Abstract Purpose To present the outcomes of corneal hydrops diathermocoagulation with amniotic membrane transplantation in eyes with keratoconus. Methods Studied group consisted of 15 persons, 6 women and 9 men (mean age 31,14± 9,92 years).All patients had extensive and persistent hydrops in the course of keratoconus,present for more than 20 weeks and refractory to traditional therapy.Time of observation ranged from 1.5 to 3.5 years.Central corneal thickness (Visante OCT, Carl Zeiss),corneal protuberance,BSCVA,subjective eye’s discomfort symptoms before and after the surgery,time to hydrops resolution and postoperative complications were assessed. Results Hydrops was successfully resolved in all eyes.The mean time of hydrops resolution was 15,7±5,78 days.The mean central corneal thickness was 487,24±19,57 µm 4 weeks after surgery and 463,59±17,21 µm 8 weeks after surgery.BSCVA was 0,18±0,28 4 weeks after surgery (before surgery 0,042±0,27).Eye’s discomfort symptoms (pain, tearing) collected 4 weeks after surgery completely receded in 5 patients (33,3%),decreased in 7 patients (46,6%),did not change in 3 patients (20%).Postoperative complications were:loss of contact lenses,suture loosening and corneal vascularization.In 3 patients,penetrating keratoplasty was performed with no episodes of rejection. Conclusion Diathermocoagulation of hydrops provides faster complete recession of the edema.Amniotic membrane transplantation strongly and sucsesfull reduces inflamation,scarring and vascularization of patient’s cornea.This kind of combined therapy effectively treats persistent hydrops,increases the comfort of patient’s life and stabilize ocular condition before penetrating keratoplasty.