Psychological resilience is the ability to maintain personal and professional wellbeing in the face of on-going work stress and adversity. The aim is to investigate the state of the psychological resilience of Health Care Professionals (HCP) and the potential risk factors. The study that we conducted carries out a sample of 230 persons (150 nurses and 80 doctors) belonging to the different services of Ibn Sina Hospital of Rabat/Morocco, using two scales. One is a questionnaire containing most of the socio-demographic characteristics, and clinical characteristics. The second is the Dispositional Resilience Scale-15 (DRS15). Otherwise, our results indicate a relatively low rate of resilience of health staff practicing at Ibn Sina Hospital in Rabat/Morocco. 81% of HCP have “low resilience”, 16% have shown “moderate resilience” and only 3% are in the “good resilience” range, based on analyzes of resilience scale results DSR15. The results of the DRS15 validation study indicate a positive correlation between engagement, control and challenge, as well as improved inter and intra-item correlation. Our study also indicates a statistically significant relationship between resilience and socio-economic difficulties of HCP. Sex, marital status, seniority, work schedule and medical history are risk factors. Indeed, women are more resilient than men, single people are more vulnerable than married couples, and new recruits are less resistant than older ones. In addition, the 12/36 continuous work schedule has a protective factor for HCP. These results go in the same direction as those found by some studies. Thus, the results of our study are encouraging and can be used for decision-making in this case.