With the worldwide spreading of the dreaded COVID-19 epidemic, wearing masks becomes the most effective approach to prevent infectious respiratory diseases from transmission, for continuous monitoring of respiratory signals acts as a significant status in the treatment of respiratory diseases. Herein, a convenient mask-based respiration sensor was designed to access multiple high-resolution respire-related states in a wearable and noninvasive manner. Combining the intrinsically low compression strains and large contact domains of the melt-blown fibers with continuously optimized multi-purpose (improve electrical property, regulate mechanical modulus, and enhance environmental stability) conductive materials together, the fabricated sensor exhibited a high sensitivity of 43.6 per kilopascal, a rapid response time of 28 ms as well as low fatigue over 10,000 s. Furthermore, a wearable mask that integrated respiration sensor is capable of collecting a variety of breathing states, including cough, exercise, sit, and other multiple patterns correlated respiratory dynamics. As a result, it can provide a facile and low-overhead designing strategy for human respiratory analysis, which enables real-time respiratory monitoring with this wearable device to protect against respire-related diseases.