The paper discusses of transaction costs into self-regulation of institutionalization of appropriation of informatively-digital intellectual product. The aim of this research is a detecting of varieties of transaction costs, intrinsic to institutionalization of appropriation of informatively-digital intellectual product in the national economy of Ukraine. A variant of integration method was used for achieving of the aim of the research. Evolution of scientifically fundamental and empiric developments of the transaction costs was exposed. Self-regulation of institutionalization of appropriation of informatively-digital intellectual product as one of types of institutional organization, submission, regulation of transaction costs in social and economic spheres was outlined. Self-creating of conditions of permanent reproduction of institutionalization of appropriation of informatively-digital intellectual product via transaction costs was found. Was circumscribe the varieties of transaction costs, what intrinsic to self-regulation of institutionalization of acquisition of legitimate of informatively-digital intellectual product, namely: creation (in the cluster of creators), saving (in the cluster of producers), distribution (in the cluster of mediators-entrepreneurs). Was dissociated the varieties of transaction costs, the varieties of transaction costs, what intrinsic to self-regulation of institutionalization of belonging of legitimate of informatively-digital intellectual product, namely: search of information (in the cluster of creators), measuring (in the cluster of producers), contracting (in the cluster of mediators-entrepreneurs). Further researches must be goal-seeking to the self-regulation of institutionalization of appropriation of informatively-digital intellectual product, what mediated by transaction costs. Practical importance of the paper was represented in an availability for government regulation of institutionalization of appropriation of informatively-digital intellectual product in Ukraine with the high degree of scientific accompaniment of types of industrial activity on the newest technological basis.