Research Funding Research Articles

Abstract P105: Comparative Effectiveness between Angiotensin Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors on Mortality: a Nationwide, Population-based, Prospective Cohort Study in China

Background: Contemporary evidence comparing the efficacy of angiotensin-converting enzyme inhibitors (ACEIs) versus angiotensin II receptor blockers (ARBs) on long-term outcomes in patients with hypertension is sparse and inconsistent. The aim is to compare the effectiveness of ACEI monotherapy versus ARB monotherapy on all-cause death and cardiovascular death. Methods: Based on a nationwide, population-based prospective cohort project, which covered 318 study sites from 2014 to 2021 in China. Detailed information was collected by questionnaire, physical measurement, and blood test. Participants aged 35-75 years with hypertension and taking ACEI or ARB monotherapy once daily, and with good medication adherence at baseline were included. Information on mortality was followed up until 31 December 2021. Stabilized inverse probability treatment weighting (IPTW) was applied to compare the effectiveness. Results: 68 771 (49326 ARB, 19445 ACEI) participants were finally included, with a mean age of 59.9±8.3 years and 40.2% being female. During a median follow-up time of 44 months, 785 cardiovascular deaths and 1657 deaths were recorded. Compared with ACEI monotherapy, ARB monotherapy was associated with a quarter relative risk reduction of cardiovascular death (IPTW rates: 0.95 % Vs 1.43%, HR =0.73 [ 95%CI , 0.62-0.87]) and one-fifth relative risk reduction of all-cause death (IPTW rates: 2.13% Vs 2.84%, HR =0.80 [ 95%CI , 0.71-0.89]). These differences remained consistent after further adjusting for blood pressure and with differences more pronounced in patients with controlled and newly onset hypertension. Sensitive analysis and subgroup analysis yielded consistent results. Conclusions: Attention should be paid that ARB can be preferred to ACEI in patients with hypertension in terms of long-term health outcomes. Funding: This work was supported by the Chinese Academy of Medical Sciences Innovation Fund for Medical Science (2021-I2M-1-011), and the National High Level Hospital Clinical Research Funding (2022-GSP-GG-4, NCRCSZ-2023-016). Keywords: Hypertension, Angiotensin receptor blocker, Angiotensin-converting enzyme inhibitor, Mortality, Comparative effectiveness

S12-06 Finding European research funding and writing a competitive research proposal

S12-06 Finding European research funding and writing a competitive research proposal

경제안보기술의 특허출원에 대한 비공개 방안 - 일본의 특허출원비공개제도를 중심으로

In establishing the 6th Basic Plan for Science and Technology (2021.4.1-2026.3.31), Japan recognized the need for innovation in converging humanities and social sciences with science technology and revised the “Basic Act on Science and Technology” to the “Basic Act on Science and Technology and Innovation” and the “R&D Power Enhancement Act” to the “Act on Promotion of Science and Technology and Innovation Creation”. In its basic plan and important policies, goals such as the development of innovative technologies related to the convergence of cyber and physical spaces are set. Even though the purpose of developing such innovative technologies is set, in order to strongly promote the R&D and patent protection policy of high-tech (specific important technologies) that can be used maliciously in international disputes or cyber terrorism, etc., the “Economic Security Promotion Act” has been enacted and implemented as a separate legislation. The Act stipulates R&D policies for securing specific critical materials and specific critical technologies to protect national security and public safety and the system that allows patent applications to be non-disclosed was introduced and implemented on May 1, 2024 in cases where patent applications of research results could harm Japan's economic security and public stability. It is necessary to reflect it in Korea's technical security policy through in-depth analysis and review of the law relating to measures to secure specific important materials, research and development and research funding policy of specific critical technologies, and the Non-Disclosure System of Patent Applications of research results thereof. In particular, by analyzing in-depth the purpose and intention of the Japanese government to strongly promote it by separately legislating it, not by ordinary legislation, it is necessary to refer to the research and development related to national security in Korea and the patent protection policy of the research results. In particular, it is necessary to analyze in-depth the purpose and intention of the Japanese government to promote it separately, not by ordinary legislation, and refer to Korea's national security-related research and development and patent protection policies of its research results.

Continuation versus Interruption of Oral Anticoagulation during TAVI.

One third of patients undergoing transcatheter aortic-valve implantation (TAVI) have an indication for oral anticoagulation owing to concomitant diseases. Interruption of oral anticoagulation during TAVI may decrease the risk of bleeding, whereas continuation may decrease the risk of thromboembolism. We conducted an international, open-label, randomized, noninferiority trial involving patients who were receiving oral anticoagulants and were planning to undergo TAVI. Patients were randomly assigned in a 1:1 ratio to periprocedural continuation or interruption of oral anticoagulation. The primary outcome was a composite of death from cardiovascular causes, stroke from any cause, myocardial infarction, major vascular complications, or major bleeding within 30 days after TAVI. A total of 858 patients were included in the modified intention-to-treat population: 431 were assigned to continuation and 427 to interruption of oral anticoagulation. A primary-outcome event occurred in 71 patients (16.5%) in the continuation group and in 63 (14.8%) in the interruption group (risk difference, 1.7 percentage points; 95% confidence interval [CI], -3.1 to 6.6; P = 0.18 for noninferiority). Thromboembolic events occurred in 38 patients (8.8%) in the continuation group and in 35 (8.2%) in the interruption group (risk difference, 0.6 percentage points; 95% CI, -3.1 to 4.4). Bleeding occurred in 134 patients (31.1%) in the continuation group and in 91 (21.3%) in the interruption group (risk difference, 9.8 percentage points; 95% CI, 3.9 to 15.6). In patients undergoing TAVI with a concomitant indication for oral anticoagulation, periprocedural continuation was not noninferior to interruption of oral anticoagulation during TAVI with respect to the incidence of a composite of death from cardiovascular causes, stroke, myocardial infarction, major vascular complications, or major bleeding at 30 days. (Funded by the Netherlands Organization for Health Research and Development and the St. Antonius Research Fund; POPular PAUSE TAVI ClinicalTrials.gov number, NCT04437303.).

Opportunities and Challenges in Implementing Information Technology Innovations in the Indonesian Education Sector

This research explores the opportunities and challenges in implementing information technology (IT) innovations in Indonesia's education sector. The study examines key variables such as infrastructure, internet access, and teacher training, using qualitative methodologies including case studies and literature reviews. Data were collected from various sources over the past decade. Findings highlight that while IT can enhance education quality and access, particularly through e-learning and digital tools, significant barriers remain due to Indonesia's geographical diversity and unequal infrastructure. The research suggests strategies for overcoming these challenges, such as accelerated infrastructure development, increased research funding, and comprehensive teacher training programs. These insights aim to inform policy and practice, enhancing IT integration in Indonesian education.

Gut bacterial type III secretion systems aggravate colitis in mice and serve as biomarkers of Crohn’s disease

Mesenteric adipose tissue (mAT) hyperplasia, known as creeping fat, is a pathologic characteristic of Crohn's disease (CD). In our previously reported cohort, we observed that Achromobacter pulmonis was the most abundant and prevalent bacteria cultivated from creeping fat. A whole genomic sequencing and identification of T3SS orthologs of mAT-derived A. pulmonis were used. A functional type III secretion system (T3SS) mediated the pathogenic potential of A. pulmonis invitro and in mouse colitis model. Furthermore, a T3SS Finder pipeline was introduced to evaluate gut bacterial T3SS orthologs in the feces of CD patients, ulcerative colitis and colorectal cancer patients. Here, we reveal that mAT-derived A. pulmonis possesses a functional T3SS, aggravates colitis in mice via T3SS, and exhibits T3SS-dependent cytotoxicity via a caspase-independent mechanism in macrophages and epithelial cells, which demonstrated the pathogenic potential of the T3SS-harboring A. pulmonis. Metagenomic analyses demonstrate an increased abundance of Achromobacter in the fecal of Crohn's disease patients compared to healthy controls. A comprehensive comparison of total microbial vT3SS abundance in various intestine diseases demonstrated that the specific enrichment of vT3SS genes was shown in fecal samples of CD, neither ulcerative colitis nor colorectal cancer patients, and ten T3SS gene-based biomarkers for CD were discovered and validated in a newly recruited CD cohort. Furthermore, treatment with exclusive enteral nutrition (EEN), an intervention that improves CD patient symptomatology, was found associated with a significant reduction in the prevalence of T3SS genes in fecal samples. These findings highlight the pathogenic significance of T3SSs in the context of CD and identify specific T3SS genes that could potentially function as biomarkers for diagnosing and monitoring the clinical status of CD patients. This work is supported by the National Key Research and Development Program of China (2020YFA0907800), the China Postdoctoral Science Foundation (2023M744089), the National Natural Science Foundation of China (32000096), the Shenzhen Science and Technology Programs (KQTD20200820145822023, RCIC20231211085944057, and ZDSYS20220606100803007), National Key Clinical Discipline, Guangdong Provincial Clinical Research Center for Digestive Diseases (2020B1111170004), Qingfeng Scientific Research Fund of the China Crohn's & Colitis Foundation (CCCF) (CCCF-QF-2022B71-1), and the Sixth Affiliated Hospital, Sun Yat-sen University Clinical Research 1010 Program 1010CG(2023)-08. These funding provided well support for this research work, which involved data collection, analysis, interpretation, patient recruitment and so on.

Economical Experimental Device for Evaluating Thermal Conductivity in Construction Materials under Limited Research Funding

African scientific research faces formidable challenges, particularly with limited access to state-of-the-art measurement instruments. The high cost associated with these devices presents a significant barrier for regional research laboratories, impeding their ability to conduct sophisticated experiments and gather precise data. This predicament not only hampers the individual laboratories but also has broader implications for the African scientific community and the advancement of knowledge in developing nations—the financial cost barrier considerably impacts the research quality of these laboratories. Reflection on technical and economical solutions needs to be quickly found to help these countries advance their research. In civil engineering, the thermal conductivity property is the most important measurement for characterizing heat transfer in construction materials. Existing devices (i.e., conductometers) in a laboratory are expensive (approximately EUR 30,000) and unavailable for some African laboratories. This study proposes a new and affordable device to evaluate thermal conductivity in construction materials. The method involves establishing a thermal flux between a heat source (from the Joule effect provided by steel wool where a current is circulating) and a cold source (generated by ice cubes) under steady-state conditions. The development of the cylindrical prototype is based on the comparative flux-meter method outlined in the measuring protocol of the ASTM E1225 standard document. Experiments were conducted on four distinct materials (polystyrene, wood, agglomerated wood, and rigid foam). The results indicate a correct correlation between the experimental values obtained from the newly developed prototype and the reference values found in the literature. For example, concerning the experimental polystyrene study, the detailed case analysis reveals a good correlation, with a deviation of only 4.88%. The percent error found falls within the acceptable range indicated by the standard recommendations of the ASTM E1225 standard, i.e., within 5% acceptable error.

Enhancing life cycle assessment methodologies for carbon capture and utilization technologies: A comprehensive guideline for improved decision-making

Carbon Capture Utilization and Storage (CCUS) is an emerging technology that aims to reduce carbon dioxide (CO₂) emissions from industrial processes and power generation. This paper presents a comprehensive Life Cycle Analysis (LCA) of CCUS, evaluating its environmental impacts from cradle to grave. The LCA includes the stages of CO₂ capture, transportation, utilization, and storage. The goal is to provide a holistic understanding of the potential benefits and drawbacks of CCUS, guiding policymakers and industry stakeholders in decision-making processes. Although LCA is a standardized method, there is significant variability in current LCA practices due to differing methodological choices, which limits their effectiveness for decision support. Applying LCA to CCU technologies introduces additional challenges, particularly because CO₂ serves both as an emission and a feedstock. The guidelines aim to enhance the comparability of LCA studies by providing clear methodological directions and predefined assumptions regarding feedstock and utilities. Increased transparency is achieved through detailed interpretation and reporting guidance. By improving comparability, the guidelines support more informed decision-making, enabling more efficient allocation of research funds and time towards the development of technologies for climate change mitigation and negative emissions.

Venous thromboembolism prevention program implementation in a community oncology practice: a cohort study

While national guidelines recommend Venous Thromboembolism (VTE) risk assessment in cancer outpatients and consideration of pharmacologic prophylaxis in high-risk patients, prophylaxis rates are low in community oncology practices. A successful model for guideline implementation (the Vermont Model, VM) is validated in an academic tertiary oncology setting. We undertook an implementation study to determine the success of this model in a multi-site community oncology practice. The study objectives were to: 1) adapt the VM to the community practice setting; 2) implement the adapted VM into practice; and 3) evaluate clinical and implementation outcomes. The study was carried out in three phases: (1) Pre-implementation, a multidisciplinary team addressed the need to adapt the VM to the local context including electronic medical record (EMR) optimisation and clinician education; (2) implementation of the strategies adapted to the local context, informed by VM and adapted based on stakeholder feedback; (3) prospective evaluation of clinical and implementation outcomes at six months after implementation. Following creation of a comprehensive initiation roadmap for the adaptation of VM program to the community practice, 302 cancer outpatients initiating new treatment met inclusion criteria over a 6 month implementation period. VTE risk education was provided to 100% of patients, and 98% (296) of patients received a VTE risk assessment. Of 52 patients (18%) who scored as high risk based on a modified Khorana (Protecht) score, 14 (27%) initiated prophylaxis. Barriers to program adaptation included EMR optimization challenges and practice-level responsibility assignment, time constraints, concern about potential drug interactions, and financial & insurance issues. Implementation of a multidisciplinary VTE prevention model in the community-based oncology setting successfully increased VTE education and risk assessment rates. AC prophylaxis rates were modestly increased, highlighting the need to understand and address barriers to anticoagulant prophylaxis prescribing in this setting. Northern New England Clinical Oncology Society Research Funding Program.

How Does Artificial Intelligence Shape Audit Firms?

Does artificial intelligence (AI) displace auditors? We exploit the staggered hiring of AI employees at audit office locations across the United States as a proxy for the use of AI at local audit offices. The main findings are as follows. First, relative to audit offices that do not yet hire AI employees, those that do hire AI employees have a 4.3% increase in the number of auditor jobs, particularly among junior and midlevel auditors. Second, using AI is associated with an increased demand for soft skills (e.g., cognitive skills) in auditor jobs. Third, audit offices that use AI have more accurate going concern and internal control opinions. Semistructured interviews of 11 seasoned audit partners confirm that investment in AI is centralized at the national level, but the decision to deploy it often resides at the local audit office level. Notably, none of the partners believe that AI has replaced or will replace human auditors. Overall, our study—comprising both empirical and qualitative data—suggests that using AI does not replace auditors, but rather changes the skills required for these jobs and improves audit quality. This paper was accepted by Suraj Srinivasan, accounting. Funding: K. K. F. Law’s research is supported by the Start-Up Grant from Nanyang Technological University and the Ministry of Education (MOE), Singapore, under its Academic Research Fund Tier 1 [Grant RG128/20]. M. Shen’s research is supported by the Start-Up Grant from the National University of Singapore [Grant A-0003914-00-00] and the MOE under its Academic Research Fund Tier 1 [Grant A-8000098-00-00]. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.04040 .

Promoting research integrity in funding: Co-creating guidelines for research funding organizations.

Research Funding Organizations (RFOs) play an important role in promoting research integrity (RI). Not only do they allocate resources to research institutions and researchers, but they also set and monitor research standards in their funded projects. In spite of their crucial role, there is a paucity of guidance on how RFOs can promote research integrity. As part of the EU-Funded SOPs4RI project, we aimed to address this gap by co-creating guidelines to help RFOs promote RI, engaging a diverse group of stakeholders. Based on a Delphi survey, reviews of evidence and stakeholder interviews, three guideline topics were identified: 1) the selection and evaluation of proposals; 2) monitoring of funded projects; and 3) prevention of unjustified interference. Four sets of co-creation workshops were conducted for each guideline topic, and the input revised and finalized. Understanding these debates could help RFOs from diverse cultural and organizational backgrounds who are developing their own RI guidelines. Therefore, in this paper, we summarize the key results and emphasize the final recommendations. Further, we provide the main points of discussion that occurred during the workshops and explain how they were addressed or resolved in the final guidelines and how they can help in future endeavors to improve funders' practices to foster RI.

Breast cancer research gaps: a questionnaire-based study to determine overall priorities and compare the priorities of patients, the public, clinicians and scientists

ObjectiveThis study aims to prioritise the themes identified from the three gap analyses performed by a combination of scientists, clinicians, patients and members of the public to determine areas in...

The Core of Housing Markets from an Agent’s Perspective: Is It Worth Sprucing up Your Home?

We study housing markets as introduced by Shapley and Scarf. We investigate the computational complexity of various questions regarding the situation of an agent a in a housing market H: we show that it is [Formula: see text]-hard to find an allocation in the core of H in which (i) a receives a certain house, (ii) a does not receive a certain house, or (iii) a receives a house other than a’s own. We prove that the core of housing markets respects improvement in the following sense: given an allocation in the core of H in which agent a receives a house h, if the value of the house owned by a increases, then the resulting housing market admits an allocation in its core in which a receives either h or a house that a prefers to h; moreover, such an allocation can be found efficiently. We further show an analogous result in the Stable Roommates setting by proving that stable matchings in a one-sided market also respect improvement. Funding: This work was supported by the Hungarian Scientific Research Fund [Grants K124171, K128611]. I. Schlotter is supported by the Hungarian Academy of Sciences under its Momentum Programme (LP2021-2) and its János Bolyai Research Scholarship. The research reported in this paper and carried out by T. Fleiner at the Budapest University of Technology and Economics was supported by the “TKP2020, National Challenges Program” of the National Research Development and Innovation Office [BME NC TKP2020 and OTKA K143858] and by the Higher Education Excellence Program of the Ministry of Human Capacities in the frame of the Artificial Intelligence research area of the Budapest University of Technology and Economics (BME FIKP-MI/SC). P. Biró gratefully acknowledges financial support from the Hungarian Scientific Research Fund, OTKA [Grant K143858] and the Hungarian Academy of Sciences [Momentum Grant LP2021-2].

Public perspectives on increased data sharing in health research in the context of the 2023 National Institutes of Health Data Sharing Policy.

The National Institutes of Health (NIH) is the largest public research funder in the world. In an effort to make publicly funded data more accessible, the NIH established a new Data Management and Sharing (DMS) Policy effective January 2023. Though the new policy was available for public comment, the patient perspective and the potential unintended consequences of the policy on patients' willingness to participate in research have been underexplored. This study aimed to determine: (1) participant preferences about the types of data they are willing to share with external entities, and (2) participant perspectives regarding the updated 2023 NIH DMS policy. A cross-sectional, nationally representative online survey was conducted among 610 English-speaking US adults in March 2023 using Prolific. Overall, 50% of the sample identified as women, 13% as Black or African American, and 7% as Hispanic or Latino, with a mean age of 46 years. The majority of respondents (65%) agreed with the NIH policy, but racial differences were noted with a higher percentage (28%) of Black participants indicating a decrease in willingness to participate in research studies with the updated policy in place. Participants were more willing to share research data with healthcare providers, yet their preferences for data sharing varied depending on the type of data to be shared and the recipients. Participants were less willing to share sexual health and fertility data with health technology companies (41%) and public repositories (37%) compared to their healthcare providers (75%). The findings highlight the importance of adopting a transparent approach to data sharing that balances protecting patient autonomy with more open data sharing.

Hot potato: Force-multiplying technological innovation for food and agricultural decarbonization

Despite being a widely recognized problem, there is little U.S. public sector support for development of technologies that can directly or indirectly mitigate agricultural emissions, particularly at the production step of the supply chain. Increasing government funding in research and development (R\&D) of food and agriculture innovations, such as rumen methane mitigation and alternative protein production could spur much needed innovation in mitigation of agricultural emissions and enable commercial adoption of these technologies.

The effect of prior hysterosalpingo-foam sonography or hysterosalpingography on tubal patency: a secondary analysis of a randomized controlled trial.

Does hysterosalpingo-foam sonography (HyFoSy) prior to hysterosalpingography (HSG) or HSG prior to HyFoSy affect visible tubal patency when compared HSG or HyFoSy alone? Undergoing either HyFoSy or HSG prior to tubal patency testing by the alternative method does not demonstrate a significant difference in visible tubal patency when compared to HyFoSy or HSG alone. HyFoSy and HSG are two commonly used visual tubal patency tests with a high and comparable diagnostic accuracy for evaluating tubal patency. These tests may also improve fertility, although the underlying mechanism is still not fully understood. One of the hypotheses points to a dislodgment of mucus plugs that may have disrupted the patency of the Fallopian tubes. This is a secondary analysis of the randomized controlled FOAM study, in which women underwent tubal patency testing by HyFoSy and HSG, randomized for order of the procedure. Participants either had HyFoSy first and then HSG, or vice versa. Here, we evaluate the relative effectiveness of tubal patency testing by HyFoSy or HSG prior to the alternative tubal patency testing method on visible tubal patency, compared to each method alone. Infertile women aged between 18 and 41 years scheduled for tubal patency testing were eligible for participating in the FOAM study. Women with anovulatory cycles, endometriosis, or with a partner with male infertility were excluded. To evaluate the effect HyFoSy on tubal patency, we relied on HSG results by comparing the proportion of women with bilateral tubal patency visible on HSG in those who underwent and who did not undergo HyFoSy prior to their HSG (HyFoSy prior to HSG versus HSG alone). To evaluate the effect of HSG on tubal patency, we relied on HyFoSy results by comparing the proportion of women with bilateral tubal patency visible on HyFoSy in those who underwent and who did not undergo HSG prior to their HyFoSy (HSG prior to HyFoSy versus HyFoSy alone). Between May 2015 and January 2019, we randomized 1160 women (576 underwent HyFoSy first followed by HSG, and 584 underwent HSG first followed by HyFoSy). Among the women randomized to HyFoSy prior to HSG, bilateral tubal patency was visible on HSG in 467/537 (87%) women, compared with 472/544 (87%) women who underwent HSG alone (risk difference 0.2%; 95% CI: -3.8% to 4.2%). Among the women randomized to HSG prior to HyFoSy, bilateral tubal patency was visible on HyFoSy in 394/471 (84%) women, compared with 428/486 (88%) women who underwent HyFoSy alone (risk difference -4.4%; 95% CI: -8.8% to 0.0%). The results of this secondary analysis should be interpreted as exploratory and cannot be regarded as definitive evidence. Furthermore, it has to be noted that pregnancy outcomes were not considered in this analysis. Tubal patency testing by either HyFoSy or HSG, prior to the alternative tubal patency testing method does not significantly affect visible tubal patency, when compared to alternative method alone. This suggests that both methods may have comparable abilities to dislodge mucus plugs in the Fallopian tubes. The FOAM study was an investigator-initiated study, funded by ZonMw, a Dutch organization for Health Research and Development (project number 837001504). IQ Medical Ventures provided the ExEm®-FOAM kits free of charge. The funders had no role in study design, collection, analysis, or interpretation of the data. H.R.V. reports consultancy fees from Ferring. M.v.W. received a travel grant from Oxford University Press in the role of Deputy Editor for Human Reproduction and participates in a Data Safety and Monitoring Board as an independent methodologist in obstetrics studies in which she has no other role. M.v.W. is coordinating editor of Cochrane Fertility and Gynaecology. B.W.J.M. received an investigator grant from NHMRC (GNT1176437) and research funding from Merck KGaA. B.W.J.M. reports consultancy for Organon and Merck KGaA, and travel support from Merck KGaA. B.W.J.M. reports holding stocks of ObsEva. V.M. received research grants from Guerbet, Merck and Ferring and travel and speaker fees from Guerbet. The other authors do not report conflicts of interest. International Clinical Trials Registry Platform No. NTR4746.

Marshaling science to advance large landscape conservation

AbstractApplying science to conservation requires deliberate planning and action infrequently taught in academic settings. To illustrate impactful analysis and science communication, we describe scientific activities targeting the needs of land trusts, NGOs, landowners, and government agencies working to conserve the Florida Wildlife Corridor (“Corridor”). This 7.2 million hectare area is prioritized for habitat connectivity conservation in the US state of Florida. Our activities are built on decades of science guiding Florida land conservation. We quantified threats (e.g., average of over 14,000 ha of development/year from 2001 to 2019) and socio‐ecological benefits of Corridor conservation, prioritized yet‐to‐be‐conserved Corridor areas, produced and shared a new statewide connectivity model, and convened groups to identify campaign science needs. The new connectivity model—the Florida Circuit Model—supported the geography of the Corridor, as designated, and facilitates local (10 km radius, or less) conservation planning. Our efforts have contributed to allocation of over $2 billion for land conservation and the permanent protection of over 82,000 ha within the Corridor by state agencies from June 2021 to March 2024. Targeting science to outreach and policy, planning, and management decisions can motivate public, media, researcher, and government support for land conservation, improve conservation interventions, and attract research funding.

Interrogating basal ganglia circuit function in people with Parkinson's disease and dystonia.

The dichotomy between the hypo- versus hyperkinetic nature of Parkinson's disease (PD) and dystonia, respectively, is thought to be reflected in the underlying basal ganglia pathophysiology. In this study, we investigated differences in globus pallidus internus (GPi) neuronal activity, and short- and long-term plasticity of direct pathway projections. Using microelectrode recording data collected from the GPi during deep brain stimulation surgery, we compared neuronal spiketrain features between people with PD and those with dystonia, as well as correlated neuronal features with respective clinical scores. Additionally, we characterized and compared readouts of short- and long-term synaptic plasticity using measures of inhibitory evoked field potentials. GPi neurons were slower, bustier, and less regular in dystonia. In PD, symptom severity positively correlated with the power of low-beta frequency spiketrain oscillations. In dystonia, symptom severity negatively correlated with firing rate and positively correlated with neuronal variability and the power of theta frequency spiketrain oscillations. Dystonia was moreover associated with less long-term plasticity and slower synaptic depression. We substantiated claims of hyper- versus hypofunctional GPi output in PD versus dystonia, and provided cellular-level validation of the pathological nature of theta and low-beta oscillations in respective disorders. Such circuit changes may be underlain by disease-related differences in plasticity of striato-pallidal synapses. This project was made possible with the financial support of Health Canada through the Canada Brain Research Fund, an innovative partnership between the Government of Canada (through Health Canada) and Brain Canada, and of the Azrieli Foundation (LM), as well as a grant from the Banting Research Foundation in partnership with the Dystonia Medical Research Foundation (LM).

Interrogating basal ganglia circuit function in people with Parkinson’s disease and dystonia

Background:The dichotomy between the hypo- versus hyperkinetic nature of Parkinson’s disease (PD) and dystonia, respectively, is thought to be reflected in the underlying basal ganglia pathophysiology. In this study, we investigated differences in globus pallidus internus (GPi) neuronal activity, and short- and long-term plasticity of direct pathway projections.Methods:Using microelectrode recording data collected from the GPi during deep brain stimulation surgery, we compared neuronal spiketrain features between people with PD and those with dystonia, as well as correlated neuronal features with respective clinical scores. Additionally, we characterized and compared readouts of short- and long-term synaptic plasticity using measures of inhibitory evoked field potentials.Results:GPi neurons were slower, bustier, and less regular in dystonia. In PD, symptom severity positively correlated with the power of low-beta frequency spiketrain oscillations. In dystonia, symptom severity negatively correlated with firing rate and positively correlated with neuronal variability and the power of theta frequency spiketrain oscillations. Dystonia was moreover associated with less long-term plasticity and slower synaptic depression.Conclusions:We substantiated claims of hyper- versus hypofunctional GPi output in PD versus dystonia, and provided cellular-level validation of the pathological nature of theta and low-beta oscillations in respective disorders. Such circuit changes may be underlain by disease-related differences in plasticity of striato-pallidal synapses.Funding:This project was made possible with the financial support of Health Canada through the Canada Brain Research Fund, an innovative partnership between the Government of Canada (through Health Canada) and Brain Canada, and of the Azrieli Foundation (LM), as well as a grant from the Banting Research Foundation in partnership with the Dystonia Medical Research Foundation (LM).

Research on the Joint Supervision System of Finance, Audit and Inspection in Universities

With the continuous improvement of the global economy and information technology, the education sector has entered an unprecedented new stage of development. As an important component of the education sector, the scale of universities are expanding year by year. With the continuous development of universities, the multi campus education model has quietly emerged, and research projects are increasing day by day. The diversification of research funding channels has put forward higher requirements for government supervision of universities, and relying solely on single department supervision is no longer applicable. At present, the supervision subject of finance, auditing, and inspection in universities generally work independently and perform their duties independently, lacking communication, resulting in poor supervision effectiveness and resource waste. Therefore, integrating the supervisory forces of universities and establishing a joint system is an urgent need for the rapid development of universities. So, this article analyzes the current situation of financial, auditing, and inspection supervision in universities, explores the significance, principles, and methods of constructing a joint supervision system for financial, auditing, and inspection in universities, and strives to provide some suggestions for the construction of joint supervision system for financial, auditing, and inspection in universities, in order to provide reference for other researchers.