Shale gas reservoirs are abound in multi-scale pore media and have strong heterogeneity. Gas migration mechanism in different scale pores is complex. Understanding the applicability of mass transfer characterization method for multi-media fluid is of great significance to develop numerical simulation of shale gas reservoirs. On the basis of multi-scale media distribution characteristics and the gas migration characteristics in multi-scale media of shale gas reservoirs, this paper establish the discrete media REV model, transient-cross-flow dual-media REV model, and pseudo-state-cross-flow dual-media REV model for microcells in different regions of reservoirs. The flow behavior of the microcells calculated by the above three models is compared with reservoir conditions and fracture parameters. The suitable rang of different mass transfer characterization methods for multiple media is proposed. The results showed that the cross-flow mode have a great effect on mass transfer on the early period. The greater the difference of dual media, the bigger the difference of mass transfer calculated by different cross-flow mode, the longer the duration of the difference of mass transfer. The transient-cross-flow dual-media model, and pseudo-state-cross-flow dual-media model can both accurately describe the mass transfer between porous kerogen and inorganic matrix. Mass transfer between inorganic matrix and secondary fractures should be described by discrete media model. The discrete fracture network coupled porous kerogen-inorganic matrix dual medium model can be more accurately for description of gas migration in shale gas reservoirs with stimulated reservoir volume. The model has important theoretical significance for developing numerical simulator for shale gas reservoirs.