Reproductive Processes Research Articles

Depopulation and Limitations of Demographic Statistics in the Republic of Belarus

The article considers the problems in the demographic processes of the Republic of Belarus. The fluctuations in the modern demographic "waves" of Belarus are analyzed. It is argued that the reproductive processes of the Republic are characterized by changes in the depopulation spiral. Concern about the prospects for its demographic development is substantiated. The problems of the state demographic policy in overcoming depopulation are noted. The state of the Belarusian demographic science in developing approaches to the implementation of demographic policy is highlighted. A characteristic of management decisions is given, both their positive and negative role in the implementation of demographic policy. The significance of the Concept of National Security of the Republic of Belarus and the role of ensuring demographic security in it are shown. In the light of the Concept of National Security of the country, the consequences of restrictions on statistical information for demographic science and demographic policy of Belarus are studied. The role of demographic information in ensuring the national security of the Republic is revealed. The results of the mechanism for recounting the population from the results of the 2019 population census are disclosed. Methodological approaches to calculating the indicators of the reproductive situation of Belarus in 2020-2023 are presented. in conditions of limited demographic statistics.

Selection and Regulatory Network Analysis of Differential CircRNAs in the Hypothalamus of Goats with High and Low Reproductive Capacity

The objectives of this investigation were to identify differentially expressed circular RNAs (circRNAs) in the hypothalamus of goats with high and low prolificacy and construct a circRNA-mRNA regulatory network to uncover key potential circRNAs that influence goat prolificacy. Transcriptome analysis was performed on hypothalamus samples from low-prolificacy (n = 5) and high-prolificacy (n = 6) Chuanzhong black goats to identify circRNAs that influence prolificacy in these goats. Differential expression analysis identified a total of 205 differentially expressed circRNAs, comprising 100 upregulated and 105 downregulated circRNAs in the high-prolificacy group compared with the low-prolificacy group. Enrichment analysis of these differentially expressed circRNAs indicated significant enrichment in Gene Ontology terms associated with mammalian oogenesis, negative regulation of neurotransmitter secretion, reproductive developmental processes, hormone-mediated signaling pathways, and negative regulation of hormone secretion. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis highlighted significant enrichment in the oxytocin signaling pathway, GnRH signaling pathway, and hormone-mediated oocyte maturation. The hypothalamus of low- and high-prolificacy goats contains circular RNAs (circRNAs), including chicirc_063269, chicirc_097731, chicirc_017440, chicirc_049641, chicirc_008429, chicirc_145057, chicirc_030156, chicirc_109497, chicirc_030156, chicirc_176754, and chicirc_193363. Chuanzhong black goats have the potential to influence prolificacy by modulating the release of serum hormones from the hypothalamus. A circRNA-miRNA regulatory network was constructed, which determined that miR-135a, miR-188-3p, miR-101-3p, and miR-128-3p may interact with differentially expressed circRNAs, thereby regulating reproductive capacity through the hypothalamic-pituitary-gonadal axis. The results of this study enhance our knowledge of the molecular mechanisms that regulate prolificacy in Chuanzhong black goats at the hypothalamic level.

Morphophysiological Assessment of the Cervix during the Reproductive Cycle and Early Pregnancy in Does Using Computed Tomography and Oxytocin Receptor Immunohistochemistry.

This study aimed to elucidate the morphophysiology and oxytocin receptor (OXTR) expression in the cervix of doe goats during various reproductive stages to enhance reproductive management strategies. A total of 40 cervical samples were categorized into follicular (n = 15), luteal (n = 10), and early pregnancy (n = 15) stages. Utilizing advanced imaging based on functional and morphological markers, the study employed computed tomography (CT) scans, histochemical staining (Masson trichrome and alcian blue), immunohistochemistry, Western blotting, and quantitative PCR (qPCR) to assess structural changes in the cervix and in OXTR expression during the estrous cycle and early pregnancy. CT scans revealed consistent cervical folds and a significant reduction in cervical width during pregnancy, suggesting structural adaptations for gestational integrity. Histochemical analyses indicated a well-organized collagen network and presence of mucins, essential for cervical function and integrity. Immunohistochemistry and Western blotting demonstrated elevated OXTR protein levels during the follicular stage, which were markedly reduced during pregnancy, indicating a role in facilitating cervical relaxation and sperm transport during estrus and maintaining cervical closure during gestation. qPCR analysis showed stable OXTR mRNA levels during follicular and luteal stages with a slight, non-significant increase during pregnancy, pointing towards posttranscriptional regulatory mechanisms. In conclusion, this study demonstrates that cervical morphology and OXTR expression in doe goats undergo significant changes across reproductive stages, with elevated OXTR protein levels during the follicular phase and notable reductions in cervical width and OXTR protein levels during pregnancy, indicating structural and functional adaptations for both reproductive processes and gestational integrity.

Impact of rising CO2 and temperature on grass phenology, physiology, and pollen release patterns in northern latitudes

Climate change has complex effects on vegetation, including native grasses and those used as fodder plants. Like many other plant species, grasses respond to climate change by altering their phenology and physiological behavior, leading to changes e.g. in growth, reproduction and metabolic processes. Our study is the first to explore how Phleum pratense and Alopecurus pratensis respond to rising CO2 and temperatures projected for northern latitudes for two growing seasons. We investigated growth, phenology, pollen release, and physiological parameters in plants cultivated under these conditions, simulated within environmentally controlled chambers.Treatment with elevated temperature reduced the number of generative tillers and, consequently, decreased both the number of inflorescences and the season pollen integrals. Pollen release from P. pratense started up to 17 days earlier, and the daily peak concentration of released pollen was observed 1–2 h earlier in chambers with elevated temperatures when compared to the present climate conditions. Similar effects were noted in A. pratensis. Elevated CO2 (EC) increased net photosynthesis of P. pratense, but this effect was reduced under elevated temperature (ET), suggesting an antagonistic interaction. In A. pratensis, both elevated CO2 and temperature had an additive effect on increasing net photosynthesis, with the highest rate observed under the combined ETEC treatment. The elevated temperature or CO2 did not affect the plant biomass.Our findings propose that the rising temperatures in northern latitudes decrease the flowering of studied grasses and shift the seasonal and daily start of the pollen release. Changes in tiller proportions, reduced pollen integrals, and fewer inflorescences suggest that a warmer climate may negatively impact reproductive success, ecological fitness, and allergenic burden of these grasses.

Women’s support-seeking for reproductive decision-making in Australia: rationales and socio-demographic contexts

ABSTRACT While a positive relationship between social support and women’s reproductive decision-making outcomes exists, little is known about the reasons why women engage supporters to assist them when making reproductive decisions. This study explores Australian women’s reasons for engaging supporters for reproductive decision-making and whether women’s socio-demographic characteristics are suggestive of any such reasons. A modified content analysis approach, combining directed and summative analysis methods, was applied to data from two qualitative Australian studies exploring women’s support-seeking for reproductive decision-making. Findings suggest that the most important rationales for engaging supporters were ‘understanding or empathy’, ‘informed or educated’, ‘on the same page’, ‘little interference’, ‘close’ and ‘stake in the decision’. Some socio-demographic characteristics, particularly regional area and partner status, helped to explain some reasons, while other reasons were better explained by the nature of the decision being made. Further research is required to enhance our understanding of reproductive decision-making processes and enable women to access support that facilitates decisions appropriate to their bodies and life circumstances.

Regulatory Involvement of Kisspeptin in Energy Balance and Reproduction.

The hypothalamic-pituitary-gonadal axis, which regulates steroidogenesis and germ cell formation, closely regulates the reproduction process. Nonetheless, other chemical mediators, such as kisspeptin, influence this axis. Kisspeptin is a hypothalamic neuropeptide that modulates the function of this axis and also plays a central role in energy balance. The present study reviews the impact and associated mechanisms of kisspeptin on male and female reproduction based on available evidence in the literature. Kisspeptin and its neurons exert anorexigenic activity, thus maintaining adequate energy balance for optimal reproductive function. Also, they stimulate the release of GnRH, resulting in the optimal performance of gonadal physiological processes viz. production of steroid sex hormones and germ cells. However, studies linking kisspeptin to reproduction are yet scanty. Hence, studies exploring the upstream and downstream signaling pathways activated by kisspeptin concerning reproduction in an attempt to better understand the associated mechanisms of the regulatory activities of kisspeptin on reproduction are recommended. In addition, potential factors that may modulate kisspeptin activities may be useful in the management of infertility and perhaps, in the development of contraceptives for those who do not intend to achieve conception.

Gut Microbiota Dynamics and Phenotypic Changes Induced by Tetracycline in Drosophila melanogaster

Gut microbiota plays a crucial role in both physiological and pathological processes in humans and animals. Antibiotics, designed to combat bacterial infections, can induce alterations in the composition and abundance of the gut microbiota over prolonged exposure. This study addresses the limited understanding of the connections between gut microbiota and phenotypic profiles of metazoan species. We investigated the impact of early-life exposure to tetracycline in wild-type D. melanogaster, which were fed a standard diet, comparing them to a control group not exposed to tetracycline. The primary objective was to examine the consequences of early-life tetracycline exposure on gut microbiota and its implications for phenotypic profiles, including survival, locomotor activity, and reproduction in adult flies. Results revealed a significant reduction in lactic acid bacteria in adult flies exposed to tetracycline. However, tetracycline exhibited no interference with fly development, allowing them to maintain a normal lifespan. In adult flies, tetracycline significantly decreased the lifespan on day 35 at a concentration of 1000 µg/mL and reduced locomotion on day 27 at concentrations of 10 µg/mL and 1000 µg/mL. Remarkably, tetracycline did not impact the reproductive capabilities of the flies. This study demonstrates that while tetracycline led to a decline in lactic acid bacteria, locomotion, and lifespan in adult flies, it did not disrupt their development or reproductive processes.

Анализ и оценка уровня воспроизводства человеческого капитала на региональном уровне

The relevance of this study is due to the following circumstances. Successful human capital management is the basis for solving strategic tasks of regional development, since it is the availability of qualified and motivated personnel necessary for successful professional activity that ensures the effective development of the region's economy. It is also known that investments aimed at improving public health have a significant impact on the dynamics of changes in the gross regional product. In this regard, it seems necessary to assess the state of the processes of reproduction of human capital in the region on the example of such a subject of the Russian Federation as the Republic of Adygea. The analysis shows that the Republic of Adygea implements a regional policy aimed at ensuring the expanded reproduction of the territory's human capital. If there are a number of certain problems, it can be argued that it allows to ensure that the trained specialists meet the requirements imposed on them in the regional labor market.

Exploring the harmony between contemporary values and Islamic identity through the lens of the Gülen movement's teachings

There is a growing need for new Muslim identities that reflect global realities. Fethullah Gülen, a notable Turkish-Muslim cleric, is influential and persuasive. Gülen emphasizes spirituality, religious pluralism, discussion, and education to promote peaceful coexistence and integrate faith and reason in Western democracies. This study examines how Gülen's ideas and the global volunteer organization he created promote Muslim-non-Muslim harmony. We use text linguistics' seven principles—cohesion, coherence, intentionality, acceptability, informativity, situation, and intertextuality—to assess Gülen's teachings and movement. In the social sciences, we also use textual language norms as a fresh theoretical and methodological approach to studying social movements and events. This study's focus on movement-text relationships and cognitive processes in information creation, reproduction, and dissemination makes it distinctive. This study investigates these issues in Muslim countries, multicultural cultures, and liberal democracies. This research is useful because it explains the Gülen movement's domestic and worldwide advancements. This article figuratively depicts Fethullah Gülen as the author, his movement as the text, and humanity as the readers.

Особенности развития генеративных структур некоторых цветковых растений

The paper presents the results of a comparative study of the reproductive biology of a number of Crimean flora species and valuable plants introduced to the south of Russia belonging to various families (Magnoliaceae, Annonaceae, Ericaceae, Campanulaceae, Anacardiaceae, Lamiaceae, Ranunculaceae, Davidiaceae, Nyssaceae, Onagraceae, Papaveraceae), which made it possible to establish some features and regularities in the formation of the generative structures of the reproductive system, consisting in the conjugation of the development of male and female elements, the maturation of sexual gametes and the process of pollination in entomophilous plants. A conclusion was drawn concerning the high reproductive potential of the studied species, which is expressed in the formation of a sufficient number of full-fledged seeds to reproduce. The possibilities of using the knowledge of the reproductive processes of flowering plants in solving certain issues of taxonomy, determining the strategy of reproduction and conservation of phytodiversity, and showing the importance of antecological aspects in plant reproduction, breeding and nature protection were demonstrated. The material is of scientific interest to botanists, ecologists, breeders and other specialists.

Симптомы теологии в письме Луи Альтюссера

The aim of the study is to examine Louis Althusser’s writing for traces, theological concepts and theological rhetorical figures. While several of Althusser’s texts discuss the Church as an ideological apparatus – a social organism that reproduces specific ideologies – his work largely sidesteps direct engagement with theol-ogy. The article pays special attention to the interpellation theory of the subject and the concept of “overdeter-mination”. The key thesis of the article is that L. Althussers’ writing can reveal symptoms and traces of theologi-cal thought, in particular with regard to one of the most significant motives of L. Althusser’s theory – the general structure of Ideology. As a result, the presence of traces of theological thought is shown in those fragments of L. Althusser’s writing that relate to the interpellation theory of the subject, the material practice of ideology and the determination of the processes of reproduction of the total structure.

Poisoned schools and automated students: The crisis of social reproduction

In contemporary societies, schools play an important role in reproducing the social system. Those who want to maintain the status quo find social reproduction desirable, while more radical scholars are critical regarding the social inequality and injustice perpetuated through this reproduction process. Traditionally, schools and families have assumed the more significant share of this ‘duty’ of educating for social reproduction, and, for better or worse, they have been largely successful. However, the landscape has shifted as automation and digitization have exploded. In the 90s, the Internet’s increasing presence in the public domain revolutionized communications, and accordingly, capitalism found new avenues of exploitation, dramatically increasing social entropy. Using the works of Bernard Stiegler, this article problematizes the social reproduction field with a focus on schools. It argues that in this era of big data and digitization, schools have unknowingly allowed their traditional socialization and the cultivation of the youth’s intelligence functions to be sabotaged. This increasing erosion of schooling’s functions leads to a new, entropic reproduction that poisons the youth. Educators and parents cannot control this process; we all struggle to describe and fully understand it.

Dynamic Membrane Lipid Changes in Physcomitrium patens Reveal Developmental and Environmental Adaptations.

Membrane lipid composition is critical for an organism's growth, adaptation, and functionality. Mosses, as early non-vascular land colonizers, show significant adaptations and changes, but their dynamic membrane lipid alterations remain unexplored. Here, we investigated the temporal changes in membrane lipid composition of the moss Physcomitrium patens during five developmental stages and analyzed the acyl content and composition of the lipids. We observed a gradual decrease in total lipid content from the filamentous protonema stage to the reproductive sporophytes. Notably, we found significant levels of very long-chain polyunsaturated fatty acids, particularly arachidonic acid (C20:4), which are not reported in vascular plants and may aid mosses in cold and abiotic stress adaptation. During vegetative stages, we noted high levels of galactolipids, especially monogalactosyldiacylglycerol, associated with chloroplast biogenesis. In contrast, sporophytes displayed reduced galactolipids and elevated phosphatidylcholine and phosphatidic acid, which are linked to membrane integrity and environmental stress protection. Additionally, we observed a gradual decline in the average double bond index across all lipid classes from the protonema stage to the gametophyte stage. Overall, our findings highlight the dynamic nature of membrane lipid composition during moss development, which might contribute to its adaptation to diverse growth conditions, reproductive processes, and environmental challenges.

THE SIGNIFICANCE AND ROLE OF LIVESTOCK BREEDING AS PART OF THE AGRICULTURAL SECTOR IN PELAGONIA REGION

Livestock breedeing is one of the most important economic sectors in our country, directly influencing the overall progress of the agricultural sector. Its continuous development significantly impacts economic stability, food supply, rural development, and societal well-being. In the research, the objectives are clearly defined to provide a comprehensive description and classification of the conditions, current status, and possibilities for the development of livestock production. The main goal of the research is to identify the components of the reproduction process in the agricultural and food industry and their influence on macroeconomic movements. Various scientific methods were used in the preparation of the thesis, including analytical, synthetic, inductive, deductive, descriptive, and statistical methods. The most relevant conclusions obtained through the analysis of the results from the "Questionnaire" encompass aspects such as identifying agriculture as a primary source of income for many farmers, particularly in crop farming and livestock husbandry. Additionally, challenges like a lack of workforce, delayed subsidy payments, and issues with water supply for livestock hydration are identified. The significance of a strategy to protect clean water is emphasized as a response to the water scarcity challenge. The future of the agricultural sector depends on factors such as product placement, subsidies, timely payment for finished products, and ensuring the workforce, highlighting them as key aspects for the sector's future development. The research provides significant data contributing to the improvement of the current state in livestock farming, both in the Pelagonian region and in our country.

PCP-bε is a novel positive regulator of pollen germination in Arabidopsis thaliana

small cysteine-rich peptides play essential roles in different stages of the plant reproductive process. Pollen germination is a prerequisite for double fertilization and is directly related to seed formation and crop yield. However, the small cysteine-rich peptides that are involved in pollen germination remain to be identified. In this study, identification and phylogenetic analysis of PCP-Bε genes in sequenced Brassicaceae show that pollen coat protein B-class protein PCP-Bε gene is widespread in Arabidopsis and its high relatives, but lost in some Brassica species. Expression analyses display that AtPCP-Bε gene is expressed in Arabidopsis pollen. Arabidopsis PCP-Bε knockout mutants are generated by CRISPR/Cas9, Phenotypic analyses show that the absence of AtPCP-Bε obviously impairs in vitro pollen germination, but has no influence on pollen tube growth, which demonstrates that AtPCP-Bε is a novel positive regulator of pollen germination. It is speculated that AtPCP-Bε should interact with the receptor from pollen to perform its function. These findings are useful for further analysis on the molecular mechanism of pollen germination.

PSIV-13 Changes in Interferon-γ and Tumor necrosis factor-α in the vaginal environment of cattle during early gestation

Abstract The embryo must create an immuno-tolerant uterine environment via cytokine signaling to prevent rejection and facilitate embryo attachment. Cytokines have a variety of roles in both reproductive and pregnancy-related processes. Cytokines and chemokines are important in inflammatory pathways for uterine remodeling and recruitment of immune cells during pregnancy. Interferon-γ (INFγ) and tumor necrosis factor-a (TNFα) influence T-helper cell immune responses, which can assist in early pregnancy establishment. Therefore, we hypothesized that INFγ and TNFα concentrations following breeding will be differentially expressed based on mating type, time, and pregnancy outcome. To test this, we completed two experiments in which INFγ and TNFα were quantified in vaginal fluid samples on d 0, d 7, d 14, d 21, d 28, and d 35 following mating. In experiment one, Angus heifers (n = 9) were used to determine cytokine concentrations in the vaginal environment between d 0 to d 35, and between artificial insemination (AI) and natural mating. In experiment 2, lactating dairy cows (n = 88) were used to determine if cytokines could be used as a potential biomarker for successful pregnancy. All vaginal flush samples were collected via Foley catheter in 20 mL of sterile saline. Statistical analysis was completed in SAS 9.4 to determine differences in cytokine concentrations based on day of gestation, mating type, and pregnancy outcome. In experiment 1, vaginal concentrations of TNFα were least (P = 0.05) in AI-bred heifers on d 35 (1.15 ± 2.97 pg/mL) and intermediate in non-pregnant heifers (4.39 ± 2.97 pg/mL) compared with natural service-bred heifers on d 7 (18.09 ± 2.97 pg/mL). INFγ was increased (P = 0.05) on d 7 following natural service (3.86 ± 0.76 pg/mL) compared with AI (0.86 ± 0.76 pg/mL). TNFα was increased (P = 0.02) on d 7 following natural service (18.09 ± 2.89 pg/mL) compared with AI (1.93 ± 2.89 pg/mL) and was increased (P = 0.02) by d 7 after a natural mating compared with a pregnancy resulting from AI mating. In experiment two, concentrations of IFNγ were greater (P = 0.04) on d 7 (1.36 ± 0.57 pg/mL) compared with d 8 (0.24 ± 0.57 pg/mL) of gestation. There was also a tendency for TNFα concentrations to decrease (P = 0.09) from d 7 (60.06 ± 26.94 pg/mL) to d 8 (19.67 ± 26.94 pg/mL) of gestation. In conclusion, concentrations of INFγ and TNFα may not be indicative of a viable embryo or pregnancy outcome but do differ based on day of gestation and mating type, which may aid in understanding the role these cytokines play during early gestation.

Transcriptome analysis reveals miRNA expression profiles in hypothalamus tissues during the sexual development of Jining grey goats

BackgroundExploring the physiological and molecular mechanisms underlying goat sexual maturation can enhance breeding practices and optimize reproductive efficiency and is therefore substantially important for practical breeding purposes. As an essential neuroendocrine organ in animals, the hypothalamus is involved in sexual development and other reproductive processes in female animals. Although microRNAs (miRNAs) have been identified as significant regulators of goat reproduction, there is a lack of research on the molecular regulatory mechanisms of hypothalamic miRNAs that are involved in the sexual development of goats. Therefore, we examined the dynamic changes in serum hormone profiles and hypothalamic miRNA expression profiles at four developmental stages (1 day (neonatal, D1, n = 5), 2 months (prepubertal, M2, n = 5), 4 months (sexual maturity, M4, n = 5), and 6 months (breeding period, M6, n = 5)) during sexual development in Jining grey goats.ResultsTranscriptome analysis revealed 95 differentially expressed miRNAs (DEMs) in the hypothalamus of goats across the four developmental stages. The target genes of these miRNAs were significantly enriched in the GnRH signalling pathway, the PI3K-Akt signalling pathway, and the Ras signalling pathway (P < 0.05). Additionally, 16 DEMs are common among the M2 vs. D1, M4 vs. D1, and M6 vs. D1 comparisons, indicating that the transition from D1 to M2 represents a potentially critical period for sexual development in Jining grey goats. The bioinformatics analysis results indicate that miR-193a/miR-193b-3p-Annexin A7 (ANXA7), miR-324-5p-Adhesion G protein-coupled receptor A1 (ADGRA1), miR-324-3p-Erbb2 receptor tyrosine kinase 2 (ERBB2), and miR-324-3p-Rap guanine nucleotide exchange factor 3 (RAPGEF3) are potentially involved in biological processes such as hormone secretion, energy metabolism, and signal transduction. In addition, we further confirmed that miR-324-3p targets the regulatory gene RAPGEF3.ConclusionThese results further enrich the expression profile of hypothalamic miRNAs in goats and provide important insights for studying the regulatory effects of hypothalamic miRNAs on the sexual development of goats after birth.

Exploring swine oviduct anatomy through micro-computed tomography: a 3D modeling perspective.

The oviduct plays a crucial role in the reproductive process, serving as the stage for fertilization and the early stages of embryonic development. When the environment of this organ has been mimicked, it has been shown to enhance in vitro embryo epigenetic reprogramming and to improve the yield of the system. This study explores the anatomical intricacies of two oviduct regions, the uterotubal junction (UTJ) and the ampullary-isthmic junction (AIJ) by using micro-computed tomography (MicroCT). In this study, we have characterized and 3D-reconstructed the oviduct structure, by measuring height and width of the oviduct's folds, along with the assessments of fractal dimension, lacunarity and shape factor. Results indicate distinct structural features in UTJ and AIJ, with UTJ displaying small, uniformly distributed folds and high lacunarity, while AIJ shows larger folds with lower lacunarity. Fractal dimension analysis reveals values for UTJ within 1.189-1.1779, while AIJ values range from 1.559-1.770, indicating differences in structural complexity between these regions. Additionally, blind sacs or crypts are observed, akin to those found in various species, suggesting potential roles in sperm sequestration or reservoir formation. These morphological differences align with functional variations and are essential for developing an accurate 3D model. In conclusion, this research provides information about the oviduct anatomy, leveraging MicroCT technology for detailed 3D reconstructions, which can significantly contribute to the understanding of geometric-morphological characteristics influencing functional traits, providing a foundation for a biomimetic oviduct-on-a-chip.

Theoretical approaches to the reproduction of the fixed assets of industrial enterprises

The process of reproduction of fixed assets is of great significance to industrial enterprises. Currently, scientific literature contains various viewpoints on the definition of the categories of “fixed assets” and “reproduction”. Moreover, the peculiarities of the stages of reproduction cycle in the industrial sphere are not disclosed in proper detail. The purpose of the study is to analyze and systematize theoretical approaches to the content of the conceptual apparatus of the problem of reproduction of fixed assets with the consideration of the specificity of the stages of the process at the industrial enterprises. The object of the study is the process of reproduction of fixed assets of industrial enterprises. The research is based on the combination of general scientific and special methods which were applied to ensure the reliability and objectivity of the research results. During the research the authors used methods of comparative analysis, generalization, systematization, analysis and synthesis, and grouping. As the result of theoretical overview of the categories of “fixed assets”, “reproduction”, “reproduction of fixed assets” the authors suggest the definition of the “reproduction of fixed assets of industrial enterprises” concept which is connected with the basic peculiarities of the stages of the reproduction cycle and the ways of their implementation at the industrial enterprises. Comprehension of the basic characteristics of fixed assets and the mechanism of their reproduction are crucial for making managerial decisions which is especially important for planning production processes in the conditions of reindustrialization, import substitution and growing sanction pressure on the Russian economy. A perspective direction for further studies is development of detailed recommendations on realization of the stages of the reproduction cycle at the industrial enterprises under the current conditions.

Analysis of Public Health Care Management in Women Suffering from PCOS in India

The concept of "health" is multifaceted and goes beyond simply being free from sickness or illness. Because the concept of health is so nebulous, it is difficult to define. Not only have the most common types of health problems changed over time, but so has our comprehension of health. In the modern world, behaviour often affects one's health because it is influenced by biological, psychological, and social factors. Reproductive processes and events mix with psychological and physiological aspects. In a similar vein, psychological disorders influence reproductive physiology and control reproductive processes. The empirical data points to several aspects that require attention for a deeper comprehension of psychological suffering and ultimately its avoidance. It is quite difficult to learn about the evolution of distress, which means that it is hard to distinguish between acute and persistent manifestations of this condition. According to the few studies that have looked into the problem of psychological discomfort in gynaecology out-patient clinics, women who frequent these clinics are thought to be more distressed than typical—about 50% of them, on average. Additionally, this study will identify the psychosocial variables and aetiology of PCOS in women.