Mandibular reconstruction following resection for oral carcinoma requires an implant that is functionally and cosmetically acceptable. A preliminary study was performed to design a simple, yet effective way to do this. Neoosteogenesis was found at the interface of autoclaved, reimplanted bone and simulated free periosteal grafts. This indicates the possible clinical applicability of heat-treating resected bone to kill viable cells and reimplanting the bone with a free periosteal graft covering to reconstruct segmental mandibular defects.