This article addresses the social stigma associated with tuberculosis (TB) and its influence on patients, their families, and communities, impacting the prevention, diagnosis, and treatment of the disease. It highlights the historical origins of stigma, stemming from a lack of understanding about the transmission and causes of the disease, associated with unfavorable socioeconomic conditions and representations in popular culture. Stigma manifests in various ways, including social isolation, discrimination, negative stereotypes, and delays in diagnosis and treatment. These manifestations have profound impacts on the quality of life and physical and emotional health of patients. To combat stigma, comprehensive strategies are proposed, such as public education, promotion of empathy, community engagement, universal access to healthcare, and psychosocial support. These approaches aim to challenge misconceptions, reduce social isolation, strengthen emotional support, and promote a more compassionate understanding of the disease. The article highlights the importance of treatment adherence and emotional support for patients, emphasizing that support from healthcare professionals, family, and the community is crucial in addressing treatment challenges and promoting better long-term health outcomes. It is concluded that mitigating tuberculosis stigma requires collective and ongoing effort, with an integrated, patient-centered approach. By promoting empathy, understanding, and support, it is possible to create a more inclusive and supportive environment, advancing towards a society where health and well-being are accessible to all.