ABSTRACT This study examines the socio-environmental impacts of pine (Pinus taeda) monocultures established by forestry companies on Guaraní territories in the Province of Misiones, Argentina. Conducted from an interdisciplinary perspective, the research addresses the concerns of a Guaraní community (Puente Quemado II) about the effects on their way of life and the potential toxicological risks resulting from changes to their territory including large monocultures of pine. By incorporating inputs from ethnography, ethnobiology, biology, ecology, ecotoxicology and toxicology, the study provides a comprehensive analysis of the impacts of the forest monoculture system on the communities. The findings indicate that the implementation of the monoculture system has negative impacts on the communities in terms of cultural and material resources, as well as toxicological risks. Collectively, these factors represent a high risk to their existence within the territory. However, conditions in the area allow for rapid ecological restoration, which, with appropriate policies, could serve as a strategy for historical repair efforts and the fulfillment of indigenous communities’ rights.