The emerge of daytime radiative cooling as a promising cooling technology, has attracted the attention of scientists to investigate its performance for different applications. The building sector as one of the highest energy consumers has a notable cooling demand and consequently, has a crucial need for sustainable cooling systems. In this paper, an active radiative cooling system as a standalone solution is proposed for a single-family house that cools the people by a hydroponic cooling system inside the house, the case study of Isfahan city in Iran as a hot and semi-arid climate. Results of the feasibility study demonstrated that cooling potential of rooftop panels can reach up to 96 W/m2 and generate up to 6 kW cooling in total. The proposed cooling system could provide thermal comfort for the occupants in 99 % of the hours in summer. Further investigations indicated that the storage tank and the number of panels directly affect the performance of the system but the water flow rate has an optimum value followed by the storage tank volume. Accordingly, larger storage tanks and higher water flow rates yield higher cooling energy. Also, it was seen that as the area and view factor of radiant surfaces inside the building increases, the required water temperature in the storage to keep the occupants in the thermal comfort stage increases. On the other hand, a more air-tight building has more comfort hours with this system. Evaluating the performance of the system in multiple climates indicated that the effectiveness of this system intensely drops in humid cities, where passive designs and ceiling fans alongside the proposed system, can compensate for the issue.