Sandstone-type uranium deposits hold significant value and promise within China’s uranium resource portfolio, with the majority of these deposits found at the junctions of basins and mountains within Mesozoic and Cenozoic basins. The Kamust uranium mining area, located in the eastern part of the Junggar Basin, represents a significant recent discovery. Prior research on this deposit has been confined to two-dimensional analyses, which pose limitations for a comprehensive understanding of the deposit’s three-dimensional characteristics. To address the issue of uranium resource reserve expansion, this study employs 3D geological modeling and visualization techniques, guided by uranium deposit models and mineral prediction methods. First, a 3D model database of the Kamust uranium deposit was constructed, comprising drill holes, uranium ore bodies, ore-controlling structures, interlayer oxidation zones, and provenance areas. This model enables a transparent and visual representation of the spatial distribution of favorable mineralization horizons, structures, stratigraphy, and other predictive elements in the mining area. Second, based on the three-dimensional geological model, a mineral prediction model was established by summarizing the regional mineralization mechanisms, ore-controlling factors, and exploration indicators. Combined with big-data technology, this approach facilitated the quantitative analysis and extraction of ore-controlling factors, providing data support for the three-dimensional quantitative prediction of deep mineralization in the Kamust uranium deposit. Finally, using three-dimensional weights of evidence and three-dimensional information-quantity methods, comprehensive information analysis and quantitative prediction of deep mineralization were conducted. One prospective area was quantitatively delineated, located east of the Kalasay monocline, which has been well-validated in geological understanding. The research indicates that the area east of the Kalasay monocline in the Kamust mining district has significant exploration potential.