The article presents the content and modes of treatment and rehabilitation of children and adolescents with related neuropsychiatric disorders accompanied by behavioral abnormalities. The complexity and ambiguity of solving this problem by many researchers, as well as the tendency to deepen the understanding of the content, means and methods of rehabilitation of children and adolescents in various directions related to school and social and labor maladjustment, risk factors for various forms of behavioral disorders, were noted. The general trend is to develop and carry out for this contingent of sick children and adolescents not only effective drug therapy, but also special measures for their sufficient social adaptation in the future. On the basis of methodological and organizational principles, which include partnership, comprehensiveness of influence, the unity of psychosocial and biological methods of influence, the sequence of rehabilitation measures, the implementation of a systemic approach to the rehabilitation of children and adolescents with deviant behavior and neurotic-like pseudoneurasthenic states of residual organic genesis is revealed. On the basis of the results of the examination and the identification of the causes of the formation of behavioral disorders of 576 children and adolescents aged 7 to 17 years, developed and tested medically differentiated rehabilitation regimens are given, the effectiveness of which is confirmed by the final examinations and the 1-3-year catamnesis of 438 children and adolescents or 76.0 % of the total number who received a full course of restorative therapy and correction of behavioral disorders. It was concluded that the results of restorative therapy and correction of behavioral disorders of children and adolescents with deviant behavior and neurotic-like pseudoneurasthenic states of residual organic genesis require further stabilization of positive premorbid traits in family relationships. In this regard, it is important to further correct the communication difficulties of adolescents in social and psychological training for the formation of self-regulation skills in establishing and maintaining positive relationships with peers and significant adults.