This paper explores the Critical Success Factors in e-commerce in Uzbekistan. First, the most essential variables are identified through a literature review. Then, experts in the Uzbekistan e-commerce industry evaluate each potential success factor. Third, the most outstanding factors are elicited through Factor Analysis. While some of the research findings suggest addressing IT-related variables to help secure customers in line with previous studies in developing countries, an unexpected discovery is human resources emphasis, which is typically emphasized in more developing countries. A qualitative part of the research makes an important contribution to e-commerce development. In particular, responsible institutions are recommended to revisit their counterfeit products policies. The paper serves as a guide for Uzbekistan e-commerce entities. Besides its practical value, the study contributes to the extant literature by enlarging the research body of critical success factors among developing countries.