Hyperspectral (HS) satellites like PRISMA (PRecursore IperSpettrale della Missione Applicativa) offer remarkable capabilities, yet they are constrained by a relatively coarse spatial resolution, curbing their efficacy in those applications that require pinpoint accuracy. Here we propose a fusion process, aimed at the enhancement of PRISMA HS spatial resolution by using the spatial and spectral information of Sentinel-2 multispectral (MS) data (HS-MS fusion process), validated against four airborne HS flights simultaneous to satellite overpasses on different land use distributions. Adopting the PRISMA panchromatic (PAN) image, the proposed solution was also compared with the results of a HS-PAN pansharpening process. A two-steps operational workflow is proposed, based on two state-of-the-art and open-source algorithms. The first step consisted of the geocoding of PRISMA L2 products using Senintel-2 as reference and was accomplished with the phase-based algorithm implemented in AROSICS (Automated and Robust Open-Source Image Co-registration Software). The geometric displacement in L2 data was found to be between 80 m and 250 m, irregularly spatially distributed throughout the same scene and among scenes, and it was corrected by means of thousands of regularly spatially distributed tie points. A second-order polynomial transformation function was integrated in the algorithm. The second step consisted of employing the HySure (HS Super resolution) fusion algorithm to perform both the HS-MS fusion and the HS-PAN pansharpening, returning a PRISMA HS improved dataset with a spatial resolution of 10 m and 5 m, respectively. Four different per-band accuracy metrics were used to evaluate the accuracy of both products against airborne data. Overall, HS-MS data achieved increased accuracy in all validation metrics, i.e. + 28 % (root mean square error, RMSE), +23 % (spectral angle mapper, SAM), +7% (peak signal-to-noise ratio, PSNR) and + 11 % (universal image quality index, UIQI), with respect of HS-PAN data. These outcomes showed that using the spectral information of Sentinel-2 both spectral and spatial patterns were reconstructed more consistently in three different urban and rural scenarios, avoiding the presence of blur and at-edge artefacts as opposed to HS-PAN pansharpening, therefore suggesting an optimal strategy for satellite HS data resolution enhancement.