End-of-life care for cancer patients is one of the most challenging experiences encountered by nurses. Cancer nurses providing end-of-life care may experience compassion fatigue due to prolonged exposure to the suffering and intense emotional reactions of patients, death and the dying, and grieving families. However, the development of resilience and effective coping skills can decrease nurse turnover rates and increase the quality of palliative cancer care. This article discusses the concept of compassion fatigue, how it develops, compassion fatigue experienced by nurses providing palliative cancer care, and the Compassion Fatigue Resiliency Program (CFRP) coping method. Author experience and journal articles were used. Compassion fatigue can occur from secondary traumatic stress and burnout after nurses' prolonged and intense exposure to helping suffering patients, resulting in decreased ability to care, expend energy, or exhibit empathy and compassion. The CFRP is a structured, comprehensive training program designed to educate nurses about compassion fatigue and enable them to develop a support network, strengthen their coping skills, and improve resilience. It is recommended that the CFRP be included in in-service training in institutions and be applied to oncology nurses at regular intervals in a block program format (1-2 days). Newly recruited oncology nurses in particular should be supported with such training in orientation programs. Institutional managers play an important role in organizing such programs and screening for the risk of compassion fatigue in nurses who provide end-of-life care.