objectives: Acute myocardial infarction(AMI) is becoming increasingly important problem in developing countries, and thrombolysis is the main modality of treatment here. About 25-50% of patients fail to achieve successful reperfusion and these patients have poor prognosis. Since alternative modes of reperfusion are available, it is important to identify them. This study was aimed at defining the extent of failed thrombolysis and identifying its demographic and clinical predictorsMethods: 50 cases of thrombolysed AMI patients were studied. Failed thrombolysis considered if there is 0.05), percentage of females was 25% v/s 16.7%(P>0.05), mean time for resolution of chest pain was 3.55±1.1 hrs v/s. 1.98±0.93 hrs (P 0.05), inferior wall MI was 30% v/s 46% (P>0.05) in failed and successful group respectivly. Interpretation and conclusion.Late presentation is an important risk factor for failed thrombolysis in AMI. Persistence of chest pain and non-resolution of reciprocal ST depression are significantly associated with failed thrombolysis.