Abstract. Relevance. In the regions of Asian Russia, there are problems and contradictions in the development of the social sphere, differentiation of urban and rural settlements in terms of infrastructure provision and transport accessibility. Achieving social sustainability of the territories of Asian Russia is the most important condition for the long-term crisis-free development of these territories, maintaining national security and ensuring the national interests of the country. Problems of assessing public health, the effectiveness of the health care system, and demographic development are of particular importance and relevance at the present time. The aim and objectives. As a result, the development of methodological tools for assessing public health, the level of health care development, and demographic development in the regions of Asian Russia became the goal of this study.The objectives of the study included a generalization of Russian and foreign practice in assessing public health, as well as the development of tools for multi-criteria assessment of public health and the level of healthcare development in the regions of Russia based on integral indicators of the effectiveness and resource availability of the healthcare system. Materials and methods. In this study, the authors consider public health as an economic category that reflects the expenditures of the country's economic resources allocated to the protection of public health and the effectiveness of the state policy of the state aimed at protecting public health. As the main indicators characterizing public health, the indicators of healthy life expectancy, total fertility rate, infant mortality rate, mortality rate of the working-age population are defined. Results. The results of the public health assessment indicate that 18 regions of Asian Russia, or two thirds, are characterized by a low level of health system performance in terms of healthy lifestyle expectancy, fertility and mortality rates. A low level of resource provision of the healthcare system is observed in half of the territories, or 14 regions of Asian Russia. Conclusion. As recent experience in the fight against COVID-19 has shown, despite the effective work of all medical organizations and the dedicated work of the country’s medical workers, all the problems that have existed for a long time in the development of the infrastructure of both the healthcare system and other sectors of the country’s social sphere have emerged. There is a general understanding that the infrastructural development of any territory of vast Russia must be carried out according to modern standards and requirements, regardless of its geographical location and administrative status.