The sustainability and economic viability of the microalgae-based processes and products remain questionable by requiring high fossil energy demands. Therefore, herein, we seek to evaluate from an environmental and economic point of view the integration potential of green electricity into microalgae production facilities. Ten geographic positions with commercial microalgae cultivation plants were investigated as to the potential to generate photovoltaic solar and onshore wind energy and as to the economic feasibility of the implementation of these systems. The results reveal that for the production of 1 ton/month of whole dried biomass, pigments, and polyunsaturated fatty acids, the greatest impact, with the exception of the land use category, was for fossil energy consumption. In this line, replacing fossil energy with onshore wind and photovoltaic solar energy, these impacts were reduced in the order of 20–100% and 9–87%, respectively. The investment return period for the renewable energy systems was found to be within a range of 0.85–4.86 years. The solar and wind potential, and the investment return period are highly dependent on geospatial location. The results of this study demonstrate that the implementation of a renewable energy system can supply part of the plant's energy demand, reducing electricity costs, and its environmental footprints.