The importance of right speed, effectiveness, efficiency and learning in Multi Business Model Innovation (MBMI) is vital to meet today’s Volatile, Uncertainty, Complex and Ambiguous (VUCA) challenges to survive as a Business in Business Model EcosystemS (BMES). Coronavirus pandemic, war in Ukraine, volatile global material and resource prices and deliveries, cyberattacks make big external VUCA events to Businesses. VUCA can also come from the inside of the Business as management style change, interventions or a burn down of the Business. How can Businesses under these VUCA conditions still do high quality MBMI? How can MBMI participants and teams in these processes increase their MBMI output? This paper investigates the impact of positive emotions, relatedness and creativity on the outcome of three different MBMI processes in three different Business Model Ecosystems influenced by VUCA. Positivity, relatedness and creativity are hypothesized as components to strengthen the individuals’ search for meaning in VUCA and for their motivation to act in MBMI processes influenced by VUCA. The study is conducted as a mix method research project in the view of MBMI and psychological theory – particularly the concept of positive emotions and relatedness as mental states for learning and knowledge creation. Interviews and observations show that individuals in networks and teams with a mood of positivity strengthen MBMI and the MBMI learning and creation process. Thus, our intention for further research is twofold: Training in positivity in teams can stimulate the courage to make disruptive solutions sufficient for VUCA. Secondly, in searching for the MBMI mindset psychological traits will be studied by the Big Five profile test. This opens for recruitment of participants to optimizing MBMI teams. Main contributions are: • Positive emotions and relatedness strengthen the urge to learn and to create in VUCA – searching for meaning and motivation to act is related to this concept. • Learning and creative processes increase, since the basis of positivity and relatedness in individuals, teams and networks are strengthened. • Innovative outcome seems of a higher quality when based on positive emotions. Research in positive emotions in Business Model Innovation is rare. • Positive emotion is the core concept and by training of positivity, it may strengthen the MBMI processes and the VUCA competences. • The outcomes and solution of the MBMI processes in the case study show mainly incremental and radical MBMI – only one is disruptive.