Magnetotactic bacteria magnetosomes are magnetic nanoparticles enclosed by biofilms and arrange in the form of a chain. Magnetic nanoparticles formed by the biomineralization of magnetosome usually have regular shape, uniform particle size and high crystallinity, which have attracted extensive attention of researchers. The magnetosome membrane is composed of phospholipids and fatty acids, and the magnetosome membrane lipid vesicle acts as a nanoreactor which controls the precise synthesis of magnetic nanoparticles. A series of biomineralization proteins in the magnetosome membrane control the iron transport, redox reaction, nucleation and growth of the magnetic nanoparticles. At present, the specific biomineralization process of magnetosome is still unclear and the large-scale production of magnetosome is difficult, so the biomimetic synthesis of magnetosome has been initiated. In vivo studies have shown that magnetosome proteins of magnetotactic bacteria including Mms6, MamC, MmsF, MamG and MamD play an important role in regulating the size and morphology of the magnetosome, and they have been identified as the best candidates for the biomimetic synthesis of magnetosome. Biomimetic synthesis of magnetic nanoparticles mediated by recombinant magnetosome proteins such as Mms6, MamC and MmsF has been studied. These studies can not only help us better understand the biomineralization process of magnetosome, but also help us prepare high-quality magnetosome-like magnetic nanoparticles without the use of organic solvents, surfactants and high reaction temperature. This article mainly reviews the research progress of the biomimetic synthesis of magnetic nanoparticle mediated by several key magnetosome proteins and prospects its future development. Mms6 seems to mainly control over the growth kinetics of magnetic crystal by acting as an iron reservoir. MamC seems to preferably control the nucleation kinetics of magnetic crystals due to the ionotropic and template effects. MamP as an iron oxidase can support to form ferrihydrite which required for the formation of magnetite crystals in vivo . Although Mms6 is the most abundant magnetosome protein and there are the most researches on Mms6 mediated biomimetic synthesis of magnetic nanoparticles, the specific regulation mechanism of Mms6 is still unclear. In addition, the production cost of Mms6 is relatively high. These are all the shortcomings of Mms6 mediated biomimetic synthesis of magnetic nanoparticles. Therefore, in order to realize large scale biomimetic preparation of high-quality magnetic nanoparticles with controllable size and morphology, it is necessary to further clarify the regulation mechanism of Mms6 and develop cheaper and simpler methods to prepare Mms6 based functional polypeptides and additives. The biomineralization of magnetosome is a process regulated by a variety of mineralization proteins. Therefore, if several kinds of magnetosome proteins with different functions were used together to regulate the formation process of magnetic nanocrystal in the biomimetic synthesis methods, magnetic nanocrystals with more abundant morphology, size and surface crystal structure would be synthesized. Particularly, if MamP, MamE and other magnetosome proteins which control the redox reaction were used to assist the biomimetic synthesis of magnetic nanocrystals, the synthesis conditions might be further optimized, and the yield and performance of magnetic nanoparticles might be improved. In addition, constructing a micro lipid vesicle reactor which like the magnetosome membrane through the surface assembly of key magnetosome proteins and phospholipid molecules to control the biomimetic synthesis process is expected to introduce novel ideas and methods for the biomimetic synthesis of magnetic nanoparticles.