Repeated Stimulus Presentations Research Articles

Repetitive Stimulation Enhances V1 Encoding Efficiency

Repeated stimulus presentations reduce neuronal responses across many brain areas (repetition suppression) while improving performance in associated tasks (repetition priming). The neuronal mechanisms that enhance performance in the face of reduced brain activity are unknown. Here we demonstrate that stimulus repetition increases encoding efficiency among cortical neurons, which enhances stimulus representations despite reduced spiking activity. Using a repetition priming-evoking stimulus sequence, we recorded laminar responses in monkey primary visual cortex (V1). We found that repetition suppression is most pronounced outside the V1 layers that receive retinogeniculate input and is robust to alternating stimuli between the two eyes, suggesting that repetition suppression is of cortical origin. This V1 spiking suppression is accompanied by sharpened neural tuning as well as increased neuronal synchrony, however not by decreased response latency. These results suggest that repetition priming and repetition suppression arise from modulated cortical neuronal processing that enhances encoding efficiency as stimuli repeat.

Evidence for spatiotemporally distinct effects of image repetition and perceptual expectations as measured by event-related potentials

Repeated stimulus presentation leads to reductions in responses of cortical neurons, known as repetition suppression or stimulus-specific adaptation. Circuit-based models of repetition suppression provide a framework for investigating patterns of repetition effects that propagate through cortical hierarchies. To further develop such models it is critical to determine whether (and if so, when) repetition effects are modulated by factors such as expectation and attention. We investigated whether repetition effects are influenced by perceptual expectations, and whether the time courses of each effect are similar or distinct, by presenting pairs of repeated and alternating face images and orthogonally manipulating expectations regarding the likelihood of stimulus repetition. Event-related potentials (ERPs) were recorded from n = 39 healthy adults, to map the spatiotemporal progression of stimulus repetition and stimulus expectation effects, and interactions between these, using mass univariate analyses. We also tested for another expectation effect that may contribute to repetition effects in many previous experiments: that repeated stimulus identities are predictable after seeing the first stimulus in a trial, but unrepeated stimulus identities cannot be predicted. Separate blocks were presented with predictable and unpredictable alternating face identities. Multiple repetition and expectation effects were identified between 99 and 800ms from stimulus onset, which did not statistically interact at any point and exhibited distinct spatiotemporal patterns of effects. Repetition effects in blocks with predictable alternating faces were smaller than in unpredictable alternating face blocks between 117-179 ms and 506–652ms, and larger between 246 and 428ms. The distinct spatiotemporal patterns of repetition and expectation effects support separable mechanisms underlying these phenomena. However, previous studies of repetition effects, in which the repeated (but not unrepeated) stimulus was predictable, are likely to have conflated repetition and stimulus predictability effects.

Habituation and conditioning: Salience change in associative learning.

Repeated presentation of a single stimulus produces habituation-engages a learning process that results in a reduction of the ability of the stimulus to evoke its customary response. Repeated stimulus presentation is a feature of the standard procedure for classical conditioning, although, in this case, subjects experience repeated presentations of 2 stimuli occurring in sequence: S1-S2. We ask how habituation to each of these stimuli (S1 and S2) is influenced by this form of sequential presentation and what implications any effects might have for the understanding of both conditioning and habituation itself. Our review of the experimental evidence demonstrates no clear effect on habituation to S2 of preceding this stimulus with S1. Habituation to S1, however, is attenuated or prevented by the occurrence of S2: Some orienting responses are maintained when S2 follows S1 inconsistently; other responses (habituation of which may be taken to indicate a reduction in the effective salience of the stimulus) are maintained when a salient S2 reliably follows S1. We discuss the implications of these changes in the properties of S1 for associative theories of conditioning and, in particular, for the proposal that the rules that govern changes in the associability of a stimulus differ from those governing changes in its effective salience. (PsycINFO Database Record

Novel response patterns during repeated presentation of affective and neutral stimuli.

Repeated stimulus presentations are commonly used in social and affective neuroimaging tasks, but much remains to be known about how the brain processes such repetitions. Using functional magnetic resonance imaging, we found three groups of brain regions with distinct response patterns during repeated presentations of natural scene images. One group consisted of several limbic, paralimbic, frontoparietal and medial prefrontal areas and showed a habituation-like response across pleasant, unpleasant, and neutral image categories. A second group of occipital and adjacent posterior cortical regions showed a pattern of diminishing responses with repeated presentations of affective images but not for neutral images, and also plateaued to activation levels above baseline for all image categories. A third group involved bilateral frontopolar areas and the precuneus and exhibited a novel, non-monotonic response pattern. Activity was low on the first presentation, peaked upon the second presentation (first repetition) and subsequently diminished. These findings indicate that the transition from novel to increasingly familiar, and also arousing to less arousing, involves a broad array of neural mechanisms alluding to both passive learning and active inference strategies.

Reduced habituation of auditory evoked potentials indicate cortical hyper-excitability in Fragile X Syndrome.

Sensory hypersensitivities are common, clinically distressing features of Fragile X Syndrome (FXS). Preclinical evidence suggests this abnormality may result from synaptic hyper-excitability in sensory systems. This model predicts reduced sensory habituation to repeated stimulus presentation. Fourteen adolescents and adults with FXS and 15 age-matched controls participated in a modified auditory gating task using trains of 4 identical tones during dense array electroencephalography (EEG). Event-related potential and single trial time–frequency analyses revealed decreased habituation of the N1 event-related potential response in FXS, and increased gamma power coupled with decreases in gamma phase-locking during the early-stimulus registration period. EEG abnormalities in FXS were associated with parent reports of heightened sensory sensitivities and social communication deficits. Reduced habituation and altered gamma power and phase-locking to auditory cues demonstrated here in FXS patients parallels preclinical findings with Fmr1 KO mice. Thus, the EEG abnormalities seen in FXS patients support the model of neocortical hyper-excitability in FXS, and may provide useful translational biomarkers for evaluating novel treatment strategies targeting its neural substrate.

Prenatal and acute cocaine exposure affects neural responses and habituation to visual stimuli.

Psychostimulants have many effects on visual function, from adverse following acute and prenatal exposure to therapeutic on attention deficit. To determine the impact of prenatal and acute cocaine exposure on visual processing, we studied neuronal responses to visual stimuli in two brain regions of a transgenic larval zebrafish expressing the calcium indicator GCaMP-HS. We found that both red light (LF) and dark (DF) flashes elicited similar responses in the optic tectum neuropil (TOn), while the dorsal telencephalon (dTe) responded only to LF. Acute cocaine (0.5 μM) reduced neuronal responses to LF in both brain regions but did not affect responses to DF. Repeated stimulus presentation (RSP) led to habituation of dTe neurons to LF. Acute cocaine prevented habituation. TOn habituated to DF, but not LF, and DF habituation was not modified by cocaine. Remarkably, prenatal cocaine exposure (PCE) prevented the effects of acute cocaine on LF response amplitude and habituation later in development in both brain regions, but did not affect DF responses. We discovered that, in spite of similar neural responses to LF and DF in the TO (superior colliculus in mammals), responses to LF are more complex, involving dTe (homologous to the cerebral cortex), and are more vulnerable to cocaine. Our results demonstrate that acute cocaine exposure affects visual processing differentially by brain region, and that PCE modifies zebrafish visual processing in multiple structures in a stimulus-dependent manner. These findings are in accordance with the major role that the optic tectum and cerebral cortex play in sustaining visual attention, and support the hypothesis that modification of these areas by PCE may be responsible for visual deficits noted in humans. This model offers new methodological approaches for studying the adverse and therapeutic effects of psychostimulants on attention, and for the development of new pharmacological interventions.

Spontaneous prospective-memory processing: Unexpected fluency experiences trigger erroneous intention executions

Event-based prospective memory is the ability to remember to execute an intention when an environmental cue occurs. It has been argued that, due to their special meaning, these cues are discrepant from their environment and therefore are sometimes spontaneously noticed. In line with this assumption, the likelihood that an intention will be executed increases with increased cue-discrepancy. It is not yet clear, however, whether these improvements are due to facilitated spontaneous noticing rather than to an increase in the efficiency of controlled cue-processing. To further investigate the spontaneous nature of cue-discrepancy benefits, we presented participants with stimuli that were unrelated to the intention but discrepant from other stimuli. Therefore, we experimentally increased the processing fluency of some stimuli for participants currently holding an intention by using different priming procedures. We found that stimuli whose fluency was increased via spaced repeated stimulus presentation (Experiment 1) or via short pre-exposure (Experiment 2a to 3) elicited a tendency to fulfill the intention despite its actual inappropriateness. Findings were inconsistent as to whether cue-memory uncertainty fosters the reliance on cue discrepancy for intention retrieval (Experiments 2a and 3). Taken together, the present findings provide converging evidence for a spontaneous discrepancy-based prospective-memory process which works independent of controlled processes.

Cortical state determines global variability and correlations in visual cortex.

The response of neurons in sensory cortex to repeated stimulus presentations is highly variable. To investigate the nature of this variability, we compared the spike activity of neurons in the primary visual cortex (V1) of cats with that of their afferents from lateral geniculate nucleus (LGN), in response to similar stimuli. We found variability to be much higher in V1 than in LGN. To investigate the sources of the additional variability, we measured the spiking activity of large V1 populations and found that much of the variability was shared across neurons: the variable portion of the responses of one neuron could be well predicted from the summed activity of the rest of the neurons. Variability thus mostly reflected global fluctuations affecting all neurons. The size and prevalence of these fluctuations, both in responses to stimuli and in ongoing activity, depended on cortical state, being larger in synchronized states than in more desynchronized states. Contrary to previous reports, these fluctuations invested the overall population, regardless of preferred orientation. The global fluctuations substantially increased variability in single neurons and correlations among pairs of neurons. Once this effect was removed, pairwise correlations were reduced and were similar regardless of cortical state. These results highlight the importance of cortical state in controlling cortical operation and can help reconcile previous studies, which differed widely in their estimate of neuronal variability and pairwise correlations.

Genetic control of startle behavior in medaka fish.

Genetic polymorphisms are thought to generate intraspecific behavioral diversities, both within and among populations. The mechanisms underlying genetic control of behavioral properties, however, remain unclear in wild-type vertebrates, including humans. To explore this issue, we used diverse inbred strains of medaka fish (Oryzias latipes) established from the same and different local populations. Medaka exhibit a startle response to a visual stimulus (extinction of illumination) by rapidly bending their bodies (C-start) 20-ms after the stimulus presentation. We measured the rates of the response to repeated stimuli (1-s interval, 40 times) among four inbred strains, HNI-I, HNI-II, HO5, and Hd-rR-II1, and quantified two properties of the startle response: sensitivity (response rate to the first stimulus) and attenuation of the response probability with repeated stimulus presentation. Among the four strains, the greatest differences in these properties were detected between HNI-II and Hd-rR-II1. HNI-II exhibited high sensitivity (approximately 80%) and no attenuation, while Hd-rR-II1 exhibited low sensitivity (approximately 50%) and almost complete attenuation after only five stimulus presentations. Our findings suggested behavioral diversity of the startle response within a local population as well as among different populations. Linkage analysis with F2 progeny between HNI-II and Hd-rR-II1 detected quantitative trait loci (QTL) highly related to attenuation, but not to sensitivity, with a maximum logarithm of odds score of 11.82 on linkage group 16. The three genotypes (homozygous for HNI-II and Hd-rR-II1 alleles, and heterozygous) at the marker nearest the QTL correlated with attenuation. Our findings are the first to suggest that a single genomic region might be sufficient to generate individual differences in startle behavior between wild-type strains. Further identification of genetic polymorphisms that define the behavioral trait will contribute to our understanding of the neural mechanisms underlying behavioral diversity, allowing us to investigate the adaptive significance of intraspecific behavioral polymorphisms of the startle response.

The effects of incidentally learned temporal and spatial predictability on response times and visual fixations during target detection and discrimination.

Responses are quicker to predictable stimuli than if the time and place of appearance is uncertain. Studies that manipulate target predictability often involve overt cues to speed up response times. However, less is known about whether individuals will exhibit faster response times when target predictability is embedded within the inter-trial relationships. The current research examined the combined effects of spatial and temporal target predictability on reaction time (RT) and allocation of overt attention in a sustained attention task. Participants responded as quickly as possible to stimuli while their RT and eye movements were measured. Target temporal and spatial predictability were manipulated by altering the number of: 1) different time intervals between a response and the next target; and 2) possible spatial locations of the target. The effects of target predictability on target detection (Experiment 1) and target discrimination (Experiment 2) were tested. For both experiments, shorter RTs as target predictability increased across both space and time were found. In addition, the influences of spatial and temporal target predictability on RT and the overt allocation of attention were task dependent; suggesting that effective orienting of attention relies on both spatial and temporal predictability. These results indicate that stimulus predictability can be increased without overt cues and detected purely through inter-trial relationships over the course of repeated stimulus presentations.

Repetition suppression of face‐selective evoked and induced EEG recorded from human cortex

In functional MRI studies, repetition suppression refers to the reduction of hemodynamic activation to repeated stimulus presentation. For example, the repeated presentation of a face reduces the hemodynamic response evoked by faces in the fusiform gyrus. The neural events that underlie repetition suppression are not well understood. Indeed, in contrast to the hemodynamic response, the face-specific N200 recorded from subdural electrodes on the ventral occipitotemporal cortex, primarily along the fusiform gyrus, has been reported to be insensitive to face-identity repetition. We have previously described a face-specific broadband gamma (30-100 Hz) response at ventral face-specific N200 sites that is functionally dissociable from the N200. In this study, we investigate whether gamma and other components of the electroencephalogram spectrum are affected by face-identity repetition independently of the N200. Participants viewed sequentially presented identical faces. At sites on and around the fusiform gyrus, we found that face repetition modulated alpha (8-12 Hz), low-gamma (30-60 Hz), and high-gamma (60-100 Hz) synchrony, but not the N200. These findings provide evidence of a spatially co-localized progression of face processing. Whereas the N200 reflects an initial obligatory response that is less sensitive to face-identity repetition, the subsequent spectral fluctuations reflect more elaborative face processing and are thus sensitive to face novelty. It is notable that the observed modulations were different for different frequency bands. We observed repetition suppression of broadband gamma, but repetition enhancement of alpha synchrony. This difference is discussed with regard to an existing model of repetition suppression and behavioral repetition priming.

Impaired emotional contagion following severe traumatic brain injury

Empathy deficits are widely-documented in individuals after severe traumatic brain injury (TBI). This study examined the relationship between empathy deficits and psychophysiological responsivity in adults with TBI to determine if impaired responsivity is ameliorated through repeated emotional stimulus presentations. Nineteen TBI participants (13 males; 41years) and 25 control participants (14 males; 31years) viewed five repetitions of six 2-min film clip segments containing pleasant, unpleasant, and neutral content. Facial muscle responses (zygomaticus and corrugator), tonic heart rate (HR) and skin conductance level (SCL) were recorded. Mean responses for each viewing period were compared to a pre-experiment 2-min resting baseline period. Self-reported emotional empathy was also assessed. TBI participants demonstrated identical EMG response patterns to controls, i.e. an initial large facial response to both pleasant and unpleasant films, followed by habituation over repetitions for pleasant films, and sustained response to unpleasant films. Additionally, an increase in both arousal and HR deceleration to stimulus repetitions was found, which was larger for TBI participants. Compared to controls, TBI participants self-reported lower emotional empathy, and had lower resting arousal, and these measures were positively correlated. Results are consistent with TBI producing impairments in emotional empathy and responsivity. While some normalisation of physiological arousal appeared with repeated stimulus presentations, this came at the cost of greater attentional effort.

Temporal properties of shape processing by event-related MEG adaptation

Object recognition is a fundamental mechanism of visual processing and requires the extraction of shape information. Early visual areas have been linked to the analysis of local image features, while higher visual areas of the ventral visual pathway rather mediate the perception and recognition of global shapes. Investigations of the spatiotemporal characteristics of shape analysis in the human visual cortex by rapid event-related fMRI adaptation in combination with a region of interest analysis suggested a transient manner of contour integration and shape processing in early visual areas compared to sustained processing in higher visual areas. fMRI adaptation (or repetition suppression) paradigms offer the possibility to enhance the restricted spatial resolution of conventional fMRI by focusing on decreased responses for repeated stimulus presentation. However, improving our understanding of complex neuronal mechanisms in the human brain requires the investigation not only at high spatial but also temporal resolution. A limitation of fMRI adaptation can be found in its poor temporal resolution which EEG- and MEG-techniques can overcome, though at a lower spatial resolution. The present study aimed to investigate temporal characteristics of shape processing in the human brain by adapting the principles of fMRI adaption in a MEG study. In parallel to an earlier fMRI study, the two stimuli of a trial were presented at varied interstimulus intervals. Additional analyses by means of a dipole analysis and co-registration of MEG and fMRI data were conducted. Adaptation was observed for the short as well as the longer interstimulus interval. Interestingly, the latency of the adaptation effects varied with the interstimulus interval. The findings support a late onset of adaption that possibly underlies global discrimination processes and recognition in higher areas of the ventral visual pathway. Further, the present results indicate a useful extension of adaptation paradigms and 'region of interest'-analyses from fMRI to MEG at a high temporal resolution.

A Model of the Differential Representation of Signal Novelty in the Local Field Potentials and Spiking Activity of the Ventrolateral Prefrontal Cortex

Local field potentials (LFPs) and spiking activity reflect different types of information procssing. For example, neurophysiological studies indicate that signal novelty in the ventrolateral prefrontal cortex is differentially represented by LFPs and spiking activity: LFPs habituate to repeated stimulus presentations, whereas spiking activity does not. The neural mechanisms that allow for this differential representation between LFPs and spiking activity are not clear. Here, we model and simulate LFPs and spiking activity of neurons in the ventrolateral prefrontal cortex in order to elucidate potential mechanisms underlying this differential representation. We demonstrate that dynamic negative-feedback loops cause LFPs to habituate in response to repeated presentations of the same stimulus while spiking activity is maintained. This disassociation between LFPs and spiking activity may be a mechanism by which LFPs code stimulus novelty, whereas spiking activity carries abstract information, such as category membership and decision-related activity.

P300-based brain-computer interface: The effect of the stimulus position in a stimulus train

The most popular type of brain-computer interfaces (BCIs) are based on the detection of the P300 wave of the evoked potentials appearing in response to a stimulus chosen by the subject. In order to increase the speed of operation of these BCIs, it is possible to decrease the number of repeated stimulus presentations. It is associated with an increase in the relative importance of the response to the first stimulus in a train for correct recognition of the stimulus chosen. Event-related potentials (ERPs) in response to the first stimulus presentations are known to have their own specificity. Particularly, in many cases, the amplitude of the response to the first presentations is enhanced, which makes it very suitable for recognition in a BCI. However, this effect has not been studied to date. In this study, the ERPs recorded in healthy subjects in a standard BCI paradigm (n = 14) with ten presentations of stimuli or during triple-trial (n = 6) and single-trial (n = 6) presentations of stimuli in a modified BCI paradigm with moving objects have been analyzed. In both cases, first presentations of the target stimuli or single-trial presentation of the target stimulus were associated with higher amplitudes of ERPs. The opportunity to use specific differences between the responses to the first or single-trial presentations and the responses to later stimuli during their repeated presentations for improving high-speed operations in the P300-based BCI is discussed.

SVMT: A MATLAB toolbox for stereo-vision motion tracking of motor reactivity

This article presents a Matlab-based stereo-vision motion tracking system (SVMT) for the detection of human motor reactivity elicited by sensory stimulation. It is a low-cost, non-intrusive system supported by Graphical User Interface (GUI) software, and has been successfully tested and integrated in a broad array of physiological recording devices at the Human Physiology Laboratory in the University of Granada. The SVMT GUI software handles data in Matlab and ASCII formats. Internal functions perform lens distortion correction, camera geometry definition, feature matching, as well as data clustering and filtering to extract 3D motion paths of specific body areas. System validation showed geo-rectification errors below 0.5mm, while feature matching and motion paths extraction procedures were successfully validated with manual tracking and RMS errors were typically below 2% of the movement range. The application of the system in a psychophysiological experiment designed to elicit a startle motor response by the presentation of intense and unexpected acoustic stimuli, provided reliable data probing dynamical features of motor responses and habituation to repeated stimulus presentations. The stereo-geolocation and motion tracking performance of the SVMT system were successfully validated through comparisons with surface EMG measurements of eyeblink startle, which clearly demonstrate the ability of SVMT to track subtle body movement, such as those induced by the presentation of intense acoustic stimuli. Finally, SVMT provides an efficient solution for the assessment of motor reactivity not only in controlled laboratory settings, but also in more open, ecological environments.

Adaptation in phasic auditory units of the frog midbrain is sensitive to changes in stimulus frequency and ear of input

Event Abstract Back to Event Adaptation in phasic auditory units of the frog midbrain is sensitive to changes in stimulus frequency and ear of input Abhilash Ponnath1, Kim Hoke2 and Hamilton Farris1* 1 Louisiana St. University Health Sciences Center, Neuroscience, United States 2 Colorado State University, Biology, United States Neural adaptation, a reduction in response to a constant or maintained stimulus, is an important mechanism for detecting stimulus change. Contributing to stimulus change detection is the fact that neural adaptation is often stimulus specific: adaptation to a particular stimulus reduces excitability to only a subset of stimuli, while the ability to respond to other stimuli is unaffected. Phasic cells (e.g., responding to stimulus onset), with their fast adaptation, are considered good candidates for detecting the most rapid changes in natural auditory scenes, as they adapt quickly to the initial presentation of a stimulus and do not require adaptation buildup from many repeated stimulus presentations. Our study uses in vivo, single unit recordings to show that the fast and complete adaptation of phasic auditory units in the frog torus semicircularis is specific to stimulus frequency and ear of input. In response to an instantaneous frequency step in a 200 ms tone, 28% of cells exhibit frequency specific adaptation (FSA) based on relative frequency change (delta-f = +/-16%). FSA is not limited to frequency steps, however, as adaptation is also overcome during continuous frequency modulated stimuli. When temporal gaps in tones produce frequency transients, FSA cells outperform non-FSA cells in gap detection. When gaps in noise produce only temporal cues, however, gap detection is identical in the two cell classes. The results suggest that adaptation is separated for peripheral (e.g., frequency) channels, which we tested directly using dichotic stimuli. In 45% of binaural phasic units, adaptation was ear specific: adaptation to stimulation of one ear does not affect responses to stimulation of the other ear. Thus, adaptation exhibits specificity during processing of frequency and lateralization at the level of the midbrain. This mechanism could be employed to detect stimulus change within and between acoustic sources in rapidly changing complex acoustic environments. Acknowledgements KLH and HEF were supported in part by a Grass Faculty Fellowship at the Marine Biological Laboratory, Woods Hole, MA (2009). AP and HEF were supported by NIH grant P20RR016816 (to N. Bazan). Keywords: adaptation, auditory scene, chorus, critical band Conference: Tenth International Congress of Neuroethology, College Park. Maryland USA, United States, 5 Aug - 10 Aug, 2012. Presentation Type: Poster Presentation (see alternatives below as well) Topic: Sensory: Audition Citation: Ponnath A, Hoke K and Farris H (2012). Adaptation in phasic auditory units of the frog midbrain is sensitive to changes in stimulus frequency and ear of input. Conference Abstract: Tenth International Congress of Neuroethology. doi: 10.3389/conf.fnbeh.2012.27.00157 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Apr 2012; Published Online: 07 Jul 2012. * Correspondence: Dr. Hamilton Farris, Louisiana St. University Health Sciences Center, Neuroscience, New Orleans, Louisiana, 70112, United States, hfarri@lsuhsc.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Abhilash Ponnath Kim Hoke Hamilton Farris Google Abhilash Ponnath Kim Hoke Hamilton Farris Google Scholar Abhilash Ponnath Kim Hoke Hamilton Farris PubMed Abhilash Ponnath Kim Hoke Hamilton Farris Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

Time and time again: Temporal influences of repeated stimuli

Temporal perception does not always correspond to objective time. Several factors contribute to distort perceived timing of stimuli. This work investigates the effect of repeated stimulus presentation (either a sound or a light) on perceived timing of a subsequent audiovisual pair. At the beginning of each trial, a series of sounds or lights is presented with a constant interval. One final stimulus is presented either rhythmically or with a temporal shift. In a psychophysical task, participants judged whether the last stimulus in the sequence is presented before or after a temporal probe in the other modality. Results indicate two types of effects. First, the last stimulus of the sequence appears to be delayed with respect to the probe in the other modality. Second, deviations from regular rhythm tend to be perceptually compensated. Overall, perceived stimulus timing is shown to be affected by the temporal context, and the effect is consistent with a change in perceptual latency. The change depends on the modality of the repeated stimulus and can be explained as a combined effect of an temporal adaptation (i.e., slowing down perception) plus a temporal expectation acting on the slightly arrhythmic stimuli.

A doubly-stochastic model to analyze neuronal activity in the visual cortex

Event Abstract Back to Event A doubly-stochastic model to analyze neuronal activity in the visual cortex Robbe L. Goris1*, Eero P. Simoncelli1 and J. Anthony Movshon1 1 NYU, United States Sensory neurons encode information probabilistically: repeated stimulus presentations elicit variable firing. This variability is often described using a cascade model, in which spikes arise from a Poisson process whose rate is a deterministic function of the stimulus. However, it has recently been shown that time-dependent rate variability is a wide-spread phenomenon in cortex (Churchland et al 2010, 2011). Consequently, the Poisson noise model commonly underestimates the variability of visual cortical recordings, which can lead to systematic errors in inferring neuronal characteristics. We measured responses to a variety of stimuli in visual cortex in anesthetized monkeys. The fluctuations in neural responsiveness that typically occur over the timescale of these experiments are significantly greater than predicted by a Poisson model – estimated Fano factors as high as 10 occur in the acute preparation. We propose a doubly stochastic model, in which the stimulus-driven firing rate is modulated according to a stimulus-independent gamma-distributed random variable. This fluctuating rate generates spikes according to a Poisson process. Fitting the resulting mixture of Poisson processes to neural data reveals that the model is statistically superior for all neurons, and therefore provides an improved framework for analyzing neuronal tuning. The framework offers two further advantages over existing methods. First, it provides a natural means of estimating and tracking fluctuations in responsiveness (state changes) that occur during the course of an experiment. Second, it offers an efficient and accurate estimate of the upper bound on discrimination performance that can be supported by each neuron. Application of this new method can substantially improve the analysis of neuronal data, both in fitting explicit models and in assessing the limits of neuronal performance. References Churchland AK et al. Neuron 69: 818-831, 2011. Churchland MM et al. Nat Neurosci. 13: 369-378, 2010. Keywords: Neural coding, spike count distributions, Visual Cortex Conference: Bernstein Conference 2012, Munich, Germany, 12 Sep - 14 Sep, 2012. Presentation Type: Poster Topic: Data analysis, machine learning, neuroinformatics Citation: Goris RL, Simoncelli EP and Movshon J (2012). A doubly-stochastic model to analyze neuronal activity in the visual cortex. Front. Comput. Neurosci. Conference Abstract: Bernstein Conference 2012. doi: 10.3389/conf.fncom.2012.55.00222 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 11 May 2012; Published Online: 12 Sep 2012. * Correspondence: Dr. Robbe L Goris, NYU, New York City, United States, robbe.goris@nyu.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Robbe L Goris Eero P Simoncelli J. Anthony Movshon Google Robbe L Goris Eero P Simoncelli J. Anthony Movshon Google Scholar Robbe L Goris Eero P Simoncelli J. Anthony Movshon PubMed Robbe L Goris Eero P Simoncelli J. Anthony Movshon Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

Dyslexic adults can learn from repeated stimulus presentation but have difficulties in excluding external noise.

We examined whether the characteristic impairments of dyslexia are due to a deficit in excluding external noise or a deficit in taking advantage of repeated stimulus presentation. We compared non-impaired adults and adults with poor reading performance on a visual letter detection task that varied two aspects: the presence or absence of background visual noise, and a small or large stimulus set. There was no interaction between group and stimulus set size, indicating that the poor readers took advantage of repeated stimulus presentation as well as the non-impaired readers. The poor readers had higher thresholds than non-impaired readers in the presence of high external noise, but not in the absence of external noise. The results support the hypothesis that an external noise exclusion deficit, not a perceptual anchoring deficit, impairs reading for adults.