Residence Time Research Articles

Continuous-flow synthesis of di-(2-ethylhexyl) peroxydicarbonate in a packed-bed microreactor: Process optimization and kinetic modeling

Di-(2-ethylhexyl) peroxydicarbonate (EHP) is a low-temperature liquid organic peroxide commonly used as an initiator for polymerization of vinyl chloride and ethylene. The exothermic nature of peroxidation and the instability of this peroxide product pose safety challenges during synthesis. Therefore, batch reaction processes for synthesizing such products often prioritize safety over efficiency. In this work, an efficient and safe protocol was proposed for EHP production with the use of a packed-bed microreactor. Response surface methodology was applied to optimize critical process parameters, resulting in a remarkable yield of 95.48% in a residence time of 23.8 min. It proves that the efficiency was significantly improved by the packed-bed microreactor compared with batch reactors. Additionally, an operational window was established to guide the process development for synthesizing EHP in flow. Finally, a kinetic model was established, which was of crucial theoretical significance and practical value for better understanding peroxidation processes and parameter optimization.

Hydrophobic C60-modified PVDF membrane with micro-nano structures for mitigating CaSO4 scaling in Direct Contact Membrane Distillation (DCMD)

Membrane scaling is a non-negligible problem for membrane distillation (MD) in the treatment of high-salinity wastewater (e.g., calcium sulfate and calcium carbonate). In this study, fullerene (C60) was adhered to a polyvinylidene fluoride (PVDF) membrane using a polydimethylsiloxane (PDMS) solution to create a micro-nano structure, fabricating the C60/PDMS-PVDF membrane. This membrane was then re-immersed in a PDMS solution to further reinforce the C60 nanoparticles on the surface, forming the PDMS/C60/PDMS-PVDF membrane. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) were used to characterize the membrane surface morphology. Fourier transform infrared (FT-IR) was used to explore the membrane chemical composition. Liquid entry pressure (LEP) and water contact angle (WCA) measurements were employed to assess the membrane wettability. The results showed that C60-modification created the micro-nano structure on the membrane surface. The WCA of the PVDF membrane was 112.7 ± 2.4°, with a sliding angle far greater than 90°, whereas the PDMS/C60/PDMS-PVDF membrane exhibited a WCA of 147.9 ± 3.2° and a sliding angle of 6.3°. Compared to the virgin PVDF membrane, the LEP value of the PDMS/C60/PDMS-PVDF membrane increased from 68.4 ± 2.7 kPa to 87.2 ± 3.3 kPa. In direct contact membrane distillation (DCMD), a CaSO4 solution (2g/L) was used to test the membrane performance. After 48hours of operation, the flux of the PDMS/C60/PDMS-PVDF membrane remained at approximately 3.57kg/(m2·h), and the salt rejection rate was over 99.96%. This could be attributed to the C60 modification forming a micro-nano structure on the membrane surface, which trapped an air layer. This air layer could reduce the contact area between the crystal and the membrane, decrease nucleation probability, and shorten the residence time of liquid on the membrane surface. Additionally, the PDMS/C60/PDMS-PVDF membrane exhibited superior stability during the ultrasonic destruction experiment due to the encapsulation of PDMS. In summary, a novel hydrophobic membrane with a micro-nano structure was fabricated through C60 modification, offering superior anti-scaling properties and stability in treating high-salinity wastewater.

Watershed hydrology mediates the recovery of an arsenic impacted subarctic landscape

A holistic understanding of the chemical recovery of lakes from arsenic (As) pollution requires consideration of within-lake biogeochemical cycling of As and processes occurring in the surrounding catchment. This study used a watershed mass balance approach, complemented by experimental sediment incubations, to assess the mobility and transport of As within a subarctic watershed (155 km2) impacted by more than 60 years of atmospheric mining emissions. The period of record spanned a transition from drought to high streamflow between September 2017 and September 2019, which yielded insights into the interacting effects of hydrology and within-lake biogeochemical cycling of As. Internal loading of As from contaminated lake sediments (25 – 46 kg As year-1) and contributions from terrestrial sources (16 – 56 kg As yr-1) continue to negatively impact lake water quality (19 – 144 μg As L-1), but the relative importance of these loads varies seasonally and inter-annually in response to changing hydrological conditions. Wet conditions resulted in greater transport of As from terrestrial reservoirs and upstream areas, shorter lake water retention time, and increased the downstream export of As. During dry periods, the lake was disconnected from the surrounding watershed resulting in limited terrestrial contributions and longer lake water residence time, which delayed recovery due to the greater relative influence of internal loading from contaminated sediments. This study highlights that changing hydroclimatic regimes will alter trajectories of chemical recovery for arsenic impacted lakes through the coupling of within-lake and watershed transport processes.

Probing the energy landscape of the lipid interactions of the serotonin1A receptor

G protein-coupled receptors (GPCRs) are lipid-regulated transmembrane proteins that play a central role in cell signaling and pharmacology. Although the role of membrane lipids in GPCR function is well established, the underlying GPCR-lipid interactions have not been thermodynamically characterized due to the complexity of these interactions. In this work, we estimate the energetics and dynamics of lipid association from coarse-grain simulations of the serotonin1A receptor embedded in a complex membrane. We show that lipids bind to the receptor with varying energetics of 1–4 kT, and timescales of 1–10 μs. The most favorable energetics and longest residence times are observed for cholesterol, glycosphingolipid GM1, phosphatidylethanolamine (PE) and phosphatidylserine (PS) lipids. Multi-exponential fitting of the contact probability suggests distinct dynamic regimes, corresponding to ps, ns and μs timescales, that we correlate with the annular, intermediate and non-annular lipid sites. The timescales of lipid binding correspond to high barrier heights, despite their relatively weaker energetics. Our results highlight that GPCR-lipid interactions are driven by both thermodynamic interactions and the dynamical features of lipid binding.

A bilateral semi-resolved CFD-DEM approach for cost-effective modelling in a rotary drum

It is of significance to numerically describe particle-flow interphase flow details at a feasible computational cost. Inspired by the semi-resolved Computational Fluid Dynamics-Discrete Element Method (CFD-DEM), an improved bilateral semi-resolved CFD-DEM approach (BSM) approach is developed in this work. Compared with the conventional divided particle volume method (DPVM) and recent semi-resolved CFD-DEM (SM) approach, the BSM approach allows a higher-resolution mesh and achieves higher accuracy as well as applicability when simulating the transient flow with sharp gradients of solid volume fraction and velocity etc. Then the BSM approach is applied to a rotary drum to demonstrate the effectiveness by investigating the internal hydrodynamics details. The typical flow behaviours are detailed; then the effects of the restitution and friction on the internal flow are analysed with details to demonstrate its effectiveness in terms of repose angle, active–passive zone, solid residence time, particle mixing and axial dispersion. The results show a positive correlation of the active depth, mixing degree, and particle dispersion with the friction, while restitution increasing depicts no significant effects on this particulate flow. This work provides an improved numerical tool for understanding the multiphase transient flows involving sharp gradients.

An integrated approach for characterization of a fractured-rock carbonate aquifer in the Zagros Region of Iran

Karst aquifers typically exhibit a wide range of dissolution effects that include end-members of matrix, fractured-rock, and conduit-dominated types. This study employs an integrated approach involving geological studies, hydrogeological assessments, hydrochemical and isotopic analysis, and dye tracer tests to investigate the Sarvak limestone aquifer (SLA) in the Zagros Region, southwest Iran. Key characteristics of the SLA include numerous stratification boundaries, thin limestone layers with intercalated siliceous and marl impurities, extensive joint and fracture networks, predominant autogenic recharge, and absence of notable point recharge features (e.g., sinkholes, dolines), and the exchange flow with the Bakhtiari River (B-R) has made it a unique aquifer. Numerous pieces of evidence, such as low spatial and temporal changes in groundwater level, insignificant seasonal variations in the hydrochemical and isotopic composition of water samples, and the supersaturation state of groundwater with calcite and dolomite minerals, suggested a slow flow regime in many parts of the SLA. This regime is characterized by low velocity and long residence time of groundwater. The results reveal that despite the high solubility of carbonate rocks, extensive joint networks can limit significant karst development, leading to fluid flow behavior similar to that of fractured-rock aquifers. Therefore, SLA can be considered a fractured-rock and karst aquifer. The identified paths with fast flow in the dam area are unremarkable and cannot provide a large portion of the Pelle Khan Spring discharge.

Recycling food waste to agriculture through hydrothermal carbonization sustains food-energy-water nexus

Recycling underutilized resources from food waste (FW) to agriculture through hydrothermal carbonization (HTC) has been proposed to promote a circular economy (CE) in food-energy-water (FEW) nexus. However, most HTC studies on FW were conducted at laboratory scale, and little is known on the efficacy and feasibility of field application of HTC products from FW, i.e. the aqueous phrase (AP) and solid hydrochar (HC), to support agriculture production. An integrated pilot-scale HTC system was established to investigate practical HTC reaction conditions treating FW. A peak temperature of 180 °C at a residence time of 60 min with 3 times AP recirculation were recommended as optimal HTC conditions to achieve efficient recovery of nutrients, and desirable AP and HC properties for agriculture application. Dilution of the raw AP and composting of the fresh HC are necessary as post-treatments to eliminate potential phytotoxicity. Applying properly diluted AP and the composted HC significantly improved plant growth and nutrient availability in both greenhouse and field trials, which were comparable to commercial chemical fertilizer and soil amendment. The HTC of FW followed with agricultural application of the products yielded net negative carbon emission of −0.28 t CO2e t−1, which was much lower than the other alternatives of FW treatments. Economic profit could be potentially achieved by valorization of the AP as liquid fertilizer and HC as soil amendment. Our study provides solid evidences demonstrating the technical and economic feasibility of recycling FW to agriculture through HTC as a promising CE strategy to sustain the FEW nexus.

Kinetic insights and pollution mitigation in waste tire pyrolysis: Targeting sulfur, nitrogen, and PAHs emissions

Waste tires have potential to be used for generation of fuel via thermal degradation because of their non-biodegradable nature. Nevertheless, the formation of various pollutants such as sulfur-based and nitrogen-based are inevitable due to presence of nitrogen and sulfur containing compounds during waste tires production. The main purpose was to examine the effect of variating heating rates on pollutants release because heating rate is an important parameter which influences the pollutants releasing profile. Moreover, Ar and CO2 as reaction medium were used to identify their behavior for restraining the PAHs in gas phase. The present study investigates the influence of heating rates and carrier gas environment (Argon and CO2) to reduce the pollutants emission. Thermogravimetry-Mass Spectrum coupled with Fourier transform infrared spectrometer was used to evaluate the thermal degradation and pollutants formation. The major degradation of waste tires occurred between 300 and 500 ℃. The sulfur-based (H2S, CS2, COS, SO2, and CH3SH), nitrogen-based (NH3, HNCO, NO, and HCN) and 9 series of PAHs pollutants were detected. The higher heating rates promoted the pollutants emission. The degradation of compounds having sulfur content formed -SH radials and -SH helped in further release of sulfur based-pollutants. The NH3 releasing profile started after 200 ℃ and released till around 800 ℃ for 30 ⁰C/min and 40 ⁰C/min but its emission was very low after 600 ⁰C for heating rates 5 ⁰C/min, 10 ⁰C/min, and 20 ⁰C/min. The aromatic compounds fraction was more at higher heating rate due to short residence time for pyrolytic products to go through secondary reaction. The 5 ℃/min and 10 ℃/min were considered favorable heating rates in terms of achieving lowest activation energy in both gas environments. The thermodynamic parameters analysis suggested that waste tires pyrolysis was non-spontaneous and endothermic reaction as well as feedstocks showed potential to be utilized for waste conversion.

Comparative analysis of mechanical wall shear stress and hemodynamics to study the influence of asymmetry in abdominal aortic aneurysm and descending thoracic aortic aneurysm

An aneurysm's rupture is commonly associated with its maximum diameter, yet biomechanical studies emphasize the significant influence of mechanical wall shear stress (WSS) in this process. This study focuses on two models of aortic aneurysms: abdominal aortic aneurysm and descending thoracic aortic aneurysm. Five cases, comprising two for model 1 and three for model 2, are examined to explore both axisymmetric and asymmetric shapes, as patient geometry may manifest as either fusiform (axisymmetric) or saccular (asymmetric), while maintaining a consistent aneurysm diameter and adjusting the bulge shape factor to induce asymmetry. Hemodynamic factors, including WSS and wall shear stress gradient, are computed to evaluate thrombus formation and rupture risk within the aneurysms. Our results indicate the presence of recirculation zones in both the medial and transverse planes, generating vortices within the aneurysm. These vortices are more prominent in asymmetric cases compared to axisymmetric cases, leading to increased blood residence time within the aneurysm and a higher likelihood of thrombus formation. Thrombus formation can further impede blood flow, heightening the risk of embolism or ischemic events. Rupture occurs when the WSS surpasses tissue strength; thus, if the tissue strength of all aneurysms is same, our findings suggest that rupture risk varies according to asymmetry. In the transverse direction, our results demonstrate that in model 1, case 1 exhibits uniform WSS on both sides, while in case 2, WSS is higher at the posterior sides of the aneurysm sac. Conversely, in model 2, WSS is higher at the anterior side of the aneurysm. In the medial direction of the aneurysm, WSS is highest for case 5, followed by case 3, case 4, case 2, and case 1, respectively, indicating elevated WSS when the anterior bulge dominates over the posterior bulge for each model. Overall, a higher rupture risk is observed in model 2 compared to model 1 due to increased mechanical stresses.

Biochar and syngas from wet torrefaction of oil palm empty fruit bunches and palm oil mill effluent: A renewable energy approach

Abstract Palm oil mill effluent (POME) and oil palm empty fruit bunches (EFB) constitute the highest waste generated in the mill. This study investigates thermochemical approaches, specifically wet torrefaction and gasification, aiming to transform these wastes into higher-value products such as biochar. Wet torrefaction was initially applied to EFB and POME at 200 °C, with a heating rate of 5 °C/min for 30-min residence time under nitrogen-inert conditions, resulting in a solid yield of 82%. This process led to a notable increase in the heating value of raw EFB by 30.6%, from 17.3 to 22.6 MJ/kg. Subsequently, the product underwent gasification at various temperatures ranging from 600 to 800 °C, with a constant heating rate of 10 °C/min, gas flow rate of 20 ml/min, and a retention time of 30 min. The gasification reaction improved the solid yield and resulted in the generation of liquid products and syngas. The results indicated that 45-59% of biochar, 12-17% of bio-oil, and 30-39% of syngas were produced. The syngas composition, determined using gas chromatography, revealed the presence of CO2, H2, CH4, and CO. The solid product, characterised by a higher heating value, is a viable alternative for solid fuel. The findings suggested that both wet torrefaction and the gasification process have the potential to address the abundance of palm mill waste issues and offer an alternative approach for utilising and generating energy within the mill.

Multi-decadal geochemical evolution of drainage from underground coal mines in the Appalachian basin, USA

Coal mine drainage (CMD) in Appalachia is a widespread source of dissolved metals, SO4, and acidity that can degrade aquatic habitats and water supplies for decades following mine closure and flooding. In the bituminous coalfield of Pennsylvania, the Irwin Coal Basin (ICB) contains a series of partly to completely flooded, abandoned underground mines separated by leaky barriers within the Pittsburgh coal seam. CMD originated throughout the basin from minepool aquifers that formed after mine closures dating from 1910 to 1957. Historical and recent water quality data for eight CMD sites across the ICB, plus mineralogy and cation-exchange capacity of overburden lithologies, were analyzed to quantify important reactants and evaluate spatial and temporal water-quality trends. As overburden thickness and residence time increase along a ~ 50-km flowpath northeast to southwest in the basin, CMD becomes more alkaline, and Na concentrations increase. Since the 1970s, all eight ICB discharges have become less acidic, with exponential decreases in acidity, SO4, and Fe concentrations; only two CMD remain net-acidic (acidic pH at equilibrium). Exponential decay models that include a steady-state asymptote consistent with background groundwater chemistry and siderite equilibrium describe the early-stage, rapid contaminant concentration decay immediately after the “first flush” (initial flooding) and the progressive evolution toward late-stage background conditions. A geochemical evolution PHREEQC model indicates that spatial and temporal trends in pH, net-acidity, SO4, Fe, and major cations could be explained by the continuous dilution of first flush water by ambient groundwater combined with sustained water-mineral reactions involving pyrite and carbonates (calcite, dolomite, siderite) plus cation-exchange by clays (illite, chlorite, mixed-layer illite/smectite). These data and model results indicate that 1) cation-exchange reactions enhance calcite dissolution and alkalinity production, resulting in the evolution of CMD to Na-SO4-HCO3 type waters, and 2) siderite equilibrium could maintain dissolved Fe >16 mg/L over the next 40 years.

Elimination of microplastics, PFAS, and PPCPs from biosolids via pyrolysis to produce biochar: Feasibility and techno-economic analysis

Biosolids from municipal wastewater treatment contain many contaminants of emerging concern, including microplastics (MPs), per- and polyfluoroalkyl substances (PFAS), pharmaceuticals and chemicals from personal care products (PPCPs). Many of these contaminants have very slow biotic or abiotic degradation rates and have been shown to have human and ecological health impacts. Application of biosolids to agriculture, a common disposal method, can result in extended environmental contamination. An approach for eliminating the contaminants is pyrolysis, which can also generate biochar, enhancing carbon sequestration as a side-benefit. We pyrolyzed biosolid samples from an operating facility at various temperatures from 400 to 700 °C with a 2-hour residence time. We then evaluated contaminant removal, which in many cases was 100 %, with only a few residuals. No trace of PFAS was detectable even at 400 °C. Overall mass removal of PPCPs, including PFAS, was over 99.9 %. MP removal via pyrolysis ranged from 91 to 97 %. The biochar contains significant amounts of Fe and P, which make it a useful fertilizer amendment. The techno-economic analysis indicates that pyrolysis may generate significant cost savings, and revenue from the sale of biochar, sufficient to more than cover the investment and operating costs of the dryer and pyrolysis unit.

High-efficiency phosphorus recovery from hypophosphite and phosphite-containing wastewater via a new electrodialysis enrichment and hydrothermal oxidation coupling process

Hypophosphite is an ideal reducing agent used in industries such as electroplating. However, the presence of high concentrations of hypophosphite and phosphite in industrial wastewater necessitates the consumption of large amounts of strong oxidants to oxidize hypophosphite to phosphate for subsequent removal by precipitation. This study introduces an innovative application of green hydrothermal process for the oxidation treatment of inorganic materials, combined with the ion enrichment advantages of electrodialysis. This novel coupling process achieves efficient enrichment and rapid oxidation of high-concentration hypophosphite and phosphite with minimal chemical consumption and more economical operating costs, yielding high-quality phosphate resources. Under electrodialysis conditions with a particle electrode dosage of 3 %, a voltage of 20 V, and a residence time of 10 h, the total phosphorus in the middle chamber was reduced from 2801.17 mg/L to 119.05 mg/L, achieving an anodic enrichment rate of 95.75 %. Under hydrothermal conditions of 400 °C for 15 min, with an H2O2 doping ratio of 7 % and a Ca(OH)2 doping ratio of 35 g/L, the peak oxidation rates of H2PO2− and HPO32− reached 99.38 %, and 99.39 % of phosphorus was transferred from the liquid phase to the solid phase in recyclable forms such as Ca5(PO4)3OH, Ca3(PO4)2, and FePO4·H2O2 enhances the hydrothermal oxidation process by increasing the concentration of free radicals. Ca(OH)2 acted as a catalyst to enhance •OH generation during the hydrothermal reaction, provided Ca2+ required for phosphorus recycling, and increased the pH to obtain crystalline products with a high Ca/P molar ratio. Compared to conventional advanced oxidation processes, the electrodialysis and hydrothermal coupling process offers a clean alternative for treating high-concentration hypophosphite and phosphite in plating wastewaters, achieving a cost saving of 22.99 %.

CFD modeling of H2S removal from liquid sulfur in a pilot-scale gas-liquid contactor

Removal of hydrogen sulfide (H2S) from liquid sulfur is essential to product quality and safe operation in sulfur processing recovery. This paper presents computational fluid dynamics (CFD) models of sulfur degassing performance in a pilot-scale gas-liquid contactor. Two mass transfer models with and without considering the decomposition of hydrogen polysulfide (H2Sx) to H2S are established. They are then used to explore the effects of various operating parameters, including residence time, injected liquid sulfur flow rate, impeller type, and agitation speed, on degassing efficiency. Results show that the relative errors between calculation and experimental data are within ±6.2 %. Furthermore, the impeller geometry is optimized, and the efficiencies of three degasser shapes are compared using the verified CFD tool. The optimized impeller structure can increase degassing efficiency by about 9 % compared to the original one. The CFD model can be further improved to guide the design and scale-up of diverse H2S degassers.

La imagen de estasis predice el riesgo de eventos cardioembólicos tras el infarto agudo de miocardio: el estudio ISBITAMI

Introduction and objectivesIn the setting of ST-segment elevation myocardial infarction (STEMI), imaging-based biomarkers could be useful for guiding oral anticoagulation to prevent cardioembolism. Our objective was to test the efficacy of intraventricular blood stasis imaging for predicting a composite primary endpoint of cardioembolic risk during the first 6 months after STEMI. MethodsWe designed a prospective clinical study, Imaging Silent Brain Infarct in Acute Myocardial Infarction (ISBITAMI), including patients with a first STEMI, an ejection fraction ≤ 45% and without atrial fibrillation to assess the performance of stasis metrics to predict cardioembolism. Patients underwent ultrasound-based stasis imaging at enrollment followed by heart and brain magnetic resonance at 1-week and 6-month visits. From the stasis maps, we calculated the average residence time, RT, of blood inside the left ventricle and assessed its performance to predict the primary endpoint. The longitudinal strain of the 4 apical segments was quantified by speckle tracking. ResultsA total of 66 patients were assigned to the primary endpoint. Of them, 17 patients had 1 or more events: 3 strokes, 5 silent brain infarctions, and 13 mural thromboses. No systemic embolisms were observed. RT (OR, 3.73; 95%CI, 1.75-7.9; P<.001) and apical strain (OR, 1.47; 95%CI, 1.13-1.92; P=.004) showed complementary prognostic value. The bivariate model showed a c-index=0.86 (95%CI, 0.73-0.95), a negative predictive value of 1.00 (95%CI, 0.94-1.00), and positive predictive value of 0.45 (95%CI, 0.37-0.77). The results were confirmed in a multiple imputation sensitivity analysis. Conventional ultrasound-based metrics were of limited predictive value. ConclusionsIn patients with STEMI and left ventricular systolic dysfunction in sinus rhythm, the risk of cardioembolism may be assessed by echocardiography by combining stasis and strain imaging. Registered at ClinicalTrials.gov (NCT02917213).

Liposomal delivery of organoselenium-cisplatin complex as a novel therapeutic approach for colon cancer therapy

Cisplatin is a widely-used chemotherapeutic agent for the treatment of various solid neoplasms including colon cancer. Cisplatin-induced DNA damage is restricted due to dose-related adverse reactions as well as primary resistance mechanisms. Therefore, it is imperative to utilize novel therapeutic approaches to circumvent cisplatin limitations and attenuate its normal tissues toxicity. In this study, we exploited a novel PEGylated liposomes with greater efficiency to treat colon cancer. For this, an organoselenium compound (diselanediylbis decanoic acid (DDA)) was synthesized, and liposomes composed of Egg PC or HSPC, as well as DOPE, mPEG2000-DSPE, cholesterol and DDA at varying molar ratios were prepared by using thin-film method. Cisplatin loading was performed through incubation with liposomes. Characterization of nanoliposomes indicated a favarable size range of 91 to 122nm and negative zeta potential of -9 to -22 mv. The organoselenium compound significantly improved cisplatin loading efficiency within the liposomes (83.4%). Results also revealed an efficient bioactivity of cisplatin liposome on C26 cells compared to the normal cells. Further, DDA bearing liposomes significantly improved drug residence time in circulation, reduced toxicity associated with the normal tissues, and enhanced drug accumulation within the oxidative tumor microenvironment. Collectively, results indicated that cisplatin encasement within liposomes by using this method could significantly improve the therapeutic efficacy in vivo, and merits further investigations.

Hydrothermal carbonisation of manure-derived digestates: Chemical properties and heavy metals distribution in end-products

Hydrothermal carbonisation (HTC) presents a promising method for converting high-moisture biomass into hydrochars, which can serve as valuable sources of carbon and nutrients for soil applications. However, there is a lack of comprehensive understanding regarding the characterisation and potential environmental risks of hydrochars with respect to different feedstock types and operating conditions especially when compared to those obtained from dry pyrolysis. This research aims to investigate the chemical properties and re-partitioning of Ni, Cd, Cr and Pb in the HTC-treated mono-and co-digestates derived from the anaerobic digestion of pig manure and ensiled maize. The hypothesis states that HTC will further reduce the potential availability of these metals, enhancing the quality of the digestates as bio-based fertilisers or soil improvers. Hydrochars were produced from homogeneous digestate slurries, derived from a unique source facility, VeDoWs system, and maize from contaminated land, containing potentially higher concentrations of heavy metals (HMs) compared to pig slurry. The derived hydrochars were further analysed for their composition and HMs extractability. Higher yields were observed for both digestates at lower temperatures and shorter residence times, whereas the total nitrogen and carbon content showed an opposite trend. The composition of the digestates and the HTC operating parameters influenced the enrichment of nutrients and release of the HMs from the hydrochars, enabling their classification as potential solid organic fertilisers according to the Fertilising Products Regulation (EU) 2019/1009. Notably, the HTC treatment at 200–220 °C for 4 h resulted in the highest immobilization of Ni, Cd, Cr, and Pb in both digestates. This treatment strategy effectively reduced the ecological risk index of these products, thereby mitigating potential environmental impacts associated with the HMs contamination.

Impact of Process Parameter on the Behavior of Pyrocarbon Deposition in Chemical Vapour Infiltration (CVI)Process

Carbon-carbon composite manufactured by deposition of pyrocarbon (PyC) through chemical vapor infiltration (CVI) has the key issue of being process parametric sensitive which necessitates the detailed study of the effect of process parameters on the rate of PyC deposition. Conventional method of studying the parametric effect by changing one variable at a time keeping the other variables constant has a limitation of more number of experiments and missing the interaction effect among the variables. Here, the effect of process parameters including temperature, pressure, methane gas flow rate, and nitrogen gas flow rate on the mass gain and PyC deposition was studied by Taguchi method, a statistical optimization method, which has the advantage of very few experiments performed at specific pairs of process parameters only. The experiments were performed at three levels of the process parameters. Carbon-Carbon composite material is processed through the CVI process where PyC was deposited on porous carbon fiber preforms at various process conditions as per the Taguchi method. The impact of gas residence time, Reynolds number, Prandtl number, and Peclet number were also investigated. It was observed that the CVI process parameters significantly affect the rate of PyC deposition. Optimized CVI process parameters are essential for achieving a high rate of PyC deposition to reduce the processing time. The findings have revealed that a higher PyC deposition rate arises under high temperatures, pressure, methane gas flow rate, and optimal nitrogen gas flow rate. The effect of the critical interaction of the CVI process parameters on the rate of PyC deposition was also obtained. Based on the experimental studies, process guidelines are proposed for the densification of carbon fibers preform to realize C/C composite products.

Internal dosimetry and biodistribution of indigenously prepared 177Lu-DOTA-rituximab in lymphoma and other hematological malignancies treated with rituximab.

The aim of this study was to evaluate the biodistribution and dosimetry of lutetium-177-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (177Lu-DOTA)-rituximab in CD20+ non-Hodgkin's lymphoma and other hematological malignancies treated with rituximab. The standard dosimetry protocol was used, with cold rituximab infusion, then a diagnostic activity of 177Lu-DOTA-rituximab. Planar images were acquired at multiple time points. Normal organs and tumor dosimetry were performed by using organ and tumor-specific regions of interest and whole-body counts were obtained serially after pixel matched, background, scatter, and attenuation correction. The mean radiation absorbed doses were obtained from OLINDA/EXM v2.1.1 and ORIGIN software. A total of 22 patients were included in this study. Prolonged blood pool clearance of 177Lu-DOTA-rituximab with long residence time in the blood pool and normal organs were observed. The whole body effective half-life was 104.5 ± 22 h. The mean total body radiation absorbed dose was 0.208 ± 0.03 mGy/MBq and the mean total body effective dose was 0.196 ± 0.05 mGy/MBq of 177Lu-DOTA-rituximab. The mean radiation absorbed doses of 0.613 ± 0.21, 1.68 ± 2, 1.01 ± 0.42, and 0.136 ± 0.02mGy/MBq were seen for the liver, spleen, kidneys, and bone marrow, respectively. Tumor lesion uptake was noticed in two patients with tumor radiation absorbed doses were 0.842 mGy/MBq in one and 9.9 mGy/MBq in the other patient. A strong correlation was obtained between the cumulative activities of radiation-absorbed doses derived from ORIGIN and OLINDA software methods at a significant P value less than 0.001. The results of our study demonstrated favorable biodistribution and dosimetry of indigenously produced 177Lu-DOTA-rituximab in patients with CD20+ lymphoma. These results can be used for future studies of radioimmunotherapy employing 177Lu-DOTA-rituximab.

Synergistic pyrolysis with Refuse-Derived Fuel (RDF) can neutralize bauxite residue

It is estimated that approximately 1.2 tons of bauxite residue (BR) was generated per tonne of alumina produced, and less than 3 % of the annual generation is used. The high alkalinity makes it technically and economically challenging to reuse this material. The study investigated the alkaline neutralization of BR through synergistic pyrolysis with products from Refuse-Derived Fuel (RDF). Two types of RDF, from different producers, were used and BR (pH 12) was generated by an alumina refinery in Brazil. Different mass proportions (0, 10, 20 and 50 % w/w) of RDF were used for synergetic pyrolysis. A pyrolysis was performed at 200, 400, 600, and 800 ºC using muffle furnace and crucibles with a residence time of 20 min. The pH of the mixtures after pyrolysis, decreased as the proportion of RDF increased. The results showed that the neutralization of the BR occurred at temperatures of 200 and 400 ºC. However, as the temperature increases (600 and 800 ºC) the pH neutralization is reduced. The best performance was observed for 50 % RDF at 400 ºC with a final pH 8 (33 % reduction). Synergistic pyrolysis of BR and RDF was effective in promoting reduction in the alkaline content of the bauxite residue.