Stress Tolerance Research Articles

Deep phenotyping reveals CRH and FKBP51-dependent behavioral profiles following chronic social stress exposure in male mice.

The co-chaperone FKBP51, encoded by FKBP5 gene, is recognized as a psychiatric risk factor for anxiety and depressive disorders due to its crucial role in the stress response. Another key modulator in stress response regulation is the corticotropin releasing hormone (CRH), which is co-expressed with FKBP51 in many stress-relevant brain-regions and cell-types. Together, they intricately influence the balance of the hypothalamic-pituitary-adrenal (HPA) axis, one of the primary stress response systems. Previous research underscores the potential moderating effects these genes have on the regulation of the stressful life events towards the vulnerability of major depressive disorder (MDD). However, the specific function of FKBP51 in CRH-expressing neurons remains largely unexplored. Here, through deep behavioral phenotyping, we reveal heightened stress effects in mice lacking FKBP51 in CRH co-expressing neurons (CRHFKBP5-/-), particularly evident in social contexts. Our findings highlight the importance of considering cell-type specificity and context in comprehending stress responses and advocate for the utilization of machine-learning-driven phenotyping of mouse models. By elucidating these intricacies, we lay down the groundwork for personalized interventions aimed at enhancing stress resilience and individual well-being.

Father-child attachment on children’s screen time: mediating role of ego resilience

BackgroundChildren spend a significant amount of time engaging in sedentary behaviors, defined as activities that do not increase energy expenditure significantly above resting levels, such as watching TV and playing PC/video games. Increased screen time is a significant public health concern because children are in a developmental stage where lifestyle behaviors predict various health outcomes in adulthood and beyond. This study explores the links between parent-child attachment, ego resilience, and children’s screen time.MethodsThis cross-sectional correlation study uses 1,163 parents and their children data from the 12th Panel Survey of Korean Children. The study instruments were a modified Armsden and Greenberg scale of parent-child attachment and modified the children’s ego resilience scale of the Block and Kremen. Children’s screen time was classified as more than 2 h per day spent watching television, playing on computers, or playing video games in their leisure time.ResultsStudy results show a negative association between father-child attachment and children’s screen time (ß = -0.43, p < .001) and a positive association between father-child attachment and ego resilience (ß = 0.24, p < .001). Ego resilience showed a negative link to children’s screen time after adjusting for parental attachment (ß =- 0.03, p = .009). Father-child attachment link to children’s screen time (ß = -0.36, p < .001) continued even though the association was slightly reduced in magnitude after adjusting for ego resilience.ConclusionsOur findings show the mediating role of ego resilience on a negative path of father-child attachment to children’s screen time. This finding emphasizes the importance of fostering solid father-child relationships and enhancing children’s psychological resilience as critical strategies for reducing excessive screen time. By addressing emotional support and resilience-building, interventions can more effectively promote healthier behavioral outcomes in children.

Role of Biocontrol Agents in Suppressing Plant Pathogen: A Compressive Analysis

Biocontrol agents have emerged as important tools in the quest for sustainable agriculture, offering environmentally friendly alternatives to chemical pesticides for managing plant pathogens and pests. This comprehensive review explores the advancements in biocontrol agent research, focusing on the exploration of new agents, genetic engineering, and integration into Integrated Pest Management (IPM) systems. The discovery of novel biocontrol agents from diverse environments, including plant microbiomes and marine ecosystems, has expanded the arsenal available for agricultural use, while genetic engineering and synthetic biology have enhanced the efficacy of existing agents by improving their production of antimicrobial metabolites and stress tolerance. Additionally, the development of synthetic microbial consortia and innovative delivery systems, such as encapsulation and nanotechnology, has improved the stability and application efficiency of biocontrol agents in various agricultural settings. The review also highlights the importance of sustainable and eco-friendly approaches, such as the use of organic amendments and crop rotation, to enhance the effectiveness of biocontrol strategies. These methods not only improve soil health and biodiversity but also reduce the reliance on chemical inputs. However, the widespread adoption of biocontrol agents faces challenges, including environmental variability, host specificity, and the need for supportive regulatory frameworks. Harmonizing regulatory processes, promoting public awareness, and providing incentives for sustainable practices are essential for overcoming these barriers. International cooperation and knowledge exchange are crucial for advancing research and ensuring that biocontrol agents become integral components of modern agriculture. This review underscores the potential of biocontrol agents to contribute significantly to global food security and environmental sustainability, provided that ongoing research and innovation continue to address existing challenges and expand their practical applications in diverse agricultural contexts.

Evaluating a peer-support mind-body medicine intervention for healthcare leaders.

Mind-body medicine (MBM) is an evidence-based intervention associated with trauma and stressful events. The MBM intervention alleviates symptoms of work-related stress and builds resilience by utilizing self-care techniques facilitated in small group settings. Healthcare leaders who experienced traumatic stress through the COVID-19 pandemic may benefit from interventions aimed at their needs. We evaluated the effects of a peer support MBM intervention on perceived stress, resilience, well-being, and empathy for nurse leaders and compassionate care leaders. A pre-post intervention was conducted via 7 virtual and 2 on-site groups, recruiting from a large multihospital health system in the United States. Participants engaged in an 8-week program facilitated by a certified faculty group leader from The Center for Mind-Body Medicine and engaged in resilience skills building activities along with facilitated sharing. Validated instruments were used to measure outcomes at pre, post, 1 month, and 6 month follow-up intervals. Surveys included open-ended questions for qualitative feedback related to facilitators, barriers, and group experiences. Seventy-three leaders completed the MBM program, and 22 completed the four research surveys; all qualitative responses were included for feedback. Perceived stress decreased after the intervention (p < .008) and was maintained for 6 months post intervention (p < .005). Resilience increased after the intervention (p < .034) and for 1 month (p < .049) but decreased after 6 months. Qualitative responses showed that time and workload factors were the most significant barrier to participation, while the benefits included protected time with peers, learning well-being skills, and having a safe place to process emotions. Healthcare leaders face unique challenges, including workplace trauma and crises. Interventions that support their stress response, resilience, and overall well-being should take into consideration the nature of their work, the balance of time demands, and the need for peer support to overcome barriers to sustainable interventions.

NARRATIVE TECHNOLOGY FOR THE DEVELOPMENT OF PERSONAL LIFE COMPETENCE

The article addresses the issue of developing personal life competence within the framework of the psychological-hermeneutic, specifically narrative, approach. The feasibility of using narrative technologies in the context of developing personal life competence is substantiated: by constructive problem-solving, effective setting and solving of life tasks, strengthening psychological resilience, enhancing self-awareness and reflection, and building productive adaptive strategies during the prolonged war in Ukraine. The article characterizes the author's narrative technology as "Core Personal Questions," aimed at developing personal life competence through self-reflection, defining personal values, motives, and goals, and forming a holistic self-image. The proposed technology helps individuals understand their own experiences, current resources, beliefs, behavioral strategies, self-presentations, and life and personal projects, which is of significant importance during the war. The narrative technology "Core Personal Questions" is directed towards constructing retrospective, current, and prospective self-narratives, through which the understanding of life and personal experiences, determination of meaningful priorities and prospects, and adaptation to the current crisis conditions occur. The use of this technology involves the development of personal life competence in three dimensions: routine-selective, adaptive, and innovative. The methodological tools are based on key questions, the search for answers to which fosters self-reflection, independent setting, clarification, and redefinition of the main life tasks by the individual. The article illustrates the possibilities of applying the proposed narrative technology in working with vulnerable populations during the war in Ukraine. Keywords: personality, life competence, development, dimensions of development, reflection, narrative, narrative technologies, personal questions, war in Ukraine

Bouncing back from life's perturbations: Formalizing psychological resilience from a complex systems perspective.

Experiencing stressful or traumatic events can lead to a range of responses, from mild disruptions to severe and persistent mental health issues. Understanding the various trajectories of response to adversity is crucial for developing effective interventions and support systems. Researchers have identified four commonly observed response trajectories to adversity, from which the resilient is the most common one. Resilience refers to the maintenance of healthy psychological functioning despite facing adversity. However, it remains an open question how to understand and anticipate resilience, due to its dynamic and multifactorial nature. This article presents a novel formalized framework to conceptualize resilience from a complex systems perspective. We use the network theory of psychopathology, which states that mental disorders are self-sustaining endpoints of direct symptom-symptom interactions organized in a network system. The internal structure of the network determines the most likely trajectory of symptom development. We introduce the resilience quadrant, which organizes the state of symptom networks on two domains: (1) healthy versus dysfunctional and (2) stable versus unstable. The quadrant captures the four commonly observed response trajectories to adversity along those dimensions: resilient trajectories in the face of adversity, as well as persistent symptoms despite treatment interventions. Subsequently, an empirical illustration, by means of a proof-of-principle, shows how simulated observations from four different network architectures lead to the four commonly observed responses to adversity. As such, we present a novel outlook on resilience by combining existing statistical symptom network models with simulation techniques. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Low psychological resilience and physical fitness predict attrition from US Marine Corps Officer Candidate School training

ABSTRACT The objective is to examine the predictors of attrition in male and female candidates undergoing a 10-week early career military training program. 1006 candidates (79.5% male, 24.7 ± 3.2 years) consented to participating in a larger study examining predictors of injury during US Marine Corps Officer Candidates School (OCS). Participants completed a blood draw, demographic and psychological characteristics questionnaires, and two fitness tests. Participants were then grouped based on successful completion of OCS or not. Associations between potential predictors and attrition were analyzed using simple logistic regression analyses, followed by a backward stepwise elimination method. Area under the curve (AUC) of the receiver operating characteristic (ROC) curve was used to determine the accuracy of the attrition prediction model. 260 candidates (25.8%) attritted over the 10-week training, with the highest number of discharges during week 5. Musculoskeletal injury (MSKI) was the most common cause of attrition (30%), followed by non-MSKI medical (21.5%), and volitional withdrawals (19.6%). Sex, body mass index (BMI), resilience, initial physical fitness test score, combat fitness test (CFT) score, and prior military service were all significantly associated with attrition from OCS (all p < .05). The final prediction model of attrition included CFT score (p = .027) and resilience (p = .018). Multiple demographic, psychological, and fitness characteristics are associated with attrition from an early career military training course (OCS) and may be utilized as part of early screening procedures to identify and provide guidance for individuals at risk for not completing OCS.

Sll1019 and slr1259 encoding glyoxalase II improve tolerance of Synechocystis sp. PCC 6803 to methylglyoxal- and ethanol- induced oxidative stress by glyoxalase pathway.

The glyoxalase pathway is the primary detoxification mechanism for methylglyoxal (MG), a ubiquitous toxic metabolite that disrupts redox homeostasis. In the glyoxalase pathway, glyoxalase II (GlyII) can completely detoxify MG. Increasing the activity of the glyoxalase system can enhance the resistance of plants or organisms to abiotic stress, but the relevant mechanism remains largely unknown. In this study, we investigated the physiological functions of GlyII genes (sll1019 and slr1259) in Synechocystis sp. PCC 6803 under MG or ethanol stress based on transcriptome and metabolome data. High-performance liquid chromatography (HPLC) results showed that proteins Sll1019 and Slr1259 had GlyII activity. Under stress conditions, sll1019 and slr1259 protected the strain against oxidative stress by enhancing the activity of the glyoxalase pathway and raising the contents of antioxidants such as glutathione and superoxide dismutase. In the photosynthetic system, sll1019 and slr1259 indirectly affected the light energy absorption by strains, synthesis of photosynthetic pigments, and activities of photosystem I and photosystem II, which was crucial for the growth of the strain under stress conditions. In addition, sll1019 and slr1259 enhanced the tolerance of strain to oxidative stress by indirectly regulating metabolic networks, including ensuring energy acquisition, NADH and NADPH production, and phosphate and nitrate transport. This study reveals the mechanism by which sll1019 and slr1259 improve oxidative stress tolerance of strains by glyoxalase pathway. Our findings provide theoretical basis for breeding, seedling, and field production of abiotic stress tolerance-enhanced variety.IMPORTANCEThe glyoxalase system is present in most organisms, and it is the primary pathway for eliminating the toxic metabolite methylglyoxal. Increasing the activity of the glyoxalase system can enhance plant resistance to environmental stress, but the relevant mechanism is poorly understood. This study revealed the physiological functions of glyoxalase II genes sll1019 and slr1259 in Synechocystis sp. PCC 6803 under abiotic stress conditions and their regulatory effects on oxidative stress tolerance of strains. Under stress conditions, sll1019 and slr1259 enhanced the activity of the glyoxalase pathway and the antioxidant system, maintained photosynthesis, ensured energy acquisition, NADH and NADPH production, and phosphate and nitrate transport, thereby protecting the strain against oxidative stress. This study lays a foundation for further deciphering the mechanism by which the glyoxalase system enhances the tolerance of cells to abiotic stress, providing important information for breeding, seedling, and selection of plants with strong stress resistance.

Microbiomes-Plant Interactions and K-Humate Application for Salinity Stress Mitigation and Yield Enhancement in Wheat and Faba Bean in Egypt’s Northeastern Delta

Salinity, resulting from climate change and excessive mineral fertilization, burdens farmers and negatively impacts soil and water ecosystems in the Northeastern Nile Delta. Organic and biological approaches are crucial for addressing these issues. This study examined the effects of individual and combined inoculations with cyanobacteria, yeast, and Arbuscular Mycorrhizal Fungi (AMF), with or without K-Humate and reducing Nitrogen, phosphorus and potassium (NPK) mineral fertilizers application rates to crop quality of wheat and faba bean. In preliminary laboratory experiments, the interactive effects of these microbiomes on plant antioxidant and soil enzyme production were examined under salinity stress. Results showed that co-inoculation, especially with K-Humate, yielded superior outcomes compared to individual inoculations. These findings were validated by a field trial conducted in saline-alkaline soil in the Northeastern Nile Delta region. All biological treatments 25% of recommended doses, and enhancing salinity tolerance, increasing yield, and improving enhanced rhizosphere microbial activity, including soil enzyme activity, AMF colonization, spore density, and the total numbers of bacteria, cyanobacteria, and yeast. These effects were further amplified by K-Humate and were more pronounced with combined inoculations than with individual ones, leading to improved soil fertility and significant increases in both crop quantity and quality compared to control treatments. The triple treatment, combining cyanobacteria, yeast, and mycorrhizae in the presence of K-Humate while reducing the mineral NPK rate by 75%, achieved superior increases in the productivity of wheat grains and faba bean seeds, reaching 54.72% and 128.92%, respectively, compared to the 100% NPK mineral control. This treatment also significantly improved crop quality, with notable increases in nitrogen, potassium, phosphorus, and protein percentages in wheat grains and faba bean seeds. Microbiomes-interaction increased potassium uptake over sodium, enhancing the plant’s potassium/sodium ratio and improving salt stress tolerance. This approach reduces reliance on costly mineral fertilizers, enabling bio-organic farming in marginal lands, optimizing resource utilization, and preserving natural resources.

HIP is involved in NaCl and endoplasmic reticulum stress resistance in Arabidopsis

Heat shock protein 70 (HSP70)-interacting proteins (HIPs) have been studied in animals. HIPs perform diverse cellular functions, ranging from alleviating stress to suppressing the formation of insoluble protein, but how their orthologs function in plants is less known. This study shows that Arabidopsis HIP is a cytosolic and nuclear protein associated with HSP70. The hip mutants showed compromised tolerance to NaCl and endoplasmic reticulum (ER) stress, although they grew normally under standard growth conditions. Furthermore, hip mutants presented a decreased HSP70 level compared with the wild type under NaCl and ER stress conditions. These findings suggest the involvement of HIP in NaCl and ER stress tolerance.

GWAS for Drought Resilience Traits in Red Clover (Trifolium pratense L.)

Red clover (Trifolium pratense L.) is a well-appreciated grassland crop in temperate climates but suffers from increasingly frequent and severe drought periods. Molecular markers for drought resilience (DR) would benefit breeding initiatives for red clover, as would a better understanding of the genes involved in DR. Two previous studies, as follows, have: (1) identified phenotypic DR traits in a diverse set of red clover accessions; and (2) produced genotypic data using a pooled genotyping-by-sequencing (GBS) approach in the same collection. In the present study, we performed genome-wide association studies (GWAS) for DR using the available phenotypic and genotypic data. Single nucleotide polymorphism (SNP) calling was performed using GBS data and the following two red clover genome assemblies: the recent HEN-17 assembly and the Milvus assembly. SNP positions with significant associations were used to delineate flanking regions in both genome assemblies, while functional annotations were retrieved from Medicago truncatula orthologs. GWAS revealed 19 significant SNPs in the HEN-17-derived SNP set, explaining between 5.3 and 23.2% of the phenotypic variation per SNP–trait combination for DR traits. Among the genes in the SNP-flanking regions, we identified candidate genes related to cell wall structuring, genes encoding sugar-modifying proteins, an ureide permease gene, and other genes linked to stress metabolism pathways. GWAS revealed 29 SNPs in the Milvus-derived SNP set that explained substantially more phenotypic variation for DR traits, between 5.3 and 42.3% per SNP–trait combination. Candidate genes included a DEAD-box ATP-dependent RNA helicase gene, a P-loop nucleoside triphosphate hydrolase gene, a Myb/SANT-like DNA-binding domain protein, and an ubiquitin–protein ligase gene. Most accessions in this study are genetically more closely related to the Milvus genotype than to HEN-17, possibly explaining how the Milvus-derived SNP set yielded more robust associations. The Milvus-derived SNP set pinpointed 10 genomic regions that explained more than 25% of the phenotypic variation for DR traits. A possible next step could be the implementation of these SNP markers in practical breeding programs, which would help to improve DR in red clover. Candidate genes could be further characterized in future research to unravel drought stress resilience in red clover in more detail.

Expression of the LlBANMT Gene from Sea Lavender Leads to the Accumulation of β-alanine Betaine and Enhanced Stress Resilience in Transgenic Tobacco Plants

Expression of the LlBANMT Gene from Sea Lavender Leads to the Accumulation of β-alanine Betaine and Enhanced Stress Resilience in Transgenic Tobacco Plants

Fostering Psychological Resilience in Dyslexic Children: Exploring the Psychosocial Dynamics of Interpersonal Relationships and Community Support

The present work assumes a study of such multifaceted psychosocial formations, forming the basis of creating a psychological resilience framework concerning dyslexic children. Under the study due to the conceptual vagueness of this concept, the present work is investigating the toll generated by the quality of interpersonal relations along with the trait of the supported community-based environmental factor in the psychosocial well-being of dyslexic individuals, taking into account potential gender specifics of boys and girls experiencing dyslexia. Considering the widespread volume of academic literature in this area and the realistic original dataset at my disposal, the present work reveals differences in how frequent deviations of the reciprocity established positive powers of such interpersonal unity and the continuous repetition of the exposure to the established community-based model affects the resistance against negative relation circumstances and other psychosocial powers that can lead to negative dyslexia-related consequences. In summary, the present work examines the action of reciprocally targeted multiple mechanisms in several psychosocial concepts to identify the potential mechanism of resistance development and the environment formation of possibilities to act concerning persons with dyslexia underscoring the sex-specific heuristic patterns due to dyslexia. Therefore, at the concluding point, the present work is directing potentially relevant further investigations on psychosocial resilience determinants and providing targeted recommendations for everyday practice, taking into account boy and girl skills and special needs.

Religion on the brain: A look into the neurological impact of religion and spirituality

Beliefs are the inherent, underlying nature of our identity, motives, and actions. One of the most significant and developed forms of belief is religion. This paper outlines the development of beliefs and provides evidence on how religion and spirituality impact the brain. Through neurotheological studies like the one done with Carmelite nuns in 2006, researchers can uncover what the brain looks like during religious/spiritual experiences. Results show that religious experiences increase activation in various regions such as the IPL, MPFC, ACC, and more. Studies have also shown that many of the results related to religion on the brain align with studies done to decipher the difference between a mentally healthy patient and a mentally unhealthy patient. One such example is that there is a similar increase in the PDR and the EEG when comparing results from a neurotheological study and brain imaging depicting positive and negative mental health. This relationship is proved through statistics revealing how religion has been known to significantly decrease the rate of depression in an individual and decrease the rate of suicide in a community. The findings suggest that integrating religious and spiritual dimensions into mental health treatment can enhance therapeutic outcomes. Ultimately, this exploration affirms beliefs’ profound role in shaping our identities and promoting psychological resilience.

AI Based Chatbots for Mental Health Care: A Systematic Review

Medicinal utilization of Expert systems for psychological resilience maintenance have proficient a accelerated float in the spent a small number of years. AI empowered chatbot shareware and administration have been supervising fundamental therapeutical hospitalization that were beforehand unique feasible from master and skilled medicare executives. Such resources, which orbit from “essential psychologist” to “community cybermens” in mental health, attempt to enhance serving production and cost handling, as well as gathering the mental health needs of unprotected and disadvantaged citizenery. Nevertheless, there is still a substantial gap between recent progress in AI mental health and the widespread use of these solutions by healthcare exponents in therapeutic settings. Furthermore, therapy are recurrently developed without clear ethical proceedings. While AI-enabled solutions show promise in the realm of mental health, further research is needed to address the ethical and communal aspects of these technologies, as well as to establish efficient exploration and therapeutic practices in this fresh sector.

Role of Gibberellic Acid (GA3) in Improving Salt Stress Tolerance of Wheat (Triticum avestivum)

Salinity is a critical environmental factor that adversely affects crop growth and productivity. This study aimed to evaluate the effects of gibberellic acid (GA3) on germination, shoot length, root length, and biomass of two wheat cultivars (Demirhan and Fazılbey) under varying levels of salt stress (0, 5, and 10 dS/m NaCl). GA3 was applied at concentrations of 100 and 200 ppm to assess its potential in alleviating the adverse effects of salinity. The results revealed that GA3 significantly improved germination percentage, shoot length, and root length in both cultivars, with the Demirhan cultivar showing more pronounced responses under higher salt stress. A biplot analysis highlighted the interaction between GA3 treatment, salinity levels, and cultivar performance, confirming the positive role of GA3 in mitigating the detrimental effects of salinity. These findings suggest that GA3 can be an effective strategy for enhancing wheat growth in saline soils. Further studies are recommended to optimize GA3 concentrations and evaluate its long-term effects under field conditions.

Cerium Oxide Nanoparticles (CeO2 NPs) Enhance Salt Tolerance in Spearmint (Mentha spicata L.) by Boosting the Antioxidant System and Increasing Essential Oil Composition

Salinity represents a considerable environmental risk, exerting deleterious effects on horticultural crops. Nanotechnology has recently emerged as a promising avenue for enhancing plant tolerance to abiotic stress. Among nanoparticles, cerium oxide nanoparticles (CeO2 NPs) have been demonstrated to mitigate certain stress effects, including salinity. In the present study, the impact of CeO2 NPs (0, 25, and 100 mg L−1) on various morphological traits, photosynthetic pigments, biochemical parameters, and the essential oil profile of spearmint plants under moderate (50 mM NaCl) and severe (100 mM NaCl) salinity stress conditions was examined. As expected, salinity reduced morphological parameters, including plant height, number of leaves, fresh and dry weight of leaves and shoots, as well as photosynthetic pigments, in comparison to control. Conversely, it led to an increase in the content of proline, total phenols, malondialdehyde (MDA), hydrogen peroxide (H2O2), and antioxidant enzyme activities. In terms of CeO2 NP applications, they improved the salinity tolerance of spearmint plants by increasing chlorophyll and carotenoid content, enhancing antioxidant enzyme activities, and lowering MDA and H2O2 levels. However, CeO2 NPs at 100 mg L−1 had adverse effects on certain physiological parameters, highlighting the need for careful consideration of the applied concentration of CeO2 NPs. Considering the response of essential oil compounds, combination of salinity stress and CeO2 treatments led to an increase in the concentrations of L-menthone, pulegone, and 1,8-cineole, which are the predominant compounds in spearmint essential oil. In summary, foliar application of CeO2 NPs strengthened the resilience of spearmint plants against salinity stress, offering new insights into the potential use of CeO2 NP treatments to enhance crop stress tolerance.

Comparing the Effectiveness of In-person and Telehealth Cognitive-Behavioral Therapy on Psychological Distress and Resilience in People Recovered from COVID-19: A Randomized Control Study

Background: In addition to the physical effects caused by coronavirus disease 2019 (COVID-19), the disease is also associated with various psychological problems that have required research and clinical attention. Objectives: The purpose of this study was to compare the effectiveness of in-person and telehealth cognitive-behavioral therapy (CBT) in people who have recovered from COVID-19. Methods: This study was a randomized controlled trial with a pre-post design, a control group, and a three-month follow-up. The statistical population consisted of patients who had recovered from COVID-19 in Tehran between 2022 and 2023. From this population, 45 patients were selected using a convenience sampling method and randomly divided into three groups: An in-person CBT group, a telehealth CBT group (15 patients in each), and a control group (15 patients). The in-person CBT group received 11 sessions, while the telehealth CBT group received 12 sessions. Research instruments included the Depression, Anxiety, and Stress Scale (DASS-21) and the Resilience Scale (RS). The data were analyzed using repeated measures analysis of variance. Results: The results showed that although both treatments led to improvements in psychological distress (P &lt; 0.01) and resilience (P &lt; 0.01), the effectiveness of in-person CBT was greater and statistically significant. The effect sizes for depression, anxiety, stress, and resilience were 0.37, 0.38, 0.44, and 0.64, respectively. Conclusions: The results indicate that both in-person and virtual CBT lead to improvements in psychological distress and resilience in patients with a history of COVID-19, compared to the control group. However, the improvement rate was higher for in-person CBT compared to the virtual group. In-person CBT led to significant improvements in both psychological distress and resilience.

The effect of paternal support on dyadic adjustment, happiness and psychological resilience: a randomized controlled trial

The effect of paternal support on dyadic adjustment, happiness and psychological resilience: a randomized controlled trial

Transcription Factor OsMYB2 Triggers Amino Acid Transporter OsANT1 expression to Regulate Rice Growth and Salt Tolerance.

Amino acid transporters play important roles in plant growth and stress tolerance; however, whether the abscisic acid signaling pathway regulates their transcription in rice (Oryza sativa) under salt stress remains unclear. In this study, we report that the transcription factor OsMYB2 (MYB transcription factor 2) of the abscisic acid signaling pathway mediates the expression of the gene encoding the amino acid transporter OsANT1 (aromatic and neutral amino acid transporter 1), which positively regulates growth and salt tolerance in rice. OsANT1 was mainly expressed in the leaf blade and panicle under normal conditions and transports leucine, phenylalanine, tyrosine and proline, positively regulating tillering and yield in rice. Nevertheless, salt stress induced the accumulation of abscisic acid and strongly increased the expression level of OsANT1 in the root, resulting in enhanced salt tolerance of rice seedlings, as evidenced by higher proline concentration and antioxidant-like enzyme activities and lower malondialdehyde and hydrogen peroxide concentrations. Moreover, we showed that OsMYB2 interacts with the promoter of OsANT1 and promotes its expression. Overexpression of OsMYB2 also improved tillering, yield, and salt tolerance in rice. In conclusion, our results suggest that the transcription factor OsMYB2 triggers OsANT1 expression and regulates growth and salt tolerance in rice, providing insights into the role of the abscisic acid signaling pathway in the regulatory mechanism of amino acid transporters in response to salt stress.