Research Studies Research Articles

Use of diabetes technologies in the primary school environment: a scoping review protocol.

The objective of this scoping review is to map the literature on the use of diabetes technologies in the primary school environment by children with type 1 diabetes (T1D) and/or their parents. T1D is a complex chronic disorder that is one of the fastest growing diseases in childhood. Technological advances in recent times have seen a growth in the use of diabetes technologies. Despite these advances, having T1D still creates challenges for parents' and children's school experiences. Furthermore, the literature on the use of diabetes technologies during the primary school day is under-investigated. This review will consider peer-reviewed primary research studies or systematic reviews that include children with T1D aged 6 to 12 years who use diabetes technologies in the primary school environment and/or their parents. This review will be conducted in accordance with JBI methodology for scoping reviews and will be reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. Following an initial limited search, a full search strategy was developed using index terms and key text words. This strategy will be used across relevant databases, including Embase, MEDLINE (Ovid), CINAHL (EBSCOhost), and Web of Science Core Collection for the full scoping review. There will be no limitations on language or year. Two reviewers will independently screen titles, abstracts, and full-text articles and extract relevant data using the JBI data extraction instrument. Data will be presented in a descriptive manner, supported by tables and charts, and accompanied by a narrative summary.

Model Predictive Control of Magnetic Helical Swimmers in Two-Dimensional Plane

Magnetic micro/mini-swimmers have a great potential application in biomedical research and have gained broad attention. Recent research studies focus on the automatic control methods of magnetic micro/mini-swimmers, such as artificial intelligence methods. However, their autonomous manipulation remains a challenge since they are subject to various disturbances from the external environment and model uncertainties. The current methods employ a status observer to estimate these disturbances and uncertainties. In this paper, we apply a data-driven technique that utilizes the nonlinear approximation ability of neural networks (NNs). To be specific, a flexible structure of NNs, Broad Learning System (BLS), is employed to model the input-output mapping relationship between the direction of the rotating magnetic field and the swimming direction of the helical miniature swimmer. Then, according to the dual-variable decoupling control, a levitation controller is formulated and a path following controller is proposed based on a planar three-degree-of-freedom model of magnetic helical swimmers, which is inspired by the model of wheeled mobile robots. Simulations and experiments are conducted to quantitatively validate the proposed control method using different planar paths. The experiment results show that the mean absolute error of the path following control is about 3 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\%$</tex-math> </inline-formula> of the body length which is less than 0.5 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$mm$</tex-math> </inline-formula> . Our proposed control method provides a preliminary study to alleviate the impact of disturbances and uncertainties on the control performance of magnetic micro/mini-swimmers. <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Note to Practitioners</i> —This paper is mainly motivated by the potential application of artificial intelligence methods in magnetic micro/mini-robot community, especially for the applications that reject disturbances and uncertainties. In practice, a path planner is employed to compute a pre-defined reference path that connects the start and the targeted locations. Then our control method is applied to the magnetic helical swimmer and it is guided to follow the reference path. Tackling external disturbances and model uncertainties is still challenging during the control progress. Neural network-based technique is an intuitive approach since their nonlinear modeling ability and generalization are suitable for estimating these disturbances and uncertainties. As for training the neural-network model, the training data about the angle parameters should be recorded by manual control of the helical swimmer. These angle parameters define the rotating axis of the uniform rotating magnetic field and the self-rotating axis of the magnetic helical swimmer. According to the planar motion model, the optimal controller is formulated using the feedback distance error and angle error, and the sum of the control signal and the prediction of the compensating model is used as the final control input. Our electromagnetic coil system features easy operation and configuration of cameras or other sensors. Simulations and experiments validate the performance of the neural network-based compensating method and the proposed optimal control method using magnetic micro/mini-swimmers.

Mapping Actionable Gaps in Patient Journey for Depression in the United Arab Emirates: A Strategic Framework

Background: Depression is on a steady rise across the United Arab Emirates (UAE), causing much socio-economic burden to the country. Identifying patient journey gaps for depression, beginning with awareness and screening, diagnosis, and treatment to sustained remission and rehabilitation, can help design health policies with actionable solutions, mitigating the burden of the disease. Methods: Studies in the English language between 2010 and 2021 were shortlisted using a structured search in electronic databases followed by an unstructured search using government websites and Google Scholar and anecdotal data from local professional experts. Synthesized data was subjected to weighted mean calculation, and an evidence gap map was charted. Results: Varying prevalence of depression (5.1%-82.2%) was reported across different settings and population sample sizes in the UAE. One study reported that 13.0% of the UAE population was aware of their depressive condition. Screening rates of depression were reported to be relatively high (34.2%-90.5%), while depression was diagnosed in 0.5%-48.5% of patients. The treatment rate was 36.1%, while adherence rates were estimated to be low at 0.3%. No evidence of control or remission of depression could be gathered. : The reviewed studies used only the Diagnostic and Statistical Manual of Mental Disorders (DSM) diagnostic criteria for diagnosing depression. The review also lacked large-scale research studies that may have limited the actual representation of the prevalence of depression across the country. Conclusion: Addressing the gaps identified through evidence mapping methodology can shape a ‘model of care’ for depression. This model should aim to harmonize collaborations among the mental health stakeholders and advocate for the social reintegration of patients.

Sport, migration and diaspora: the case of Ivorian track and field athletes

PurposeThis study focused on Ivorian track and field athletes who were current or former members of the Ivorian national team to understand athletes’ experiences with migration, diaspora and sport.Design/methodology/approachParticipatory action research (PAR) methodology was used in this research study (Lenette and Nesvaderani, 2021). According to Schinke and Blodgett (2016), PAR is a type of qualitative research used to engage the researcher and researched. The researcher and researched work together to understand the issues of a situation and communicate a plan to work toward resolving those issues (Kemmis et al., 2014). Using PAR helped to engage multiple people in the study, and as more research studies explore forced migration and sport, more scholars are starting to lean on the methodology to create a more diverse perspective and to include marginalized populations in the world of scholarly research (Stone, 2018; Robinson et al., 2019).FindingsKey findings illustrate Ivorian athletes’ ability to forge a bond that transcended tribal and political differences through geographical proximity and sport opportunity, allowing them to (re)connect with their Ivorian diaspora by representing the national team.Originality/valueThis research paper expands on past studies in sport and migration by showcasing the fluid nature of how diaspora constructs an athlete’s national identity once they are forced to leave their homeland.

An LMI-based robust state-feedback controller design for the position control of a knee rehabilitation exoskeleton robot: Comparative analysis

Rehabilitation exoskeleton robots play a crucial role in restoring functional lower limb movements for individuals with locomotor disorders. Numerous research studies have concentrated on adapting the control of these rehabilitation robotic systems. In this study, we investigate an affine state-feedback control law for robust position control of a knee exoskeleton robot, taking into account its nonlinear dynamic model that includes solid and viscous frictions. To ensure robust stabilization, we employ the Lyapunov approach and propose three methods to establish stability conditions using the Schur complement, the Young inequality, the matrix inversion lemma, and the S-procedure lemma. These conditions are formulated as Linear Matrix Inequalities (LMIs). Furthermore, we conduct a comprehensive comparison among these methods to determine the most efficient approach. At the end of this work, we present simulation results to validate the developed LMI conditions and demonstrate the effectiveness of the adopted control law in achieving robust position control of the knee exoskeleton robot.

Clinical Insights Into the Use of Speech Amplification Devices for Managing Hypophonia: Interviews With Speech-Language Pathologists.

The purpose of this qualitative interview study was to identify themes regarding considerations in the usage of speech amplification device usage for people with Parkinson's disease (PD) and hypophonia from the perspective of speech-language pathologists (SLPs). Eligible participants included SLPs currently practicing in the United States or Canada with experience working with clients with PD for at least 2 years. Ten SLPs participated in 60-min interviews conducted via Zoom. A semistructured interview guide was created prior to the interviews. The interviews were transcribed following their completion, and an iterative coding process was used to identify themes using thematic analysis. Three main themes were identified from the interviews. The first theme encapsulated how clinicians described amplification devices as a potential treatment tool, which highlighted the nuances that may impact selecting an amplification device as a treatment option such as increased hypophonia or dysarthria severity and cognitive decline. The second theme highlighted how device selection depends on the individual needs of the user. Individual client characteristics (such as disease symptoms and individual needs and preferences) may impact the choice of amplification device. The last theme outlined the importance of involving family members in all stages of device use and involving other health care team members on a case-by-case basis. The insights provided by the SLP participants help to understand the clinical decisions that are made when determining device candidacy, selecting a device, and evaluating device success. These insights can be used to improve research studies of augmentative management of hypophonia and guide more personalized management decisions.

Attentional disengagement, craving, and mentalizing: a preliminary experimental study among older-aged male gamblers

IntroductionEmpirical studies have demonstrated the role that attentional bias, the mutual excitatory relationship between attentional bias and craving, and mentalizing play in problem gambling. Although problem gambling rates among older-aged adults have steadily increased in recent years, research studies among this cohort are scarce. The present study is the first to empirically investigate attentional bias, as well as the joint role of attentional bias, craving, and mentalizing among older-aged gamblers.MethodThirty-six male older-aged gamblers were administered the South Oaks Gambling Screen (SOGS), the Gambling Craving Scale (GACS), and the Reflective Functioning Questionnaire (RFQ-8) to assess gambling severity, craving levels, and mentalizing, respectively. Participants also performed a modified Posner Task to investigate attentional biases.ResultsHierarchical linear regression analysis showed that among older-aged male gamblers, GACS Anticipation and RFQ-8 Uncertainty about mental states, as well as disengagement bias at 100 ms, significantly predicted gambling severity.ConclusionThe present study provides the first empirical support for the role of attentional bias, craving, and mentalizing among older-aged gambling. More specifically, a difficult in disengaging attention away from gambling, the anticipation of pleasure deriving from gambling, and hypomentalizing predicted gambling severity among older-aged gamblers. The findings make an important contribution, by identifying the factors responsible for problem gambling among this specific age cohort and suggesting that timely interventions for mentalizing and attentional bias may be necessary to prevent problem gambling in old age.

Can the Interfacial Solar Vapor Generation Performance Be Really “Beyond” Theoretical Limit?

AbstractThe interfacial solar vapor generation (ISVG) process is an environmentally friendly approach that utilizes solar to produce steam, which can solve the water shortage. Despite many previous research studies, claims beyond the theoretical limit have risen due to limitations in the efficiency of converting solar to vapor and the rate of solar evaporation, which are still being debated. Energy losses remain even under ideal conditions, which means that the efficiency of the system will never be ≥100%. This review primarily analyzes the theoretical values of evaporation rate and energy efficiency in the ISVG process. Utilizing a theoretical formula for energy distribution, the factors contributing to the current exceedance of conversion efficiency and evaporation rate are scrutinized. By examining various strategies, such as the reduction of vaporization enthalpy for photothermal materials and the utilization of environmental energy for evaporation, these studies seek to enhance evaporation efficiencies, but they ignore the problem of the theoretical limit of evaporation. Therefore, this review emphasizes misconceptions about efficiencies beyond theoretical limits and aims to guide researchers to provide plausible explanations for such breakthroughs under specific conditions, alongside established reference conditions. Ultimately, this study lays a solid theoretical foundation for practical solar water purification.

Study of the Readiness of Specific Services for Senior High School’s Health Clinic in Jayapura

Senior High School (SMA) as an educational institution is responsible for ensuring the healthy environment that supports students' learning activities. However, in reality, the health of the school environment cannot be fully guaranteed. Various previous research studies have found various threats to the health of students originating from within the school environment, such as schools that are not yet free from cigarette smoke. The purpose of this study is to describe the current condition of the availability of School's Health Clinic facilities and infrastructure in high schools in Jayapura City and Jayapura District. The method used was descriptive quantitative approach with cross sectional design and Univariate Analysis. The research instruments refers to the minimum standard of Senior High School's health clinic according to the Regulation of the Minister of National Education of the Republic of Indonesia Number 24 Year 2007. The sample consisted of 32 public and private schools in Jayapura city and Jayapura district. The results showed that there was no extreme difference between the readiness of Senior High School's Health Clinic facilities and infrastructure in Jayapura City and District. However, public schools mostly have more adequate availability of Senior High School's Health Clinic facilities and infrastructure compared to private schools spread across the City and District areas.

Iapetus Equatorial Ridge: The Understanding from The Quran and The Hadith

This research studies the statement about the splitting of the Moon into two as narrated by Quran &amp; Hadith in accordance to scientific studies related to the subject. The author suggests that current scientific findings of the formation of the equatorial ridge on Iapetus differs from the Islamic classical scholars’ opinions are not in tandem regarding the splitting and fusing of the moon. This research also applies the methodology of hadith from the writings given from various narrations and hadith literature. The application of document analysis methodology is applied to current concepts by the geologists and astrophysicists on the formation of the equatorial ridge of Iapetus and the ice ridge in Antarctica. The findings establishes that the Iapetus equatorial ridge is a genuine existence that occurred, which split into two and fused back. This image was captured by the satellite sent to Saturn.

Reliability testing of the Health of the Nation Outcome Scales 2018.

The Health of the Nation Outcome Scales (HoNOS) is a widely used clinical measure designed to rate and monitor the outcomes of service users accessing specialist mental healthcare. Since its development (in 1996), numerous research studies have confirmed the HoNOS captures the aspects of care that it purports to (validity), and that clinicians' ratings are consistent both over time, and between different raters (reliability). In 2018, the HoNOS was reviewed with updates made to some terminology and other revisions intended to remove ambiguity in the guidance for raters. However, although the new version (HoNOS 2018) was accompanied by a recommendation that its validity and reliability be re-tested this was not undertaken. To our knowledge, this is the first study to re-assess the updated tool's reliability by measuring the level of agreement between different raters. Our findings confirm that there is an acceptable level of consistency between student mental health nurses that have been trained to use the (new) HoNOS 2018. The HoNOS is nationally mandated for use by all specialist mental healthcare providers in the UK. Our findings provide some assurance that, with appropriate update training and monitoring of organisational-level data sets, the original HoNOS glossary can safely be replaced with the HoNOS 2018 to ensure more contemporary routine outcome measurement can occur. INTRODUCTION: The Health of the Nation Outcome Scales (HoNOS) is a well-established clinician rated outcome measure for use in mental health services. Following an international review, an updated version (HoNOS 2018) was published with a recommendation that its psychometric properties be re-tested prior to widespread implementation. To date, only one such study has been published. To test the inter-rater agreement levels for HoNOS 2018. Third-year student mental health nurses received training to complete the HoNOS 2018. Following this timetabled session, they were each invited to independently rate two, randomly selected, videos of (simulated) patient interviews. The resulting data were then analysed to calculate the tool's internal consistency and inter-rater agreement levels. The 55 participants provided 106 ratings from four vignettes. Cronbach's alphas and McDonalds omegas confirmed the revised tool's internal consistency was acceptable. Average measure intraclass correlation coefficients for the four patient vignettes indicated excellent reliability. This study provides initial assurance that the HoNOS 2018 is a reliable clinician rated outcome measure suitable for use in routine clinical practice by relatively inexperienced mental health practitioners with limited training.

Pregnancy Care Utilization, Experiences, and Outcomes Among Undocumented Immigrants in the United States: A Scoping Review

BackgroundUndocumented immigrants face many barriers in accessing pregnancy care, including language differences, implicit and explicit bias, limited or no insurance coverage, and fear about accessing services. With the national spotlight on maternal health inequities, the current literature on undocumented immigrants during pregnancy requires synthesis. ObjectiveWe aimed to describe the literature on pregnancy care utilization, experiences, and outcomes of undocumented individuals in the United States. MethodsWe performed a scoping review of original research studies in the United States that described the undocumented population specifically and examined pregnancy care utilization, experiences, and outcomes. Studies underwent title, abstract, and full-text review by two investigators. Data were extracted and synthesized using descriptive statistics and content analysis. ResultsA total of 5,940 articles were retrieved and 3,949 remained after de-duplication. After two investigators screened and reviewed the articles, 29 studies met inclusion criteria. The definition of undocumented individuals varied widely across studies. Of the 29 articles, 24 showed that undocumented status and anti-immigrant policies and rhetoric are associated with lower care utilization and worse pregnancy outcomes, while inclusive health care and immigration policies are associated with higher levels of prenatal and postnatal care utilization as well as better pregnancy outcomes. ConclusionsThe small, heterogeneous literature on undocumented immigrants and pregnancy care is fraught with inconsistent definitions, precluding comparisons across studies. Despite areas in need of further research, the signal among published studies is that undocumented individuals experience variable access to pregnancy care, heightened fear and stress regarding their status during pregnancy, and worse outcomes compared with other groups, including documented immigrants.

Onshore power supply–trends in research studies

Restrictive regulations introduced by the European Parliament and the United Nations have forced the seaport authorities to reach net zero gas emissions by 2030. An important source of pollution emitted in ports involves exhaust gas emissions from ships powered by ship engines while they are berthed in seaports. One of the ways to reduce the level of pollution and nuisance caused by ship engines is to equip ships with Onshore Power Supply (OPS). Unfortunately, still few ports can boast this type of systems at their quays. There are many publications devoted to the analysis of this phenomenon in the technical and engineering terms, but a significant part also concerns the economic, financial, logistic and organizational aspects. The aim of this research is to identify the directions of development as for research into OPS, to organize the terminology devoted to OPS, and to define scientific disciplines of research in the field of OPS. This research was conducted on the basis of the data mining method using the Scopus, EBSCO and Web of Science databases, applying the multi-stage selection of criteria. The research results may provide an interesting material for scientists to identify the gaps of research regarding OPS.

Comparative analysis of adolescent pregnancy causes in Tanzania: A comprehensive review of literature

Teenage pregnancy remains a global challenge with profound implications, necessitating a thorough exploration of its causes and contributing factors. This study provides a comprehensive review of research studies conducted in Tanzania from 2019 to 2023, contributing to the ongoing discourse on the complex interplay of socio-cultural, economic, and educational factors shaping the experiences of Tanzanian adolescents. Twelve studies, comprising seven journals and five master theses, were purposefully selected to identify commonalities and disparities in their findings. The study systematically examines the identified studies, shedding light on the prevailing factors associated with teenage pregnancies in Tanzania. Several themes emerged from the reviewed literature, with all studies unequivocally pinpointing poor knowledge on sexual and reproductive health as a common factor contributing to teenage pregnancies. Moreover, a substantial majority, 75%, highlighted the significance of low economic status in this context, emphasizing the intersectionality of socio-economic factors. Furthermore, this comparative analysis delves into the nuanced findings of the selected studies, revealing that 50% of the reviewed research identified peer influence as a significant contributor to teenage pregnancies. These findings not only underscore the multifaceted nature of the issue but also highlight the need for targeted interventions addressing both individual knowledge gaps and broader socio-economic challenges.

Cognitive phenomena measurement with time window-based multispectral brain mapping.

Cognitive neuroscience experiments require accurate and traceable methods of measuring cognitive phenomena, analyzing and processing data, and validating results, including measurement of impact of such phenomena on brain activity and consciousness. EEG measurement is the most widely used tool for evaluation of the experiment's progress. To extract more information from the EEG signal, continuous innovation is necessary to provide a broader range of information. This paper presents a new tool for measuring and mapping cognitive phenomena using time window-based multispectral brain mapping of electroencephalography (EEG) signals. The tool was developed using Python programming language and enables users to create brain maps images for six spectra (Delta, Theta, Alpha, Beta, Gamma, and Mu) of EEG signal. The system can accept an arbitrary number of EEG channels with standardized labels based on the 10-20 system, and users can select the channels, frequency bandwidth, type of signal processing, and time window length to perform the mapping. The key advantage of this tool is its ability to perform short-time brain mapping, which allows for the exploration and measurement of cognitive phenomena. The tool's performance was evaluated through testing on real EEG signals, and results demonstrated its effectiveness in accurately mapping cognitive phenomena. The developed tool can be used in various applications, including cognitive neuroscience research and clinical studies. Future work involves optimizing the tool's performance and expanding its capabilities.

Multispecies comparative prostate anatomy by imaging: Implications for experimental models of prostatic disease.

There is an increasing interest in using preclinical models for development and assessment of medical devices and imaging techniques for prostatic disease care. Still, a comprehensive assessment of the prostate's radiological anatomy in primary preclinical models such as dogs, rabbits, and mice utilizing human anatomy as a reference point remains necessary with no optimal model for each purpose being clearly defined in the literature. Therefore, this study compares the anatomical characteristics of different animal models to the human prostatic gland from the imaging perspective. We imaged five Beagle laboratory dogs, five New Zealand White rabbits, and five mice, all sexually mature males, under Institutional Animal Care and Use Committee (IACUC) approval. Ultrasonography (US) was performed using the Vevo® F2 for mice (57 MHz probe). Rabbits and dogs were imaged using the Siemens® Acuson S3000 (17 MHz probe) and endocavitary (8 MHz) probes, respectively. Magnetic resonance imaging (MRI) was also conducted with a 7T scanner in mice and 3T scanner in rabbits and dogs. Canine transrectal US emerged as the optimal method for US imaging, depicting a morphologically similar gland to humans but lacking echoic zonal differentiation. MRI findings in canines indicated a homogeneously structured gland similar to the human peripheral zone on T2-weighted images (T2W) and apparent diffusion coefficient (ADC). In rabbits, US imaging faced challenges due to the pubic symphysis, whereas MRI effectively visualized all structures with the prostate presenting a similar aspect to the human peripheral gland on T2W and ADC maps. Murine prostate assessment revealed poor visualization of the prostate glands in ultrasound due to its small size, while 7T MRI delineated the distinct prostates and its lobes, with the lateral and dorsal prostate resembling the peripheral zone and the anterior prostate the central zone of the human gland. Dogs stand out as superior models for advanced preclinical studies in prostatic disease research. However, mice present as a good model for early stage studies and rabbits are a cost-effective alternative and serve as valuable tools in specific research domains when canine research is not feasible.

From Voting Bloc to Fragmentation: The Chinese Opposition Votes in the 2021 Sarawak State Election

This study analyses the voting patterns among the Sarawakian Chinese and their pro-opposition inclination in the 2021 Sarawak State Election (SSE21). It begins by recounting how the national opposition alliances, former Pakatan Harapan (PH) alliances—Barisan Alternatif (BA) and Pakatan Rakyat (PR)—gained popularity among the Chinese voters in Sarawak since the 2006 state elections. The voting trends reveal changes in Chinese voting patterns, from a voting bloc to fragmented votes, and their openness to local opposition parties in the recent state elections. In order to examine the plurality voting pattern and the extent of fragmentation, this research studies two Chinese-majority urban constituencies, Batu Lintang and Bukit Assek in Sarawak. It contends that the Chinese political leanings, including their tendency to embrace regionalism, are profoundly shaped by local and national political developments. In the past two decades, ethnopatronage politics and prevalent corruption practices partly explain the Chinese’s quest for regime change. The Sarawak government’s emphasis on regional identity and multiculturalism in its official narrative nurtures a sense of belonging, which also impacts Chinese identity politics. This article argues that the decision to support minor parties advocating for separatism can be read as strategic voting of the regional minority who feel deprived of their equal rights. It also contends that political fragmentation among the Chinese might persist if PH fails to consolidate its previous support. Otherwise, it spells the decline of Parti Sarawak Bersatu (PSB) and Parti Bumi Kenyalang (PBK). The sustainability of local opposition parties depends on the internal reform of parties. The parties should reduce the influences of personal politics as it tends to breed party-hopping, which places parties’ future or institutional development at risk of uncertainty.

Measuring health-related quality of life in children with suspected genetic conditions: validation of the PedsQL proxy-report versions.

Measuring health-related quality of life (HRQoL) of children with suspected genetic conditions is important for understanding the effect of interventions such as genomic sequencing (GS). The Pediatric Quality of Life Inventory (PedsQL) is a widely used generic measure of HRQoL in pediatric patients, but its psychometric properties have not yet been evaluated in children undergoing diagnostic GS. In this cross-sectional study, we surveyed caregivers at the time of their child's enrollment into GS research studies as part of the Clinical Sequencing Evidence Generating Research (CSER)consortium. To evaluate structural validity of the PedsQL 4.0 Generic Core Scales and PedsQL Infant Scales parent proxy-report versions, we performed a confirmatory factor analysis of the hypothesized factor structure. To evaluate convergent validity, we examined correlations between caregivers' reports of their child's health, assessed using the EQ VAS, and PedsQL scores by child age. We conducted linear regression analyses to examine whether age moderated the association between caregiver-reported child health and PedsQL scores. We assessed reliability using Cronbach's alpha. We analyzed data for 766 patients across all PedsQL age group versions (1-12months through 13-18years). Model fit failed to meet criteria for good fit, even after modification. Neither age group (categorical) nor age (continuous) significantly moderated associations between PedsQL scores and caregiver-reported child health. Cronbach's alphas indicated satisfactory internal consistency for most PedsQL scales. The PedsQL Generic Core Scales and Infant Scales may be appropriate to measure HRQoL in pediatric patients with suspected genetic conditions across a wide age range. While we found evidence of acceptable internal consistency and preliminary convergent validity in this sample, there were some potential problems with structural validity and reliability that require further attention.

Elucidating the Non-Covalent Interactions that Trigger Interdigitation in Lead-Halide Layered Hybrid Perovskites.

Two-dimensional (2D) hybrid organic-inorganic perovskites constitute a versatile class of materials applied to a variety of optoelectronic devices. These materials are composed of alternating layers of inorganic lead halide octahedra and organic ammonium cations. Most perovskite research studies so far have focused on organic sublattices based on phenethylammonium and alkylammonium cations, which are packed by van der Waals cohesive forces. Here, we report a more complex organic sublattice containing benzotriazole-based ammonium cations packed through interdigitated π-π stacking and hydrogen bonding. Single crystals and thin films of four perovskite derivatives are studied in depth with optical spectroscopy and X-ray diffraction, supported by density-functional theory calculations. We quantify the lattice stabilization of interdigitation, dipole-dipole interactions, and inter- as well as intramolecular hydrogen bonding. Furthermore, we investigate the driving force behind interdigitation by defining a steric occupancy factor σ and tuning the composition of the organic and inorganic sublattice. We relate the phenomenon of interdigitation to the available lattice space and to weakened hydrogen bonding to the inorganic octahedra. Finally, we find that the stabilizing interactions in the organic sublattice slightly improve the thermal stability of the perovskite. This work sheds light on the design rules and structure-property relationships of 2D layered hybrid perovskites.

Lower Prevalence of Diabetic Ketoacidosis at Diagnosis in Research Participants Monitored for Hyperglycemia.

In Colorado children, the prevalence of diabetic ketoacidosis (DKA) at diagnosis of type 1 diabetes (T1D) has been increasing over time. Evaluate the prevalence of and factors involved in DKA at T1D diagnosis among participants followed in monitoring research studies before diagnosis compared to patients from the community. Patients<18 years diagnosed with T1D between 2005 and 2021 at the Barbara Davis Center for Diabetes. Prevalence of and factors associated with DKA at diagnosis among participants in preclinical monitoring studies compared to those diagnosed in the community. Of 5049 subjects, 164 were active study participants, 42 inactive study participants, and 4843 were community patients. Active study participants, compared to community patients, had lower HbA1c (7.3% vs 11.9%]; P<0.001) and less frequently experienced DKA (4.9% vs 48.5%; P<0.001), including severe DKA (1.2% vs 16.2%; P<0.001). Inactive study participants had intermediate levels for both prevalence and severity of DKA. DKA prevalence increased in community patients, from 44.0% to 55%, with less evidence for a temporal trend in study participants. DKA prevalence was highest in children <2 years (13% in active study participants vs 83% in community patients). In community patients, younger age (P=0.0038), public insurance (P<0.0001), rural residence (P<0.0076), higher HbA1c (P<0.0001), and ethnicity minority status (P<0.0001) were associated with DKA at diagnosis. While DKA prevalence increases in community patients over time, it stayed <5% in active research participants, who have a 10 times lower prevalence of DKA at diagnosis, including in minorities.