Repair Of Aortic Arch Aneurysm Research Articles

Endovascular Approaches to Complex Thoracic Aortic Disease

Diseases of the thoracic aorta remain among the most lethal and difficult to treat conditions. In 2005, the US Food and Drug Administration approved the first endoprosthesis for the treatment of aneurysms of the descending thoracic aorta; at present, there are 3 thoracic devices approved by the US Food and Drug Administration. Although approved only for the treatment of descending aneurysms, thoracic endografting has other potential off-label applications, including acute and chronic aortic dissection and traumatic aortic transection. Endovascular repair of thoracic aortic pathology is emerging as the preferred treatment strategy in certain patients, as increasing data suggest that endovascular repair may be performed with lower peri-operative morbidity and mortality rates and similar midterm survival, when compared with standard open repair. However, because of anatomic constraints related to required endograft seal zones, a significant number of patients are excluded from standard endovascular repair. Hybrid techniques, including open aortic arch and thoracoabdominal debranching procedures, have been described to allow creation of proximal and/or distal landing zones for the stent graft seal. This review describes the surgical and anesthetic considerations relevant to thoracic endografting, with an emphasis on hybrid procedures used to treat more complex thoracic aortic pathology. Hybrid techniques may be performed with lower rates of morbidity and mortality than conventional open repair, and they appear to be a safe alternative to open repair for thoracoabdominal and aortic arch aneurysms in properly selected patients with significant comorbidity or prior open aortic surgery.

The TachoSil-Pledget Stitch: Towards Eradication of Suture Hole Bleeding

We describe a novel suture consisting of a small piece of TachoSil (Nycomed, Copenhagen, Denmark) and a felt pledget-the TachoSil-pledget stitch-which was used to facilitate mechanical and biologic hemostasis in 5 patients undergoing aortic arch aneurysm repair. The TachoSil-pledget stitch achieved good or very good hemostasis at all 56 bleeding points to which it was applied, while 5 of 12 points to which a conventional felt-pledget stitch was applied required additional stitching or an additional hemostatic method.

Endovascular Repair of a Thoracic Arch Aneurysm With a Fenestrated Stent-Graft

To report a new endovascular technique for thoracic aortic arch aneurysm repair with a fenestrated stent-graft. A 75-year-old man presented with a 5.5-cm thoracic aneurysm involving the inner curve and left anterior lateral aspect of the aortic arch. The innominate and left carotid arteries shared a common trunk, and the right vertebral artery was dominant. Endovascular repair was performed utilizing a fenestrated stent-graft that allowed perfusion of the innominate and left carotid arteries but occluded the left subclavian artery. At 8 months post procedure, the patient is well; imaging documented the continued exclusion of the aneurysm and perfusion of the common trunk branches. Fenestrated endovascular grafts for specific thoracic aortic arch aneurysm can be used safely in the high-risk patient.

Endovascular Repair of an Aortic Arch Aneurysm using a Branched-Stent Graft

Introduction Aortic arch aneurysm repair continues to pose a formidable technical challenge in a patient population with significant co-morbidity. Report We present a successful endovascular repair of an 8.4 cm aortic arch aneurysm, in a 74 year old man, who's previous median sternotomy showed signs of delayed healing, precluding open repair. Discussion Applied endovascular techniques obviated the need for aortic clamping, cardiac bypass, or hypothermic circulatory arrest, via an approach that was potentially infected.

Surgical Repair of Left-Sided Cervical Aortic Arch Aneurysm: Case Report and Literature Review

Cervical aortic arch (CAA) is a rare vascular malformation which sometimes accompanies other cardiovascular malformations. Surgical approaches such as a lateral thoracotomy and a median sternotomy are selected depending on the position and type of aneurysm and other associated malformations. We herein report the case of a CAA patient who was a 38-year-old female and demonstrated an aneurysm between the left common carotid artery and left subclavian artery in addition to the persistence of the left superior vena cava (PLSVC). During surgery, the aortic arch from the distal right brachiocephalic trunk bifurcation to the proximal left subclavian artery bifurcation was replaced with a prosthetic graft to reconstruct the left common carotid artery. The median sternotomy approach was selected. Hypothermic circulatory arrest was performed using a cardiopulmonary bypass (CPB), and anterograde cerebral perfusion was conducted from the brachiocephalic trunk. The patient was discharged from the hospital without any complications 16 days after surgery. Magnetic resonance angiography was useful for diagnosing the precise position of the aneurysm. When encountering an aneurysm associated with the CAA in the transverse aortic arch or PLSVC, the median sternotomy approach is considered the treatment of choice.

Stent graft treatment for transverse arch and descending thoracic aorta aneurysms

The aim of this article is to review the recent relevant literature on endovascular repair of thoracic aortic aneurismal disease. The introduction of endovascular stent graft technology has ushered in a new era in therapy for diseases of the aortic arch and descending thoracic aorta. The technical challenges of stent graft deployment in the descending thoracic aorta, such as proximity to the great vessels and arch tortuosity, have been and remain a device engineering focus. More recently, repair of aortic arch aneurysms has been accomplished using both 'hybrid' (open and endovascular) and totally endovascular techniques. Endovascular stent grafting of aneurismal disease processes of the thoracic aorta is feasible and relatively safe. Exquisite judgment is essential for good results. These results generally rest on a broad knowledge base of thoracic aortic disease processes and experience in both open and endovascular surgery. Careful attention to patient anatomy and device specifications must be maintained. The key to the successful implementation of this technology lies in careful preoperative planning, intraoperative execution with safe device delivery, and prevention of central nervous system injury. Routine follow-up imaging is imperative to better understand the long-term results and indications for these new procedures.

Hybrid repair of an aortic arch aneurysm with complex anatomy: Right aortic arch and anomalous origin of supra-aortic vessels

We performed a one-stage hybrid surgical and endovascular procedure to manage a 6.5-cm right aortic arch aneurysm associated with anomalous origin of the supra-aortic vessels in a 70-year-old man. Complete surgical rerouting of the supra-aortic vessels was followed by the endovascular repair of the right aortic arch aneurysm with a Zenith TX2 stent graft (Cook, Bloomington, Ind) and Z-track plus introducer system. The procedure was successfully completed with exclusion of the aortic arch aneurysm, and the patient was discharged on postoperative day 7. Aortic arch aneurysms with complex anatomy may be successfully treated with a less invasive hybrid approach using new generation devices.

Endoluminal repair of distal aortic arch aneurysms causing aorto-vocal syndrome

We have evaluated the efficacy of endovascular repair of distal aortic arch aneurysms (DAAA) causing recurrent laryngeal nerve palsy. Eight patients (five male and three female) with median age of 72 years (range: 59-80) presented with left recurrent laryngeal nerve palsy associated with DAAA. All patients were considered unfit for open surgery. The median aneurysm size was 5.9 cm (range: 5-7.3). Thirteen stents were deployed: eight Gore, four Endofit and one Talent. Epidural anaesthesia was used in all patients. The left subclavian artery was covered in all and the left common carotid in three who had a preliminary right to left carotid-carotid bypass. Routine follow-up (FU) was with computed tomography (CT) at 3-6 months and yearly thereafter. Exclusion of the aneurysm sac was achieved in all patients. Thirty-day mortality was 0%, with no paraplegia or stroke. Early complications included: rupture of the external iliac artery (one) and common femoral artery thrombectomy (one). One patient died of unknown cause at 17 months. The mean FU in the remaining seven patients was 21 months (range: 6-51). Aneurysm size decreased in five, was unchanged in one and increased in one. Three patients had improvement in voice quality postoperatively. One patient had a recurrent type 1 endoleak which was restented twice. No late deaths have occurred. Though technically the procedures involved were more complicated, endovascular repair of DAAA causing aorto-vocal syndrome is safe and offers a realistic alternative to open surgery. Hoarseness of the voice can improve postoperatively and is associated with reduction in aortic sac diameter.

Hybrid Repair of Aortic Arch Aneurysms: A Totally Extrathoracic Approach with Branched Endografts in Two Patients

Of all of the aortic segments, the aortic arch is the last frontier for endovascular treatment. The main difficulty for arch repair is the lack of an appropriate proximal landing zone of at least 2 to 3 cm required for endograft sealing and anchoring to diminish the risk of endoleaks or migration. We used branched endografts to treat two cases of aortic aneurysms that required complete arch endografting, with successful aneurysm exclusion.

The Hybrid Total Arch Repair: Brachiocephalic Bypass and Concomitant Endovascular Aortic Arch Stent Graft Placement

Repair of aortic arch aneurysm is technically demanding, requiring complex circulatory management. Very large atherosclerotic saccular aneurysms of the arch are grave markers of extensive arch and brachiocephalic atheromatous disease and represent high surgical risks for perioperative neurologic complications. Operative morbidity and mortality may be prohibitive with traditional surgical intervention. We described our experience with a hybrid procedure for total arch repair with a brachiocephalic bypass with a trifurcated graft followed by concomitant placement of a stent graft in the arch. Since June 2005, we have performed the hybrid total arch repair in eight patients. A retrospective review was performed to evaluate the new technique. The mean age of the patients was 67 years with a mean aneurysm size of 8 cm (range, 4.4 to 10 cm). Significant comorbidities included carotid stenosis, chronic renal insufficiency, peripheral vascular disease, hypertension, and coronary artery disease. Two patients had previous Abdominal aortic aneurysm (AAA) repairs. Three patients had previous sternotomy for type A dissection, ascending aortic aneurysm repair, and coronary artery bypass grafting. Transesophageal echocardiogram demonstrated grade IV or V atheromatous disease in the arch and ascending aorta. Stent grafts were deployed antegrade directly into the ascending aorta in three patients and retrograde from the femoral artery in five patients. Technical success with complete aneurysmal exclusion was achieved in all patients (100%). At a mean follow-up period of 11.7 months, there was no incidence of endoleak. There was one death resulting from a perioperative myocardial infarction (first patient). Documented perioperative neurologic events (stroke) occurred in two patients, with both patients demonstrating no residual deficit at the time of discharge. Saccular arch aneurysms can be technically treated by total arch repair with brachiocephalic bypass and concomitant aortic arch stent graft placement. Hybrid arch repair provides an alternative to patients otherwise considered prohibitively high risk for traditional open arch repair.

Hybrid Repair of Aortic Arch Aneurysm

Background: Conventional surgical repair of the aortic arch using cardiopulmonary bypass and deep hypothermic circulatory arrest still carries a substantial rate of mortality and morbidity especially myocardial injury, and predicts a high incidence of permanent neurological injury.Endovascular stent-graft placement has been developed as an effective treatment modality in various diseases of the descending aorta. Technological improvements nowadays allow deployment in the distal arch in most instances. However, in case of total involvement of the aortic arch endovascular Sg repair, the challenge is to maintain blood flow to the brain and upper extremities, that may require covering one or more aortic branches in order to establish a secure proximal landing zone, and to ensure complete exclusion of the lesion.The aim of this study is to report our ongoing experience with endovascular treatment of aortic arch aneurysms. Methods: During two years, 16 patients were treated with thoracic stent-grafts, after aortic arch debranching for repair of aortic arch aneurysm. All patients were at high risk for open repair and not candidates for standard endovascular repair due to inadequate proximal landing zones.Device design and implant strategy were on the basis of evaluation of aortic morphology with spiral CT. Stent grafts were inserted to repair the arch after supra-aortic vessel transposition was performed. Follow-up was 100% complete (mean 18 ±2.5 months, range 12–24 months). Follow-up included clinical examination, chest X-ray and computed tomography at discharge, 6 months after stent-graft placement and yearly thereafter.Results: Primary technical success rate was 100%. Patency of all endografts and conventional bypasses was 100%. No endoleak or graft migration was observed. There were no neurological complications. Surgical conversion was never required.Conclusion: Hybrid aortic arch repair is technically challenging but feasible. This novel approach may be an alternative to standard open procedures in high-risk patients and emergency cases. However, the promising early results need to be confirmed by longer follow-up and larger series.

Endovascular repair of aortic arch and type-I thoracoabdominal aortic aneurysm after surgical supra-aortic revascularization – how to do it?

Objective: Open aortic arch aneurysm repair is associated with high morbidity and mortality rates. To minimize complications in high-risk patients suffering from extensive aneurysms of the aortic arch and the descending aorta, we performed off-pump endovascular stent-graft repair after surgical supra-aortic revascularization.

Endovascular repair of aortic arch aneurysm after achievement of local anesthesia

Endovascular repair of aortic arch aneurysm after achievement of local anesthesia

Activation of a Neutrophil-Derived Inflammatory Response in the Airways During Cardiopulmonary Bypass

Cardiopulmonary bypass (CPB) is believed to cause postoperative lung dysfunction. To more closely examine the inflammatory processes occurring in the airways during CPB, we serially measured inflammatory mediators, with the assistance of a new bronchoscopic microsample probe, in 11 patients undergoing repair of aortic arch aneurysms. Epithelial lining fluid (ELF) and arterial blood were sampled simultaneously after induction of anesthesia, at the time of pulmonary reperfusion, and at the end of surgery. A decrease in the PaO2/FiO2 ratio was observed at the end of surgery (P = 0.029). Although the ELF concentrations of interleukin (IL)-8, IL-6, and neutrophil elastase had increased significantly at the end of surgery (median = 23,200, 1818, and 12,900 microg/mL, respectively), they did not correlate with the degree of hypoxemia. Neutrophil elastase increased significantly at the time of pulmonary reperfusion, before IL-8 and IL-6, and independently of blood transfusions. At the end of surgery, IL-6 in ELF correlated with total blood transfusion volume (rho = 0.731, P = 0.011). These results indicate that a neutrophil-derived inflammatory response is activated in the airway in the early phase of CPB.

Combined surgical and endovascular treatment of aortic arch aneurysms

Traditional repair of aortic arch aneurysms requires cardiopulmonary bypass, hypothermia, and circulatory arrest and is associated with considerable morbidity and mortality. Endovascular stent-graft placement has developed as a safe and effective treatment for various diseases of the descending aorta and, recently, even in delicate anatomic regions such as the aortic arch. The aim of this study is to review our clinical experience with endovascular treatment of aortic arch aneurysms after surgical transposition of supra-aortic vessels. Fifteen patients received thoracic stent-graft implants after aortic debranching for repair of aortic arch aneurysms during the 3-year period ending December 31, 2005. All patients were not candidates for standard endovascular repair due to inadequate proximal landing zones on the aortic arch. Device design and implant strategy were determined by an evaluation of aortic morphology with angiography and computed tomography (CT) scanning. Stent-grafts were used to repair the arch after supra-aortic vessel transposition was performed. The endografts were implanted transfemorally or via an iliac Dacron conduit graft using standardized endovascular techniques. Follow-up was 100% complete (mean, 18 +/- 2.5 months; range, 12 to 36 months). Outcome variables included death and treatment failure (endoleak, aortic rupture, reintervention, or aortic-related or sudden death). Follow-up included clinical examination, chest radiograph, and CT at discharge, 6 months after stent-graft placement, and yearly thereafter. Stent-graft deployment success was 100% after staged supra-aortic vessel transposition. Patency of all endografts and conventional bypasses was 100%. No endoleak or graft migration was observed. There were no neurologic complications. One patient died 2 months after the procedure from pulmonary complications. Repair of aortic arch aneurysms by sequential transposition of the supra-aortic branches and endovascular stent-graft placement is feasible. Extended application of this technique will enable safe and effective treatment of a highly selected subgroup of patients with aortic aneurysms by avoiding conventional arch aneurysm repair in deep hypothermia and circulatory arrest.

Endovascular repair of a proximal aortic arch aneurysm: A novel approach of supra-aortic debranching with antegrade endograft deployment via an anterior thoracotomy approach

Although open surgical repair continues to be the standard therapy for thoracic aortic aneurysms, endovascular intervention has evolved into an acceptable strategy for patients who have prohibitive risks for conventional surgical treatments. Aortic arch aneurysm, in particular, is associated with substantial surgery-related morbidities, yet is typically not suitable for endovascular intervention. We describe a combined technique of supra-aortic trunk debranching through an anterior thoracotomy followed by endovascular repair of a large proximal arch aneurysm in an 82 year-old man 8 years after an ascending aortic aneurysm repair.

Transverse Aortic Arch Replacement Associated with MAGIC Syndrome: Case Report and Literature Review

We report a case of ascending and transverse aortic arch aneurysm repair with aortic valve replacement in a patient with MAGIC syndrome (mouth and genital ulcers with inflamed cartilage), the unusual setting of both Behçet's disease and relapsing polychondritis.

Experiences of Intentional Carotid Stenting in Endovascular Repair of Aortic Arch Aneurysms—Two Case Reports

Endovascular repair of thoracic aneurysms has emerged as an attractive alternative especially in patients at high risk. However, the left common carotid artery limits the use of stent-grafts in aneurysms located in the aortic arch or close to the left subclavian artery. We report two cases with aneurysms in the distal arch and proximal descending aorta, where we have used a carotid stent in juxtaposition to an aortic stent-graft, to gain a longer proximal neck in the aortic arch in an attempt not to rely only on a by-pass graft feeding the left carotid artery.

Important contributions to cardiothoracic surgery by Japanese Thoracic and Cardiac Surgeons

Cardiothoracic surgeons in Japan have made outstanding contributions to our knowledge and therapy of diseases and anomalies of the heart, lungs, esophagus, chest wall and diaphragm. It is an honor for me to address this subject at the 57th Annual Meeting of the Japanese Association for Thoracic Surgery in Sapporo because your President, Tomio Abe, is a valued friend and colleague who worked with me and my group as a Research Fellow at Washington U. from 1970-1973. He was recommended by Prof. Juro Wada, then the Chief in Sapporo. I was privileged to meet Prof. Wada at U.S. meetings. One of Prof. Wada's many contributions was the first cardiac transplant in Japan. Dr. Abe's work in St. Louis led to 12 publications and he was the first author of two papers. Since, his contributions expanded to more than 550 publications on treatment of complex congenital heart diseases, ventricular assistance, myocardial protection, valvular heart disease and aortic aneurysms. An operation for correction of Taussig-Bing malformation reported in 1984 is now referred to as the Abe operation. Torikata, in 1925, introduced "free thoracotomy" with no differential pressure. In 1933, Ohsawa successfully resected the esophagus with immediate reconstruction-the first in the world. Wada, in 1963, developed a thermodisc oxygenator and in 1966 the first tilting disc heart valve-the Wada Cutter Valve and other contributions as a worldwide ambassador for Japanese Surgery. Kawata, et al. showed better ventricular function after patch reconstruction of left ventricular aneurysms. Ueda, et al. revived retrograde cerebral perfusion for repair of aortic arch aneurysms. Nakayama, Akiyama and Isono made important contributions to esophageal cancer surgery. Kimoto, et al., in 1956, performed open cardiac surgery under direct vision with brain cooling by irrigation. Sakakibara, et al., Hikasa, et al., Atsumi, et al., and Takano and Akutsu made contributions to cardiac surgery. There were many other contributions by Japanese Surgeons.

Introduction of off-pump coronary artery bypass into aortic arch aneurysm repair: A new solution for the surgical treatment of multiorgan arteriosclerosis

T he simultaneous operation of aortic arch repair (AAR) and coronary artery bypass grafting has been associated with considerable operative morbidity and mortality. This combined procedure has been considered inevitable, with prolonged myocardial ischemia and cardiopulmonary bypass (CPB) time, which are significant risk factors for adverse outcome in aortic arch surgery. Appropriate myocardial protection is also mandatory to avoid perioperative myocardial failure. Recent technical improvements in off-pump coronary artery bypass (OPCAB) encouraged us to introduce OPCAB into this simultaneous operation to minimize the period of myocardial ischemia and CPB for improved surgical outcome in these patients with multiorgan arteriosclerosis.