In order to carry out parametric analysis of eccentric structure–soil interaction system, an analytical model based on branch mode decoupling method is presented in this paper. The solution of system equations is implemented in the frequency domain by assuming that the superstructure maintains classic normal modes. The transfer functions of translational and torsional response are derived later. The influence of eccentricity ratio, torsional to translational frequency ratio, height-to-base ratio and foundation flexibility on the curve and peak value of transfer functions and torsionally coupled degree are analyzed and discussed systematically. Results of analysis indicate that the flexibility of foundation soil can weaken the torsional response of superstructure substantially, and the natural frequencies of interaction system reduce as the flexibility of foundation soil increase. The influence of eccentricity ratio on the peak values of transfer functions varies with the torsional to translational frequency ratio, which can be summarized as the decrease of translational component and the increase of torsional component. The translational displacement of SSI system is larger than that of fixed-base condition, while the deformation amplitude is notably reduced. The torsional response decreases as well. As the height-to-base ratio increase, the varying tendency of response is further enhanced. The torsionally coupled degree of eccentric structure is remarkably affected by the torsional to translational frequency ratio, which is significantly reduced under soft soil condition.