Introduction: In contemporary scientific and clinical research, legal and ethical issues pertaining to subjects and researchers, subject dignity preservation, and research publication play a significant role. Nonetheless, when nurses engage in research, they must navigate three distinct value systems: nursing, science, and society. These systems may clash with the values of the research subjects, communities, and cultures, leading to conflicts and challenges within the nursing profession. Definition: The definition of ethics in nursing research is "the act of moral principles that the researcher has to follow while conducting nursing research is to ensure the right and welfare of individuals, groups, or communities under study, as well as the extent of confidentiality of study and medical records." Ethics in Nursing Research Is Important. Keep the other research participants and the vulnerable group safe from the negative impacts of the experimental interventions. Prevent researchers from taking advantage of the subjects. The following are the rights of patients: emergency care, information, records, and reports; informed consent; confidentiality; and another opinion. The Ethical Obligations of a Nurse Investigator: makes ensuring that study participants' autonomy is respected when giving their agreement to engage in research and makes sure that the necessary safeguards are in place to keep them safe. In order to provide the best possible protection for the vulnerable groups included in the study—children, the elderly, pregnant women, mentally ill patients, people with physical disabilities, people who are terminally ill, and institutions—it is necessary to minimize potential risks and maximize potential benefits for each and every subject. The study's risks and rewards must be split equally between preserving the promised level of proficiency in the designated research methodologies.