This paper explores the application of Nonlinear Model Predictive Control (NMPC) techniques, based on the Pontryagin Minimum Principle, for a minimum-propellant autonomous rendezvous maneuver in non-Keplerian Lunar orbits. The relative motion between the chaser and the target is described by the nonlinear dynamics of the circular restricted three body-problem, posing unique challenges due to the complex and unstable dynamics of near-rectilinear halo orbits. Key aspects of the proposed NMPC include trajectory optimization, maneuver planning, and real-time control, leveraging on its ability to satisfy complex mission requirements while ensuring safe and efficient spacecraft operations and in the presence of input and nonlinear/non-convex state constraints. The proposed formulation allows the design of a minimum-propellant controller, whose optimal control signal results to be bang–bang in time. A case study based on the Artemis III mission – where the docking of the Orion spacecraft to the Gateway station is planned – is illustrated in order to demonstrate the efficiency of the proposed approach, showcasing its potential for enhancing target tracking accuracy, while reducing propellant consumption.