This review paper delves into the escalating challenge of safeguarding supply chains against cyber-physical system (CPS) attacks, emphasizing the critical role of CPS in modern supply chains and the multifaceted vulnerabilities they introduce. We systematically outline a comprehensive framework encompassing preventive measures, detection and response strategies, and recovery and resilience planning to mitigate these risks. Furthermore, we explore the implementation challenges inherent in integrating cybersecurity and physical security strategies, highlighting innovative technological solutions and the crucial role of policy and regulatory compliance. This paper aims to offer actionable insights for enhancing the security posture of supply chains, underscoring the importance of collaborative efforts among stakeholders to navigate the complex landscape of cyber-physical threats. Keywords: Cyber-Physical Systems, Supply Chain Security, Cybersecurity, Physical Security, Recovery and Resilience, Policy and Regulation.