You have accessJournal of UrologyKidney Cancer: Surgical Therapy I1 Apr 2015PD29-08 PREDICTIVE FACTORS FOR THE DEVELOPMENT OF RENAL INSUFFICIENCY FOLLOWING PARTIAL NEPHRECTOMY AND SUBSEQUENT RENAL FUNCTION RECOVERY Kyo Chul Koo, Dae Keun Kim, Sang Un Park, Kwang Hyun Kim, Woo Jin Bang, Hyung Joon Kim, Sung Yul Park, Changhee Yoo, Byung Ha Chung, Jin Seon Cho, and Koon Ho Rha Kyo Chul KooKyo Chul Koo More articles by this author , Dae Keun KimDae Keun Kim More articles by this author , Sang Un ParkSang Un Park More articles by this author , Kwang Hyun KimKwang Hyun Kim More articles by this author , Woo Jin BangWoo Jin Bang More articles by this author , Hyung Joon KimHyung Joon Kim More articles by this author , Sung Yul ParkSung Yul Park More articles by this author , Changhee YooChanghee Yoo More articles by this author , Byung Ha ChungByung Ha Chung More articles by this author , Jin Seon ChoJin Seon Cho More articles by this author , and Koon Ho RhaKoon Ho Rha More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.1795AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To evaluate predictors of renal insufficiency and subsequent renal function recovery following partial nephrectomy (PN). METHODS Data from 6 institutions on 393 patients who underwent PN for solid renal tumors between March 2001 and November 2013 were retrospectively reviewed. Clinicopathological features including age, sex, body mass index, histories of hypertension and diabetes mellitus, ASA score, tumor size, RENAL nephrometry score, operative time, clamp type, ischemic time, blood loss, and serum chemistry were assessed. Renal insufficiency was defined as a new onset eGFR <60 mL/min/1.73m2 after the operation on the second of two consecutive tests at least 3 months apart. Renal function recovery was defined as ≥eGFR 60 ml/min/1.73m2 following renal insufficiency. Multivariate models were performed to evaluate predictors of renal insufficiency and subsequent renal function recovery. RESULTS The median (IQR) age, tumor size, and follow-up period were 53 (45-63) years, 2.6 (1.9-3.8) cm, and 36 (12-48) months, respectively. Tumors were of low complexity in 48.9% of cases. Tumor complexity significantly correlated with ischemic time (p=0.001); however, not with postoperative renal insufficiency. Clavien-Dindo complication ≥GIII occurred in 10.5% patients and were mostly hemorrhagic. Renal insufficiency developed in 53 (13.5%) patients in which age ≥60 years (HR=3.457, 95% CI 1.947-6.137; p<0.001) and preoperative Cr ≥1.1 mg/ml (HR=3.533, 95% CI 2.047-6.100; p<0.001) were independent predictors. Among these patients, 20 (37.7%) patients exhibited renal function recovery within a median (IQR) period of 18 (12-36) months of which preoperative Cr <1.1 mg/ml revealed to be an independent predictor (HR=5.937, 95% CI 1.454-24.24; p=0.013). Retrospective nature of the study was a limitation. CONCLUSIONS Age ≥60 years and preoperative Cr ≥1.1 mg/ml were risk factors for renal insufficiency following PN; however, among patients exhibiting renal insufficiency, those with preoperative Cr <1.1 mg/ml may be expected for renal function recovery. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e652 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Kyo Chul Koo More articles by this author Dae Keun Kim More articles by this author Sang Un Park More articles by this author Kwang Hyun Kim More articles by this author Woo Jin Bang More articles by this author Hyung Joon Kim More articles by this author Sung Yul Park More articles by this author Changhee Yoo More articles by this author Byung Ha Chung More articles by this author Jin Seon Cho More articles by this author Koon Ho Rha More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...