivity through enhanced photosynthesis, the associated rise in temperature counteracts these benefits. Therefore, mitigation strategies such as nutrient management, drip and sprinkler irrigation, and sustainable agricultural practices are essential. Natural farming is a sustainable agricultural practice that offers chemical-free, healthy food while promising to increase farmers' income, improve environmental health, restore soil fertility, and reduce greenhouse gas emissions. Conclusion: Climate change poses a significant threat to global food and nutritional security by altering agricultural productivity and sustainability. Understanding these impacts and developing effective mitigation strategies is crucial. This review provides valuable insights for policymakers, researchers, and practitioners to address these challenges and ensure resilient agricultural systems capable of sustaining future food security.