Research Project Grant Research Articles

Association of publication record and independent NIH funding.

BackgroundPublications may be a modifiable factor toward research project grant (RPG) funding decisions, the objective was to determine the association of publication record with later RPG receipt.MethodsThis was a retrospective cohort study of recipients of K01, K08, or K23 US career development awards (CDAs) starting from 2000–2015. Exposures were CDA awardees’ first-, middle-, and last-author publication counts, and the quartile of awardees’ highest and mean publication impact factors. The independent association of each exposure with time to RPG (R01 or equivalent) was determined using a Cox model, after adjustment for CDA type, awardee change in institution, and institutional CDA count. The proportion of CDA recipients with later independent funding was also determined by publication count.ResultsAmong 6744 CDA awardees, 3943 obtained an RPG. The median time to RPG was 5.6 years (interquartile range 4.2–7.5). The number of first-authorships was associated with a shorter time to RPG (1–4 versus 0: hazard ratio [HR] 1.22, 95% confidence interval [CI] 1.10–1.36; 5–9: 1.59, 95% CI 1.40–1.79; 10–24: 1.78, 95% CI 1.54–2.07; 25+: 2.40, 95% CI 1.61–3.56). Last-authorships were associated with a shorter time to RPG (1–4 versus 0: HR 1.99, 95% CI 1.83–2.16; 5–9: 2.72, 95% CI 2.45–3.03; 10–24: 3.17, 95% CI 2.78–3.62; 25+: 3.12, 95% CI 2.17–4.50). Higher maximum impact factor was associated with a shorter time to RPG (Q2 versus lowest: HR 1.28, 95% CI 1.12–1.46; Q3: 1.45, 95% CI 1.24–1.70; Q4: 1.67, 95% CI 1.39–2.02). Mean impact factor and middle-authorships were not associated with time to RPG. Among 687 CDAs with zero associated first- or last-authorships, 158 (23%) achieved later RPG funding. Among those with at least 10 total first- or last-authorships, 1288/1554 (83%) obtained a later RPG.ConclusionsA higher number and impact of publications was associated with later independent funding.

Financial payments from the pharmaceutical industry to U.S. cancer centers, 2014-2019.

1582 Background: Payments from the pharmaceutical industry to US health care providers were made public through Open Payments in 2013. Since then, industry payments to individual physicians have been studied extensively, but payments to hospitals remain uncharacterized. The goal of this study was to examine trends in industry payments to US cancer centers. Methods: We identified all US cancer centers that were National Comprehensive Cancer Network (NCCN) members or were National Cancer Institute (NCI) comprehensive cancer center as of 2019. Each institution was manually mapped to Open Payments, which contains industry payment data. Where applicable, subsidiary hospitals were included with the parent center. Among the NCCN centers, we used National Plan and Provider Enumeration System data to identify medical oncologists practicing there. Oncologists were linked to Open Payments by name and address. We analyzed “research payments” (RP), which include payments related to preclinical and clinical research, and “general payments” (GP), which include non-research-related payments in categories such as speaker fees, consulting fees, meals, grants, charitable contributions, and licensing fees. We ascertained public research support from NIH data, and included all research project grants. We used correlation analysis and linear regression models to assess the association between industry payments to a cancer center and to oncologists practicing at that center. All dollar values were inflation-adjusted to 2019 dollars using the Consumer Price Index for medical care from the US Bureau of Labor Statistics. Results: Overall industry RP to US cancer centers increased from $527 million in 2014 to $653 million in 2019, while GP increased from $346 million to $786 million. NCI research funding increased from $1,397 million in 2014 to $1,583 million in 2019 (13.3% increase) while overall industry payments (RP+GP) increased from $873 million to $1,439 million (64.8% increase). Industry payments were highest as a portion of total income (industry + NCI) at MD Anderson (64.2%) and lowest at St. Jude (0.1%). Among NCCN institutions, industry payments to cancer centers and the oncologists practicing at those centers were correlated (coefficient = 0.382). A $1,000 increase in GP to a cancer center from a given pharmaceutical company was associated with a $1.00 ($0.61 - $1.30) increase in GP from that company to oncologists at that cancer center. Conclusions: From 2014-2019, cancer center funding from industry sources grew quickly, driven by an increase in non-research payments, and now approaches the amount of public research funding cancer centers receive. Cancer center acceptance of industry payments is associated with increased industry payments to its employed physicians, which are known to sway prescribing practices. These trends raise concerns regarding the ability of these institutions to fulfill their public missions.

227-OR: Disruption of Adipocyte YAP Improves Glucose Homeostasis in Mice and Decreases Adipose Tissue Fibrosis

Adipose tissue is a dynamic metabolic organ that is essential for the regulation of whole-body glucose homeostasis. Dysfunctional adipose tissue hypertrophy with obesity is associated with glucose intolerance and insulin resistance underlying type 2 diabetes. Yes-associated protein 1 (YAP) is a transcription cofactor important in the Hippo signaling pathway. However, the role of YAP in adipose tissue and glucose homeostasis is unknown. To understand the role of YAP in vivo under metabolic stress conditions, we assessed how increased weight and insulin resistance impact YAP protein levels. We found that YAP protein levels increase in adipose tissue in humans with type 2 diabetes and mouse models. This suggests that YAP signaling may contribute to adipocyte dysfunction and insulin resistance under metabolic stress conditions. To further investigate the role of YAP in adipose tissue and glucose homeostasis in vivo, we developed adipose tissue-specific YAP knockout (YAP-KO) mice and placed them on either chow or high fat diet (HFD) for 12-14 weeks. On an HFD, adipose tissue YAP-KO mice show improved glucose tolerance compared to controls. Perigonadal fat pad weight was also decreased in knockout animals, with smaller adipocyte size. Adipose tissue fibrosis and gene expression associated with fibrosis was decreased in vivo and in 3T3-L1 cells treated with a YAP inhibitor. Together, these data indicate that YAP is increased in adipose tissue with weight gain and insulin resistance. Disruption of YAP in adipocytes improves glucose tolerance and adipose tissue fibrosis; suggesting that YAP plays an important role in adipose tissue and modulating glucose homeostasis under metabolic stress conditions. Disclosure D.Han: None. R.Aslam: None. T.Ojha: n/a. D.Yuen: Consultant; Fibrocor Therapeutics. C.T.Luk: None. Funding NSERC Discovery Grant (RGPIN-2018-05671) BBDC Gales Family Charitable Foundation Pilot and Feasibility GrantCanadian Institutes of Health Research Project Grant (PJT 168996)

Automation of the Updated Food Label Information Program (FLIP 2020): A Comprehensive Canadian Branded Grocery and Restaurant Food Composition Database

ObjectivesTraditional methods for creating food composition databases struggle to cope with the large number of products and the rapid pace of turnover in the food supply. The objective is to overview the updated Food Label Information Program (FLIP2020), a big data approach for the evaluation of the Canadian food supply and present the latest methods used in the development of this database.MethodsThe University of Toronto's Food Label Information Program (FLIP) is a database of Canadian prepackaged and chain restaurant foods and beverages collected since 2010. FLIP 2020 was developed using website “scraping” and machine learning (ML) coupled with artificial intelligence-enhanced optical character recognition (AI-OCR) to collect and manage food labelling information (e.g., nutritional composition, price, product images, ingredients, brand, etc.) on all foods and beverages available on seven major Canadian e-grocery retailer websites and 201 Canadian chain restaurants between May 2020 and February 2021.ResultsFLIP 2020 is comprised of 74,445 prepackaged food products and 21,225 menu items available on websites of seven retailers, 2 location-specific duplicate retailers and 141 chain restaurants. Food products were classified under multiple national and international categorization systems, in order to analyse similar foods under different systems. Of 57,006 food and beverage products available on seven retailers’ websites, nutritional composition data were available for about 60% of the products and ingredients were available for about 45%. Data for energy, protein, carbohydrate, fat, sugar, sodium and saturated fat were present for 54–65% of the products, while fibre information was available for 37%. Of the 201 eligible chain restaurants with ≥ 20 national outlets, 70% provided nutritional information. All provided energy, 84% provided saturated fat, total sugar and sodium, and 50% provided all 13 required nutrients listed on the Nutrition Facts table.ConclusionsFLIP, with its comprehensive sampling and granularity and use of ML/AI-OCR, is a powerful tool for evaluating and monitoring the Canadian food supply environment.Funding SourcesThis research was supported by funds from a Canadian Institutes of Health Research Project Grant.

PAS-MCI: Design and Rationale for a Randomized Controlled Trial to Enhance Prefrontal Cortical Plasticity and Working Memory in Individuals with Amnestic Mild Cognitive Impairment

<h3>Introduction</h3> Amnestic Mild Cognitive Impairment (aMCI) is a prodromal stage to Alzheimer's disease dementia (AD). Improving prefrontal cortical function in individuals with MCI could prevent progression from aMCI to AD. A key mechanism that has been linked to memory formation and thus may underlie this progression is cortical plasticity. Paired Associative Stimulation (PAS) is an intervention that uses transcranial magnetic stimulation (TMS) to enhance cortical plasticity. When delivered to the prefrontal cortex in individuals with AD, it has shown promise to improve prefrontal cortical plasticity and working memory. PAS-MCI is a randomized controlled trial (RCT) that aims to assess: (1) dorsolateral prefrontal cortex (DLPFC) plasticity in individuals with aMCI and compare it to cognitively unimpaired control participants, (2) the efficacy of PAS delivered for 10 days bilaterally to the DLPFC of individuals with aMCI in enhancing their DLPFC plasticity, working memory, and executive function, and (3) whether changes in DLPFC plasticity mediate changes in working memory and executive function. <h3>Methods</h3> 100 aMCI and 50 cognitively unimpaired (CU) control participants will be assessed clinically and cognitively, and then undergo a baseline PAS combined with electroencephalography (PAS-EEG) to characterize left DLPFC plasticity. The aMCI participants are randomized (1:1) to receive 10 daily sessions of either active or sham PAS delivered to the left and right DLPFC. On Day 0, 7, and 28 following the 10-day PAS course, participants undergo repeat cognitive testing and PAS-EEG to assess changes in working memory, executive function, and left DLPFC plasticity. <h3>Results</h3> Recruitment started on October 12, 2020 and as of October 16, 2021, we have already consented 9 aMCI and 7 CU participants. Of the 16 participants, 4 MCI and 4 CU participants were enrolled and 3 MCI and 4 CU completed the study (1 MCI participant is still active). Among the 5 participants who did not enroll, 3 were excluded because of: a contraindication for TMS (n = 1), having dementia and not MCI (n = 1), and having non-amnestic MCI (n = 1); 1 withdrew before enrolment due to fatigue; and 1 is still undergoing eligibility assessments. Among the 3 CU participants who did not enroll, 2 were excluded because of low cognitive scores and 1 is still undergoing eligibility assessments. <h3>Conclusions</h3> Despite the COVID-19 pandemic, we were able to initiate recruitment over the past year. If successful, this RCT will establish the short-term efficacy of PAS, a new TMS approach to enhance prefrontal cortical function in individuals with aMCI. A follow-up longer-term trial will be then needed to assess whether PAS could prevent cognitive decline and progression to AD. <h3>This research was funded by</h3> Canadian Institutes of Health Research (CIHR) Project Grant # 201809 (PI: Rajji)

What evidence exists for the impact of climate change on the physiology and behaviour of important aquaculture marine crustacean species in Asia? A systematic map protocol

BackgroundClimate is one of the most important driving factors of future changes in terrestrial, coastal, and marine ecosystems. Any changes in these environments can significantly influence physiological and behavioural responses in aquatic animals, such as crustacea. Crustacea play an integral role as subsistence predators, prey, or debris feeders in complex food chains, and are often referred to as good indicators of polluted or stressed conditions. They also frequently have high production, consumption, and commercial significance. However, crustacean’s responses to climate change are likely to vary by species, life-history stage, reproduction status and geographical distribution. This map is undertaken as part of the Long-Term Research Grant project which aims to identify any interactive effect on physiological compensation and behavioural strategy of how marine organisms, especially crustaceans, deal with stress from environmental change. Our proposed map will aim to outline the evidence currently existing for the impacts of climate change on the physiology and behaviour of important aquaculture crustacean species within Asia.MethodsWe will document peer-reviewed articles in English using published journal articles and grey literature. Two bibliographic databases (Scopus and Web of Science) and multiple organizational websites with Google scholars will be searched. The systematic map protocol will follow in accordance with the Collaboration for Environmental Evidence Guidelines and Standards. Literature will be screened at the title, abstract, and full-text level using pre-defined inclusion criteria. The map will highlight marine crustacea physiological compensation and behavioural strategies to cope with climate change. It will also improve our knowledge of the available evidence and current gaps for future research recommendations.

PetSavers interview

Dr Penny Watson has been the recipient of several BSAVA PetSavers grants for undergraduate student projects and clinical research projects. Her most recent funds a Master’s student in a project entitled An investigation of novel immunohistochemical markers and serum auto-antibodies in cats with chronic biliary tract disease.

A multilevel, multidimensional scale for measuring housing insecurity in urban slums and informal settlements: a psychometric study

BackgroundHousing insecurity is a pervasive challenge in the cities and urban areas of low-income and middle-income countries (LMICs), particularly in the informal settlements where disproportionately high number of urban residents live. Despite this persistent challenge and its impact on health and well-being, there are currently no comprehensive, standardised, and validated instruments for measuring housing insecurity in these regions. We aimed to develop and validate a housing insecurity scale that can be used in urban slums and informal settlements in LMICs. MethodsUsing a complementary set of qualitative and quantitative techniques, we used data collected from three urban slums in Ghana (n=1036) on housing deprivations and characteristics, slum severity, resource insecurity, health outcomes, and socio-demography in the development of the scale. Following item generation, domain identification, and content validation, we identified 28 items that were tested for tetrachoric and Biserial correlations. We extracted an optimal number of factors and tested for dimensionality using confirmatory factor analysis and second-order confirmatory factor analysis. We also tested for reliability and validity of the scale. Tests of concurrent and predictive validity were assessed against slum severity scores, and indoor air quality and health status, respectively. FindingsThe resultant scale is a multilevel multidimensional scale consisting of 17 items that subdivide into three subscales: lack of essential utility (α=0·63), built environment deficiency (α=0·80), and tenancy challenges (α=0·82). The composite scale was reliable, with a coefficient alpha of 0·83. Concurrent validity showed a significant association between the composite housing insecurity scores and slum severity scores (β=0·29, 95% CI 0·26–0·32). For predictive validity, housing insecurity increased the likelihood of poor indoor air quality (OR 1·35, 1·29–1·42) and poor health (β=0·03, 0·01–0·04). Convergent and discriminant validity and known group comparisons also supported the validity of the scale. Using the mean scores for housing insecurity, about 53·3% of our study population would be classified as experiencing severe housing insecurity in the past year. InterpretationTo our knowledge, this is the first reliable and validated scale developed to measure housing insecurity in urban slums and informal settlements in LMICs. It can be used to test a range of hypotheses about the role of housing insecurity in several environmental and health outcomes; to assess and plan clinical, programmatic, and policy interventions; and to aid in tracking progress made on Sustainable Development Goal 11. FundingCenter for Research and Scholarship Pilot Project Grant (313420) at the University of Texas at Arlington and the Keough School of Global Affairs at the University of Notre Dame.

A Ten-Year Analysis of Recent National Institutes of Health Funding for Anesthesiology Research in United States Medical Schools

The characteristics of recent National Institutes of Health (NIH) grant funding to anesthesiology researchers in United States (US) medical schools have not been systematically quantified. NIH funding to cardiac anesthesiologists has also not been estimated. The author conducted an internet-based analysis of NIH awards to anesthesiology researchers from 2011-2020 to identify the types, duration of funding, and amount of grants, and the terminal degree(s), faculty rank, gender, board certification status, and type of appointment of the grant recipients including those with an interest in cardiac anesthesiology. Observational study. Internet analysis. NIH grants recipients. None. NIH grant recipients affiliated with anesthesiology departments were identified from the Blue Ridge Institute for Medical Research website. The number of grants, years of support, and total amount of funding were quantified for research project grants (R series), mentored career development awards (K series), and other grants (U and P series) using NIH Research Portfolio Online Reporting Tools. The terminal degree(s), faculty rank, gender, and type of appointment of grant recipients were identified using department web pages. American Board of Anesthesiology (ABA) certification, National Board of Echocardiography Advanced Perioperative Transesophageal Echocardiography (TEE) certification, and previous or current Foundation for Anesthesia Education and Research (FAER) awards to NIH grant recipients were obtained from each organization's website. A total of 532 researchers received 1250 grants with 3844 cumulative years of funding amounting to $1,676,482,440. R series grants accounted for three-quarters of all funding. PhDs were awarded more than one-half of NIH grants. MDs had lower median numbers of projects, R01 grants, and total R series grants than their colleagues with PhD or MD PhD degrees, but MDs received more K awards. One hundred ninety-eight MD and MD PhD NIH grant recipients were ABA diplomates. These physician-scientists received 26.0% and 53.1% of R and K series grants, respectively. Thirty physician-scientists also held TEE certification; these individuals with an interest in cardiac anesthesiology were awarded 4.8% of all NIH grants. Full Professors were awarded more than three-quarters of R grants and amassed more than $1.3 billion in funding, whereas assistant and associate professors received the majority of K series grants. Male investigators received greater median R grants but fewer median K awards than female researchers. One hundred-fifteen previous or current holders of FAER grants were identified; these individuals earned a total of 240 NIH awards totaling $357.7 million. PhDs, Professors, and male researchers receive the majority of R01 and other R series grants to anesthesiology departments at US medical schools. Physician-scientists, including those interested in cardiac anesthesiology, are awarded a minority of R series grants. FAER continues to provide an important stimulus for subsequent NIH funding of physician-scientists in anesthesiology.

Internal factors improving viability of small food and beverage businesses: The case of Indonesia

Small food and beverage business is considered highly contributing to the economy as it has a close linkage with local micro and small businesses, both upstream and downstream. However, this business group faces challenges; many of them are unable to survive, grow, and compete with large ones. This study is intended to analyze internal factors affecting the performance of small food and beverage businesses in Indonesia. With the use of 100 samples of small businesses, the study applied OLS multiple regression to examine the four internal factors, which are entrepreneurial characteristics, marketing strategies, business capital, and innovation activity. The study results show that marketing strategies, business capital, and innovation activities have a positive and significant effect on the performance of small food and beverage businesses. These findings indicate that small businesses depend mostly on those three factors with different levels of intensity for different business locations. Businesses located in universities and hospital areas are likely to have low intensity compared to those located in office areas or crowded places. Differently, entrepreneurial characteristics do not affect performance. Likely, small entrepreneurs did not have a strong business interest, still expecting to work in government organizations and companies. They established a business due to family encouragement and economic needs. AcknowledgmentThe study on the small businesses in food and beverage sector is part of a research grant project from Hasanuddin University conducted by LP2M (Institute for Research and Community Services Institute of Hasanuddin University). In carrying out this study, the involvement of a number of agencies cannot be ignored: Cooperatives and Small and Medium Size Regional Office of South Sulawesi Province and Cooperatives and Small and Medium Size Regional Office of Makassar City.

Publication Rates and Citations in Practice Guidelines from R01 Grants in Obstetrics

NIH funding to OBGYN departments represents a core inequity: 1% of the $14.3 billion in NIH funding is designated to OBGYN (Rice LW et al 2020). Thus, it is important to ascertain the rate of publications from NIH funded Research Project Grants (R01). The purpose of this study was to assess the extent to which R01 grants in obstetrics result in publications and incorporation into ACOG practice bulletins (PB) or committee opinions (CO).

Sense and sensibility: of synthetic biology and the redesign of bioreporter circuits.

Sense and sensibility: of synthetic biology and the redesign of bioreporter circuits.

Inequalities in the distribution of National Institutes of Health research project grant funding

Previous reports have described worsening inequalities of National Institutes of Health (NIH) funding. We analyzed Research Project Grant data through the end of Fiscal Year 2020, confirming worsening inequalities beginning at the time of the NIH budget doubling (1998-2003), while finding that trends in recent years have reversed for both investigators and institutions, but only to a modest degree. We also find that career-stage trends have stabilized, with equivalent proportions of early-, mid-, and late-career investigators funded from 2017 to 2020. The fraction of women among funded PIs continues to increase, but they are still not at parity. Analyses of funding inequalities show that inequalities for investigators, and to a lesser degree for institutions, have consistently been greater within groups (i.e. within groups by career stage, gender, race, and degree) than between groups.

The Hip Instructional Prehabilitation Program for Enhanced Recovery (HIPPER) as an eHealth Approach to Presurgical Hip Replacement Education: Protocol for a Randomized Controlled Trial.

BackgroundOsteoarthritis (OA), leading to hip replacement (THR), is a primary contributor to global mobility impairment. In 2018, more than 59,000 THR surgeries were performed in Canada. Health promotion education, such as prehabilitation, is vital to optimizing surgical outcomes.ObjectiveThis study aims to evaluate the feasibility of the Hip Instructional Prehabilitation Program for Enhanced Recovery (HIPPER), an eHealth approach to prehabilitation education.MethodsA single-blind (assessor-blind), 2-arm, feasibility randomized controlled trial will be conducted. We will recruit 40 (HIPPER group, n=20; control group, n=20) older adults with hip OA and on a waitlist for a THR. The HIPPER intervention consists of 12 online, interactive modules. The control group will receive the current standard practice consisting of 2 online educational sessions lasting 2 hours each (webinars). Feasibility outcomes (eg, recruitment and retention rates) will be evaluated.ResultsRecruitment started in March 2021. As of April 20, 2021, 18 participants were recruited. All 18 completed T1 measures. Only 1 participant has been scheduled to have a surgery and therefore has been scheduled to complete T2 measures. The remainder of the participants are waiting to be notified of their surgery date. This project was funded by a Canadian Institutes of Health Research Project Grant. Our institute’s research ethics board approved this study in November 2016.ConclusionsResults will lead to refinement of the HIPPER protocol in order to evaluate a standardized and geographically accessible prehabilitation program.Trial RegistrationClinicalTrials.gov NCT02969512; https://clinicaltrials.gov/ct2/show/NCT02969512International Registered Report Identifier (IRRID)DERR1-10.2196/29322

The Association between Cd8+ Tumor-Infiltrating Lymphocytes and Response to Cancer Immunotherapy: A Systematic Review and Meta-Analysis

Background: The response of cancer patients to immune checkpoint inhibitors (ICIs) vary in success. CD8+ tumor infiltrating lymphocytes (TILs) play a key role in killing cancer cells. This study aimed to evaluate the prognostic role of CD8+ TILs in cancer patients treat with immune checkpoint inhibitors (ICIs).Methods: We systematically searched all publications from PubMed, EMBASE, and Cochrane Library until 31 Jan 2021 without any restriction of language or article types. Studies assessing high versus low CD8+ TILs in predicting survival of various cancer patients were included. The outcomes included overall survival (OS), progression-free survival (PFS), objective response rate (ORR). Findings: A total of 32 studies consisting of 2546 cancer patients were included . The result showed that high CD8+ TILs was significantly associated with better OS (HR, 0.52; 95% confidence interval: 0.41-0.67; P < 0.001), PFS (HR, 0.54; 95% confidence interval: 0.42-0.70; P < 0.001) and ORR (OR = 3.88; 95% confidence interval: 2.59-5.82;P < 0.001) in patients treated with ICIs. Subgroup analyses suggested that patients with high CD8+ TILs had better clinical benefit regardless of different treatment (ICI monotherapy, or combination therapy), cancer types (NSCLC, melanoma and other), and CD8+ T cells location (intratumor, stroma, and invasive margin). Higher baseline circulating CD8+ T cells from peripheral blood did not contribute to improved OS (HR, 0.93; 95% confidence interval: 0.67-1.29; P = 0.67) and PFS (HR, 0.89; 95% confidence interval: 0.60-1.32;P = 0.56) when compared with low baseline. Interpretation: The result showed that high intratumoral, stromal, or invasive marginal, but not circulating CD8+ TILs can predict treatment outcomes in patients with ICIs therapy across different cancer , in either single-agent ICIs or combination with other therapies. Funding: China National Science Foundation (Grant No. 82022048, 81871893), Key Project of Guangzhou Scentific Research Project (Grant No. 201804020030), High-level university construction project of Guangzhou medical university (Grant No. 20182737, 201721007, 201715907, 2017160107); National key R & D Program (Grant No. 2017YFC0907903 & 2017YFC0112704) and the Guangdong high level hospital construction reaching peak plan. Declaration of Interest: No potential conflicts of interest were disclosed.

Modification of short-range repulsive interactions in ReaxFF reactive force field for Fe–Ni–Al alloy* *Project supported by the National Magnetic Confinement Fusion Energy Research Project (Grant Nos. 2019YFE03120003, 2018YFE0307100, and 2017YFE0302500) and the National Natural Science Foundation of China (Grant Nos. 11975034, 11921006, 12004010, and U20B2025).

The short-range repulsive interactions of any force field must be modified to be applicable for high energy atomic collisions because of extremely far from equilibrium state when used in molecular dynamics (MD) simulations. In this work, the short-range repulsive interaction of a reactive force field (ReaxFF), describing Fe–Ni–Al alloy system, is well modified by adding a tabulated function form based on Ziegler–Biersack–Littmark (ZBL) potential. The modified interaction covers three ranges, including short range, smooth range, and primordial range. The short range is totally predominated by ZBL potential. The primordial range means the interactions in this range is the as-is ReaxFF with no changes. The smooth range links the short-range ZBL and primordial-range ReaxFF potentials with a taper function. Both energies and forces are guaranteed to be continuous, and qualified to the consistent requirement in LAMMPS. This modified force field is applicable for simulations of energetic particle bombardments and reproducing point defects' booming and recombination effectively.

PetSavers interview

Aarti Kathrani is currently working on the PetSavers-funded study ‘Defining the duodenal mycobiota in dogs with chronic enteropathy’. She has also just been awarded a new PetSavers clinical research project grant for a study entitled ‘The characterization and clinical significance of intestinal fibrosis in cats with chronic inflammatory enteropathy’.

Angular dependence of vertical force and torque when magnetic dipole moves vertically above flat high-temperature superconductor* *Projects supported by the National Natural Science Foundation of China (Grant No. 11572232) and the China Three Gorges Corporation Research Project (Grant No.202103407).

The interaction between a permanent magnet (PM) assumed as a magnetic dipole and a flat high-temperature superconductor (HTS) is calculated by the advanced frozen-image model. When the dipole vertically moves above the semi-infinite HTS, the general analytical expression of vertical force and that of torque are obtained for an arbitrary angle between the magnetization direction of the PM and the c axis of the HTS. The variations of the force and torque are analyzed for angle and vertical movements in both zero-field cooling (ZFC) condition and field cooling (FC) condition. It is found that the maximum vertical repulsive or attractive force has the positive or negative cosine relation with the angle. However, the maximum torque has the positive or negative sine relation. From the viewpoint of the rotational equilibrium, the orientation of the magnetic dipole with zero angle is deemed to be an unstable equilibrium point in ZFC, but the same orientation is considered as a stable equilibrium point in FC. In addition, both of the variation cycles of the maximum force and torque with the angle are π.

Extracting knowledge of NCI research directions from funding data using language processing.

e13547 Background: In fiscal year (FY) 2019, 42% of the $6 billion NCI budget went towards nearly 5,000 research project grants, of which about 60% are R01 type. Given the enormity of allocated resources, there is a need for the scientific community to have a more rigorous understanding of the cancer research landscape. While the NCI Budget Fact Book publishes statistics based on pre-designated codings, it is unclear if this method yields the best representation of fields within oncology. Open questions include: how many distinguishable areas of cancer research are being funded? Are there differences in growth rate, publication rate and geographic distribution among those areas? Addressing these questions in a systematic manner is a well-suited problem for unsupervised machine learning. Methods: We analyzed 55,362 R-type grants from FY 2010-2021 (up to 1/31/21) from NIH ExPORTER. Preprocessing was done on ‘Project Terms’ to weight their importance using TF*IDF vectorization and principal component analysis. We used minibatch K-means clustering repeated 100 times, with the best iteration chosen by Calinski-Harabasz clustering quality score. Over 100 repetitions, the Adjusted Rand Index was 0.9907±0.0037 (mean ±standard deviation), indicating robustness to initial conditions of K-means. For publication rate analysis, FY 2020 and 2021 grants were excluded, and 2021 grants were excluded for trajectory analysis. Optimal cluster number was determined based on a combination of inertia, Calinski-Halabasz, and silhouette scores. Results: We found the optimal number of 24 clusters to best represent separation of the R-type grant research directions. These 24 clusters clearly represent topics such as immunotherapy, cohort risk-factor studies, and imaging. Notable trends include increased funding of immunotherapy and targeted inhibitor clusters averaging +$9.9M and +$9.2M growth per year respectively over 10 years, and decreased funding of pathway regulation and genetics clusters averaging -$7.8M and -$5.7M per year. These examples suggest a broader trend that funding is shifting from basic to translational science. Further analysis shows that the targeted inhibitor cluster is most geographically skewed, with 30% of grants going to institutions in just three cities. The number of journal articles (per grant) also shows a bias, with development/training and genetics clusters having publication rates of 32.6 and 20.8 and randomized control trials having a publication rate of 6.3. The average publication rate of NCI was 14.8. Conclusions: Using a novel framework for unsupervised clustering of NCI grant key-phrases, we can organize research projects more holistically than keyword searching, and more efficiently than manual categorization. Our model identifies growing and shrinking areas of research and points out biases in location and publication rate across these areas.

Gender Differences in Research Project Grants and R01 Grants at the National Institutes of Health.

ObjectivesThe National Institutes of Health (NIH), which is the world's largest funding source for research, offers various types of competitive grants depending on the duration, research type, and budget. The Research Project Grant (RPG) is the oldest mechanism for grant allocation that is used by the NIH. In this study, we explored the gender trends of NIH RPGs and R01 grants over the last two decades.MethodsBy utilizing the NIH Research Portfolio Online Reporting Tool (RePORT), data for gender were extracted, and the percentage of women as RPGs Investigators, R01-equivalent grant including R01 type 1 and type 2 grant awardees, from 1998 to 2019 were tabulated. The absolute change was calculated.ResultsFrom 1998 to 2019, the percentage of female RPG awardees has increased. However, the success rates for female RPG applicants have decreased during the same period. The funding and success rates for new R01 awards have been similar for both men and women, but women have been less successful at the renewal of R01-equivalent awards.ConclusionGender disparity exists in awardees of higher RPGs, including the R01 award. This highlights the need for further actions to ensure gender parity in grant allocations at the NIH.