The aim of this research was to study the risks for myocardial infarction associated with long term exposure to residential road traffic noise exposure using refined epidemiological methods (The ROM study). To control for potential risk factors, a large Swedish population-based case-control study (Stockholm Heart Epidemiology Program [SHEEP]) of first-time myocardial infarction was used for the investigation. Road traffic noise exposure was calculated for a total of 7,700 addresses from 1970 and onwards. A novel approach to assess individual noise exposure over several decades was used to study the relation between longitudinal traffic noise exposure and myocardial infarction.