Representative Categories Research Articles

Automatic Building Detection for Multi-Aspect SAR Images Based on the Variation Features

Multi-aspect synthetic aperture radar (SAR) images contain more information available for automatic target recognition (ATR) than images from a single view. However, the sensitivity to aspect angles also makes it hard to extract and integrate information from multi-aspect images. In this paper, we propose a novel method based on the variations features to realize automatic building detection in the image level. First, to get a comprehensive description of target variation patterns, statistical characteristic variances are derived from three representative and complementary categories. Then, these obtained features are fused and put in the K-means classifier for prescreening, whose results are used as the training sets in supervised classification later to avoid manual labeling. Second, for more precise detection performance, finer features in vector forms are obtained by principal component analysis (PCA). The variation patterns of these feature vectors are explored in two different manners of correlation and fluctuation analyses and processed by separate support vector machines (SVMs) after fusion. Finally, the independent SVM detection results are fused according to a maximum probability rule. Experiments conducted on two different airborne data sets demonstrate the robustness and effectiveness of the proposed method, in spite of significant target signature variabilities and cluttered background.

Perception of violin performance expression through expressive musical terms

Expressive musical terms (EMTs) are often used in classical Western music as verbal instructions to performers to convey particular forms of expression. Recently, Sulem et al. (2019) analyzed the perception of EMTs by professional string players without reference to heard musical performances, defining four representative categories of EMTs located in the four quadrants of the two-dimensional model of affect whose parameters are valence and arousal. The present study focuses on listeners’ perceptions of musical expression in short excerpts from the violin repertoire, played according to the four representative categories and in a Neutral (i.e., non-expressive) manner. In Experiment 1, listeners’ perceptions of the performances were examined in terms of these five categories. In Experiment 2, listeners concentrated on the playing and sound characteristics of the performances, and paired-comparison analysis was used to estimate the perceived similarities between the performances in terms of their expression. The findings of the two experiments show that performances can be mapped in a three-dimensional perceptual space in which the valence and arousal dimensions are supplemented by a third dimension that can be associated with degree of expressiveness. This demonstrates the relevance of valence and arousal as fundamental parameters for characterizing the musical expression conveyed by the EMTs, as perceived by listeners, and introduces the concept of degree of expressiveness, reflecting the contrast between Neutral and expressive performances.

Residual levels and health risk assessment of rare earth elements in Chinese resident diet: A market-based investigation

The widespread use of rare earth elements (REEs) in agriculture and high-tech industry resulted in significant release of REEs into the environment. However, there is a scarcity of studies focusing on the presence of REEs in the food worldwide. The present study investigated the residual levels of REEs in 14 representative food categories collected from 33 major cities of China. The measured total REEs (ΣREE) levels in the foods of aquatic origin were 174.97 μg kg−1 wet weight (ww), which was 6.35 times higher than those of terrestrial origin. It is interesting to observe a trophic dilution effect for REEs in both terrestrial and aquatic food samples. REEs in food samples at low trophic levels exhibited relatively high REEs levels; while for high trophic level food, relatively low REEs levels were observed. The distribution patterns of REEs varied across the different food categories and regions, with Ce being the most abundant REEs in all food samples, followed by La, Nd and Sm. High levels of ΣREE in food samples were observed in Midland, while low levels were found in the Northeast. Cereals was the dominant contributor to the estimated daily intake of REEs. The health risk of REEs by daily food consumption in China was acceptable.

What Peace Means for Deforestation: An Analysis of Local Deforestation Dynamics in Times of Conflict and Peace in Colombia

Using Colombia as a case study, this analysis provides insights on deforestation dynamics in times of conflict and peace and the different factors driving these dynamics. We performed time series clustering of yearly deforestation data (2001–2018) from 708 out of 1,122 mainland Colombian municipalities (accounting for 98% of the total deforestation areas in Colombia) and produced regression models using a gradient tree boosting framework (XGBoost) to identify drivers that explain varying, local-level deforestation dynamics. Municipalities were characterized by seven categories of deforestation dynamics, with the Amazon region being largely represented by only four categories and the Andes region displaying all categories of deforestation dynamics. Notably, six of the seven representative categories exhibit substantial increases in deforestation in the years following the peace agreement. The regression analysis revealed that coca cultivation area, number of cattle, and municipality area are the top three drivers of deforestation dynamics at national, regional, and category levels. However, the importance of the different variables varied according to the different spatial dimensions. Results provide further understanding on how the drivers of deforestation change not only at a regional scale, as assumed by much of the current literature about drivers of deforestation, but also at a lower scale of analysis (intraregional and intradepartmental variation in the case of Colombia). Insights from this study can be used to understand deforestation dynamics in other countries experiencing times of conflict and peace and will support decision-makers in creating programs that align actions for peacebuilding, climate change mitigation, and biodiversity conservation more effectively.

Oncologic Drugs Approval in Europe for Solid Tumors: Overview of the Last 6 Years.

Simple SummaryWe present a systematic overview of EMA-approved oncologic drugs, both as new or extensions of indications, over 6 years, from 2015 to 2020. Our analysis confirms a long-standing trend in drug development for which most of the efforts led to broadening indications of pre-existing molecules, with immunotherapy and signal transduction inhibitors contending the leadership. Many drugs with the same or a very similar mechanism of action are approved for the same indication without a direct head-to-head comparison. Moreover, we show that the majority of drugs entered the market without evidence of overall survival or quality of life benefit but based on surrogate outcomes. Our data support some considerations about the modern drug development in oncology, where the goal is to provide the patients with the fastest possible access to new drugs. The debate on the optimal methodology to develop new drugs remains an unmet need.(1) Background: Drug development in oncology is changing rapidly. The aim of the present study was to provide an insight into the features of anti-tumor drugs approved in Europe; (2) Methods: We included all the indications for solid tumors issued by the European Medicines Agency (EMA) between 2015 and 2020. We extracted data from European Public Assessments Reports (EPAR), including drug name, mechanism of action, setting, features of pivotal clinical trials, primary end-points, quality of life (QoL); (3) Results: In the explored period, EMA issued 132 new indications (81 indications’ extensions) for 62 oncology drugs. In about half of indications (47%), the approval was biomarker-based. Immune check point inhibitors (ICIs) and signal transduction inhibitors were the two most representative drug categories (62%). Most of the indications were for the advanced setting (91%) and front-line therapy (66%). The most common tumor types were non-small cell lung cancer (24%), breast (16%), and melanoma (10%). Two thirds of the indications (73%) were approved based on phase III trials. Overall survival (OS) represented the primary end-point only in 39% of indications, mainly limited to advanced setting (98%) and ICI trials (80%). Almost all (94%) cell cycle and DNA repair mechanism inhibitors were approved based on progression free survival (PFS) data. In pivotal trials with signal transduction inhibitors, objective response rate (ORR) was the prevalent (45%) primary end-point. QoL was never considered as primary end-point; (4) Conclusions: In this analysis, we intended to offer an updated picture of the recent drug development in oncology. Most of the efforts led to broadening indications of pre-existing molecules, with signal transduction inhibitor and ICIs contending the leadership. Twenty-seven percent of the indication were approved without a phase III trial. The majority of drugs entered the market without evidence of OS or QoL benefit but based on surrogate outcomes.

Getting Insights into Structural and Energetic Properties of Reciprocal Peptide-Protein Interactions.

Peptide-protein interactions play a key role for many cellular and metabolic processes involved in the onset of largely spread diseases such as cancer and neurodegenerative pathologies. Despite the progress in the structural characterization of peptide-protein interfaces, the in-depth knowledge of the molecular details behind their interactions is still a daunting task. Here, we present the first comprehensive in silico morphological and energetic study of peptide binding sites by focusing on both peptide and protein standpoints. Starting from the PixelDB database, a nonredundant benchmark collection of high-quality 3D crystallographic structures of peptide-protein complexes, a classification analysis of the most representative categories based on the nature of each cocrystallized peptide has been carried out. Several interpretable geometrical and energetic descriptors have been computed both from peptide and target protein sides in the attempt to unveil physicochemical and structural causative correlations. Finally, we investigated the most frequent peptide-protein residue pairs at the binding interface and made extensive energetic analyses, based on GRID MIFs, with the aim to study the peptide affinity-enhancing interactions to be further exploited in rational drug design strategies.

Kansei evaluation on shape design and color of PET bottle

In this study, we propose an evaluation method based on Kansei Engineering to clarify the main factors that affect the impression of the shape and label design of PET bottles. Focusing only on PET bottles of natural water, we classified them by clustering method using physical shape and label design features, evaluated them by Kansei engineering method, determined design parameters by Preference Set-Based Design (PSD) analysis, and clarified the main factors of impression. First, PET bottle samples were prepared, and cluster analysis was conducted to classify them into representative categories. These samples were subjected to online and offline sensory evaluation by various subjects, and the impressions of the PET bottles were clarified from the sensory evaluation. In order to eliminate the bias of the subjects, cluster analysis is conducted to classify them into representative categories with similar preferences for PET bottles. Finally, PSD analysis is conducted to identify the main factors that influence the impression of the bottle shape and label design.

Assessing Sample Number Requirements for Municipal Solid Waste Composition Studies

Solid waste decision makers use waste composition studies in sustainability planning and as metrics to measure their environmental benefits (e.g., recycling rates). In many of these studies, there are varying waste components and number of samples assessed. Often, studies will rarely determine whether the number of samples sorted was actually sufficient to be statistically representative. We collected 24 US studies and assessed whether their material categories were statistically representative at a 90% confidence level and 10% precision following current standards. For each study and each material category, we calculated the number of samples required to be representative and compared it with the number of samples conducted by the study. Of the 24 studies, 17 had one to seven representative material categories, where 12 had one or two representative materials out of the average 44 original materials assessed per study. Nonrigid plastic film and food waste were most frequently statistically representative. Each study's original category list was condensed into 12 categories, and the analysis was repeated. Two studies that originally had no categories representative now had at least one. With the condensed materials, the mixed paper, mixed plastic, and food categories were most representative. The findings can be used by decision makers to gain a more comprehensive understanding of the importance of data quality analysis since most materials were not statistically representative; two approaches to being more representative are to sort more samples or condense the material list.

Systematic analysis of the pharmacological function of Schisandra as a potential exercise supplement.

[Purpose] Exercise can prevent conditions such as atrophy and degenerative brain diseases. However, owing to individual differences in athletic ability, exercise supplements can be used to improve a person’s exercise capacity. Schisandra chinensis (SC) is a natural product with various physiologically active effects. In this study, we analyzed SC using a pharmacological network and determined whether it could be used as an exercise supplement.[Methods] The active compounds of SC and target genes were identified using the Traditional Chinese Medicine Database and Analysis Platform (TCMSP). The active compound and target genes were selected based on pharmacokinetic (PK) conditions (oral bioavailability (OB) ≥ 30%, Caco-2 permeability (Caco-2) ≥ -0.4, and drug-likeness (DL) ≥ 0.18). Gene ontology (GO) was analyzed using the Cytoscape software.[Results] Eight active compounds were identified according to the PK conditions. Twenty-one target genes were identified after excluding duplicates in the eight active compounds. The top 10 GOs were analyzed using GO-biological process analysis. GO was subsequently divided into three representative categories: postsynaptic neurotransmitter receptor activity (53.85%), an intracellular steroid hormone receptor signaling pathway (36.46%), and endopeptidase activity (10%). SC is related to immune function.[Conclusion] According to the GO analysis, SC plays a role in immunity and inflammation, promotes liver metabolism, improves fatigue, and regulates the function of steroid receptors. Therefore, we suggest SC as an exercise supplement with nutritional and anti-fatigue benefits.

Efficient reductive and oxidative decomposition of haloacetic acids by the vacuum-ultraviolet/sulfite system

Haloacetic acids (HAAs), as a representative category of halogenated disinfection byproducts, are widely detected in disinfected water. In this work, the vacuum ultraviolet (VUV)/sulfite process under N2 saturated conditions was proposed to eliminate a series of HAAs (i.e., monochloroacetic acid (MCAA), difluoroacetic acid (DFAA), trifluoroacetic acid (TFAA), dichloroacetic acid (DCAA), etc.). The in situ generated hydrated electron (eaq−) demonstrated to be the main species to fulfill the initial degradation and dechlorination of MCAA, while hydroxyl radicals (˙OH) were in charge of the mineralization of MCAA. This means that the VUV/sulfite system is a combination of advanced reduction and oxidation processes (ARPs and AOPs). A significant enhancement of MCAA removal was observed with increasing pH values from 6.0 to 10.0, and surprisingly, kobs correlated well with the proportion of SO32- as the pH changed. This can be explained by the production of eaq− from VUV irradiation of SO32− rather than HSO3− and also due to eaq− being more stable under alkaline conditions. Increasing the sulfite dosage also elevated the degradation of MCAA. However, the addition of certain anions (i.e., chloride (Cl−), bicarbonate (HCO3−), and nitrate (NO3−)) and dissolved organic matter (DOM) inhibited the removal of MCAA to varying degrees. The VUV/sulfite system was effective toward various types of halogenated disinfection byproducts, supporting its broad applicability. Nevertheless, even in real waters, the VUV/sulfite system was also promising for the simultaneous abatement of HAAs and other oxyanions.

Content comparison of neck pain outcome measures using the international classification of functioning, disability and health.

The purpose of this study was to compare the content covered by existing neck pain measures based on the linkage to the International Classification of Functioning, Disability and Health (ICF) framework to examine the extent to which the existing measures represent ICF categories and to identify content gaps in existing measures that would inform further research. Ten commonly used measures were identified, and their content was linked to ICF categories using established coding systems. Two clinical experts reviewed every measure independently and identified the central meaningful concepts from individual items of each measure. A total of 177 concepts were identified from 193 items across 10 measures. Body functions were the most represented category across measures (23-64%). The representation of activities ranged from 14 to 61% whereas the representation of participation ranged from 6 to 31% across measures. The ProFitMap-Neck was the only measure that addressed the environmental factors. The ProFit-Map neck captured a majority of concepts from body structures and function and the neck outcome score captured maximum concepts from the activities and participation categories. A combination of ProFit-Map neck and Neck Outcome Score can be used with caution to obtain a more comprehensive assessment of the impact of neck pain on function, activities and participation.

Bringing innovation back in–strategies and driving forces behind entrepreneurial responses in small-scale rural industries in Sweden

PurposeThe paper contributes to the debate about local food and conceptualization of rural entrepreneurship by analysing the performance of small-scale dairies departing from their relation to innovations, innovative activities and risk.Design/methodology/approachThe authors use phenomenography to identify representative categories, and to draw conclusions about how these are consistent or different from dominant definitions of rural entrepreneurship and self-employment. The authors conducted semi-structured interviews, participatory workshops and compiled a database of all small-scale dairies established between 1968 and 2020.FindingsA focus on innovations contributes to differentiate between rural entrepreneurship and self-employment and how these interact in the process of economic growth. Innovations are seldom disruptive. Instead, innovative behaviour is strongly related to business models and to imitation. Social capital and collective action play a key role for the innovative capacity of small businesses, especially to realize disruptive innovations, such as the establishment of a new market.Research limitations/implicationsThe innovative capacity of rural businesses can be understood through their ability to break patterns, alter institutions and turn embededdness into assets. Rural entrepreneurship and self-employment are intertwined in the economic growth process.Practical implicationsInnovative behaviour is a significant aspect for firm survival over time, and it is also strongly related to new business models. Most rural firms can be characterized as self-employment, the latter are essential because they provide rural livelihoods and help bring maturity to newly established markets.Social implicationsThe right type of support, e.g. adopting enabling industrial regulations and granting access to constructive experiences of others, contributes to the innovative behaviour of small-scale rural firms.Originality/valueThis study differentiates rural entrepreneurship from rural self-employment by analysing the role of innovation. The authors show how innovations and innovative behaviour work their way through the process of economic growth and how innovation can break patterns by turning rural embeddedness into assets; and how innovative behaviour related to self-employments contributes to the creation of value and interacts with entrepreneurship in the process of economic growth.

Ethics appraisal procedure in 79,670 Marie Skłodowska-Curie proposals from the entire European HORIZON 2020 research and innovation program (2014-2020): A retrospective analysis.

Horizon 2020 was the most significant EU Research and Innovation programme ever implemented and included the Marie Skłodowska-Curie Actions (MSCA). Proposals submitted to the MSCA actions awere subject to the Ethics Appraisal Procedure. In this work we explored the ethics appraisal procedure in MSCA H2020. Using a retrospective analysis of pooled anonymized data, we explored the ethics appraisal procedure on proposals submitted to Marie Skłodowska-Curie Actions (MSCA) during the entire Horizon 2020 program period (N = 79,670). Our results showed that one of the most frequently identified ethics categories was Data protection. We also detected slight differences between applicants' and the ethics reviewers' awareness of ethical issues. Trajectory analysis of all ethics screened proposals appearing on main lists showed that a minimal portion of all screened submissions required additional ethics checks in the project implementation phase. Personal data protection is one of the most represented ethics categories indicated among MSCA actions which exhaust ethics assessment efforts and may lead to "overkills" in ethics requirements. Excluding the majority of personal data protection assessment from the ethics assessment, except for parts which are directly related to ethics like "Informed consent procedures", might be necessary in the future. A gap in understanding of ethics issues between applicants and reviewers' points to the necessity to further educate researchers on research ethics issues.

US Migration Policy Towards the States of the North American Continent

The article aims at characterizing the content, problems, and consequences of the US interaction with the countries of the North American continent in the sphere of migration. The objective is to identify the main directions and assess the prospects for the overdue reform of the US regional migration policy. The author examines migration policy in the framework of NAFTA-USMCA and multi-vector initiatives aimed at managing movements within the region.The results show that migration on the continent, primarily from Mexico and Central America to the United States, is characterized by a high level of regionalization. Due to massive spontaneous flows of migrants who lack the required documents for entering, staying, and working in the country of destination, including asylum seekers, the region's countries face serious challenges aggravated by the pandemic. The US cooperates in various forms and directions with the region's countries in the sphere of migration. It includes limited liberalization of specific categories of specialists and business representatives from the three member-states of the NAFTA-USMCA. Nevertheless, such interaction focuses on curbing the inflow of migrants without documents to the United States, which makes these relations asymmetric along the center-periphery axis. Such a policy is inconsistent and leads to acute humanitarian crises on the borders of the region's states. The administration of Joe Biden faces difficulties in reforming migration policy during the pandemic and growing public concern. The issue urges regional cooperation on a fairer and more equitable basis; otherwise, it is impossible to advance towards the promotion of legal migration.

An Improved Bibliometric Analysis on Antibiotics in Soil Research.

Antibiotic compounds can enter the environment and eventually into drinking water, when manure containing non-metabolized antibiotic residues is applied to agricultural land. In this study, the publication data was analyzed from the aspects of countries, subject categories and keywords during the period of 1946-2016 from Web of Science. The results indicated that, during the period of 2004-2016, the United States, followed by China, dominated the publication of antibiotics in soil. Three most representative subject categories were "Microbiology", "Environmental science and ecology" and "Chemistry". The most studied antibiotic was tetracycline. Antibiotic resistance bacteria (ARB) and antibiotic resistance genes (ARGs) with the fate and transport mechanisms such as degradation, adsorption and desorption were the hot research topics in this field. This study suggests that research on ARB, ARGs and antibiotics in soil should be paid more attention in the future research.

L’asthme professionnel et l’asthme aggravé par le travail. Quelles différences en termes de facteurs de risque et d’aptitude au travail ?

IntroductionAllergic asthma is currently the most frequent respiratory pathology in the workplace. Whether induced or aggravated by the work environment, the adequacy between this morbid state and work is often subject to re-evaluation. Aim to studyThe socio-professional, clinical, para-clinical and medico-legal characteristics of allergic asthma observed in the workplace, to assess their impact on the ability to work and to compare occupational asthma (OA) and work exacerbated asthma (WEA) in terms of associated professional and extra-professional factors and in terms of repercussions on aptitude. MethodsExhaustive retrospective descriptive study of all work-related allergic asthma files (OA and WEA), collected from the Department of Occupational Medicine and Occupational Pathologies of the University Hospital La Rabta in Tunis during the period from 1 January 2000 to December 31, 2020. ResultsThis is a series of 232 cases of work-related allergic asthma, including 76.7% OA and 23.3% WEA. The mean age of the patients was 40.28±8.96 years. The female gender was represented in 50.9% of cases. A personal history of atopy was reported by 16.5% of patients. The most represented professional category was that of unskilled workers (57.1%) with an average seniority of 11.43±7.96 years. The sectors that provided the most asthma were the textile sector (10%) and the health sector (10.9%). The clinical symptoms were dominated by paroxysmal wheezing dyspnea (51.5%), punctuated by work. in the majority (86.6%). The responsible agents were high molecular weight allergens (HMW) in particular vegetable textile dust (9.9%), low molecular weight (LMW) such as isocyanate (11.6%), formaldehyde (11.2%) as well as respiratory irritants, mainly mold (7.8%) and non-specific dust (3.9%). Asthma justified a workstation adaptation in 47.8% of cases and a mutation in 40.9% of patients.Comparing the cases of work-induced asthma with those that were exacerbated, we found that age and length of service were higher in the OA group, (P=0.002) and (P=0.005). In addition, this group was also associated with the grade of unskilled worker (P=0.035), exposure to HMW allergens (P=0.008), as well as the prescription for a job transfer (P≤10-3). In addition, WEA was associated with a history of personal and family atopy with respectively (P≤10–3) and (P=0.017), work in the transport sector (P≤10-3) as well as prescription temporary unfitness for the post (P≤10–3). ConclusionThe etiologies of OA and WEA differ. Indeed, the etiologies of WEA are essentially respiratory irritants while in the OA are HMW allergens. In terms of aptitude, the impact on OA is more pejorative than WEA involving more mutation.

Neuropathic Pain and Ultrasonography: A Multiperspective Literature Evaluation

Among the tools useful for the management of neuropathic pain, ultrasound presents several advantages, shown by the literature. We assessed the scientific production about neuropathic pain and ultrasound from different points of view: general topics, journal categories, geographical origin and lexical analysis. We searched papers on PubMed using the Medical Subject Headings “neuropathic pain” AND “ultrasound”. We collected data about the journals where the papers were published, the country of the affiliation of the first author. For the lexical analysis, we evaluated the presence of selected words in the papers, and we built a graph representing the connections among words and papers. The papers were focused on the use of ultrasound as a diagnostic tool and guide for the therapy, assessing its application in different diseases such as Morton’s neuroma and piriformis syndrome. The most represented journal category was anesthesia while the most common country the United States of America. The lexical analysis confirmed the importance of ultrasound for diagnosis of specific disease and treatment of pain. The described approaches provide a multiperspective evaluation of the literature and may support the interpretation of the information contained by the papers.

Applying Bayesian forecasting to predictive toxicology: The probability of innate carcinogenicity to humans of colorants synthesized from benzidine

The preclinical identification of health hazards relies on the performance (the historic concordance to the respective gold standard) of regulatorily recommended bioassays. However, any testing with less than 100% sensitivity (or 100% specificity) can deliver false results (outcomes discordant to the respective gold standard). Conversely, the predictive values approach (a.k.a. Bayesian forecasting) weighs (1) the performance of the predictive bioassay (battery, or framework) with (2) the prevalence of -positivity to the respective gold standard- in the most representative category to which the test substance can be allocated. Thus, the predictive values approach (PVA) provides the numeric probability for the toxicity to humans of chemicals that, circumstantially, are evaluable only through nonclinical data. Consequently, the PVA improves the predictivity of nonclinical toxicology, and increases the impact of hazard identifications entirely based on preclinical data. This article aimed to introduce the PVA through a worked example. Due to their toxicological homogeneity and public health relevance, the superfamily of colorants synthesized from benzidine (BZ) or some mutagenic congeners was selected (colorings hereafter mentioned as BZ-related-colorants). Through the PVA, the numeric probability of innate carcinogenicity to humans of 259 BZ-related-colorants was either estimated from rodent carcinogenesis bioassays (RCBs) or predicted from methods alternative to the RCB. A discussion was provided on (1) some limitations and implications of the PVA, and (2) the probable significance of the predictive values figured here for 259 BZ-related-colorings.

P–733 In infertile patients, risk factors for environmental reprotoxic exposure are widespread, limited in number and modifiable

Abstract Study question What are the risk factors for environmental reprotoxic exposure in infertile patients? Summary answer The most represented categories of reprotoxic risk factors (RRF) were dietary exposures (86% of patients), overweight (46%), psychoactive substances (38%) and male occupational exposures (63%). What is known already Numerous studies have reported the deleterious effects of environmental reprotoxic exposures on male or female fertility. These studies most often focus on the impact of a limited number of reprotoxic risk factors (body mass index (BMI), dietary habits, tobacco or alcohol consumption) or a limited number of chemical or physical reprotoxic exposures: phthalates, occupational exposures, or pesticides. Despite the call of several reproductive health professional societies and public health agencies for taking environmental health into account in women of childbearing age, this approach remains little realized in current practice. Study design, size, duration We conducted a prospective, monocentric study between June 2018 and February 2020 in women and men visiting the fertility unit of our University Hospital for assisted reproduction technique (ART) treatment. Participants/materials, setting, methods Patients completed a self-questionnaire to collect information about i) the various types of exposure to RRF, and ii) frequency and intensity of exposures (qualitative and semi-quantitative approach). We performed a literature search in order to define the environmental factors and the exposure level thresholds associated with a “recognized” or “suspected” RRF and we analyzed their nature and number in patients. Main results and the role of chance During the inclusion period, we received 545 couples in consultation, and 405 were included in this study (810 patients/1090, participation rate: 74%). 65% of women and 68% of men self-reported at least one “recognized” RRF. In men, they were from exposure to solvents, heat, psychoactive substances and a BMI>25; in women, from exposure to poor indoor air quality, psychoactive substances and a BMI>25. A limited number of recognized risk factors were recorded in the majority of patients (one, two or three risk factors in 65% of patients). Men were more often exposed than women to occupational risk factors (63% of men versus 28% of women) such as solvents and ambient heat, and women were more often exposed than men to poor indoor air quality and volatile organic compounds (49% of women versus 30% of men). We note that the majority of the risk factors for reprotoxic exposure found were modifiable, specifically dietary, occupational, overweight and psychoactive substance exposures. Limitations, reasons for caution One limitation is the collection of data via a self-administered questionnaire, which makes it possible to estimate the risk factors for reprotoxic exposure, but not to detect them in a measurable way, for example, through exposure biomarkers. In addition, no data is available about all RRF in the general population. Wider implications of the findings: We suggest that if the individual screening of each infertile patient’s RRF was done before ART, most patients could act on a limited number of modifiable RRF, in the aim of increasing their chances of natural pregnancy and improving ART outcomes. Trial registration number N° 2018–13–06–004 (Ethics Committee of the University of Aix Marseille) and N° 2020–27 (Assistance Publique - Hôpitaux de Marseille General Regulation on Data Protection).

Early Joint Replacement in Juvenile Idiopathic Arthritis: Trend Over Time and Factors Influencing Implant Survival.

To describe early prosthesis implantations in a cohort of patients with juvenile idiopathic arthritis (JIA) followed in a tertiary referral hospital and to analyze possible factors influencing implant survival. This was a retrospective cohort study. Charts of all patients with JIA who underwent total joint replacement at Gaetano Pini Hospital, Milan, Italy from January 1992 to June 2019 were retrieved, and relevant data were analyzed. Eighty-five patients met the inclusion criteria for this study, with a median follow-up period of 17.2 years. The median age at first prosthesis was 22.7 years. The total number of replaced joints was 198 over a period of 27 years. The hip was the most frequently replaced joint, accounting for almost two-thirds of the total number of implants; the other one-third refers mostly to knee implants. Polyarticular JIA and systemic JIA were the most represented JIA categories in the study cohort. A significant upward trend of the age at arthroplasty and of disease duration before arthroplasty over decades was found. The rates of implant survival at 5, 10, and 15 years were comparable (from 84% to 89%); 50% of implants lasted ≥20 years. We reported retrospective data on early joint replacement in a cohort of patients with JIA. We observed a progressive and significant upward trend of both age at arthroplasty and disease duration before the first arthroplasty over time. The JIA category, year of implant, and presence of complications significantly affected implant survivorship.