Incidence Of Respiratory Diseases Research Articles

Bi-level artificial intelligence model for risk classification of acute respiratory diseases based on Chinese clinical data.

Objective: The high incidence of respiratory diseases has dramatically increased the medical burden under the COVID-19 pandemic in the year 2020. It is of considerable significance to utilize a new generation of information technology to improve the artificial intelligence level of respiratory disease diagnosis. Methods: Based on the semi-structured data of Chinese Electronic Medical Records (CEMRs) from the China Hospital Pharmacovigilance System, this paper proposed a bi-level artificial intelligence model for the risk classification of acute respiratory diseases. It includes two levels. The first level is a dedicated design of the “BiLSTM+Dilated Convolution+3D Attention+CRF” deep learning model that is used for Chinese Clinical Named Entity Recognition (CCNER) to extract valuable information from the unstructured data in the CEMRs. Incorporating the transfer learning and semi-supervised learning technique into the proposed deep learning model achieves higher accuracy and efficiency in the CCNER task than the popular “Bert+BiLSTM+CRF” approach. Combining the extracted entity data with other structured data in the CEMRs, the second level is a customized XGBoost to realize the risk classification of acute respiratory diseases. Results: The empirical study shows that the proposed model could provide practical technical support for improving diagnostic accuracy. Conclusion: Our study provides a proof-of-concept for implementing a hybrid artificial intelligence-based system as a tool to aid clinicians in tackling CEMR data and enhancing the diagnostic evaluation under diagnostic uncertainty.

Analysis on the incidence of new occupational diseases in Weihai City from 2009 to 2020

Objective: To analyze the pattern and characteristics of occupational diseases in Weihai City from 2009 to 2020, and to provide scientific basis for the formulation of occupational disease prevention. Methods: In February 2021, retrospective analysis was performed on the cases of occupational diseases diagnosed from 2009 to 2020 in Weihai City. The relevant information and data were collected to analyze the types of occupational diseases, onset age, working age, diagnosis time, industry distribution, economic type and enterprise size distribution. Results: From 2009 to 2020, a total of 453 cases of new occupational diseases were reported in Weihai City. There were 431 males (95.14%) and 22 females (4.86%) . The average onset age was (49.16±8.51) years, and the average working age was (17.89±9.30) years. The incidence of pneumoconiosis and other respiratory diseases (322 cases, 71.08%) , occupational otolaryngology and oral diseases (71 cases, 15.67%) and occupational chemical poisoning (36 cases, 7.95%) were the top 3 cases, of which 313 cases were pneumoconiosis and 69 cases were noise deafness. The cases were mainly concentrated in the 40-59 years age group (357 cases, 78.81%) and the 10-19 years working age group (175 cases, 38.63%) . There were significant differences in the incidence of occupational diseases in different ages and different working ages (χ(2)=97.64, 80.74, P<0.001) . The new cases were mainly in mining industry (134 cases, 29.58%) , shipbuilding or maintenance industry (97 cases, 21.41%) , and private enterprises (350 cases, 77.26%) . Conclusion: Pneumoconiosis and noise deafness are the main emerging occupational diseases in Weihai City. Occupational disease prevention and control in private enterprises such as mining and shipbuilding or maintenance industry should be strengthened.

Respiratory risks caused by atmospheric air pollution and respiratory morbidity among residents of Omsk

Introduction. Contaminants emitted into atmospheric air and tropical to respiratory organs form maximum non-carcinogenic risks in Omsk. Respiratory risk levels over the past 12 years have not dropped below the "high risk" level and ranged from 9.4 to 20 in different years of observation. "Clean Air" Federal project, which is being implemented in Omsk, should be successful not only in terms of reducing harmful emissions, but also contribute to a sustainable reduction in the incidence rate. The study aims to determine the list of pollutants affecting the actual levels of respiratory morbidity of the Omsk population, with the establishment of intracity risk areas. Materials and methods. The study used social-hygienic monitoring data: results of laboratory studies of atmospheric air at stationary stations of Roshydromet, respiratory disease incidence of the Omsk population by age groups for the period 2009-2020. Population health risks were assessed according to health risk assessment methodology applied in case of exposure to chemicals (Guide R 2.1.10.1920-04). Correlation and two-factor variance analyses were used to assess the association between respiratory risks and respiratory disease incidence. Results. Long-term increase in the incidence of chronic bronchitis and asthma in adults and adolescents, unstable rates of asthma in children and dysfunctional health indicators in children under 1 year of age may indicate adverse effects of air-polluting chemicals. High levels of respiratory hazards in Omsk are formed mainly by suspended substances, formaldehyde, carbon (black), hydrogen chloride. The negative impact of these pollutants on the health of Omsk residents was confirmed by spatiotemporal positive connections in the system "respiratory risks - respiratory diseases". Microdistricts with the highest levels of respiratory risks and morbidity of respiratory diseases in children 0-14 years old have been identified on the territory of the city. Conclusion. A list of pollutants emitted in the atmospheric air, affecting the actual levels of respiratory morbidity of the population of Omsk, has been established. Intracity areas of respiratory risk and increased incidence of respiratory diseases in children have been identified. Risk mitigation measures are proposed.

Climate advocacy among Italian pediatric pulmonologists: A national survey on the effects of climate change on respiratory allergies.

Climate change (CC) is expected to negatively impact respiratory health due to air pollution and increased aeroallergen exposure. Children are among the most vulnerable populations due to high ventilation rates, small peripheral airways, and developing respiratory and immunological systems. To assess the current knowledge among Italian pediatric pulmonologists on the potential effects of CC on pediatric respiratory allergic diseases, a national survey was launched online from February 2020 to February 2021. The members of the Italian Pediatric Respiratory Society (SIMRI) were contacted by email and 117 questionnaires were returned (response rate 16.4%). 72.6% of respondents were females, 53.8% were academic pediatricians, 42.7% had been working >10 years. Most of the participants were aware of the potential health effects of CC and stated that they had noticed an increase in the incidence (90.6%) and severity (67.5%) of allergic respiratory diseases among their patients. About 61% and 41% of participants respectively felt that there had been an increase in the number of children sensitized to pollen and molds. When applying latent class analysis to identify the features characterizing participants with greater awareness and knowledge of CC‐related health effects, two classes were identified: almost 60% of the participants were labeled as “poor knowledge” and those with greater awareness were older, had longer work experience, and were those using the Internet to gather information about CC. There is urgent need to increase pediatricians' awareness of the detrimental effects of CC on children's respiratory health and integrate them in the educational programs of healthcare professionals.

The Effect of Coronavirus 2019 Disease Control Measures on the Incidence of Respiratory Infectious Disease and Air Pollutant Concentrations in the Yangtze River Delta Region, China.

The Yangtze River Delta is one of the top five Chinese regions affected by COVID-19, as it is adjacent to Hubei Province, where COVID-19 first emerged. We investigated the impact of COVID-19 non-pharmaceutical interventions (NPIs) on changes in respiratory infectious diseases (RIDs) incidence and air quality in the Yangtze River Delta by constructing two proportional tests and fitting ARIMA and linear regression models. Compared with the pre-COVID-19 period, the average monthly incidence of seven RIDs decreased by 37.80% (p < 0.001) and 37.11% (p < 0.001) during the COVID-19 period and the post-vaccination period, respectively, in Shanghai, and decreased by 20.39% (p < 0.001) and 22.86% (p < 0.001), respectively, in Zhejiang. Similarly, compared with the pre-COVID-19 period, the monthly overall concentrations of six air pollutants decreased by 12.7% (p = 0.003) and 18.79% (p < 0.001) during the COVID-19 period and the post-vaccination period, respectively, in Shanghai, and decreased by 12.85% (p = 0.008) and 15.26% (p = 0.001), respectively, in Zhejiang. Interestingly, no significant difference in overall incidence of RIDs and concentrations of air quality was shown between the COVID-19 period and the post-vaccination period in either Shanghai or Zhejiang. This study provides additional evidence that the NPIs measures taken to control COVID-19 were effective in improving air quality and reducing the spread of RIDs. However, a direct causal relationship has not been established.

E-Cigarettes and Cardiopulmonary Health: Review for Clinicians.

Electronic cigarettes (e-cigarettes) are battery powered electronic nicotine delivery systems that use a propylene glycol/vegetable glycerin base to deliver vaporized nicotine and flavorings to the body. E-cigarettes became commercially available without evidence regarding their risks, long-term safety, or utility in smoking cessation. Recent clinical trials suggest that e-cigarette use with counseling may be effective in reducing cigarette use but not nicotine dependence. However, meta-analyses of observational studies demonstrate that e-cigarette use is not associated with smoking cessation. Cardiovascular studies reported sympathetic activation, vascular stiffening, and endothelial dysfunction, which are associated with adverse cardiovascular events. The majority of pulmonary clinical trials in e-cigarette users included standard spirometry as the primary outcome measure, reporting no change in lung function. However, studies reported increased biomarkers of pulmonary disease in e-cigarette users. These studies were conducted in adults, but >30% of high school-age adolescents reported e-cigarette use. The effects of e-cigarette use on cardiopulmonary endpoints in adolescents and young adults remain unstudied. Because of adverse clinical findings and associations between e-cigarette use and increased incidence of respiratory diseases in people who have never smoked, large longitudinal studies are needed to understand the risk profile of e-cigarettes. Consistent with the Centers for Disease Control and Prevention recommendations, clinicians should monitor the health risks of e-cigarette use, discourage nonsmokers and adolescents from using e-cigarettes, and discourage smokers from engaging in dual use without cigarette reduction or cessation.

Veterinary drug Trametin obtained on the basis of &lt;i&gt;Trametes pubescens&lt;/i&gt; xylotroph fungi: its effect on the biosynthesis of interferons and its prophylactic activity against calf respiratory diseases

Given the spread of bacterial and viral diseases in young farm animals, the use of interferons and drugs to stimulate their biosynthesis has gained relevance. In a previous study, we examined the effect of a veterinary drug Trametin produced on the basis of Trametes pubescens (Shumach.: Fr.) Pilat. on the biosynthesis of interferons in the blood of mice. The present work is aimed at studying the biosynthesis dynamics of α- and γ-interferons when using Trametin and studying its prophylactic activity in calves. It is shown that a single oral administration of Trametin in doses ranging from 15 to 60 mg/kg causes a dose-dependent induction and production of γ-interferon in the blood of mice, whose maximum content reaches 1337.0±93.0 pg/mL at 48 h after administering a dose of 30 mg/kg. With a Trametin dose increase from 15 to 30 mg/kg, the level of α-interferon production rises to 1388.0±84.0 pg/mL at 48 h after administration. At a Cycloferon dose of 4.5 mg/kg, the production level of α-interferon and γ-interferon amounts to 1455.47±84.2 and 1447.0±90.0 pg/mL, respectively. The immunostimulatory properties of Trametin are confirmed by a scientific and economic experiment conducted using immunocompromised calves. In our studies, an immunological test of calf blood performed prior to and following the administration of Trimetin and Cycloferon constitutes criteria for the prophylactic activity of these drugs. The prophylactic efficacy of Trametin is confirmed by an increase in phagocytic activity by 10.5%, phagocytic index by 61.8%, and phagocytic number by 52.8%. After Trametin administration, the bactericidal activity of the serum increases by 60%. Cycloferon exhibits a similar immunostimulatory effect. Nonspecific prophylaxis using Trametin is shown to reduce the incidence of bacterial and viral respiratory diseases in young calves and generally improve their immunity.

Features of phagocytosis function in children of preschool age depending on the incidence of acute respiratory diseases

Background. Recently, with the emergence of new pathogenic viruses’ variants, attention is drawn to the functioning status of innate immunity components, which are able to neutralize unknown microorganisms at the early stages of infection. Therefore, the study of phagocytosis disorders in children with respiratory recurrent infectious diseases will supply the scientific data on the processes of age-dependent formation of antimicrobial protection. The purpose: to improve the diagnosis of innate immune disorders in preschool children with respiratory recurrent infectious on the background of new data on phagocytosis parameters. Materials and methods. Sixty children aged from 2 to 5 years were observed. Two groups were formed: 1) children with respiratory tract acute infectious more than 6 times per year (n = 30); 2) children with respiratory acute infectious 6 or fewer times per year (n = 30). Results. The children of group 1 presented with statistically significantly increased cases of low phagocytic counts (by 60.0 %, p &lt; 0.05), phagocytic index (by 56.0 %, p &lt; 0.05), index of phagocytosis completeness (70.0 %, p &lt; 0.05), neutrophil phagocytic activity stimulated by Staphylococcus (50.0 %, p &lt; 0.05) and high rates of spontaneous neutrophil phagocytic activity (43.3 %, p &lt; 0.05), increased serum level of interleukin-1β (46.7 %, p &lt; 0 05), interleukin-6 (43.3 %, p &lt; 0.05), interleukin-10 (by 30.0 %, p &lt; 0.05), TNF (by 46.7 %, p &lt; 0.05). Conclusions. In children aged 2–5 years with respiratory acute infectious diseases more than 6 times per year, phagocytic dysfunction was established. It is manifested itself in a decrease of phagocytosis absorption and stimulated metabolic activity on the background of increased pro- and anti-inflammatory cytokines serum level, ie cytokine imbalance.

Airborne Ultrafine Particle and Acute Physiological Effects during Maximal Aerobic Power Test

BACKGROUND: The practice of physical exercise in polluted areas could lead to adverse health effects that may contribute to the incidence and/or worsening of respiratory and cardiovascular diseases and some types of cancer. METHODS: Male recreational cyclists performed tests in a manner randomized crossover in two environmental conditions: low (environmental noise exposure) and high ultrafine particle concentration. For each trial, oxygen consumption ((VO) ̇_2), carbon dioxide production (VĊO2), respiratory frequency (Rf), tidal volume (Vt), pulmonary ventilation ((VE) ̇), and mechanical workload (WL) was measured. Gross efficiency (GE) was determined using the ratio between mechanical power output and metabolic power input. Repeated-measures ANOVA was applied to evaluate differences (P < 0.05) between physiological and mechanical parameters and compare oxygen consumption trends in the two scenarios. RESULTS: HR, Rf, and VE values do not show any significant difference. On the contrary, (VO) ̇2peak increased (P < 0.05) under high exposure (41.6 ± 4.31 mL kg-1 min-1), during high-intensity exercise, compared to a low exposure (38.4 ± 4.05 mL kg-1 min-1). VO2 and GE show differences (p < 0.05) between low and high ultrafine particle concentration conditions during exercise above 80% WLpeak. CONCLUSIONS: Present data suggest that high airborne UFPs levels impair recreational cyclists' gross efficiency.

The impact of the COVID-19 pandemic on the incidence and mortality of zoonotic diseases in China.

BackgroundIt has been reported that strict non-pharmaceutical measures can significantly reduce the incidence and mortality of respiratory and intestinal infectious diseases during the COVID-19 pandemic, but there are limited reports on the impact in terms of the rates of zoonotic diseases.MethodsWe extracted the incidence and mortality data of eight notifiable infectious zoonotic diseases from the website of the National Health Commission of the People’s Republic of China for the period of January 2015 to April 2021.ResultsFirst, the overall incidence of zoonotic diseases decreased from 0.3714 per 100 000 in 2015–2019 to 0.2756 in 2020 (25.79% reduction, p<0.001); however, a dramatic increase in activity was seen in 2021 compared with 2020 (0.4478 per 100 000 in 2021, 62.47% increase, p<0.001). Anthrax, brucellosis, leptospirosis and hydatid disease exhibited significant upward trends in 2021. Second, analysed further by stages, the monthly incidence in the routine stage (from May to December 2020) was much higher than that in the emergency stage of the COVID-19 (from January to April 2020) (55.33% increase, p<0.001). We also found that the monthly observed incidence was significantly lower than the predicted incidence of a 10.29% reduction in the emergency stage. Third, no differences were seen in mortality between 2021 and 2020, while a significant decline was found in 2020 compared with the previous 5 years (72.70%, p<0.001).ConclusionsStrict containment and feasible suppression strategies during the 2020 period of the COVID-19 pandemic had positive impacts on the overall incidence of zoonotic diseases in China. However, anthrax, brucellosis, leptospirosis and hydatid diseases might increase with the relaxation of non-pharmacological interventions in 2021.

Outbreak of Parainfluenza Virus During the COVID-19 Pandemic at a University Hospital in Korea.

The incidence of respiratory viral diseases including parainfluenza virus (PIV) infection has decreased noticeably due to strict quarantine measures during the COVID-19 pandemic. However, the recent outbreak of PIV in children occurred unexpectedly and the distribution pattern showed prominent differences from before the COVID-19 pandemic. PIV is one of the major viral pathogens related to acute lower respiratory infection in young children and the elderly. Accordingly, the authors intended to identify the incidence and distribution pattern of PIV outbreaks and to contribute to public health by providing information on it. This study was conducted retrospectively to investigate the incidence and distribution of PIV according to age group, gender, month, and season, and to analyze the co-infections from March 2020 to February 2022. The detection for respiratory microorganisms was performed through FilmArray assay. The overall incidence for at least one respiratory pathogen was 45.9% (665/1,450). PIV was not detected at all from March 2020 to August 2021. However, it was first detected in September 2021 and the rate in the month that followed, October, accounted for 60% (114/190) of the total PIV infections during the entire study period. It also accounted for 44.9% (190/423) of patients with respiratory pathogens from September 2021 to February 2022. It reached the highest proportion at 90.5% (114/126) in October 2021. As for the distribution according to the age groups, group 3 (58.4%) accounted for the highest percentage, followed by group 4 (21.1%). In the PIV positive cases, the overall rate of more than two respiratory pathogens was 32.6% (62/190). The most common pattern of co-infection was PIV3 with rhinovirus/enterovirus (67.7%), followed by PIV3 with adenovirus (8.1%) and PIV3 with rhinovirus/enterovirus and adenovirus (8.1%). The COVID-19 pandemic has brought about many changes in our daily lives. It has been confirmed that the seasonal distribution of PIV was distinctly different from before the COVID-19 pandemic. It is anticipated that this phenomenon will affect the incidence or distribution of other respiratory pathogens and viral epidemiology. Therefore, clinicians should pay attention to these changes in terms of public health.

Changes in Acute Respiratory Infection Before and After COVID-19

Objective: During the outbreak of COVID-19,several coping strategies were implemented including strengthened social distancing, wearing masks and hand hygiene. Thisinfection control method might have been effective for other respiratory infections; however, it had not yet been clearly revealed. Therefore,we investigatedwhetherthe incidence of infectious respiratory diseases has reduced after excluding the effect of decreased medical utilization because of COVID-19 control measures.Design or methods: We used the Korean national claims data and analyzed incidences of acute respiratory infections (ARI) and diseases except ARI. The incidence rates of winter 2019 and 2020 were compared.Results: Excluding ARI,the reduction in overall hospital visits decreased by only 2%; however,the number of visits due to ARI decreased by 13%, and the number of visits due to influenza particularly decreased by 26%.Conclusions: Using national database, this study confirmed that a significant reduction in ARI, including influenza, occurred during the COVID-19 pandemic. Infection control measures including nationally enforced social distancing may be effective in controlling the transmission of other respiratory infections. Further studies are necessary to clarify the causal relationship.

The impact of COVID-19 pandemic on acute otitis media among the pediatric population

BackgroundThe incidence of respiratory diseases has dropped during the school closures at the COVID-19 pandemic including acute otitis media (AOM) among the pediatric population. MethodsThis study included 2090 patients under 12 years old, that were diagnosed with AOM between March 2019 and February 2021 at the otolaryngology and pediatrics emergency room at a public tertiary hospital in Sao Paulo, Brazil. ResultsThere was a significant drop in number of AOM cases diagnosed during the quarantine. The group before the pandemic represents 87,2% of the total attendings and the first two months of quarantine had the major attendance discrepancy between the same period during pre-pandemic times. ConclusionQuarantine isolation measures and school closures may have helped reduce not only the coronavirus spread but also other infectious diseases such as AOM among the pediatric population.

Organic Food Consumption During the Complementary Feeding Period and Respiratory or Allergic Diseases Up to Age 5.5 Years in the ELFE Cohort.

Objectives: To assess (1) whether a history of allergy is associated with feeding with organic foods (OFs) during the complementary feeding period and (2) whether OF consumption in infancy is related to the incidence of respiratory and allergic diseases up to age 5.5 years.Study Design: Analyses involved more than 8,000 children from the nationwide Étude Longitudinale Française depuis l'Enfance (ELFE) birth cohort. Associations between family or infant history of allergy and frequency of OF consumption during the complementary feeding period were assessed with multinomial logistic regression. Associations between OF consumption in infancy and respiratory or allergic diseases between age 1 and 5.5 years were assessed with logistic regression.Results: A family history of allergy or cow's milk protein allergy at age 2 months was strongly and positively related to feeding with OF during the complementary feeding period. Feeding with OF during the complementary feeding period was not related to respiratory diseases or eczema up to age 5.5 years. Compared to infrequent consumption of both organic and commercial complementary foods, frequent OF consumption without commercial complementary foods was associated with a higher risk of food allergy, whereas frequent commercial complementary food consumption without OF use was associated with a lower risk of food allergy.Conclusions: This study suggests that a history of allergy strongly affects feeding with OF during the complementary feeding period. However, OF consumption was not associated with reduced odds of food allergy later in childhood but could be associated with increased odds, which should be examined more deeply.

Health risks of air pollution with fine particulate matter

The review presents up-to-date information on the health effects of ambient fine particulate matter, obtained in large cohort epidemiological studies, as well as in meta-analysis of pooled data. In addition, it summarizes the current data on the potential pathological mechanisms and existing monitoring systems. The literature search used the Scopus, PubMed, Russian Science Citation Index databases for 19902020. The results of epidemiological studies carried out in different countries indicate that fine particles in ambient air pose a serious threat to health. Scientific publications assessing the health impact of particulate matter show a wide range of adverse effects from the increasing incidence of upper and lower respiratory tract diseases, including exacerbations of bronchial asthma, pneumonia, chronic obstructive pulmonary disease, to a high incidence of myocardial infarction, strokes, diabetes mellitus type 2, as well as an increase in overall mortality from natural causes, mainly mortality from respiratory diseases, cardiovascular and cerebrovascular diseases, lung cancer. The effects of short-term exposures are described in more detail, while the effects of long-term exposure to fine particles are not well understood. Potential mechanisms of the harmful effects of fine particulate matter include oxidative stress, inflammatory reactions, disorders of autonomic regulation and heart rhythm, fine particles translocation through the alveolar barrier into the vascular bed with endothelial damage and thrombus formation, and genotoxicity. Ambient fine particulate matter is a manageable risk factor, and reductions in air pollution will have a significant impact on public health outcomes.

The Effect of Contract-Rearing on the Health Status of Replacement Dairy Heifers

Simple SummaryIn this study, we set out to compare the health of contract- vs. conventionally reared replacement dairy heifers. Contract-reared heifers are raised off-farm on another farm by another farmer, for a fee. A total of 120 dairy farmers were enrolled in the study: 55 farmers were rearing their own heifers (control farmers; CFs), and 65 were sending heifers to a contract-rearing farm (source dairy farmers; SDFs). Over two years, we monitored approximately 5500 replacement heifers from these farms to check for signs of ill health using a calf health scoring system that involved individually examining each animal at four farm visits (twice annually). Additionally, faecal and nasal swabs were taken from a proportion of heifers with clinical signs of diarrhoea and respiratory disease. Overall, the results indicated few differences in the health and infectious status of home-reared versus contract-reared heifers. Additionally, the number of source dairy farms represented and mixing of heifers from multiple farms at the rearing unit were not associated with an increased incidence of respiratory disease or diarrhoea among contract-reared heifers. Therefore, it was concluded that contract-rearing did not result in adverse health outcomes for replacement dairy heifers.The aim of this study was to compare the health status of contract- vs. conventionally reared replacement dairy heifers over a 2-year period. A total of 120 dairy farmers were enrolled in the study in spring 2018: 55 farmers were rearing their own heifers (control farmers; CFs), and 65 were sending heifers to a contract-rearing farm (source dairy farmers; SDFs). Between spring 2018 and autumn 2019, approximately 5500 replacement heifers from these farms were monitored for signs of ill health during four farm visits using a modified version of the Wisconsin calf health scoring system. Additionally, faecal and nasal swabs were taken from a proportion of heifers with clinical signs of diarrhoea and respiratory disease to determine the associated aetiological agents. Results indicate few differences in the health status and pathogen exposure status of home-reared versus contract-reared heifers. Additionally, the number of source dairy farms represented and commingling of heifers from multiple origins at the rearing unit were not associated with an increased incidence of respiratory disease or diarrhoea among contract-reared heifers. It was concluded that contract-rearing did not result in adverse health outcomes for replacement dairy heifers. This is the first study to demonstrate this finding in a robust, longitudinal, herd-level population study.

Major Ambient Air Pollutants and Toxicity Exposure on Human Health and Their Respiratory System: A Review

Indoor and outdoor air pollution is causing environmental and health issues globally. It is more challenging mainly in developing countries like India, china, and others.According to recent World Health Organization (WHO) reports, nearly 4.2 million people die prematurely because of AAP (Ambient Air Pollution). Air pollution is made up of a variety of contaminants, including gases, liquids, heavy metals in the air, and particulate matter. Suspended particulate matter (SPM), surface ozone (O3), sulfur dioxide (SO2), nitrogen oxides (NO2), and other contaminants have become major environmental threats to plant health. These pollutants also have an effect on human health because they affect the consistency of the air we breathe. They usually cause inflammation in the upper respiratory tract, resulting in cough and shortness of breath. These are also significant contributors to the exacerbation of current respiratory conditions like asthma and chronic obstructive pulmonary disease. Epidemiological, toxicological, and clinical research all support the connection between air pollution and increased incidence and severity of respiratory and cardiovascular diseases. This pollution is a major public health problem in the locations where maximum pollution sources exist. To improve air quality and reduce the adverse effects of airborne toxicity due to AAP on human health, significant approaches are needed. The main objective of this review article is to provide evidence on the adverse effects of AAP on human health, as well as to make recommendations to policymakers on how to minimize exposure to this risk factor. Only public awareness combined with a multidisciplinary approach by scientific specialists will be able to handle this problem; national and international organizations must address the rise of this threat and suggest long-term remedies.

Health literacy of ethnic minority in remote China: precise intervention is needed

Health literacy of ethnic minority in remote China: precise intervention is needed

One Health approaches to improve refugee health

One Health approaches to improve refugee health

CHANGES IN SOME FRACTIONS OF CYTOKINES IN CHILDREN WITH IRON DEFICIENCY ANEMIA

The aim of the study was to investigate the effect of iron deficiency anaemia on certain cytokine fractions (IL-2, INF-γ, TNF-α) in children aged 6 months to 5 years in Azerbaijan. Methods. The study involved 123 children. According to the hematological and biochemical blood parameters of children aged 6 months to 5 years, 95 children (58 boys, 37 girls) were diagnosed as having anaemia of varying degrees: 32 children had mild iron deficiency anaemia, 37 children had moderate iron deficiency anaemia, and 26 children had severe iron deficiency anaemia. Results. The study demonstrates the level of INF-γ is lower in the general group of children with iron deficiency anaemia compared to the control group (2.5±1.2 pg/ml and 3.9±1.6 pg/ml, respectively). In the general group of children with iron deficiency anaemia, the average correlation coefficient (r=+0.7) between INF-γ with haemoglobin and with serum ferritin (r=+0.6) has been shown. Taking into account the weakening of INF-γ in children with iron deficiency anaemia during the study period, we investigated the annual incidence of acute respiratory viral infections among the general group of children with iron deficiency anaemia and the control group (63.2% and 25%, respectively). There were no significant changes in TNF-α value ​​in children of the general group with iron deficiency anaemia compared to the control group (2.7±1.5 pg / ml, 2.7±1.1 pg / ml, respectively). The IL-2 index in the general group was lower than in the control group (1.6±1.0 pg / ml, 2.9±1.6 pg / ml, respectively). Children in the general group with iron deficiency anaemia had an average correlation coefficient (r=+0.65) IL-2 with haemoglobin and a high correlation coefficient with serum ferritin (r=+0.8). The incidence of pneumonia in the group of children with iron deficiency anaemia was 17.9%. Conclusion. The obtained lowered results of İNF-γ and İL-2 in comparison with the control group and an increased incidence of respiratory diseases indicate a possible reduction in cellular immunity.