Understanding the association between SARS-CoV-2 Spatial Transmission Risk (SSTR) and Built Environments (BE) is crucial for implementing effective pandemic prevention measures. Massive efforts have been made to examine the macro-built environment at the regional level, which has neglected the living service areas at the residential scale. Therefore, this study aims to explore the association between Street-level Built Environments (SLBE) and SSTR in Hong Kong from the 1st to the early 5th waves of the pandemic to address this gap. A total of 3693 visited/resided buildings were collected and clustered by spatial autocorrelation, and then Google Street View (GSV) was employed to obtain SLBE features around the buildings. Eventually, the interpretable machine learning framework based on the random forest algorithm (RFA)-based SHapley Additive exPlanations (SHAP) model was proposed to reveal the hidden non-linear association between SSTR and SLBE.The results indicated that in the high-risk cluster area, street sidewalks, street sanitation facilities, and artificial structures were the primary risk factors positively associated with SSTR, in low-risk cluster areas with a significant positive association with traffic control facilities. Our study elucidates the role of SLBE in COVID-19 transmission, facilitates strategic resource allocation, and guides the optimization of outdoor behavior during pandemics for urban policymakers.