Pancreatic neuroendocrine tumors (PNET) constitute a heterogeneous disease both in clinical presentation and survival outcomes. As the incidence and diagnostic rate seem to be rising worldwide, the evaluation of prognostic factors becomes even more important on the decision-making process. Many series have described survival analysis over the time but none in the Brazilian population. This retrospective single-center case series reviewed 129 consecutive patients who underwent curative resection from 1999 to 2020. Patients with metastatic disease were excluded. Most patients were female (55%) with a median age at diagnosis of 54 years (SD 13.6) and Charlson Comorbidity Index (CCI) of 3 (IQR 2-4). The majority were asymptomatic, with abdominal pain being the most common symptom, presented in 19.38% and only 7 patients had functional tumors. CT scan was the most used tool at diagnosis and staging and 20% of the entire cohort had a 68-Gallium Scan before surgery. Tumors in the body and tail of the gland were more frequent and minimally invasive surgery was performed in 54.26% of the patients. The most common surgical procedure was distal pancreatectomy with splenectomy (58%) followed by pylorus-preserving pancreaticoduodenectomy (17.8%) and Gastro duodenopancreatectomy (6.9%). Parenchyma-preserving procedures were used in 8 cases. Median hospital stay was 8 days. Clavien-Dindo complications grade III and IV occurred in 29.9% of the cases and postoperative mortality was 1.5%. Pancreatic fistula occurred in 34%, most of them biochemical leak (53%). With a median follow-up time of 46,3 months (95% IC -36,8-57.3 months), overall survival (OS) was 95,5% in 3 years (95% CI 89,4% – 98,1%) and 92,5% in 5 years (95% CI 84,5% – 96,5%). Disease-free survival (DFS) in 3 years was 87,3% (95% CI 79,0% - 92,5%) and 74,8 % in 5 years (95% CI 63,3% - 83,1%). Positive lymph nodes (LN) (HR 5,47; 95% CI 2,46 – 12,16), size of 2,0 cm or greater (HR 3,43; 95% 1,17 – 10,00), G1 PNET (HR 0,14; 95% CI 0,04 – 0,47) and Ki 67 cut 3-20 (HR 2,96; 95% 1,20 – 7,33) were associated with worse DFS on univariate analysis. On multivariate analysis, only positive LN (HR 3,48; 95% CI 1,5 – 8,11) was associated with shorter DFS while well differentiated G1 PNET (HR 0,18; 95% CI 0,05 – 0,62) was associated with a better outcome. Surgical resection represents the standard of care for pNETS, with minimally invasive approach feasible in most cases and postoperative complications compatible with the literature. Positive LN, size greater than 2 cm, tumor grade, and KI-67 are associated with worse disease-free survival.