Diseases Of Respiratory Organs Research Articles

Environmental factors affecting the mortality of population in Odesa Region

The presented research covers a significant part of the period of the COVID-19 pandemic and studies the role of environmental factors in formation of population mortality from main causes. The main causes of mortality among the population of Odesa Region during the studied period include diseases of circulatory system, COVID-19, neoplasms, external causes, diseases of digestive organs and diseases of respiratory organs. The aforesaid causes constitute 94-95% of all causes of mortality in Odesa Region. However, out of these six classes of diseases, only diseases of circulatory system, COVID-19 and diseases of respiratory organs and some of their nosological forms have simultaneous peaks in mortality, during which mortality of the Odesa Region population from all causes almost doubles. Over time, there is a certain redistribution of frequency of the causes of mortality among the six main causing diseases of the population`s mortality in the region. But this does not explain occurrence of simultaneous peaks in mortality from diseases of circulatory system, COVID-19, and diseases of respiratory organs. Formation of simultaneous peaks in mortality from non-infectious and infectious diseases cannot be explained by the influence of social or anthropogenic factors. This indicates the need to address a number of environmental factors of natural origin – meteorological, biometeorological and heliocosmic. The study shows the possibility of an existing linear statistical connection between these environmental factors and the mortality of the Odesa Region population from such classes of diseases as diseases of circulatory system, COVID-19 and diseases of respiratory organs, as well as the relevant nosological forms. The results of the correlation analysis between mortality rates from major diseases and the environmental factors studied showed weak correlations between them. It is fully consistent with the World Health Organization's view of the role of environmental conditions in shaping public health.

Мeans of restorative treatment of children of younger school age sick of bronchial asthma in rehabilitation institutions

Bronchial asthma is a problem of extreme urgency, as morbidity and mortality from it are constantly increasing throughout the civilized world. Among chronic diseases of respiratory organs, pathology occupies a leading place. In different countries, its prevalence varies from 10 to 15%. This is associated with high disability and mortality of patients with BA. Based on the analysis of literary and other sources of information, theoretical material on the use of means of restorative treatment for children of primary school age with bronchial asthma in rehabilitation institutions was studied and selected. Among the diseases of the respiratory system in children, various forms of bronchial asthma occupy a prominent place in the development of children's disability. Morbidity and mortality from it are constantly increasing throughout the civilized world. The article discusses the issues of non-drug treatment of bronchial asthma in children. The relevance of the problem of rehabilitation of children with bronchial asthma is due to the urgent need to facilitate their life and adaptation to the environment, as well as to improve the level of self-care. Accordingly, physical therapy of such children occupies an important place, because it improves their physical condition, contributes to the effective correction of functional insufficiency of the respiratory system, provides training of the cardiovascular system, which leads to better activity of the child in educational activities and adaptation in society. The aim of the study. Theoretical substantiation of the necessity and essence of the use of physical therapy in the complex rehabilitation of children of primary school age, patients with bronchial asthma, in rehabilitation institutions. Research methods. Analytical review of literary and information sources, study of the state of the issue and systematization of modern scientific and methodological knowledge and results of practical experience of leading specialists in physical rehabilitation regarding the issue of rehabilitation of children with bronchial asthma. Literary sources (scientific articles, textbooks, manuals, dissertation research abstracts) are selected from the electronic databases of the National Library of Ukraine named after V.I. Vernadskyi, Web of Science, PubMed and others.

Epidemiology of Acute and Chronic Diseases in the Population of Preschool Children (Results of A Prospective Study)

It is necessary to study and analyze the diseases of children of different age groups on the basis of improvement of medical and social assistance to children, improvement of effectiveness of preventive activities, and on the basis of these, measures aimed at maintaining and protecting children's health should be developed. In the study, diseases of preschool children were analyzed in depth, and their causes were studied. The obtained results showed that the incidence of children under seven years of age in Andijan depends on age, and the incidence rate decreases with age. In the structure of diseases, diseases of respiratory organs are leading at all ages. If the study of children's diseases under 7 years of age in the cities of Andijan region on the basis of appeals revealed the characteristics of children's diseases specific to this region, then the children who were not identified before the organization and conduct of medical examinations, without clinical symptoms, were registered in treatment-preventive institutions. allowed to identify new chronic diseases.

Medicinal products as a causative agent of occupational diseases in pharmaceutical workers (literature review)

The issue of occupational diseases in chemical and pharmaceutical workers is urgent because it stems from the rapid pace of development, the functional features, and the high biological activity of raw materials used by that industry. The study is aimed at summarizing the information on preconditions and nature of occupational diseases among chemical and pharmaceutical workers based on the analysis of literature data. An important prerequisite for the emergence of occupational diseases is the shortcomings in the production process, leading to pollution of surfaces and workspace air with chemicals through the use of semi-automatic equipment in particular. The harmful substances then enter the bodies of workers through the respiratory system, which is the main and most harmful way. The most dangerous processes are the production and processing of substances with high pharmacological activity, and thus the active pharmaceutical ingredients maybe considered to be the leading causative agents of occupational diseases in the industrial production of medicinal products. The range of diseases diagnosed in pharmaceutical workers is diverse and includes acute intoxication, effects on internal organs, reproductive function, changes in hormonal status, and changes in the hemic system and nervous system. The most common are diseases of respiratory organs and diseases of allergic origin. As a result, influential international organizations and many authors emphasize the need to develop criteria and methods for assessing the harmful effects of medicinal products on the health of workers when authorizing their production.

Atmospheric Air Pollution by Stationary Sources in Ulan-Ude (Buryatia, Russia) and Its Impact on Public Health

For the first time in the territory of the Russian Far East, a study related to the establishment of correlations between air quality and public health in Ulan-Ude (Buryatia, Russia) was carried out. This study is based on the analysis of official medical statistics on morbidity over several years, the data on the composition and volume of emissions of harmful substances into the air from various stationary sources, and laboratory measurements of air pollutants in different locations in Ulan-Ude. This study confirmed that the morbidity of the population in Ulan-Ude has been increasing every year and it is largely influenced by air pollutants, the main of which are benzo(a)pyrene, suspended solids, PM2.5, PM10, and nitrogen dioxide. It was found that the greatest contribution to the unfavorable environmental situation is made by three types of stationary sources: large heating networks, autonomous sources (enterprises and small businesses), and individual households. The main air pollutants whose concentrations exceed the limits are benzo(a)pyrene, formaldehyde, suspended particles PM2.5, PM10, and nitrogen dioxide. A comprehensive assessment of the content of various pollutants in the atmospheric air showed that levels of carcinogenic and non-carcinogenic risks to public health exceeded allowable levels. Priority pollutants in the atmosphere of Ulan-Ude whose concentrations create unacceptable levels of risk to public health are benzo(a)pyrene, suspended solids, nitrogen dioxide, PM2.5, PM10, formaldehyde, and black carbon. The levels of morbidity in Ulan-Ude were higher than the average for Buryatia by the main disease classes: respiratory organs-by 1.19 times, endocrine system-by 1.25 times, circulatory system-by 1.11 times, eye diseases-by 1.06 times, neoplasms-by 1.47 times, congenital anomalies, and deformations and chromosomal aberrations-by 1.63 times. There is an increase in the incidence of risk-related diseases of respiratory organs and the circulatory system. A strong correlation was found between this growth of morbidity and atmospheric air pollution in Ulan-Ude.

Clinical and Instrumental Characteristics of the Respiratory Organs System of the Kyrgyz Republic Population Living Under Conditions of Atmospheric Air Pollutants Exposure

Research relevance: clinical and instrumental methods are important components in determining the pathogenetic factors underlying clinical manifestations in disorder of the respiratory system. Long-term exposure to air pollution caused by transport, industrial facilities adversely affect the health conditions, in particular of respiratory system. Research objectives: to conduct a comparative analysis of clinical and instrumental signs of disorders of the respiratory system in residents of the regions of Kyrgyzstan with varying degrees of air pollution. Research materials and methods: atmospheric air pollution analysis was carried out in accordance with GOST 17.2.3.01-86. The content of dust, nitrogen dioxide, sulfur dioxide, hydrogen sulfide, formaldehyde, carbon monoxide in the air was determined. Research results: an analysis of the incidence of respiratory organs diseases among the population was carried out in three areas of Kyrgyzstan, in which samples of atmospheric air were taken in the village Papan, village Gulbar of the Aravan district, near the Osh city. Conclusions: It is extremely important to constantly monitor the atmosphere composition and assess air quality, as well as efforts to its improvement. The development of a set of appropriate organizational and medical measures will certainly help improve the health status of the population.

BLOOD BIOCHEMICAL PROFILE OF CALVES SUFFERING FROM BRONCHOPNEUMONIA

Diseases of respiratory tract organs of young farm animals hold a valuable place among all pathologies, and are in second place after gastrointestinal diseases. One of the most common diseases is bronchopneumonia. The purpose of this work was to study the effect of «Immunouracil 2% solution for injection» medication both separately and in combination with "Amoxicillin - 150" antibiotic in treatment of calves with bronchopneumonia on protein metabolism. Experimental studies were carried out on the basis of OOO Megafarma Oktyabrskiy, Cherdaklinsky district, Ulyanovsk region, in the winter-spring period of 2022. Three groups of 10 calves in each were formed,t hey were treated according to the research plan. In the control group, the antibiotic Penstrep-400 LA was used, in the first experimental group – the drug "Immunouracil 2% solution for injection" together with the antibiotic "Amoxicillin – 150 suspension" and in the second ex-perimental group – the drug "Amoxicillin - 150 suspension". In all three experi-mental groups, treatment of patients with bronchopneumonia of calves was carried out against the background of vitamin therapy. The content of total protein, albumin and globulin fractions were studied blood among biochemical parameters using an acoustic reagentless computerized analyzer ABKA 01 BIOM. As a result of the study, it was found that application of the proposed medicationsforbronchopneumoniatreatment contributed to a decrease of inflam-matory response, which resulted in activation of redox processes and improvement of metabolic processes in the body.

The excess mortality connected with COVID-19 pandemic

Background: During COVID‑19 pandemic all countries of the world face increase in mortality of the population for different kinds of causes in comparison with previous years, but this increase could be explained not only by the registered COVID‑19 death cases. In this article the problem of excess mortality in the period of COVID‑19 pandemic for all reasons is discussed.Objective: Assessment of the average scale and structure of excess mortality in the period of COVID‑19 pandemic in terms of International Classification of Diseases – 10 (ICD‑10) in the Russian Federation and also in the certain territorial subjects of the Russian Federation including those of the Southern Federal District.Material and methods: Data of the state mortality statistics during 2019–2020 are used. Level of excess mortality was defined as a difference between the number of the dead from the particular reasons during the analyzed period of time (2020) in comparison with the same period of time in previous year. Cartograms and charts are constructed by free service Datawrapper (https://app.datawrapper. de/).Results: In total in the year 2021 there were by 340279 death cases more, than in 2019. The general average mortality rate in Russia from all kinds of causes was 1460.2 ± 299.0 (variation coefficient 0.19) in 100 thousand people. That is 19.2% higher, than in 2019 (1225.1 in 100 thousand people). In structure of the excess death reasons the first place took the death causes connected with the new coronavirus infection – 42.5% of all excessive death cases. The second and third places belong to such causes as blood circulatory system diseases (28.6%) and diseases of respiratory organs (11.0%). In 2020 the number of working‑age people who died from blood circulatory system diseases was by 23432 more, than in 2019. In some types of diseases, the level of the general mortality decreased. Malignant neoplasms dominate in terms of the decrease of the number of mortal cases – in 2020 died 2939 people less, than in 2020. At the same time, the specific weight of number of the working‑age people who died of malignant neoplasms in 2020 in comparison with 2019 increased by 1.9% and was 22.0%. The general intensive indicator of mortality across Russia in such disease as “neoplasms” in 2020 was 202.0 cases, which is 2.5% higher than a target indicator of the federal project “Fight with Oncological Diseases”. This causes the need to increase the efficiency of participants activity in implementation of this federal project.Conclusion: The pandemic of such disease as COVID‑19, disproportionately affected different territories of the country in terms of death rate of the population both from the death causes connected with the new coronavirus infection and from other reasons, first of all – from blood circulatory system diseases. Despite the additional financing of oncological service from the federal budget, during the pandemic mortality of adults of working‑age from malignant neoplasms grew, which can be connected not only with weak immune system of people with cancer but also with low efficiency of participants activity of the federal project “Fight with Oncological Diseases”.

Geochemistry and therapeutic properties of Caucasian mineral waters: a review.

The Caucasian mineral water (CMW) region is a unique area where mineral waters differ by their chemical composition and balneological properties. The presence of a wide range of mineral waters with various ions and gas components and different genesis and their therapeutic properties in the restricted area is explained by complicated geological and tectonic settings. The dominant type of mineral water in the CMW region is CO2-bearing water with H2SiO3 and H3BO3 as the specific components. According to ion composition, gas phases' content into groundwater, total dissolved solids, and balneological characteristics, we would distinguish 9 groups and 16 types of these mineral waters, with each water type being of particular therapeutic interest. The CMW region includes four spa cities with a different therapeutic profile: Zheleznovodsk, Kislovodsk, Pyatigorsk, and Essentuki. Spa treatment is based on the use of different types of mineral waters, therapeutic muds within the region's diverse landscapes, and climatic conditions. Mineral waters are utilized in the form of baths, swimming pools, showers, various irrigations, inhalation, as well as drinking therapy. Therapeutic mineral waters are used to treat gastrointestinal problems, metabolic and nervous system disorders, as well as various diseases of liver, kidney, urinary tract, circulatory system, respiratory organs, and skin.

СУРФАКТАНТНАЯ СИСТЕМА ЛЁГКИХ. ОБЗОРНАЯ СТАТЬЯ

This article contains the information about the structure, functioning, and regeneration of type 2 pneumocytes. The composition of the surfactant, the processes of its synthesis, formation, secretion, distribution and redistribution of its components, as well as the biological role of the surfactant in the functioning of the lungs are described in detail. The information about the development of the surfactant system of the lungs during embryogenesis is also included. Objectives. To review modern literature on the structure and functions of the surfactant system of the lungs, the organization and structure of the surfactant, the mechanism of surfactant formation, the embryogenesis of the respiratory section, to characterize the structure and processes of the functioning of type 2 pneumocytes, as well as the processes of synthesis and secretion of the surfactant, its biological role in the functioning of the lungs. The relevance of the chosen topic is connected with a high level of the respiratory system pathology including a high incidence of respiratory system organs diseases in early childhood, associated with an insufficient level of the surfactant maturity. The problem of pulmonary pathology in newborns, including premature babies, largely determines the level of infant morbidity and mortality.

Capabilities of computer analysis of breath sounds in patients with COVID-19

Objective. To develop methods for a rapid distance computer diagnosis of COVID-19 based on the analysis of breath sounds. It is known that changes in breath sounds can be the indicators of respiratory organs diseases. Computer analysis of these sounds can indicate their typical changes caused by COVID-19, and can be used for a rapid preliminary diagnosis of this disease.
 Materials and methods. The method of fast Fourier transform (FFT) was used for computer analysis of breath sounds, recorded near the mouth of 14 COVID-19 patients (aged 1880 years) and 17 healthy volunteers (aged 548 years). The frequency of breath sound records ranged from 44 to 96 kHz. Unlike the conventional methods of computer analysis for diagnosis of diseases based on respiratory sound studying, we offer to test a high-frequency part of FFT (20006000 kHz).
 Results. While comparing the breath sound FFT in patients and healthy volunteers, we developed the methods for COVID-19 computer diagnosis and determined the numerical criteria in patients and healthy persons. These criteria do not depend on sex and age of the examined persons.
 Conclusions. The offered computer methods based on the analysis of breath sound FFT in patients and volunteers permit to diagnose COVID -19 with relatively high diagnostic parameters. These methods can be used in development of noninvasive means for preliminary self-express diagnosis of COVID-19.

INNOVATIVE TECHNOLOGIES OF CALVES REARING IN DAIRY CATTLE BREEDING

For the first time, the rationale of using polystim in the technology of calf rearing in private subsidiary plots, on small and medium farms has been scientifically substantiated and experimentally proved to activate the protective and adaptive functions of the body to the keeping conditions and to more fully realize the biological potential of resistance and productivity. Thus, live weight, average daily gain and growth rate of young cattle of the experimental group were higher by the end of the observation period (180 days) than in the control group: in the conditions of personal subsidiary plots by 6.6 kg, 33.3 g and 0.28, on small farms - by 5.2 kg, 20.0 g and 0.08, and with the technology of keeping on a medium farm - by 4.8 kg, 13.3 g and 0.23 (P<0.05 ) respectively. The dynamics of exterior measurements of animals of all groups were similar to the nature of changes in their live weight and their average daily gain. At the same time, the incidence of respiratory organs diseases and the gastrointestinal tract in newborn calves was reduced to 25-40%, the duration of the disease was reduced by 2.45; 1.31 and 1.93 days (P<0.05-0.001).

The use of public health monitoring data for the assessment of the risk of developing diseases of respiratory organs under exposure to aeropollutants

Introduction. The results of the analysis of the quality of atmospheric air have shown a different level of its impact on the development of respiratory diseases in certain Russian entities. This is due to the necessity to develop and implement measures for managing the health risks of the working population. Material and methods. For analysis, we used the all-Russian data of state and departmental statistics reports, as well as analytical data received and processed in the prescribed manner. Results. According to controlling organizations, the atmospheric air of urban settlements is the most polluted near highways in the residential area (1.00% of samples with excess MPC) and the area of stationary observation posts (0.87% of samples with an excess of hygiene standards). Air pollution is likely the cause of developing from 3.02 to 11 863.7 additional cases of respiratory diseases per 100 thousand population. Recommendations on the use of environmental data have been developed. Criteria for the development of respiratory diseases for persons living in the area of air pollution impact and working in hazardous conditions exposed to aerosols have been determined. Medical and preventive measures should be jointly carried out by supervisory and health authorities. Information and hygiene education is recommended as part of corporate events aimed at the increasing commitment to a healthy lifestyle for the working population. Health authorities determine the terms for the dynamic observation of patients, including the development of individual preventive measures and form groups of contingents for diseases, determining the frequency of the medical examination of the population. High-quality preliminary and periodic medical examinations allow the development of comprehensive programs to reduce the morbidity rate. Conclusion. An algorithm has been developed to ensure environmental monitoring aimed at reducing the risk of respiratory diseases. Measures for risk management are highlighted: technological, sanitary-technical, sanitary-hygienic, medical. The monitoring results will allow ranking the territories in areas with an increased and low risk of developing respiratory diseases.

Гигиеническая оценка аэрогенного воздействия взвешенных веществ на заболеваемость детей болезнями органов дыхания в зоне влияния источников выбросов металлургического производства

At present an outstanding task is to concentrate on chemical and fractional structure when examining and assessing influence exerted by particulate matter on morbidity among children. The main goal of any such research is to prevent negative effects produced on the respiratory organs. Our research objects were ambient air in residential areas contaminated with particulate matter that were components in emissions from non-ferrous metallurgic enterprises (the test territory) and ambient air in residential areas free of such contamination; morbidity among children was also given our attention. Our assessment of ambient air quality as per РМ10 and РМ2.5 contents revealed they exceeded the standards recommended by the WHO and were by 1.4 times higher than recommended MPCa.d. Respirable fraction of particulate matter tends to have complicated chemical structure and contains metals that are specific for emissions from metallurgic enterprises such as nickel, copper, iron, aluminum, titanium, gallium, and neodymium. The latter can enhance negative effects produced by particulate matter on the respiratory organs. Epidemiologic assessment in a contaminated zone (the test territory) allowed establishing 1.8 times higher general and primary morbidity as per respiratory organs diseases than on the reference territory; it was even up to 14.8 times higher as per specific nosologies such as chronic disease of tonsils and adenoids, asthma, and status asthmaticus. We also established authentic dependence between probability of respiratory diseases and elevated concentrations of particulate matter in ambient air. Results of the proven dependence allow predicting up to 500/1000 additional respiratory diseases cases per year on the test territory; all these additional morbidity cases among children are associated with aerogenic exposure to particulate matter.

Hygienic assessment of aerogenic exposure to particulate matter and its impacts on morbidity with respiratory diseases among children living in a zone influenced by emissions from metallurgic production

At present an outstanding task is to concentrate on chemical and fractional structure when examining and assessing influence exerted by particulate matter on morbidity among children. The main goal of any such research is to prevent negative effects produced on the respiratory organs. Our research objects were ambient air in residential areas contaminated with particulate matter that were components in emissions from non-ferrous metallurgic enterprises (the test territory) and ambient air in residential areas free of such contamination; morbidity among children was also given our attention. Our assessment of ambient air quality as per РМ10 and РМ2.5 contents revealed they exceeded the standards recommended by the WHO and were by 1.4 times higher than recommended MPCa.d. Respirable fraction of particulate matter tends to have complicated chemical structure and contains metals that are specific for emissions from metallurgic enterprises such as nickel, copper, iron, aluminum, titanium, gallium, and neodymium. The latter can enhance negative effects produced by particulate matter on the respiratory organs. Epidemiologic assessment in a contaminated zone (the test territory) allowed establishing 1.8 times higher general and primary morbidity as per respiratory organs diseases than on the reference territory; it was even up to 14.8 times higher as per specific nosologies such as chronic disease of tonsils and adenoids, asthma, and status asthmaticus. We also established authentic dependence between probability of respiratory diseases and elevated concentrations of particulate matter in ambient air. Results of the proven dependence allow predicting up to 500/1000 additional respiratory diseases cases per year on the test territory; all these additional morbidity cases among children are associated with aerogenic exposure to particulate matter.

APPLICATION OF THE METHOD OF DIMENSIONAL CHARACTERISTICS TO THE CALCULATION OF THE HUMIDITY MODE OF MULTI-LAYERED ENCLOSING BUILDING STRUCTURES

The implementation of the energy saving program in construction, adopted in the Russian Federation, has led to a signifi cant change in the design decisions of building envelopes. To achieve the normative values of heat transfer resistance, various facade systems are currently widely used for insulation of external walls using polymeric materials as heaters, which have low values of the coeffi cient of thermal conductivity with a relatively high value of the coeffi cient of vapor permeability. Therefore, when choosing a textured layer of facade systems, it is necessary to take into account the value of its resistance to diff usion of water vapor in order to avoid the accumulation of moisture in the outer walls. The problem associated with the possible accumulation of moisture is especially relevant when designing both three-layer exterior walls and walls with internal insulation. To eliminate the formation of molds on the inner surfaces of the enclosing structures, leading to dangerous diseases of skin and respiratory tract organs, as well as the destruction of building structures, it is necessary to accurately calculate the humidity mode of the enclosing structures in order to protect them from overmoistening. The article presents a methodology for determining the position of the plane of possible condensation in multilayer enclosing structures, based on the use of the dimensionless characteristics method.

The regional nosogeographical analysis and factors affecting population respiratory morbidity (on example of the Sumy region, Ukraine)

The article is devoted to consideration of the spatial-temporal structure of the primary morbidity and prevalence of the respiratory organs diseases among the population of the Sumy region. The article based on the data of annual statistical reports of medical institutions of Sumy region, which are subordinate to the Ministry of Public Health of Ukraine. The article used the methods of factor and correlation analysis, as well as methods of mathematical-statistical analysis, and ranking. The authors analyzed the spatial-temporal structure of respiratory organs pathology among the population and revealed the territorial differences and the dynamics of respiratory morbidity of the population. Nosogeographic assessment of territory of the Sumy region, which was carried out according to the integral respiratory diseases morbidity index (IMI), shows that today the highest values of IMI are obtained by analyzing the incidence rate in Putyvl’ (1.01), Krasnopillia (1.02), Konotop (1.11), Buryn’ (1.32) districts and in the city of Sumy (1.15). These are the districts where the incidence rate of respiratory diseases among the population has increased most of all during the study period. Low values of IMI are noted in Lypova Dolyna (0.63), Seredyna Buda (0.71), Velyka Pysarivka (0.72) and Nedryhailiv (0.79) districts. The higher is the IMI value, the worse the health level of the population. The average index storage respiratory diseases (ISD) in the Sumy region in 2017 was 1.27, with polarization ISD value in some areas from 1.19 in Shostka, 1.22 in Konotop, 1.23 in Yampil’ and Trostianets regions to 1.39 in Lebedyn, 1.42 in Romny and 1.61 in the Seredyna Buda districts. This indicates the predomination of chronic forms of diseases over acute ones and can be explained by the influence of environmental and socio-economic factors. It also points to the need to increase of attention of both the regional and state components of the health care system. Besides that, the issues of providing financial and human resources for the health care system in districts with high incidence rates of respiratory pathology require attention. The study of the primary morbidity and the prevalence of respiratory diseases trends is a prerequisite for the development of preventive measures in the Sumy region. They are also needed to assess the quality of medical care for residents who have the pulmonary diseases. The factor analysis results are confirmed the importance of environmental and technogenic factors in formation of the indicators of primary morbidity and prevalence of respiratory diseases among the residents of the Sumy region.

Prevalence of diseases caused by oils depending on exposure and age

The prevalence of respiratory, digestive, skin, endocrine system diseases, increased body weight and blood pressure, blood changes was found to be higher in oil workers under harmful working conditions than in acceptable ones. In 18-25 years the prevalence of diseases of respiratory organs, skin, musculoskeletal system, neoplasms, increased body weight and blood pressure was found to be higher than in the control.

Assessment of immune status in children with functional respiratory system disorders, living in aerogenic aluminium exposure zone

Aim. To assess the immune status in children of primary school age with functional disorders of the respiratory system, who live in the territory with location of industrial enterprise, producing aluminium.
 Materials and methods. Fifty-two children aged 711 years with respiratory system disorders, who live in the zone of exposure of aluminium-producing enterprise were examined. Cellular differentiation marker CD127, protein Bcl-2 and TNFR receptor expression levels were identified using the method of flow cytometry. Phagocytic activity of the cells was studied using formalinized sheep erythrocytes; IgG content was determined with radial immunodiffusion method; beta2-microglobulin level with enzyme immunoassay. Functional status of respiratory system was assessed using spirometry, rhinomanometry methods but functional reserves with calculated Skibinskaya index.
 Results. The prevalence of allergic diseases in the examined children was 2,4 times higher and allergic rhinitis was diagnosed 3,2 times more often than in the group of comparison. The prevalence of bronchial asthma, clinical signs of chronic lympho-proliferative diseases reliably exceeded the level observed in children of comparison group (29.4 %, р = 0.001). There were established the changes in immune reactivity versus the comparison group, manifested by increase in percentage of phagocyting cells, beta2-microglobulin protein, IgG, CD127, TNFR and specific IgG to aluminium by 1.1, 1.2, 1.0, 1.7, 2.5 and 1.2 times, respectively; suppression of protein
 Bcl-2 expression by 2,6 times (p 0.05) was registered.
 Conclusions. Among children aged 711 years, who live in the territory with localized aluminium-producing enterprise, the diseases of respiratory organs with allergic component, reliably associated with aluminium compound contamination, were diagnosed more often than in children of comparison group. Immunologic study detected imbalance between humoral and cellular components of immunity: hyperproduction of specific IgG to aluminium, excess expression of proteins and beta2-microglobulin receptors, IgG, CD127, TNFR and deficit of Bcl-2.

The assessment of social and economic spends conditioned by the respiratory organs diseases of military cursors

The results of the assessment of the indicators of disability; the level and structure of hospitalization for the period from 2013 to 2018 and the analysis of financial and economic spends connected with the respiratory diseases among the cadets studying in a military educational organization are presented here. In the course of the conducted study; it has been specified that respiratory diseases occupy a leading position in the morbidity structure of cadets; in conjunction with their hospitalization and temporary disability. The greatest financial and economic costs in diseases of the respiratory system are caused by community-acquired pneumonia; as well as acute bronchitis and the widespread pathology of the ear; nose and throat; such as the curvature of the nasal septum. We believe that this is connected with a long stay in hospital (21; 10 and 12 bed days; respectively); as well as the severity of the disease course and the complications. The fulfilled assessment of the socio-economic spends by the respiratory system diseases of cadet students studying in a military educational organization shows their relevance and significance; which are determined by their specific nosological forms. The results obtained can contribute to a more objective redistribution of financial resources; as well as to planning the most optimal and effective diagnostic and sanitary anti-epidemic measures. The monitoring and preventing respiratory diseases are of great social importance; since they are allow to reduce the incidence of disease; improve the treatment outcomes; as well as efficiently and competently allocate the resources. In this connection; the procedure for organizing and implementing the prophylaxis of respiratory organs diseases is one of the priority direction in the medical support of military students.