Lower-limb amputees often exhibit large fluctuation in residual-limb shape, necessitating careful observation and anthropometric measurement for prosthetists to ensure socket fit. Anthropometric measurement may become more important as an outcome measure indicating success in rehabilitation. This study investigated the accuracy and reliability of seven prosthetic anthropometric measurement devices as used by a group of eight prosthetic-orthotic practitioners and a group of five prosthetic-orthotic students to measure six common anthropometric dimensions on three foam positive models of transtibial amputee residual limbs. Two of the models were identical, enabling assessment of individual repeatability. Some clinically significant errors were noted in the results; however, the general variability in measurements was not clinically significant. Students were slightly more consistent than practitioners; students were more consistent with linear measurements, while practitioners were more consistent with circumferential measures. The results further demonstrated that the VAPC measurement device used in the study was both inaccurate and unreliable.