Background and Objectives One of the ways to deal with Covid-19 disease is 19 preventive behaviors that seem to be affected by different factors. Therefore, the aim of the present study was to predict the preventive behaviors of Covid- 19 disease based on health literacy with the mediating role of media information belief and social responsibility. Subjects and Methods This descriptive and correlational study was performed on 247 adults in Ahvaz in the summer of 2020. The research sample was selected using available sampling and they answered online the questionnaires whose validity and reliability were confirmed.. Data were analyzed using Spss, Amose software, descriptive and analytical statistics. Results The results showed that the indirect coefficients between believing in media information (P=0.000, β=0.04) and social responsibility (P=0.000, β=0.11) with preventive behaviors of corona disease were significant. The proposed research model also had a good fit (RMSEA= 0.05, P=0.20, X2/df: 1.63, X2: 1.63). Conclusion The results showed that health literacy is both directly and indirectly related to corona disease prevention behaviors through belief in media information and social responsibility. Therefore, to increase the preventive behaviors of corona disease in individuals, we can use the influence of the media and strengthen social responsibility in individuals.