Restoration Of Activity Research Articles

Novel derivative of nicotinic acid ameliorates doxorubicin-induced cardiac injury via regulation of redox homeostasis

Introduction: Doxorubicin (DOX) is an anthracycline antibiotic with considerable significance in clinics as an anticancer agent, which is limited by its cardiotoxicity, though. A large number of possible therapeutic strategies for reducing cardiotoxicity with doxorubicin have been studied. However, none of them fully meets the requirements of clinical practice. The aim of the study: to evaluate the cardioprotective effects of a new original heterocyclic compound, a pyridine-3-carboxylic acid derivative potassium 5-hydroxynicotinate. Materials and Methods: Cardiac injury was induced by intraperitoneal administration of doxorubicin (DOX) at a dose of 20 mg/kg. After 48 hours, the parameters of left ventricular contractility and StTTI coefficient were assessed on isolated heart in the Langendorff system under the conditions of 480 beats per minute for 11 seconds. Additionally, specific markers of myocardial injury were determined. The lipid peroxidation products and SOD activity were measured as well to challenge whether the compound is able to reduce oxidative stress. Results: The study showed that pretreatment by potassium 5-hydroxynicotinate (35 mg/kg, 48 h) attenuated DOX-induced damage, resulting in a significant decrease in the StТТI coefficient to 3.3 values and in the restoration of the antioxidant activity of enzymes. Conclusion: The obtained data totally demonstrate the protective effects of potassium 5-hydroxynicotinate in DOX-induced cardiomyopathy. A significant role in potassium 5-hydroxynicotinate-mediated cardioprotection is, apparently, related to the reduction of oxidative stress and down-regulation of the level of intracellular calcium.

Assessing the potential of multi-use to reduce cumulative impacts in the marine environment

The intentional combination of two or more marine activities with the purpose of sharing space, infrastructure, resources and/or operations, referred to as multi-use, is gaining attention as a means to reduce the spatial footprint of human activities but possibly also its ecological footprint. In this study, the Spatial Cumulative Assessment of Impact Risk for Management (SCAIRM) method was adapted and applied to assess whether multi-use can reduce the ecological footprint in terms of the cumulative impacts on the marine ecosystem, by integrating multiple offshore activities in different configurations as compared to these activities separated in space, referred to as single-use. These configurations combine renewable energy, aquaculture, nature restoration and tourism activities, in different combinations. For the sake of this multi-use assessment these activities were subdivided into actions, their allocation in space and time represented in scenarios (e.g. single-use versus multi-use) which were then evaluated in terms of their ecological footprint (i.e. Impact Risk). The main finding is that the calculated Impact Risk in multi-use is often lower than that in single-use and in any case never higher. This study also shows that there is still much to be gained in terms of further reduction in Impact Risk through an optimization of the multi-use design by comparing the scenario based on actual pilots deemed more realistic (i.e. co-existence with limited synergies) with a hypothetical optimal scenario (i.e. multi-functional).

Сохранить, нельзя разрушить: памятники истории и культуры горной Ингушетии

The article examines the architectural monuments of mountainous Ingushetia from the point of view of their physical preservation and preservation of historical and cultural value. These monu-ments have undergone active restoration in recent years. Patrons are involved in financing these works. It is established that there is concern for preserving historical and cultural value during these works. The reason for this is the inability to determine the original appearance in detail of most dilapidated monuments, as well as the fact that the number of restored or restored tower set-tlements over the past couple of years has exceeded a dozen, and the materials on mandatory ar-chaeological excavations are few indicating irreparable damage that can be caused to historical and cultural monuments. Also, the absence of the need for practical use of restored premises of cultural heritage sites is an indicator of the inexpediency of using such an approach. In world prac-tice, restoration is used in exceptional cases, in particular when there is an ongoing historical cul-tural process. To solve this problem, it is necessary to attract the attention of state bodies, institu-tions, commercial organizations engaged in the preservation of cultural heritage sites, the public to the need to preserve the historical and cultural value of historical and cultural monuments as tower and castle complexes, as well as religious and burial structures concentrated on the territory of modern mountainous Ingushetia, when carrying out work on their preservation, as well as the priority of their conservation over other types of work. It is concluded that a monument of history and culture is valuable insofar as it contains reliable information about human activity in previous eras, and principles for the preservation of architectural (tower and castle) complexes of moun-tainous Ingushetia have been developed, adherence to which will solve the problems identified in this study in matters of conservation work architectural monuments of mountainous Ingushetia.

Successful establishment of a coral nursery for active reef restoration in Kavaratti Island, Lakshadweep archipelago

Successful establishment of a coral nursery for active reef restoration in Kavaratti Island, Lakshadweep archipelago

Cardioprotective action of apocynin in isoproterenol‐induced cardiac damage is mediated through Nrf‐2/HO‐1 signaling pathway

AbstractThis investigation evaluated the therapeutic benefit of apocynin in isoproterenol (ISO)‐induced cardiac damage in rats. ISO‐administered male Wistar rats were treated with apocynin for 2 weeks. Blood plasma and left ventricle of heart tissues were collected and analyzed for oxidative stress‐related parameters such as malondialdehyde (MDA), advanced oxidation protein product (AOPP), and nitric oxide (NO). The activities of endogenous antioxidant enzymes such as superoxide dismutase (SOD) and catalase were also measured. The gene expressions of oxidative stress‐related proteins such as Nrf‐2, HO‐1, and HO‐2 in cardiac tissues were also measured. In silico studies like molecular docking and molecular dynamics were also performed to detect how apocynin interacts with NADPH and nitric oxide synthase at the molecular level. This investigation revealed significant elevation of serum transferase enzymes and creatinine kinase‐Muscle Brain (CK‐MB) activities in ISO‐administered rats compared to the control. Apocynin effectively normalized the serum transferases and CK‐MB activities in the blood of ISO‐stressed rats. Moreover, ISO‐induced elevations of MDA, NO, and AOPP levels were also suppressed by apocynin treatment. Consistently, apocynin restored the reduced SOD and catalase activities in ISO‐administered rats. This restoration of enzyme activity might be due to the increased expression of Nrf‐2 and HO‐1 and reduced expression of iNOS and TNF‐α in ISO‐administered rats. Histological analysis revealed that apocynin treatment ameliorated the mononuclear cell adherence and fibrosis in the cardiac tissue of ISO‐administered rats. Computational studies also support the experimental findings. This study demonstrates that apocynin prevents ISO‐induced cardiac injury not only by preventing inflammation but also by empowering the antioxidant defense system.

Potential environmental implications of sandbar afforestation: Insights from ecosystem restoration initiatives in a sandbar of Brahmaputra River Assam, India

Plantation in riverine sandbars offers an excellent opportunity for restoration of ecosystem with a vast potential for enhancing carbon stock. Afforestation on barren islands is challenging task; however, Padmashree Jadav Payeng has single-handedly transformed a sandbar of the river Brahmaputra into a forested landscape in India’s northeastern state of Assam. Such inspiring initiative needs more attention in terms of scientific assessment to quantify ecosystem value and services that can be enriched through such activities. This study uses remote sensing data viz., Landsat4–5TM and Sentinel 2 A data to provide a detailed information on spatio-temporal variability of land use land cover of study region from 1990 to 2021. It aims to conduct a scientific and systematic assessment of biophysical changes that have occurred in the sandbars, understand the status of afforestation, and evaluate the current levels of aboveground biomass (AGB), belowground biomass (BGB), and carbon stock in the selected sandbars. The spatial distribution of AGB, BGB and carbon stock is derived using linear regression model between SAR backscatter and field-based AGB. The results demonstrate that forest cover increased by 31.92 % and sandbar area is reduced by 26.87 % from 1990 to 2021. Spatially derived AGB ranges from 9 to 1295.89 Mg per ha, BGB from 2.35 to 290.50 Mg per ha and carbon stock from 6.18 to 763.34 Mg per ha. Ficus religiosa exhibits a high biomass, ranging from 564.7 Mg per ha to 994.7 Mg per ha, and a high carbon stock, ranging from 8 to 557.30 Mg per ha, attributed to its larger diameter at breast height (DBH). Moreover, phytosociological assessment was conducted for the studied forest, which reveal a total tree species richness of 79. The forest exhibits a total tree density of 395 individuals per hectare. Different biodiversity indices provide a comprehensive understanding of species composition; where results show a Shannon diversity index of 2.81, a Simpson's index of 0.08, a Menhinick's richness index of 2.7, and a Margalef's richness index of 5.26. The article provides detailed information on change in forest cover and present status of AGB, BGB and Carbon stock, providing evidence-based narratives on ecosystem restoration. The initiative by a single person has created a forested landscape and habitat for a large number of wild animals, contributing to better carbon stock and a healthier ecosystem. With regard to the current debate of carbon market, the study suggests the need of instrumentalization of carbon credits for such restoration activities to encourage increase in carbon stock. It also concludes that in-depth research should be taken up on long-term effectiveness of such plantation activities and the potential for scaling up these initiatives for ecosystem restoration in view of climate change mitigation and sustainable forest development.

Heat tolerance varies considerably within a reef-building coral species on the Great Barrier Reef

Reef-building coral populations face unprecedented threats from climate warming. Standing variation in heat tolerance is crucial for evolutionary processes necessary for corals to persist. Yet, the spatial distribution of heat-tolerant corals and the underlying factors that determine heat tolerance are poorly understood from individual to ecosystem scales. Here, we show extensive variation in the heat tolerance of a foundational coral species complex across the Great Barrier Reef. Thermal thresholds of 569 individuals differed by up to 7.3 °C across scales from meters to >1250 km. Variation in thresholds among reefs was consistent with local adaptation and acclimatization to historical and recent thermal history. However, variation within reefs was sometimes greater than among reefs and largely unexplained by environmental predictors, putative host species, or symbiont communities. This indicates that within-reef heat tolerance differences may be informed primarily by other factors, such as adaptive genomic variation. We anticipate our findings will inform conservation and restoration actions, including targeting individuals for selective breeding of enhanced heat tolerance.

Peroxyredoxin 6 Protects RIN-M5F Pancreatic Beta Cells Against Streptozotocin-Induced Senescence.

There are evidences that a decrease in the functional activity of pancreatic β-cells under type 2 diabetes conditions may be associated with their senescence, therefore, senotherapy may be a prospective strategy for the diabetes treatment. The senotherapeutic potential of peroxiredoxin 6 (PRDX6) was studied in RIN-m5F pancreatic β-cells with streptozotocin-induced senescence by measuring markers, associated with senescence. Exposure to streptozotocin (STZ) resulted in the senescence of the β-cells. The addition of PRDX6 to the culture medium of RIN-m5F β-cells before treatment with STZ decreased the levels of the following senescence markers: the percentage of SA-β-Gal-positive cells, the phosphorylation of histone H2AX and p21 proteins, and the secretion of the proinflammatory cytokine IL-6 but not the anti-inflammatory cytokine IL-10. These effects were accompanied by a decrease in the production of reactive oxygen species (ROS) and the restoration of impaired NF-κB activation. In addition, PRDX6 altered the production of the heat shock protein HSP90: the production of the constitutive form of HSP90-beta decreased, while the level of inducible HSP90-alpha increased. PRDX6 prevented the senescence of RIN-m5F cells in response to the DNA damage-inducing agent streptozotocin, indicating a potential protective role of PRDX6 in type 2 diabetes mellitus.

The Effects of Meander Reconnection and Deflector Installation on the Physicochemical Water Quality

ABSTRACTRiver restoration efforts are gaining momentum in response to the pressing need for resilient river systems, in light of escalating climate change impacts. However, achieving predefined restoration goals remains challenging due to insufficient understanding of river system responses. Of particular complexity is assessing the success of restoration measures on water quality, a critical abiotic factor in freshwater ecosystems. This study examined the impact of meander reconnection and deflector placement on water quality. Two distinct meander sections and a degraded section were meticulously sampled both upstream and downstream to assess impacts. The meander sections were reconnected using different approaches: one fully reconnected, receiving all discharge, and the other partially reconnected, receiving part of the discharge while maintaining the channelized trench. The results showed promising potential of reconnected meanders for mitigating phosphorus and carbon levels. However, the effectiveness of these improvements was compromised by deflector placement, which led to increased erosion and release of phosphorus bound to organic soil particles. Conversely, dissolved nutrients (e.g. nitrate, orthophosphate, DOC) exhibited no significant alterations, likely attributed to the absence of macrophytes and the limited extent of restorative actions, which currently do not increase water residence time sufficiently. Temporal trends revealed progressive reductions in carbon, phosphorus, and nitrogen levels suggesting that time is a crucial factor in restoration success, possibly due to soil stabilization. Seasonal dynamics also played a significant role, with discernible effects observed primarily during summer. This study underscores the importance of long‐term, watershed‐scale investigations that account for seasonal variability to fully understand the impacts of river restoration.

Competences for socio-ecological stewardship: a qualitative assessment of the transformative potential of farmers’ learning processes in Eastern Uganda

ABSTRACT Purpose: This paper identifies socio-ecological stewardship competences that smallholder farmers in the Manafwa watershed in Eastern Uganda, developed by participating in a project founded on the Participatory Integrated Planning approach. Methodology: A case study approach was applied. Data were collected by interviewing smallholder farmers and PIP trainers; observing farm practices and PIP training sessions; and conducting focus group discussions. Data were analysed thematically, inspired by the environmental competence model of Roczen, to identify socio-ecological stewardship competences. Findings: The study identified socio-ecological stewardship competences comprising different sustainability-related dimensions including: ‘environmental knowledge’ as environmental systems, action-related, effectiveness, social, and ethical knowledge; ‘connection with nature’ as establishing an identity with nature, appreciating the value of nature, social, and ethical attitudes; and ‘ecological behaviour’ as conservation and restoration, social, and ethical actions. Practical implications: Competence dimensions are interconnected thus requiring learning environments that develop them simultaneously. Additionally, social and ethical competences are relevant for supporting stewardship action. Theoretical implications: This study expands Roczen’s environmental competence model by including social, ethical, and conservation and restoration action competences. Originality/value: This study is the first to identify socio-ecological stewardship competences and the learning processes that can foster these competences.

Assisted sexual coral recruits show high thermal tolerance to the 2023 Caribbean mass bleaching event.

Assisted sexual coral propagation, resulting in greater genet diversity via genetic recombination, has been hypothesized to lead to more adaptable and, hence, resilient restored populations compared to more common clonal techniques. Coral restoration efforts have resulted in substantial populations of 'Assisted sexual Recruits' (i.e., juvenile corals derived from assisted sexual reproduction; AR) of multiple species outplanted to reefs or held in in situ nurseries across many locations in the Caribbean. These AR populations provided context to evaluate their relative resilience compared to co-occurring coral populations during the 2023 marine heat wave of unprecedented duration and intensity that affected the entire Caribbean. Populations of six species of AR, most ranging in age from 1-4 years, were surveyed across five regions during the mass bleaching season in 2023 (Aug-Dec), alongside co-occurring groups of corals to compare prevalence of bleaching and related mortality. Comparison groups included conspecific adult colonies as available, but also the extant co-occurring coral assemblages in which conspecifics were rare or lacking, as well as small, propagated coral fragments. Assisted sexual recruits had significantly lower prevalence of bleaching impacts (overall pooled ~ 10%) than conspecific coral populations typically comprised of larger colonies (~ 60-100% depending on species). In addition, small corals derived from fragmentation (rather than sexual propagation) in two regions showed bleaching susceptibility intermediate between AR and wild adults. Overall, AR exhibited high bleaching resistance under heat stress exposure up to and exceeding Degree Heating Weeks of 20°C-weeks. As coral reefs throughout the globe are subject to increasingly frequent and intense marine heatwaves, restoration activities that include sexual reproduction and seeding can make an important contribution to sustain coral populations.

Natural forest colonisation as a management strategy to restore soil functioning of abandoned agricultural lands

Abstract Land abandonment promotes forest expansion into abandoned agricultural lands in Europe. This process leads to changes that affect several ecosystem services, but it is considered a low‐cost strategy to restore soil functions in past agricultural lands. Soil microbial communities play a key role in restoring functions. However, the relationship among forest expansion, microbial communities, and soil functioning is unclear. In this study, we used a Juniperus thurifera expansion gradient on abandoned agricultural lands in Alto Tajo National Park (Spain) to discover the changes elicited by the soil microbial communities and their functions along this gradient considering two microhabitats, under the canopy and open areas. Specifically, our objectives were (i) to analyse how soil properties (organic matter and pH), microbial communities (using PLFAs‐NFLAs) and enzymatic activities (related to C, N and P cycling) varied along the forest expansion gradient and between microhabitats and (ii) to decipher the pathways by which soil properties control the carbon and nutrient cycling in soils. The forest expansion gradient had a direct negative effect on phosphatase activity. The microhabitat showed a positive direct effect on organic matter content, pH, actinomycetes and arbuscular mycorrhizal fungi biomass and on soil C and P cycling. Moreover, the biomass of gram‐positive bacteria determined the biomass of other microbial groups. Synthesis and Applications: Though its effectiveness is variable, passive restoration can be more effective than active restoration. Our research indicates that passive tree colonisation of past agricultural land is enough to achieve soil functionality similar to a mature forest for most variables studied. However, some variables would need more time to reach mature forest levels, such as total microbial biomass and organic matter content. Therefore, to support ecosystem recovery, the management of this applied forest ecology strategy requires continuous monitoring of newly established trees and soil to elucidate the time needed to achieve mature soil properties.

Mosaic of biological soil crusts and vascular plants contributes to the spatial heterogeneity of key soil properties at different successional stages of restored inland sand dunes

Abstract Background and aims Inland sand dunes constitute Natura 2000 habitat that has become a priority to ensure biodiversity protection and habitat heterogeneity at the landscape scale; however, without proper management, spontaneous succession leads to overgrowing of trees and thus to habitat degradation. Understanding succession processes, relationships between biotic and abiotic components, and their changes over time after restoration, is the key to proper planning of future restoration activities. The aim was to determine the changes of biological soil crust (BSC), vascular plants and physicochemical parameters of BSC, below-crust, rhizosphere, and bare substrate types at different stages of succession in inland dunes of the Błędowska Desert (Poland). We also analyzed the interplay between these factors to further understand the mechanism of BSC development and recognize driving factors causing changes in the soil environment. Results Our results showed that BSCs contributed to increased organic C, total N, nutrients in soil, and acidification with the succession. The content of inorganic N forms was significantly higher in bare soil compared to below-crust soil. Rhizosphere soil was enriched in organic matter and nutrients, which improves soil conditions within plant patches. Moreover, below-crust soil pH, total N content and water holding capacity drive the patterns of BSC morphological groups and species composition of lichens, bryophytes, and vascular plants. Conclusion Our study shows that spatial structure of the inland dune ecosystem is a mosaic of BSCs and plants that contribute to the spatial heterogeneity of key soil properties. We concluded that it is necessary to consider the matter of BSC in restoration treatments.

Performance analysis of the FB-PLL applied to real time monitoring of deep sleep brainwaves

Repose is indispensable for the human body, one of its main functions being to replenish energy. During sleep, the body's important restorative activities are performed by the organism, which is a basic human need. With awareness of the dimension that sleep represents and the need to improve its quality, the importance of monitoring in real time becomes evident. Based on this, the fast fourier transform is a technique capable of obtaining characteristics of a signal, such as its frequency, as well as being able to be applied to sleep waves. However, to have a good use, a considerable number of sample experimental cycles is necessary, which demands a certain computational effort. In this sense, this work we sought to apply the Phase-Locked Loop technique. Thus, a Fourier-based synchronization algorithm is proposed to track low-frequency brain waves during sleep. It is also worth noting that this method is capable of performing the estimates in just one cycle. Therefore, the objective is to obtain the estimated curve referring to the frequency and an efficient synchronization algorithm that is able to track deep sleep in real time.

Eliciting diverse perspectives to prioritize community actions for biodiversity conservation.

Communities have a strong role in protecting biodiversity. In addition to participation in restoration, a range of actions in the public or private sphere may support biodiversity. Despite this, there is a lack of clarity about what actions should be prioritized for behavior change campaigns. We developed and applied a method to prioritize community actions for biodiversity conservation that incorporates an expert-based assessment of impact and a community-informed measure of the likelihood of uptake. In stage 1, experts (n=143) completed a survey that quantified the relative impact of actions based on best-worst scaling of perceived impact. In stage 2, surveyed community members (n=3200) ranked the likelihood of adopting actions based on the ease or difficulty of performing each action, and the opportunity for change based on the proportion of respondents not yet engaging in each behavior. Experts gave the following actions the highest ranking for impact: voting for the environment (first), participating in restoration in ecological priority areas (second), and purchasing and protecting remnant bushland (third). When considering the disciplinary background and institutional background of experts, voting and participating in restoration activities remained in the upper ranked options. However, there was some divergence between these groups. For example, reducing beef consumption was ranked third by university-based experts but ranked 28th by experts based in state government. Overall, community members ranked the following behaviors as most likely to be adopted: following quarantine laws (first), reducing plastic use (second), and managing pets (third). Top likelihood ranking of actions was minimally affected by community characteristics (nature relatedness, gender, location). Integrating these findings, the action ranked most favorably for impact, likelihood, and opportunity was participating in restoration. Choosing actions for behavior change campaigns requires consideration of the entire social-ecological system-from social factors that enable or constrain adoption to the ecological impact of actions across relevant social and ecological contexts.

The Role of The International Court of Justice ICJ in Redressing the Environmental Damages Caused by States During Wartime

Over the past century, it has been more evident that one manifest consequence of conflict is the detrimental impact on the environment. Although there has been beneficial growth in international environmental law, the environment has nonetheless suffered from following international armed conflicts, including the Kosovo conflict, the Iraq war, the Israel-Lebanon war, and Ukraine. In fact, there has been no legal responsibility imposed on any State for violating the responsibilities outlined in Articles 35 and 55 of Additional Protocol I. Remarkably, the International Court of Justice ICJ has acknowledged that environmental damage is eligible for compensation and to take "active restoration measures". the main problem is that the environmental damage persists even after the war has ceased. This article attempts to analyze the strengths and weaknesses of the State responsibility for environmental damage during wartime before the ICJ. This article shows the significant contributions from ICJ to protect the environment but while also showing the ambiguity related to the development of reparation for the damage caused during wartime. The purpose of this article is to examine the extent to which international law could apply to environmental damage in wartime. How much environmental damage needs to happen how much reparation must be deliberated? The article explores a methodology for evaluating environmental damage caused during a conflict by the ICJ and takes the lessons learned from the jurisprudence of the ICJ to determine the appropriate amount of compensation for such damage. This article examines the ineffectiveness of the current international legal framework for dealing with environmental damage during wartime. It provides an overview of the historical context of environmental damage in armed conflicts and a review of existing customary and conventional laws.

Soundscape analysis can be an effective tool in assessing seagrass restoration early success

Restoration of vulnerable marine habitats is becoming increasingly popular to cope with widespread habitat loss and the resulting decline in biodiversity and ecosystem services. Lately, restoration strategies have been employed to enhance the recovery of degraded meadows of the Mediterranean endemic seagrass Posidonia oceanica. Typically, habitat restoration success is evaluated by the persistence of foundation species after transplantation (e.g., plant survival and growth) on the short and long-term, although successful plant responses do not necessarily reflect the recovery of ecosystem biodiversity and functions. Recently, soundscape (the spatial, temporal and frequency attribute of ambient sound and types of sound sources characterizing it) has been related to different habitat conditions and community structures. Thus, a successful restoration action should lead to acoustic restoration and soundscape ecology could represent an important component of restoration monitoring, leading to assess successful habitat and community restoration. Here, we evaluated acoustic community and metrics in a P. oceanica restored meadow and tested whether the plant transplant effectiveness after one year was accompanied by a restored soundscape. With this goal, acoustic recordings from degraded, transplanted and reference meadows were collected in Sardinia (Italy) using passive acoustic monitoring devices. Soundscape at each meadow type was examined using both spectral analysis and classification of fish calls based on a catalogue of fish sounds from the Mediterranean Sea. Seven different fish sounds were recorded: most of them were present in the reference and transplanted meadows and were associated to Sciaena umbra and Scorpaena spp. Sound Pressure Level (SPL, in dB re: 1 μPa-rms) and Acoustic Complexity Index (ACI) were influenced by the meadow type. Particularly higher values were associated to the transplanted meadow. SPL and ACI calculated in the 200–2000 Hz frequency band were also related to high abundance of fish sounds (chorus). These results showed that meadow restoration may lead to the recovery of soundscape and the associated community, suggesting that short term acoustic monitoring can provide complementary information to evaluate seagrass restoration success.

Results of Controlled tissue regeneration in surgery for diabetic foot syndrome

Relevance. The problem of tissue regeneration in diabetic foot syndrome has currently become particularly relevant due to the multipolarity of the mechanisms of trophic disorders, their tendency to recur, the expansion of the affected areas when using traditional treatment methods, resistance to drug treatment methods, deterioration of patients' quality of life, as well as due to the significant expenditure of time and effort required for treatment. All these factors lead to significant economic costs in the management of patients in this cohort.The aim of the study: to develop new combined methods of surgical treatment of tissue defects in patients with complicated forms of diabetic foot syndrome.Materials and methods. The paper presents an original approach to solving one of the urgent problems of modern surgery of complications of diabetes mellitus, to the treatment of pathological processes of soft tissues of the lower extremities.Conclusions. At the stages of the entire study period, rapid wound healing was registered regardless of the initial clinical data and patient's medical history. There was also a decrease in the inflammatory response and active restoration of damaged tissues.

From Stand to Forest: Woody Plant Recruitment in an Andean Restoration Project.

The growing deforestation of tropical forests requires the implementation of restoration actions capable of assisting the recovery of biodiversity and the functioning of these ecosystems. This research aimed to identify the environmental factors that influence the abundance and diversity of woody plant recruitment in an Andean forest restoration project in Medellin (Colombia). Data from woody plant individuals taller than 80 cm were collected in 22 plots of 200·m-2. The environmental factors selected were edaphic variables, plantation structure, slope, elevation, prior land use, and landscape forest cover. Generalized linear models (GLM) were used to analyze recruitment densit and Linear Mixed Models (LMM) to assess recruited species richness, diversity, and dominance. Woody plant recruitment attributes in our study area were similar to those of secondary succession in an Andean forest, but planted trees contributed little to recruitment density and diversity. While recruitment density was affected by slope, canopy closure, and landscape forest cover, recruitment diversity was influenced by physical (bulk density) and chemical (pH, aluminum, Cation Exchange Capacity) edaphic factors, planted tree diversity (species richness and composition), canopy closure, and the mortality rate of planted trees. We conclude that sites with lower mortality rates of planted trees and denser canopies enhance both recruitment density and diversity, indicating a synergy between active restoration and passive regeneration processes.

Assessing the effects of long-term habitat reconstruction on breeding shorebird populations in a steppe region

Shorebirds represent key indicator species for evaluating the health of wetlands, as they rely on specific habitats for breeding and foraging. Several restoration actions were initiated to restore these wetlands in the Hortobágy (Hungary), however, their effects have never been assessed. Since birds are good indicators of the health and quality of natural environment and sensitive to changes in land use and climate, we evaluated the restoration actions conducted in the last 20 years using bird monitoring data. Our study focuses on the long-term effects of different habitat restoration actions implemented in the region, which involved no restoration, targeted and non-targeted type of interventions for shorebird management as well as long-term and short-term management. The evaluation is based on long-term monitoring data of shorebird species: Black-winged Stilt, Northern Lapwing, Black-tailed Godwit, Common Redshank and Common Snipe. The effectiveness of restoration actions found to have a species-specific aspect, but in general, our findings indicate positive effects of targeted and long-term restoration actions on breeding shorebird populations. By contrast, targeted but short-term actions led to even worse results for shorebird breeding population size than where no restoration actions were initiated. These findings contribute to a better understanding of the specific habitat requirements of breeding shorebirds in the steppe region and can inform future habitat management strategies. The results can be used in conservation planning and management and highlight the importance of long-term and targeted habitat reconstruction projects in restoring and maintaining breeding shorebird populations.