Respiratory System In Children Research Articles

Peculiarities of acoustic diagnostic methods in pediatric practice (literature review, own research)

Diseases of the respiratory system are among the most common among the population of different age categories. Sound, as a physical phenomenon, is the propagation of longitudinal elastic waves in a medium, for example, in the air. Waves with frequencies below 16 Hz are called infrasound, and above 20,000 Hz are called ultrasound, and these waves cannot be perceived by the human ear. That is why the study of acoustic signals is extremely important for the diagnosis and monitoring of respiratory diseases. The aim of this article is to investigate the features of the use of acoustic diagnostic methods in pediatric practice through the analysis of contemporary literature over the past five years, sourced from Scopus and Web of Science databases, as well as conducting original clinical research. Results. Acoustic diagnostic methods in pediatrics have great potential due to their non-invasiveness and lack of radiation exposure. Literary sources indicate the high efficiency of these methods in detecting pathologies of the respiratory system in children, especially in the early stages of diseases. Our research with the acoustic monitoring device "Trembita-Corona" confirmed the ability to accurately determine the affected areas of the lungs with the help of highly sensitive acoustic sensors. The primary focus is paid to the comparative evaluation of the diagnostic efficacy, safety, and potential for using these methods in children of different age groups. It has been proven that acoustic methods allow the identification of pathological changes even in hard-to-reach extracostal areas. The effectiveness of the acoustic monitoring device "Trembita-Corona" developed and implemented in clinical practice is confirmed by the possibility of mathematical data processing, which significantly increases the accuracy of diagnosis, excluding the human factor. The use of acoustic methods in pediatrics opens up new opportunities for early detection and monitoring of diseases of the respiratory system. Conclusions. The implementation of acoustic methods into clinical practice is a promising direction that deserves further research and development. The conducted experimental studies demonstrated the ability of the "Trembita-Corona" device to accurately diagnose and localize lung lesions in community-acquired pneumonia, confirming the effectiveness of the developed methods and algorithms. No conflict of interests was declared by the authors.

Мeans of restorative treatment of children of younger school age sick of bronchial asthma in rehabilitation institutions

Bronchial asthma is a problem of extreme urgency, as morbidity and mortality from it are constantly increasing throughout the civilized world. Among chronic diseases of respiratory organs, pathology occupies a leading place. In different countries, its prevalence varies from 10 to 15%. This is associated with high disability and mortality of patients with BA. Based on the analysis of literary and other sources of information, theoretical material on the use of means of restorative treatment for children of primary school age with bronchial asthma in rehabilitation institutions was studied and selected. Among the diseases of the respiratory system in children, various forms of bronchial asthma occupy a prominent place in the development of children's disability. Morbidity and mortality from it are constantly increasing throughout the civilized world. The article discusses the issues of non-drug treatment of bronchial asthma in children. The relevance of the problem of rehabilitation of children with bronchial asthma is due to the urgent need to facilitate their life and adaptation to the environment, as well as to improve the level of self-care. Accordingly, physical therapy of such children occupies an important place, because it improves their physical condition, contributes to the effective correction of functional insufficiency of the respiratory system, provides training of the cardiovascular system, which leads to better activity of the child in educational activities and adaptation in society. The aim of the study. Theoretical substantiation of the necessity and essence of the use of physical therapy in the complex rehabilitation of children of primary school age, patients with bronchial asthma, in rehabilitation institutions. Research methods. Analytical review of literary and information sources, study of the state of the issue and systematization of modern scientific and methodological knowledge and results of practical experience of leading specialists in physical rehabilitation regarding the issue of rehabilitation of children with bronchial asthma. Literary sources (scientific articles, textbooks, manuals, dissertation research abstracts) are selected from the electronic databases of the National Library of Ukraine named after V.I. Vernadskyi, Web of Science, PubMed and others.

P152 Real-life impact of CFTR modulator therapy on respiratory system in children with cystic fibrosis

P152 Real-life impact of CFTR modulator therapy on respiratory system in children with cystic fibrosis

Lonicerin alleviates ovalbumin-induced asthma of mice via inhibiting enhancer of zeste homolog 2/nuclear factor-kappa B signaling pathway.

Asthma is the most common chronic disease in the respiratory system of children caused by abnormal immunity that responses to common antigens. Lonicerin exerts anti-inflammatory activity in other inflammatory models through targeting enhancer of zeste homolog 2 (EZH2) that is related to asthma. We sought to explore the role and mechanism of lonicerin in regulating allergic airway inflammation. Mice were intraperitoneally injected 10 µg ovalbumin (OVA) on postnatal day 5 (P5) and P10, and then inhaled 3% aerosolized OVA for 10 min every day on P18-20, to establish asthmatic mice model. Lonicerin (10 or 30 mg/kg) was given to mice by intragastric administration on P16-P20. Notably, the administration of lonicerin amended infiltration of inflammatory cells and mucus hypersecretion. OVA-specific IgE level, inflammatory cell count and inflammatory cytokines in asthmatic mice were reduced after lonicerin treatment. Moreover, it suppressed the activity of EZH2 and activation of nuclear factor-kappa B (NF-κB) as evidenced by decreasing tri-methylation of histone H3 at lysine 27 and reducing nuclear translocation of NF-κB p65. In a word, Lonicerin may attenuate asthma by inhibiting EZH2/NF-κB signaling pathway.

Diseases of the upper respiratory tract and their pathogenetic mechanisms in children living under conditions of chronic exposure to aldehydes and aromatic hydrocarbons

Introduction. The problem of diseases of the respiratory system in children in regions with technogenic atmospheric pollution by chemical agents is relevant. 
 The aim of the study was to study the features of the formation of the pathology of the upper respiratory tract, their pathogenetic mechanisms, and causal relationships of clinical, instrumental, and immunological disorders with toxic load in children living under conditions of chronic exposure to phenols and aromatic hydrocarbons of the industrial origin. 
 Materials and methods. one thousand one hundred fifty one 4–13 years children were examined, 883 people made up the observation group and lived in the territory with excess of hygienic standards in the air of phenol, formaldehyde, acrolein, o-xylene. The comparison group consisted of 268 children living in the territory of ecological well-being. The prevalence of pathology of the upper respiratory tract (URT), rhinomanometry, laboratory parameters were assessed, correlation-regression relationships of clinical and laboratory parameters and the concentration of chemicals in the blood were determined. 
 Results. The study established for the first time the relationship between the concentration of chemical compounds in the blood, laboratory and instrumental indicators in children with URT pathology, living in the territory with excess levels of phenol, formaldehyde, acrolein. The total nasal airflow in the observation group was 10-15% lower than in the comparison group and inversely related to the blood concentration of acrolein, o-xylene, phenol, formaldehyde, and the content of IgG specific to phenol, myelopyroxidase, total number of lymphocytes, subpopulations of CD3+CD25+ and CD3+CD95+, integral index of proliferation and frequency of cells with apoptotic bodies and circular notches of the nucleus. 
 Limitations. The results of the study can be extrapolated to 4-13 years children, boys and girls. The study did not include young children or adults. 
 Conclusion. Characteristic features of the pathology of the upper respiratory tract associated with increased levels of acrolein, o-xylene, phenol and formaldehyde in the blood are a decrease in nasal airflow against the background of specific immune-dependent and non-specific inflammation. To reduce the incidence of URT in children, it is necessary to develop programs that include measures aimed at improving the quality of the environment, therapeutic and preventive measures that increase adaptive capacity.

The Potential Role of Serum and Exhaled Breath Condensate miRNAs in Diagnosis and Predicting Exacerbations in Pediatric Asthma

Asthma is the most common chronic disease of the respiratory system in children and the number of new cases is constantly increasing. It is characterized by dyspnea, wheezing, tightness in the chest, or coughing. Due to diagnostic difficulties, disease monitoring, and the selection of safe and effective drugs, it has been shown that among the youngest patients, miRNAs fulfilling the above roles can be successfully used in common clinical practice. These biomolecules, by regulating the expression of the body's genes, influence various biological processes underlying the pathogenesis of asthma, such as the inflammatory process, remodeling, and intensification of airway obstruction. They can be detected in blood serum and in exhaled breath condensate (EBC). Among children, common factors responsible for the onset or exacerbation of asthma, such as infections, allergens, air pollution, or tobacco smoke present in the home environment, cause a change the concentration of miRNAs in the body. This is related to their significant impact on the modulation of the disease process. In the following paper, we review the latest knowledge on miRNAs and their use, especially as diagnostic markers in assessing asthma exacerbation, with particular emphasis on the pediatric population.

Connective tissue dysplasia in children with broncho-obstructive syndrome

BACKGROUND: Changes in the respiratory system in children with connective tissue dysplasia (CTD) have not been studied enough.
 AIM: To study the features of CTD in patients of the pediatric pulmonology department with broncho-obstructive syndrome and chronic inflammation of the bronchi, to assess complaints and the nature of the disease.
 MATERIALS AND METHODS: Patients admitted to the department were evaluated according to the table of diagnostic signs of CTD. 380 children were examined, aged 2 to 17 years 11 months.
 RESULTS: Out of 380 children, the following were identified: with bronchial asthma 309, with obliterating bronchiolitis 18, with bronchiectasis 11, with recurrent bronchitis 42. Three groups were distinguished: 1st patients with CTD (172; 45%), 2nd with increased dysplastic stigmatization (111; 29%), 3rd children without signs of CTD (97; 26%). Most patients admitted to the pulmonology department have signs of CTD or dysplastic stigmatization (74%). Children with CTD often complain of feeling unwell, asthenia, joint pain, they are more likely to have orthopedic pathology. Patients of the 1st group often complain of articular syndrome 19.2%, group 2 13.5%, children without CTD 4.1 % (p 0.001). Complaints about feeling short of breath were presented by 32.6% of patients with CTD, 21.6% with dysplastic stigmatization, and 7.2% in the comparison group (p 0.001). Children with CTD and dysplastic stigmatization more often had chest deformities.
 CONCLUSIONS: Patients with CTD are characterized by asthenic physique, changes in the axial skeleton chest deformities of II and III degrees, scoliotic deformity of the spine of II and III degrees, which may contribute to the development of the pathology of the respiratory system. CTD is a comorbid condition that significantly affects all organs and systems. Timely diagnosis and an integrated approach to these patients are required. Diseases proceed with severe clinical symptoms, require more active examination and aggressive treatment.

Institute of Phthisiopulmonology of the Ministry of Health

Modern functional diagnostics methods for the respiratory system in children (Part 1. Methods based on the study of tidal breathing in children) This review provides up-to-date information on practically significant functional diagnostics methods of the respiratory system in children, taking into account their physiological capabilities. In the published first part of the review, attention is paid to methods based on the study of tidal breathing in young children (tidal breathing flow-volume, computer bronchophonography, pulse oscillometry); this information is intended for functional diagnostics doctors, pulmonologists, neonatologists and pediatricians.

The effect of hydrotherapy according to Halliwick concept on children with cerebral palsy and the evaluation of their balance: a randomised clinical trial

<p><strong>Background:</strong> Hydrotherapy according to Halliwick concept is a physiotherapeutic intervention technique for disabled patients and for children with neurodevelopmental disorders. Assessing the balance in children with cerebral palsy (CP) is an extremely complex process and more difficult to evaluate the results of some therapeutic interventions in these patients. The purpose of this study is to investigate the effect of Halliwick based Hydrotherapy on the support base in children with CP. Several studies have proven the beneficial effects of hydrotherapy in the respiratory system of children, but few are studies that report the effect on the balance of children with CP.</p><p><strong>Methods:</strong> The study involved 16 children diagnosed with CP. The 10 children were following a Halliwick Concept hydrotherapy program and the 6 children classical physiotherapy program for 3 months. Their balance was assessed with the Berg, GMFM, and footprint plate. The assessment was performed at the start of the program (pre-test) and after 3 months (post-test).</p><p><strong>Results</strong>: Τhere is a statistically significant change between the 1<sup>st</sup> and 2<sup>nd</sup> measurement with the BERG and GMFM tools and better for the water intervention group. The change in the support base between the 1st and 2nd measurement was better in the water intervention group but not statistically significant.</p><p><strong>Conclusions:</strong> The results of the study showed that hydrotherapy according to Halliwick has positive effects on gross mobility and the balance of children with CP. It also appears to have a positive effect on changing the support base compared to classical physiotherapy.</p>

Intravenous lidocaine infusion in children

BACKGROUND: The problem of adequate analgesia in the early postoperative period is not relevant at present, both in our country and abroad because 50% of children experience pain after surgical interventions despite the ongoing therapy. Inadequate ideal method for assessing the pain syndrome severity, age restrictions with several drugs, and difficult communication with young children, as well as drug selection, lead to inadequate detection in pediatric practice.
 AIM: This study aimed to evaluate the effectiveness and safety of intravenous infusion of lidocaine in the early postoperative period in children operated on the abdominal cavity organs.
 MATERIALS AND METHODS: This study included 119 children who were randomized into 3 groups, in which intravenous lidocaine infusion, prolonged epidural blockade, or systemic fentanyl analgesia were used for pain relief after abdominal surgery. Hemodynamic parameters, respiratory system, pain intensity, resolution time of intestinal paresis, cortisol, glucose and lidocaine levels in blood plasma, and complications were monitored and compared intergroup.
 RESULTS: Lidocaine infusion had no effects on the hemodynamics and respiratory system in children. Cortisol level was markedly decreased through the day to baseline (32065 nmol/l). Early recovery of peristalsis corresponded to 233.75 h postoperatively. The pain syndrome intensity during the observation period did not exceed 2 points. The maximum level of free lidocaine in blood plasma was 2.811.31 g/ml, and the time spent in the intensive care unit (ICU) was 4810 h.
 CONCLUSION: Intravenous infusion of lidocaine after abdominal surgery in children is a safe method that provides effective pain relief, restores peristalsis early, and reduces the length of ICU stay.

Gastroesophageal refl ux disease and broncho- obstructive syndrome in children — a “vicious circle” or comorbidity?

This article is devoted to the comorbidity of diseases of the digestive tract and respiratory system in children. Comorbidity (polymorbidity) in the pathology of the gastrointestinal tract is widely described in modern scientific literature, however, the relationship between the digestive and respiratory systems seems to be less studied.The purpose of the study was to analyze the endoscopic signs of refl ux pathology of the digestive tract in children with a comorbid condition — GERD and respiratory diseases occurring with broncho-o bstructive syndrome (BOS).Materials and methods. An in-depth examination of 180 children from 6 to 16 years old with comorbid pathology (respiratory diseases with BOS and GERD) was carried out. Performed: X-ray examination, spirometry, intracavitary pH-metry, EFGDS and ultrasound of the gastrointestinal tract. To study the morphological features of the esophageal mucosa in this comorbidity, biopsies were examined 1 cm above the Z-line; at the same time, a biopsy of the mucosa of the antrum of the prepyloric part of the stomach was performed.Results. Respiratory diseases with biofeedback in the examined groups of patients were most often (43.9%) combined with GERD at the age of 12–14 years. The predominance of endoscopically positive grade 1 GERD is typical for patients with broncho- obstructive syndrome caused by moderate and severe persistent BA, acute and prolonged pneumonia, and recurrent bronchitis. Infl ammatory diseases of the digestive system (chronic gastritis, chronic gastroduodenitis) in BA were detected in 40.6% of patients, in pneumonia — in 45.7%, in recurrent bronchitis — in 33.3% of patients. Based on the data of a general morphological study of biopsy specimens, regardless of age and type of bronchopulmonary pathology, two variants of infl ammation were identifi ed, which are more common than others — with a predominance of dystrophic changes and with a predominance of infl ammation itself, which largely depended on the duration of the disease. In patients suff ering from both BA and pneumonia with biofeedback, morphological changes in the esophageal mucosa corresponded to the catarrhal nature of the infl ammation.

Fibroblast growth factor 21 improves lipopolysaccharide-induced pulmonary microvascular endothelial cell dysfunction and inflammatory response through SIRT1-mediated NF-κB deacetylation.

Pneumonia is a common infectious disease of the respiratory system in children. It often leads to death in children by causing acute lung injury. Fibroblast growth factor 21 (FGF21) is a peptide hormone that plays an important role in the regulation of energy homeostasis. This study aimed to investigate the role of FGF21 in alleviating the lipopolysaccharide (LPS)-induced human pulmonary microvascular endothelial cell (HPMEC) injury, as well as the underlying mechanism. The expression of sirtuin 1 (SIRT1), NF-κB p65, Ac-NF-κB p65, apoptosis-related proteins, tight junction proteins and adhesion molecules in HPMECs were analyzed by Western blotting. The viability and apoptosis of HPMECs were detected by CCK-8 and TUNEL assays. Lactate dehydrogenase level and levels of inflammatory factors were respectively determined by assay kits. The mRNA expression of adhesion molecules in HPMECs was analyzed by RT-qPCR. As a result, SIRT1 expression was decreased and the expression of NF-κB p65 and Ac-NF-κB p65 were increased in LPS-induced HPMECs, which were reversed by recombinant FGF21 (rFGF21). rFGF21 increased the viability and inhibited the apoptosis, inflammatory response, permeability, and release of cell adhesion molecules of LPS-induced HPMECs. In addition, EX527 as SIRT1 inhibitor could reverse the effect of rFGF21 on LPS-induced HPMECs. In conclusion, FGF21 improved LPS-induced HPMEC dysfunction and inflammatory response through SIRT1-mediated NF-κB deacetylation.

Psycho - physiological aspects & effect on resporatory system through Naturopathy on children age group 5-12 yrs

POSITIVELY LINK TO GLOBAL WARMING TITLE OF THE THESIS PSYCHO-PHYSIOLOGICAL ASPECT AND ITS EFFECT ON RESPIRATORY SYSTEM THROUGH NATUROPATHY ON CHILDERN AGE GROUP 5-12 YRS – POSITIVELY LINK TO GLOBAL WARMING A THESIS SUBMITTED TO THE SHRI JAGDISH PRASAD JHABARMAL TIBREWALA UNIVERSITY, VIDYANAGARI, JHUNJHUNU, RAJASTHAN. FOR THE DEGREE OF DOCTOR OF PHILOSOPHY IN (INTERDISCIPLINARY) SHILPA N. DESAI REG.NO. - 20114552 UNDER THE GUIDANCE OF Dr. NARENDRA V. DESHMUKH DEPARTMENT OF PSYCHOLOGY SHRI JAGDISH PRASAD JHABARMAL TIBREWALA UNIVERSITY, VIDYANAGARI, JHUNJHUNU, RAJASTHAN – 333001 Year 2013 SUMMARY IN BRIEF: Introduction The present study’s aim is at finding out the effect of ‘Naturopathy’ on Physiological and Psychological factor on Respiratory system of children in age group 5 – 12 years, when environmental conditions are unfavourable and averse to healthy living. The Physiological aspect has been measured by Body parameter like Age, Height, Weight, BMR, BMI. Vital parameter being measured by using laboratory instrument; Oxymeter test (O2), Fingertip Begin 2B FDA 510(k), Spirometer test (EFEV), Hudson cc/sec, Peak flow meter test (PFEV) Personal Best Full range peak flow meter(60-810 L/min), Psychological parameter is tested by selecting tool constructed by Jadgish and A K Srivastava, i.e. Mental health inventory, which integrate the personality, autonomy group oriented attitudes and environmental mastery

Assessment of the respiratory system in children with congenital scoliosis by impulse oscillometry and computed tomography (preliminary results)

BACKGROUND: Segmentation disorder of the vertebral body lateral surfaces and rib synostosis are severe variants of congenital pathology of the spine and thorax. They lead to the development of thoracic insufficiency syndrome and are manifested by the inability of the thorax to provide normal respiratory mechanics.
 AIM: This study presents the preliminary results of functional and radiological (CT-morphometric) methods of lung examinations in patients with congenital thoracic spine scoliosis with impaired segmentation of the lateral surfaces of the vertebral bodies and unilateral rib synostosis.
 MATERIALS AND METHODS: This design is represented by a small clinical series. This study is a prospective study of 10 patients aged 3 to 7 years with congenital spinal deformity, with impaired segmentation of the lateral surfaces of vertebral bodies and unilateral rib synostosis. This paper presents the preliminary results of the pulmonary function assessment by pulse oscillometry and CT morphometry in a 3D reconstruction of multispiral computer tomography (MSCT) of the thorax.
 RESULTS: The study of respiratory function using pulse oscillometry revealed no respiratory impairment in seven observations, also reflected in the CT morphometry results. According to the Institute of Medicine (IOM), three children with detected ventilatory abnormalities showed the following parameters with the most significant changes: total respiratory impedance, resonance frequency, and frequency dependence of the resistive component. In all patients, the morphometric indexes of the lung scoring revealed during 3D modeling of the lung were completely consistent with the results of the lung function study by the IOM method.
 CONCLUSIONS: Further study of the problem of respiratory function assessment in children with congenital scoliosis seems promising in diagnostic terms and for evaluating effective surgical treatment.

Prevalence of Human Bocavirus in Children Under 5 Years with Upper and Lower Respiratory Infections in Southeastern Iran

Background: Human Bocavirus (HBoV) is a parvovirus associated with mild to severe upper and lower respiratory tract infections in children. Objectives: This study aimed to detect the virus in the nasopharynx of children under 5-year-old with respiratory infection by polymerase chain reaction (PCR). Methods: Two hundred samples were taken from children referred to pediatric clinics in Kerman, southeastern Iran, with respiratory infections and were positive for virus by PCR. Next, the positive samples were genotyped by real-time PCR. Results: Out of 200 samples, 13 (6.5%) were positive for the Bocavirus gene, and all positive samples were infected by HBoV-1. We observed that 116 patients were male, and there was no difference in the prevalence of the virus based on gender (P = 0.345). The prevalence was significantly higher in infants under 10 months old (P = 0.049). Infection by Bucavirus virus was significantly correlated with symptoms, such as fever (P = 0.035, r = 0.7), otitis media (P = 0.013, r = 0.8), diarrhea, nausea, and vomiting (P = 0.001, r = 0.4). Conclusions: According to our findings, HBoV could be one of the causes of infections in the respiratory system of children, and the only type in the studied region is HBoV-1.

CHANGES IN VENTILATION FUNCTION AND RESERVES OF GAS EXCHANGE IN CHILDREN WITH ACUTE BRONCHITIS

Among the diseases of the lower part of respiratory system in children, acute bronchitis dominates, often with obstructive syndrome and ventilation disorders. To assess the severity of the obstructive syndrome spirometry is used, which is the "gold standard" for this purpose. It combines two groups of tests: spirography – graphical recording of changes in lung volumes during respiratory movements and pneumotachography – graphical recording of the air flow velocity during tidal and forced breathing. Among modern methods, non-invasive determination of blood oxygen saturation with pulse oximetry is becoming increasingly popular. The combined use of spirometry and pulse oximetry makes it possible to determine accurately the state and reserves of the cardiorespiratory system in a wide range of pathological changes. Objective. To learn the features of ventilation function and gas exchange in children with acute bronchitis. Materials and methods. The paper analyzes the results of a survey of 59 children with acute bronchitis. Patients underwent a clinical examination, spirometry, pulse oximetry; breath-hold tests were performed. The results of spirometry and pulse oximetry were compared with the data of clinically healthy children (23 children). Results. In children, the severity of bronchitis was moderate according to the BSS-7.79 ± 0.19 points, 30 patients had symptoms of obstructive syndrome. Spirometry recorded a decrease in forced respiratory volumes, peak forced expiratory flow and inspiratory flow. Pulse oximetry showed a relatively lower level of oxygen saturation in patients, which worsened during breath-hold tests. The obtained results indicate impaired ventilation and gas exchange in children with bronchitis, even with a mild course of the disease, especially in the presence of obstructive phenomena. Compensatory mechanisms for maintaining blood saturation based mainly on an increase in systemic blood flow due to an increase in heart rate. Conclusions. In acute bronchitis in children, ventilation and gas exchange rates decrease, even in those patients with a mild course. Compensatory mechanisms for maintaining blood saturation are based mainly on increased systemic blood flow due to increased heart rate.

Comparative studies of the functioning of the respiratory system in children in conditions of health institutions

Summer health camp is a seasonal preventive institution for recreation, preservation and strengthening of the health of children and adolescents, which allows you to cover a large contingent of the child population with health-improving activities. The article presents the dynamics of the functional indicators of the respiratory system in children and adolescents who were in a summer health camp. On the basis of the children’s health camp «Young railroad worker» and the camp on the basis of a secondary educational school, research was carried out, in which children aged 7–10 years took part. Respiratory function was measured using a spirometer. The data obtained were analyzed using generally accepted methods of mathematical statistics. To identify the level of significance of differences, we used Student’s t-test.In children with round-the-clock stay in the camp, there is a statistically significant increase in Lung Capacity by 101.97 ml and a daytime stay — by 80.55 ml. At the end of the shift, summer health-improving recreation led to an increase in the indicators of the Respiratory Minute Volume (at the time of arrival, the Respiratory Minute Volume indicator in children 7–10 years old was 3,71 ± 1,03 l/min, and at the end 4,31 ± 1,88 l/min with round-the-clock stay; 3,65 ± 1,04 l/min and 4,1 ± 1,54 l/min with a daytime stay) due to an increase in Tidal Volume, which indicates a favorable respiratory response.The results of the functional study revealed an increase in the reserve capacity of the respiratory organs, which indicates the positive effect of the camp on the child’s body.The results obtained in the study of the functional state of respiration will make it possible to determine the directions and forms of organization of medical care in order to prevent deviations in the state of health. These results can serve as a basis for further in-depth research in summer camps of various types and the development of control measures and means of strengthening and maintaining the health of children. Thus, summer health camps are an effective measure of recreation and preservation, strengthening the health of the child population.

Immediate effect of inhalation therapy combined with oscillatory positive expiratory pressure on the respiratory system of children with cystic fibrosis.

It is recommended the association of inhalation therapies and physiotherapy on the management of cystic fibrosis (CF); however, it is still necessary to understand the effect on respiratory mechanics of these therapies combined. This study aimed to evaluate the immediate effect of inhalation with Dornase-Alfa (DNase) and hypertonic saline solution (HSS), as well as the impact of these inhalation therapies associated with an oral high-frequency oscillation (OHFO) physiotherapy device, on the respiratory mechanics of children and adolescents with CF. Children/adolescents with CF were allocated into two groups (DNaseG and HSSG), where they performed inhalation therapy before using the OHFO device for physiotherapy. In each group, the Impulse Oscillometry System was conducted before and after inhalation therapy, and after OHFO. ANOVA was carried out to analyse the respiratory mechanics at different moments of DNaseG and HSSG. The Mann-Whitney test compared the immediate effect of each inhalation therapy and after OHFO. 30 children (6-14years old) were studied. In DNaseG, the mean value of most oscillometric parameters decreased in the evaluated moments; in HSSG, only reactance showed an immediate increase. Children/adolescents with CF showed an immediate decrease in airway resistance and reactance after the use of DNase and associated with OHFO, indicating improvement. The inhalation with HSS has an immediate effect on peripheral airways.

Respiratory sound recorder – continued Innovation

The study of external respiratory function (ERF) is important in the diagnosis of respiratory tract abnormalities in various diseases. In children, especially at an early age, there are many difficulties in conducting studies. In recent decades, due to the development of computer technology, there is great interest in the study of respiratory sounds, methods of their registration, processing and use in the assessment of the respiratory system in children and adults. Russian scientists have developed the method of respiratory airway sound investigation, which has proved its effectiveness, reliability and necessity of use in practice. Computer bronchophonography is based on the analysis of time and frequency characteristics of the spectrum of respiratory noises, arising from changes in the bronchial diameter due to increase in the stiffness of their walls or decrease in the inner diameter. Computed bronchophonography may be used for diagnostics of EFD disorders in patients of all age groups both in the in-patient and out-patient treatment.

ASSESSMENT OF THE RESPIRATORY SYSTEM OF STUDENTS IN RURAL AND URBAN SCHOOLS

The environmental conditions and lifestyle of children in rural and urban areas are significantly different. The influence of environmental factors, different levels of physical activity, social living conditions, and other factors determine the different level of functional and morphological features of the growing organism. The search for ways to improve the health of the child population is an urgent area. The article presents the data of comparative evaluation of the functional capabilities of the respiratory system of students in rural and urban schools. The results of the study demonstrate the predominance of Vital capacity of light indicators among schoolchildren of rural schools. The level of the general condition of oxygen supply systems is also higher among children living in rural areas. It is necessary to study the specific factors of the external environment and lifestyle that have a significant impact on the respiratory system of children.