Cloud computing (CC) is emerging as a new paradigm of resource acquisition and management of information and communication technologies (ICT) by firms, which can offer significant benefits, but at the same time can pose significant risks as well, so its adoption by firms has been lower than the initial expectations. Therefore, it is quite important to gain a better understanding of the factors affecting positively or negatively the adoption of CC. This paper presents an empirical investigation of the effects on a firm’s propensity to adopt CC of a set of firm characteristics referring to technological infrastructure, strategy, personnel skills, size and competition. Its conceptual foundation is the Technology, Organization and Environment theory of technological innovation adoption. Our study is based on data from 676 European manufacturing firms from the glass, ceramics and cement sectors, which have been collected through the e-Business Survey of the European Commission. The results indicate that in the above sectors ICT infrastructure sophistication has the strongest positive effect on CC adoption propensity among all examined firm characteristics. Furthermore, we have found that the existence of an ICT investment reduction strategy, the employment of specialized ICT personnel and the existence of previous experience of ICT outsourcing also have positive effects on a firm’s propensity to adopt CC. On the contrary, employees ICT skills, price and quality competition do not affect CC adoption propensity. Finally, our results also indicate that in the three examined sectors firm size has no significant influence on the propensity to adopt CC.