We investigated the feasibility of renal duplex ultrasound in the identification of renal malperfusion in acute aortic dissection and evaluated whether intervention for renal malperfusion improved outcomes over best medical management alone. All patients with acute aortic dissections involving the renovisceral aorta who underwent a duplex ultrasound were included (2004-2016). We assessed duplex findings among patients who developed acute kidney injury (AKI; 50% increase in serum creatinine) and compared AKI, 30-day mortality, and overall survival among patients who underwent a procedure to treat malperfusion versus those who did not. Of 37 patients with acute dissection involving the renovisceral aorta (73% were male, 59% had type B dissection, mean follow-up 4.6±0.6years), 70% developed AKI, 11% required dialysis, and 5% developed permanent dialysis dependence. AKI was correlated with higher peak creatinine levels (4.2 vs. 2.2mg/dL, P<0.001), although 30-day mortality and overall survival were similar (both, P≥0.24). Progression to AKI was associatedwith significantly lower end-diastolic velocity (EDV) measurements on renal duplex (17 vs. 27cm/sec, P=0.03); an EDV threshold of 23cm/sec had a positive predictivevalue of 85% for AKI. Operative intervention (n=10) was associated with lower follow-up creatinine (0.9 vs. 2.1mg/dL, P=0.002), although there was no difference in progression to dialysis dependence, 30-day mortality, or overall survival (all, P≥0.34). Patients who developed AKI demonstrated characteristic renal duplex ultrasound findings with lower EDV measurements in the distal renal arteries bilaterally. Performing a renal malperfusion procedure was associated with normalization of postoperative creatinine without affecting 30-day mortality or overall survival.