ObjectiveThis study aimed to explore the effect of resourcefulness and mindfulness training on depressive patients after percutaneous coronary intervention (PCI). MethodsThis single-center, randomized clinical trial was conducted. From October 2020 to August 2021, 132 depressive patients after PCI were selected from 4 wards of the cardiovascular department of a Class A tertiary hospital in Tangshan, China and divided into control group (CNG), resourcefulness practice group (RPG), mindfulness training group (MTG) and resourcefulness practice combined mindfulness training group (CMG). On the basis of routine nursing, the three intervention groups received resourecfulness practice, mindfulness training, and resourcefulness practice combined with mindfulness training for 12 weeks (1–6 weeks, once a week, 30 min each time; 7–12 weeks, practice three times a week and live on WeChat once a week, 30 min each time). The control group received routine nursing. Before the intervention, at 12 weeks and 24 weeks after the intervention, the Chinese version of the Cardiac Depression Scale, the Chinese Resourcefulness Scale, and the Five Facet Mindfulness Questionnaire were used to evaluate the depressive symptoms, the level of resourcefulness and the level of mindfulness among patients, respectively. ResultsA total of 132 patients completed the study (33 participants in each groups). After 12 weeks of intervention, the mixed effects model revealed that the level of resourcefulness and mindfulness were improved, and the depressive symptoms of patients were reduced in CMG as compared to CNG (the least square mean difference was −12.99, −37.19, 19.45, respectively, P < 0.01). Compared with the RPG, the level of mindfulness was improved, and the depressive symptoms were reduced in CMG (the least squares mean difference was −13.54, 10.99, respectively, P < 0.01). The level of resourcefulness of patients in CMG was higher than MTG (least squares mean difference was −8.37, P < 0.05). After 24 weeks of intervention, the level of mindfulness was improved, and the depressive symptoms were reduced in CMG, as compared to CNG (the least squares mean difference of the depressive symptoms and the level of mindfulness was −12.45, 13.03, respectively, P < 0.01) and RPG (the least squares mean difference was −7.79, 9.09, respectively, P < 0.05). Compared with the MTG, the depressive symptoms among patients were reduced in CMG (least squares mean difference was 7.37, P < 0.05). ConclusionResourcefulness practice combined with mindfulness training can be effective in reducing the symptoms of depression in patients after PCI, and the effects could last longer. Mindfulness training can supplement spiritual resourcefulness in resourcefulness practice.