Research Progress Research Articles

Research progress of breast pathology image diagnosis based on deep learning

Breast cancer is a malignancy caused by the abnormal proliferation of breast epithelial cells, predominantly affecting female patients, and it is commonly diagnosed using histopathological images. Currently, deep learning techniques have made significant breakthroughs in medical image processing, outperforming traditional detection methods in breast cancer pathology classification tasks. This paper first reviewed the advances in applying deep learning to breast pathology images, focusing on three key areas: multi-scale feature extraction, cellular feature analysis, and classification. Next, it summarized the advantages of multimodal data fusion methods for breast pathology images. Finally, the study discussed the challenges and future prospects of deep learning in breast cancer pathology image diagnosis, providing important guidance for advancing the use of deep learning in breast diagnosis.

Progress and prospects in the molecular basic research on important traits in sorghum

Sorghum (Sorghum bicolor) is a significant crop serving food, energy, feed, and industrial raw materials, featuring extensive growth adaptability and diverse utility values. Despite the achievements in sorghum breeding in the last decades, conventional breeding methods still confront challenges such as lengthy breeding cycles, low efficiency, and complex genetic backgrounds. With the rapid advancement of molecular biology, genetics, and bioinformatics, molecular breeding has carved new pathways for enhancing sorghum yield and quality. This article reviews the molecular basic research progress in the key agronomic and adaptive traits of sorghum, including grain yield, grain quality, flowering time, plant height, tillering, stress resistance, and male sterility, and discusses future research priorities, offering novel insights and approaches for sorghum breeding.

Review of Research Progress on Acoustic Test Equipment for Hydrate-Bearing Sediments

When acoustic waves propagate through hydrate samples, they carry extensive information related to their physical and mechanical properties. These details are comprehensively reflected in acoustic parameters such as velocity, attenuation coefficient, waveform, frequency, spectrum, and amplitude variations. Based on these parameters, it is possible to invert the physical and mechanical indicators and microstructural characteristics of hydrate samples, thereby addressing a series of issues in hydrate development engineering. This study first provides an overview of the current applications and prospects of acoustic testing in hydrate development. Subsequently, it systematically elaborates on the progress in research on acoustic testing systems for hydrate samples, including the principles of acoustic testing, ship-borne hydrate core acoustic detection systems, laboratory hydrate sample acoustic testing systems, and resonance column experimental systems. Based on this foundation, this study further discusses the development trends and challenges of acoustic testing equipment for hydrate-bearing sediments.

Research progress in the application of electrocardiography in evaluating atrial fibrillation

Research progress in the application of electrocardiography in evaluating atrial fibrillation

Research progress on high-value utilization technology of sludge solid waste in China

Research progress on high-value utilization technology of sludge solid waste in China

Advances in the Study of the Pathogenesis of Vogt-Koyanagi-Harada Syndrome.

Vogt-Koyanagi-Harada syndrome (VKHS) is a common type of uveitis characterized by the invasion of melanocyte-rich tissues. In recent years, the incidence of VKHS has been increasing yearly, and its specific pathogenesis has not yet been elucidated. However, its pathogenesis has been a hot topic of research. The clinical course of VKHS is characterized by the early involvement of the posterior segment of the eye, including exudative retinal detachment, optic papillitis, bilateral diffuse chorioretinitis, etc. If treated improperly or with delayed treatment, the inflammation may gradually spread to the anterior segment of the eye, leading to vision loss or even vision. This study examines the pathogenesis of VKHS. It reviews the progress of research on the pathogenesis of VKHS, which will help to improve the understanding of VKHS and provide a reference for subsequent studies.

Research progress of cardiac rehabilitation in patients with acute heart failure

Research progress of cardiac rehabilitation in patients with acute heart failure

Research Progress on Peptide Drugs for Type 2 Diabetes and the Possibility of Oral Administration

Diabetes is a global disease that can lead to a range of complications. Currently, the treatment of type 2 diabetes focuses on oral hypoglycemic drugs and insulin analogues. Studies have shown that drugs such as oral metformin are useful in the treatment of diabetes but can limit the liver’s ability to release sugar. The development of glucose-lowering peptides has provided new options for the treatment of type 2 diabetes. Peptide drugs have low oral utilization due to their easy degradation, short half-life, and difficulty passing through the intestinal mucosa. Therefore, improving the oral utilization of peptide drugs remains an urgent problem. This paper reviews the research progress of peptide drugs in the treatment of diabetes mellitus and proposes that different types of nano-formulation carriers, such as liposomes, self-emulsifying drug delivery systems, and polymer particles, should be combined with peptide drugs for oral administration to improve their absorption in the gastrointestinal tract.

Research Progress of Ovarian Tissue Cryopreservation and Transplantation

Age, disease and anti-tumor treatment may cause the decline or even loss of female fertility. Embryo cryopreservation, oocyte cryopreservation and ovarian tissue cryopreservation are commonly used at present. Cryopreservation and transplantation of ovarian tissue has become a fertility preservation method with medical indications in clinic, which is helpful for patients to successfully complete fertility through this technology. This paper reviews the international research progress on ovarian cryopreservation and transplantation in recent years. Despite the rapid development of ovarian tissue cryopreservation and transplantation technology, it still faces challenges such as how to reduce the loss of follicular reserve and thus prolong the effectiveness of ovarian tissue transplantation. More basic and clinical research is needed to promote the progress and development of ovarian tissue cryopreservation and transplantation technology.

Escaping the midway trap: A mixed method study highlighting roadblocks and coping mechanisms of female researchers in Cameroon.

Across the world, women make most of the health workforce, but remain underrepresented in academia. This is even worst in Sub-Saharan Africa where women are the least represented as first and last authors in publications, especially in francophone countries. However, there is a lack of data on the reason explaining this inequity. Therefore, we sought to describe challenges which hinder the growth of Cameroonian female researchers and conducted a mixed method study over one year from January 2020 to December 2020. We included Cameroonian female researchers in health. For the quantitative arm, data was collected through an online google questionnaire. In-depth interviews were organized for the qualitative arm. Data was analyzed using python software version 21 for the quantitative arm and content analysis was performed for qualitative data. A total of 119 participants were included in this study. Most participants were aged between 25 and 35 years (72%) and they were Christians (94%). The majority had at least a PhD degree (29.6%) and they came from the West region of Cameroon (34.2%) the Northern regions were grossly underrepresented. More than half of our participants faced issues with balancing career, work, and academia and this is linked to culture. Socioeconomic, sociocultural, institutional, and environmental roadblocks hinder the progress and research productivity of most female researchers. The burden of unpaid maternity leaves, and sexual harassment remains high for most women. The use of English language as lingua Franca is perceived as another barrier for one on two women. However, there are coping strategies adopted by female scientists including the development of soft skills such as self-confidence, determination, and hard work. Extrinsic factors such as global policy, international partnerships, workshops, mentorship, and networking are also supporting women in global health. Gender-based interventions are critical to support women in escaping the midway trap.

Recent Advances in the Utilization of Chiral Covalent Organic Frameworks for Asymmetric Photocatalysis

The use of light energy to drive asymmetric organic transformations to produce high-value-added organic compounds is attracting increasing interest as a sustainable strategy for solving environmental problems and addressing the energy crisis. Chiral covalent organic frameworks (COFs), as porous crystalline chiral materials, have become an important platform on which to explore new chiral photocatalytic materials due to their precise tunability, chiral structure, and function. This review highlights recent research progress on chiral COFs and their crystalline composites, evaluating their application as catalysts in asymmetric photocatalytic organic transformations in terms of their structure. Finally, the limitations and challenges of chiral COFs in asymmetric photocatalysis are discussed, with future opportunities for research being identified.

The Application and Research of Probiotics in the Treatment of Diabetes

This review explores the application and research progress of probiotics in the treatment of diabetes. With the rising incidence of diabetes, traditional treatments face numerous challenges, including side effects of medications and poor patient compliance. As a novel therapeutic approach, probiotics have shown potential in improving glycemic control, enhancing insulin sensitivity, and lowering inflammation levels. Research indicates that probiotics can regulate the gut microbiome, improve intestinal barrier function, promote nutrient absorption, and thus affect overall metabolic status. Furthermore, the antioxidant properties of probiotics have shown positive effects in protecting pancreatic cells and alleviating diabetes complications. Recent clinical trials have further supported the application of probiotics in diabetes management, especially in improving renal function, neuropathy, and cardiovascular health. Despite the optimistic results of existing studies, more high-quality randomized controlled trials are needed to establish the specific effects and optimal use strategies of different probiotics. This review provides a theoretical basis for future research and emphasizes the importance and potential of probiotics in the treatment of diabetes.

A Comparative Analysis of Aroma Profiles of Soju and Other Distilled Spirits from Northeastern Asia

The soju (Korean traditional distilled liquor) market is increasing worldwide. However, in contrast to well-explored distilled liquors, including baijiu (China) and shochu (Japan), soju is less investigated, with limited research on its aroma characteristics. To facilitate better understanding of the aroma characteristics of soju, this study aims to overview recent research on the flavor characteristics of soju and compare data with those of baijiu and shochu, well-established products in the market. Soju is generally made using rice and nuruk (a traditional Korean fermentation starter). Previous studies have reflected that the aroma characteristics vary with raw materials’ nutrition percentages, microbial taxa influenced in fermentation starters, and/or pressure reduction during distillation. The research on the aroma characteristics of baijiu, characterized by solid-state fermentation involving qu (a traditional Chinese fermentation starter), is focused on differences in regional characteristics of the flavor type. Research on the aroma characteristics of shochu has primarily demonstrated that the microbial community could contribute significantly to the development of specific aromatic compounds and/or attributes. Moreover, the association of the aroma characteristics of baijiu and shochu with their volatile compound development by the determination of selective ingredients has been examined. Understanding the current research progress can potentially facilitate the improvement in the aroma characteristics of soju.

Sustainable materials systems for triboelectric nanogenerator

AbstractBenefiting from the high sensitivity and electromechanical conversion efficiency, triboelectric nanogenerators (TENGs) are widely used in various fields of self‐powered sensing and mechanical energy harvesting, which have great potential for application in future smart Internet of Things. The development of sustainable triboelectric materials with high‐performance has a vital impact on the construction of TENG devices that combine high‐output performance and environmental friendliness, which have a positive impact on the sustainable development of humanity. This review systematically and comprehensively summarizes the latest research work on TENG's sustainable materials. First, an overall overview is provided based on the composition of the materials, including amino acids, polysaccharides, and synthetic polymer, and the representative research works are further classified and summarized in detail. In addition, the latest research progress of TENG with sustainable materials in the fields of self‐powered sensing and mechanical energy harvesting applications is also summarized. Finally, the overviews are provided for the various challenges in the current development of TENG's sustainable material, and the related outlooks are offered on the corresponding development strategies and directions of this field in the future.

A Critical Review of Deep Oxidation of Gaseous Volatile Organic Compounds via Aqueous Advanced Oxidation Processes.

Volatile organic compounds (VOCs) are considered to be the most recalcitrant gaseous pollutants due to their high toxicity, diversity, complexity, and stability. Gas-solid catalytic oxidation methods have been intensively studied for VOC treatment while being greatly hampered by energy consumption, catalyst deactivation, and byproduct formation. Recently, aqueous advanced oxidation processes (AOPs) have attracted increasing interest for the deep oxidation of VOCs at room temperature, owing to the generation of abundant reactive oxygen species (ROS). However, current reviews mainly focus on VOC degradation performance and have not clarified the specific reaction process, degradation products, and paths of VOCs in different AOPs. This study systematically reviews recent advances in the application of aqueous AOPs for gaseous VOC removal. First, the VOC gas-liquid mass transfer and chemical oxidation processes are presented. Second, the latest research progress of VOC removal by various ROS is reviewed to study their degradation performances, pathways, and mechanisms. Finally, the current challenges and future strategies are discussed from the perspectives of synergistic oxidation of VOC mixtures, accurate oxidation, and resource utilization of target VOCs via aqueous AOPs. This perspective provides the latest information and research inspiration for the future industrial application of aqueous AOPs for VOC waste gas treatment.

Frontier AI developers need an internal audit function.

This article argues that frontier artificial intelligence (AI) developers need an internal audit function. First, it describes the role of internal audit in corporate governance: internal audit evaluates the adequacy and effectiveness of a company's risk management, control, and governance processes. It is organizationally independent from senior management and reports directly to the board of directors, typically its audit committee. In the Institute of Internal Auditors' Three Lines Model, internal audit serves as the third line and is responsible for providing assurance to the board, whereas the combined assurance framework highlights the need to coordinate the activities of internal and external assurance providers. Next, the article provides an overview of key governance challenges in frontier AI development: Dangerous capabilities can arise unpredictably and undetected; it is difficult to prevent a deployed model from causing harm; frontier models can proliferate rapidly; it is inherently difficult to assess frontier AI risks; and frontier AI developers do not seem to follow best practices in risk governance. Finally, the article discusses how an internal audit function could address some of these challenges: Internal audit could identify ineffective risk management practices; it could ensure that the board of directors has a more accurate understanding of the current level of risk and the adequacy of the developer's risk management practices; and it could serve as a contact point for whistleblowers. But frontier AI developers should also be aware of key limitations: Internal audit adds friction; it can be captured by senior management; and the benefits depend on the ability of individuals to identify ineffective practices. In light of rapid progress in AI research and development, frontier AI developers need to strengthen their risk governance. Instead of reinventing the wheel, they should follow existing best practices. Although this might not be sufficient, they should not skip this obvious first step.

Research progress of exosomes in pathogenesis and treatment of preeclampsia.

Preeclampsia (PE) is a critical and severe disease in obstetrics, which seriously affects maternal and neonatal life safety and long-term prognosis. However, the etiology and pathogenesis of PE are complex, and no unified conclusion has been reached. The types and number of exosomes and their transport substances in PE patients changed. The study of exosomes in PE patients helps clarify the etiology, diagnosis, effective treatment, accurate monitoring, and prognosis. The published articles were reviewed. Exosomes may affect endothelial and vascular production and function, participate in maternal-fetal immune regulation, and transport substances such as miRNAs, lncRNAs, and proteins involved in the development of PE. Detection of the contents of exosomes can help in the early diagnosis of PE, and can help to improve PE by inhibiting the action of exosomes or preventing their binding to target organs. Exosomes may be involved in the development of PE, and exosomes can be used as markers for predicting the onset of PE and tracking the disease process and determining the prognosis, and exosomes have great potential in the treatment of PE.

Recent Advances of Plastic Waste‐Derived Carbon Materials for Energy Storage, Environmental Remediation and Organic Synthesis Applications

AbstractThe escalating severity of plastic waste's impact on the ecological environment and human health emphasize the crucial importance of developing resource‐conserving disposal technologies for sustainable development. Carbon‐based materials possess extensive functional applications across various fields, however, their high production costs and heavy reliance on fossil fuels pose challenges. Plastic wastes serve as ideal precursors for the green and sustainable production of carbon‐based functional materials due to high carbon content and low‐cost. This review provides a comprehensive summary of recent research progress on plastic waste‐derived carbon materials (PWCMs) including primary strategies for constructing PWCMs and their current functional applications in energy storage, environmental remediation and organic synthesis.

Advanced Applications of Nanomaterials in Atherosclerosis Diagnosis and Treatment: Challenges and Future Prospects.

Atherosclerosis-induced coronary artery disease is a major cause of cardiovascular mortality. Clinically, conservative treatment strategies for atherosclerosis still focus on lifestyle interventions and the use of lipid-lowering and anticoagulant medications. Despite achieving some therapeutic effects, these approaches are limited by low bioavailability, long intervention periods, and significant side effects. With the advancement of nanotechnology, nanomaterials have demonstrated extraordinary potential in the biomedical field. Their excellent biocompatibility, surface modifiability, and high targeting capability not only enable efficient diagnosis of plaque progression but also allow precise drug delivery within atherosclerotic plaques, significantly enhancing drug bioavailability and reducing systemic side effects. Here, we systematically review the current research progress of nanomaterials in the field of atherosclerosis to summarize not only the types of nanomaterials but also their applications in both the diagnosis and treatment of atherosclerosis. Notably, in the context of plaque therapy, we provide a comprehensive overview of current nanomaterial applications based on their targeted therapeutic systems for different cell types within plaques. Additionally, we address the persistent challenge of clinical translation of nanomaterials by summarizing current issues and providing directions for innovation and improvement in nanomaterial design. Overall, we believe that this review systematically summarizes the applications and challenges of biomedical nanomaterials in atherosclerosis diagnosis and therapy, thereby offering insights and references for the development of therapeutic materials for atherosclerosis.

A chronicle of titanium niobium oxide materials for high‐performance lithium‐ion batteries: From laboratory to industry

AbstractTitanium niobium oxide (TiNbxO2 + 2.5x) is emerging as a promising electrode material for rechargeable lithium‐ion batteries (LIBs) due to its exceptional safety characteristics, high electrochemical properties (e.g., cycling stability and rate performance), and eco‐friendliness. However, several intrinsic critical drawbacks, such as relatively low electrical conductivity, significantly hinder its practical applications. Developing reliable strategies is crucial to accelerating the practical use of TiNbxO2 + 2.5x‐based materials in LIBs, especially high‐power LIBs. Here, we provide a chronicle review of the research progress on TiNbxO2 + 2.5x‐based anodes from the early 1950s to the present, which is classified into early stage (before 2008), emerging stage (2008–2012), explosive stage (2013–2017), commercialization (2018), steady development (2018–2022), and new breakthrough stage (since 2022). In each stage, the advancements in the fundamental science and application of the TiNbxO2 + 2.5x‐based anodes are reviewed, and the corresponding developing trends of TiNbxO2 + 2.5x‐based anodes are summarized. Moreover, several future research directions to propel the practical use of TiNbxO2 + 2.5x anodes are suggested based on reviewing the history. This review is expected to pave the way for developing the fabrication and application of high‐performance TiNbxO2 + 2.5x‐based anodes for LIBs.